A passive,reusable,and resonating wearable sensing system for ondemand,non-invasive,and wireless molecular stress biomarker detection

作     者：Shingirirai Chakoma Xiaochang Pei Huiting Qin Anita Ghandehari Sahar NajafiKhoshnoo Jerome Rajendran Rahim Esfandyarpour 

作者机构：Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaIrvineCA 92697USA Laboratory for Integrated Nano BioElectronics InnovationThe Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2024年第17卷第8期

页      面：7542-7556页

核心收录：

学科分类：0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the start-up funds provided to R.E.by the Henry Samueli School of Engineering and the Department of Electrical Engineering and Computer Science at the University of California Irvine 

主　　题：cortisol wearable flexible sensors three-dimensional(3D)nanomaterials printing reusable environmentally stable 

摘      要：The significant impact of stress on health necessitates accurate assessment methods,where traditional questionnaires lack reliability and *** advancements like wearables with electrocardiogram(ECG)and galvanic skin response(GSR)sensors face accuracy and artifact *** biosensors detecting cortisol,a critical stress hormone,present a promising ***,existing cortisol assays,requiring saliva,urine,or blood,are complex,expensive,and unsuitable for continuous *** study introduces a passive,molecularly imprinted polymer-radio-frequency(MIP-RF)wearable sensing system for real-time,non-invasive sweat cortisol *** system is wireless,flexible,battery-free,reusable,environmentally stable,and designed for long-term monitoring,using an inductance-capacitance *** transducer translates cortisol concentrations into resonant frequency shifts with high sensitivity(~160 kHz/(log(μM)))across a physiological range of 0.025–1μ*** with near-field communication(NFC)for wireless and battery-free operation,and threedimensional(3D)-printed microfluidic channel for in-situ sweat collection,it enables daily activity cortisol level *** of cortisol circadian rhythm through morning and evening measurements demonstrates its effectiveness in tracking and monitoring sweat cortisol levels.A 28-day stability test and the use of cost-effective 3D nanomaterials printing enhance its economic viability and *** innovation paves the way for a new era in realistic,on-demand health monitoring outside the laboratory,leveraging wearable technology for molecular stress biomarker detection.