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Cav1.2,Cav1.3,and Cav2.1 in th. mouse h.ppocampus during and after pilocarpine-induced status epilepticus

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Cav1.2,Cav1.3,and Cav2.1 in the mouse hippocampus during and...

氨甲喋呤、长春新碱、阿霉素和顺铂方案(MVAC)与阿霉素和顺铂方案(AC)对晚期原发或复发的已转移的子宫内膜癌患者化疗效果的Ⅲ期临床研究

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jie h.XU~1,Li LONG~3,Yong C.TANG~2,h.i T.h.~1,Feng R.TANG~(1,2,4) 1 Department of Anatomy and h.stology,Sch.ol of Medicine,Xi''an Jiaotong University,Xi''an 710061,Ch.na 2 Epilepsy Research.Laboratory,National Neuroscience Institute,Singapore 3 Department of Cell Biology and Genetics,Kunming Medical College,Kunming 650031,Ch.na 4Department of Anatomy,National University of Singapore,Singapore

＜正＞Calcium binding proteins are well known to be expressed by different groups of h.ppocampal intemeurons;h.wever,wh.th.r voltage-dependent calcium ch.nnels（Cav） are also localized in th.se neurons,ch.nged during and after status epilepticus（SE）,and involved in epileptic activity h.ve not been *** th. present study,we sh.wed th. colocalization of th.ee subtypes of voltage-gated calcium ch.nnels（Cav1.2,Cav1.3,or Cav2.1） with.different calcium binding proteins such.as calbindin（CB）,calretinin（CR）,and parvalbumin（PV）.At early stages during and after pilocarpine -induced status epilepticus（PISE）,significant ch.nges of expression of Cav 1.2,Cav 1.3（L-type）,and Cav2.1（P/q.type） were found in different groups of h.ppocampal *** expression of Cav 1.3 or Cav2.1 in reactive astrocytes was sh.wn at 1 week and 2 month. after *** th. latter time point,h.gh.r percentages of colocalization of PV and Cav1.2,CB,or PV and Cav1.3 or Cav2.1,lower percentages of CR and Cav 1.3 or Cav2.1 immunoposivie neurons were observed in gliotic CAl *** th.refore conclude th.t voltage-gated calcium ch.nnels are expressed by different groups of h.ppocampal intemeurons in th. *** acute stages during and after PISE,up- or down-regulation of Cav1.2,Cav1.3,or Cav2.1 in functionally different groups of intemeurons in CA1 area may be related to th. ch.nges of th.ir ***-regulation of Cav 1.2,Cav 1.3,or Cav2.1 in granule cells may be directly related to th. occurrence of SE. Th. induced expression of Cavl.3 or Cav2.1 in reactive astrocytes at 1 week and 2 month. after PISE suggests th.t Cav1.3 or Cav2.1-related calcium signaling in reactive astrocytes may be involved in initiation,maintenance or spread of seizure *** gliotic CA1 area at ch.onic stage（i.e.,2 month. after PISE）,th. occurrence of h.gh.r percentages of colocalization of PV and Cav1.2,CB,or PV and Cav1.3 or Cav2.1,lower percentages of CR and Cav1.3 or Cav2.1 immunopositive neurons may suggest th.

关键词： calcium ch.nnels intemeurons astrocytes h.ppocampus epilepsy

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世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 46-46页

作者： Long III h.J. Nelimark R.A. Podratz K.C. 李奎 Mayo Clinic Mayo Foundation 200 First Street SW Rochester MN 55905 United States

Objectives. Th. North.Central Cancer Treatment Group Ph.se III trial compared efficacy of meth.trexate, vinblastine, doxorubicin, and cisplatin (MVAC) with.doxorubicin plus cisplatin (AC) for patients with.advanced endometrial cancer. Meth.ds. Twenty- eigh. patients were randomly assigned to treatment with.doxorubicin 30 mg/m2 + cisplatin 70 mg/m2 IV q.4 weeks vs. meth.trexate 30 mg/m2 IV days 1, 15, and 22, vinblastine 3 mg/m2 IV days 2, 15, and 22, doxorubicin 30 mg/m2 IV day 2, and cisplatin 70 mg/m2 day 2 of a 4- week cycle. Th. trial was terminated prematurely due to slow accrual. Results. Prior to early closure of th. protocol, th.re were 15 patients entered on th. AC regimen and 13 to th. MVAC regimen. Th.re were 3 PR (20% ) for AC and 3 CR (23% ) and 3 PR (23% ) for MVAC. Median PFS was 4.0 month. for AC and 6.9 month. for MVAC. Median survival was 13.2 month. for AC and 16.8 month. for MVAC. Toxicity was substantial for MVAC vs. AC with.severe leukopenia seen in 69% vs. 33% of patients and severe th.ombocytopenia 23% vs. 0% . No treatment-related death. were seen. Discussion. MVAC and AC are active regimens in th. treatment of advanced/recurrent or metastatic endometrial cancer. Th. premature closure of th. protocol resulted in small patient numbers th.t left th. protocol underpowered to address th. primary objective of demonstrating improved CR rate for MVAC over AC. MVAC h.s substantial toxicity compared to AC and is not substantially superior to AC. MVAC cannot be considered as a standard for treatment in th.s patient population.

关键词： MVAC 氨甲喋呤顺铂方案化疗效果长春新碱中位生存时间标准治疗方案白细胞减少样本量

Precision measurement of th. integrated luminosity of th. data taken by BESIII at center-of-mass energies between 3.810 GeV and 4.600 GeV

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Ch.nese Ph.sics C 2015年第9期39卷 1-7页

作者：麦迪娜 M.N.Ach.sov 艾小聪 O.Albayrak M.Albrech. D.J.Ambrose A.Amoroso 安芬芬安琪白景芝 R.Baldini Ferroli 班勇 D.W.Bennett J.V.Bennett M.Bertani D.Bettoni 边渐鸣 F.Bianch. E.Boger O.Bondarenko I.Boyko R.A.Briere 蔡浩蔡啸 O.Cakir A.Calcaterra 曹国富 S.A.Cetin 常劲帆 G.Ch.lkov 陈刚陈和生陈海云陈江川陈玛丽陈申见谌炫陈旭荣陈元柏程和平褚新坤 G.Cibinetto D.Cronin-h.nnessy 代洪亮代建平 A.Dbeyssi D.Dedovich.邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董超董静董燎原董明义杜书先段鹏飞范荆州方建房双世方馨方易 L.Fava F.Feldbauer G.Felici 封常青 E.Fioravanti M.Fritsch.傅成栋高清高原宁高榛 I.Garzia 耿聪 K.Goetzen 龚文煊 W.Gradl M.Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭玥 Y.P.Guo Z.h.ddadi A.h.fner 韩爽韩艳良郝喜庆 F.A.h.rris 何康林何振亚 T.h.ld 衡月昆侯治龙胡琛胡海明胡继峰胡涛胡誉黄光明黄光顺黄海鹏黄金书黄性涛黄勇 T.h.ssain 纪全姬清平季晓斌季筱璐姜丽丽姜鲁文江晓山焦健斌焦铮金大鹏金山 T.Joh.nsson A.Julin N.Kalantar-Nayestanaki 康晓琳康晓珅 M.Kavatsyuk B.C.Ke R.Kliemt B.Kloss O.B.Kolcu B.Kopf M.Kornicer W.Kueh. A.Kupsc 赖蔚 J.S.Lange M.Lara P.Larin C.Leng 李春花李澄李德民李飞李刚李海波李家才李瑾李康李科李蕾李培荣李腾李卫东李卫国李晓玲李小梅李小男李学潜李志兵梁昊梁勇飞梁羽铁廖广睿 D.X.Lin(Lin) 刘北江刘春秀刘福虎刘芳刘峰刘宏邦刘汇慧刘欢欢刘怀民刘杰刘觉平刘晶译刘凯刘魁勇刘兰雕刘佩莲刘倩刘树彬刘翔刘晓霞刘玉斌刘振安刘志强 Zh.q.ng Liu h.Loeh.er 娄辛丑吕海江吕军光鲁睿其卢宇卢云鹏罗成林罗民兴 T.Luo 罗小兰吕蒙吕晓睿马凤才马海龙马连良马秋梅马斯马天马旭宁马晓妍 F.E.Maas M.Maggiora q.A.Malik 冒亚军毛泽普 S.Marcello J.G.Messch.ndorp 闵建闵天觉 R.E.Mitch.ll 莫晓虎莫玉俊 C.Morales Morales K.Moriya N.Yu.Much.oi h.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛顺利牛讯伊馬鵬欧阳群 S.Pacetti P.Patteri M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 R.Poling 濮亚男祁鸣钱森乔从丰秦丽清覃拈秦小帅秦瑶秦中华邱进发 K.h.Rash.d C.F.Redmer 任海龙 M.Ripka 荣刚阮向东 V.Santoro A.Sarantsev M.Savrié K.Sch.enning S.Sch.mann 单葳邵明沈成平沈培迅沈肖雁盛华义宋维民宋欣颖 S.Sosio S.Spataro 孙功星孙俊峰孙胜森孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 I.Tapan E.h.Th.rndike M.Tiemens D.Toth.M.Ullrich.I.Uman G.S.Varner 王斌王滨龙王东王大勇王科王亮亮王灵淑王萌王平王佩良王庆娟王思广王炜王雄飞王雅迪王贻芳王亚乾王铮王志刚王志宏王至勇 T.Weber 魏代会韦江波 P.Weidenkaff 文硕频 U.Wiedner M.Wolke 伍灵慧吴智夏力钢夏宇肖栋肖振军谢宇广修青磊许国发徐雷徐庆君徐庆年徐新平严亮鄢文标闫文成颜永红杨洪勋杨柳杨迎杨永栩叶桦叶梅叶铭汉殷俊昊俞伯祥喻纯旭于海旺俞洁晟苑长征袁文龙袁野 A.Yuncu A.A.Zafar A.Zallo 曾云张丙新张炳云张驰张长春张达华张宏浩章红宇张佳佳张杰磊张 Institute of h.gh.Energy Ph.sics G.I.Budker Institute of Nuclear Ph.sics SB RAS (BINP) th. Novosibirsk State University Carnegie Mellon University Boch.m Ruh.-University University of Roch.ster Rochester University of Turin INFN University of Science and Tech.ology of Ch.na INFN Laboratori Nazionali di Frascati Peking University Indiana University INFN Sezione di Ferrara University of Minnesota Joint Institute for Nuclear Research th. Moscow Institute of Ph.sics and Tech.ology KVI-CART University of Groningen Wuh.n University Istanbul Aydin University Ankara University Dogus University th. Functional Electronics Laboratory Tomsk State University Beih.ng University Nanjing University Lanzh.u University h.angsh.n College Sh.ngh.i Jiao Tong University h.lmh.ltz Institute Mainz Joh.nnes Gutenberg University of Mainz Liaoning University Nankai University Zh.ngzh.u University Tsingh.a University University of Eastern Piedmont GSI h.lmh.ltzcentre for h.avy Ion Research.Gmbh Guang Xi University Nanjing Normal University h.nan Normal University University of h.waii Central Ch.na Normal University Sh.ndong University University of th. Punjab Uppsala University Currently at Istanbul Arel University Justus Liebig University Giessen II.Physikalisches Institut Seoul National University h.ngzh.u Normal University Beijing Institute of Petroch.mical Tech.ology University of Ch.nese Academy of Sciences Sun Yat-Sen University Sich.an University Guangxi Normal University Sh.nxi University h.nan University of Science and Tech.ology University of Texas at Dallas h.nan University Zh.jiang University COMSATS Institute of Information Tech.ology INFN and University of Perugia th. NRC "Kurch.tov Institute" University of Ferrara Uludag University Sooch.w University Ch.na Center of Advanced Science and Tech.ology Bogazici University University of South.Ch.na

From December 2011 to May 2014, about 5 fb^-1 of data were taken with.th. BESIII detector at center-of- mass energies between 3.810 GeV and 4.600 GeV to study th. ch.rmonium-like states and h.gh.r excited ch.rmonium states. Th. time-integrated luminosity of th. collected data sample is measured to a precision of 1% by analyzing events produced by th. large-angle Bh.bh. scattering process.

关键词： precision measurement luminosity Bh.bh. scattering ch.rmonium

家族性渗出性玻璃体视网膜病遗传异质性的进一步证据:在一个常染色体显性遗传大家系中排除EVR1,EVR3,EVR4

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 29-29页

作者： Toomes C. Downey L.M. Bottomley h.M. 王海燕 MolecularMedicineUnit Clinical Sciences Building St. James' s University Hospital Leeds LS9 7TF United Kingdom

Background/aims: Familial exudative vitreoretinopath. (FEVR) is an inh.rited blinding condition ch.racterised by abnormal development of th. retinal vasculature. Th. aim of th.s study was to perform linkage analysis in a large family affected with.FEVR to determine wh.th.r th. mutation involved was in one of th. th.ee known autosomal dominant FEVR loci or in anoth.r as yet unidentified gene. Meth.ds: Genomic DNA samples from family members were polymerase ch.in reaction (PCR) amplified with.fluorescently tagged microsatellite markers spanning th. EVR1/EVR4 locus (11q.3- 14) and th. EVR3 locus (11p12- 13). Th. resulting PCR products were resolved using an automated DNA seq.encer and th. alleles sized. Th.se data were used to construct h.plotypes across each.locus and linkage analysis was performed to prove or exclude linkage. Results: Th. clinical evaluation in th.s family suggested features typical of FEVR, with.deficient periph.ral retinal vascularisation being th. common ph.notype in all affected individuals. h.wever, linkage analysis proved th.t th.s family h.s a form of FEVR genetically distinct from th. EVR1, EVR3 and EVR4 loci. Conclusion: Th. exclusion of linkage in th.s family to any of th. known FEVR loci proves th. existence of a fourth.locus for autosomal dominant FEVR and sh.ws th.t th.s rare disorder is far more h.terogeneous th.n previously th.ugh..

关键词：玻璃体视网膜 EVR1,EVR3,EVR4 渗出性族性视网膜血管遗传异质性连锁分析聚合酶链反应基因位点测序仪

表面增强激光解析-电离-飞行时间-质谱蛋白质芯片分析干眼症患者泪液的特性

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 38-38页

作者： Grus F.h.Podust V.N Bruns K. 王海燕 Department of Oph.h.lmology Universitaets-Aug-enklinik Langenbeckstrasse 1 55101 Mainz Germany

PURPOSE. Protein and peptides in tears play an important role in ocular surface diseases. In previous studies, ch.nges h.ve been demonstrated in th. electroph.retic protein profiles of patients with.dry eye. Th. purpose of th.s work was to determine th. usefulness of surface-enh.nced laser desorption/ionization time-of-fligh. mass spectrometry (SELDI-TOF-MS) Protein Ch.p Array (Ciph.rgen Biosystems, Inc., Fremont, CA) tech.ology for th. automated analysis of proteins and peptides in tear fluid. METh.DS. Patients with.dry eye (DRY, n=88) and h.alth. subjects (CTRL, n = 71) were examined. Th.ir tear proteins were analyzed using SELDI-TOF-MS ProteinCh.p Arrays with.th.ee different ch.omatograph.c surfaces (CM10 cation exch.nge, q.0 anion exch.nge, and h.0 reversed-ph.se) prepared by means of a laboratory liq.id-h.ndling robotic workstation. Th. data were analyzed by multivariate statistical tech.iq.es and artificial neural networks, and th. most important biomarkers were purified and identified by tandem MS. RESULTS. Complex patterns of tear proteins and peptides were detected. Th. different ch.omatograph.c surfaces revealed th. selective enrich.ent of proteins such.as lipocalin and lysozyme. Discriminant analysis demonstrated h.gh.y significant ch.nges in th. protein profiles in patients with.dry eye (Ph.a seven-peptide multimarker panel, an artificial neural network could differentiate between patients with.dry eye and h.alth. individuals with.a specificity and sensitivity of 90% . Th. identification of biomarkers revealed an increase of inflammatory markers in patients with.dry eye and a decrease of some proteins th.t may h.ve protective functions. CONCLUSIONS. Th. SELDI-TOF-MS tech.ology seems to be ideally suitable for th. mass screening of peptides and proteins in tears. Th.s h.gh.y sensitive approach.dramatically reduces th. analysis time and provides protein profiles with.great mass accuracy. Th.s, it may become a very useful tool in th. search.for

关键词：泪液蛋白质芯片蛋白质组芯片干眼症激光解析患者表面增强飞行航空运动质谱粒子谱

在压力性尿失禁妇女外科手术队列中与尿失禁频率相关的因素

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世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 11-11页

作者： Rich.er h.E. Burgio K.L. Brubaker L. 党慧敏 Department of Obstetrics and Gynecology Division of Medical Surgical Gynecology University of Alabama at Birmingham Birmingham AL United States Dr.

Objective: Th. aim of th.s study was to identify factors associated with.urinary incontinence severity at baseline in women undergoing surgery for stress incontinence. Study design: Baseline data were obtained from 650 women (age 28 to 81 years) with.stress incontinence participating in a randomized surgical trial. Severity of incontinence was defined by th. mean number of incontinence episodes per day recorded in a 3- day bladder diary. Th. relationsh.ps between severity and several baseline variables were examined, including demograph.cs, medical, obstetric, and gynecologic h.story, body mass index, smoking status, q. tip displacement, and Pelvic Organ Prolapse q.antification stage (POP- q.. Results: In a multivariable model, severity of incontinence was positively associated with.body mass index (P = .0003) and current smoking (P = .01), and negatively associated with.prolapse stage (P q.ip displacement (P = .042). Conclusion: Incontinence severity in a surgical population was independently associated with.2 modifiable factors, obesity and tobacco use, as well as pelvic support.

关键词：压力性尿失禁外科手术频率相关盆腔器官脱垂基线数据妇科学多变量模型产科学统计学特征吸

Modern pollen distributions in q.ngh.i-Tibetan Plateau and th. development of transfer functions for reconstructing h.locene environmental ch.nges

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Modern pollen distributions in Qinghai-Tibetan Plateau and t...

Measurement of th. integrated luminosities of th. data taken by BESⅢ at √s=3.650 and 3.773 GeV

中国科学院地质与地球物理研究所第11届（2011年度）学术年会

作者： h.uyuan Lu~(a,*),Naiq.n Wu~a,Kam-biu Liu~b,Liping Zh.~c,Xiangdong Yang~d,Tandong Yao~c,Luo Wang~a, q.an Li~a,Xingq. Liu~d,Caiming Sh.n~e,Xiaoq.ang Li~f,Guobang Tong~g,h.i Jiang~h.aKey Laboratory of Cenozoic Geology and Environment,Institute of Geology and Geoph.sics,Ch.nese Academy of Sciences,Beijing 100029,Ch.na b Department of Oceanograph. and Coastal Sciences,Louisiana State University,Baton Rouge,LA 70803,USA cInstitute of Tibetan Plateau Research.Ch.nese Academy of Sciences,Beijing 100085,Ch.na d State Key Laboratory of Lake Science and Environment,Nanjing Institute of Limnology and Geograph.,Ch.nese Academy of Sciences,Nanjing 210008,Ch.na e Atmosph.ric Sciences Research.Center,State University of New York,Albany,NY 12203,USA f Institute of Vertebrate Paleontology and Paleoanth.opology,Ch.nese Academy of Sciences,Beijing 100044,Ch.na g Institute of h.drology and Geology,Ch.nese Academy of Geological Sciences,Zh.ngding 050803,Ch.na h.State Key Laboratory of Estuarine and Coastal Research.East Ch.na Normal University,Sh.ngh.i 200062,Ch.na

Th.s study investigates th. distribution of modern pollen assemblages in th. q.ngh.i-Tibetan Plateau, Ch.na,based on surface soil samples collected at 1202 sites along an altitudinal gradient of 10 -5500 m asl,wh.re mean annual precipitation(MAP) ranges from 12 to 1840 mm and mean annual temperature(MAT) from -1 to 21.5℃.A total of 153 pollen taxa were found with.relative abundances greater th.n 1%in at least two *** correspondence analysis(CCA) was used to determine th. main environmental variables influencing pollen *** results reveal th.t MAP is th. most significant dominant ***,MAT,altitude(ALT),July temperature(MT7),and relative h.midity(h.h. are also significant variables th.t clearly follow th. gradients in th. CCA ordination, suggesting th.t pollen assemblages probably not only reflect a single climatic parameter,but also a variety of oth.r climatic inter-related parameters. Transfer functions,based on locally weigh.ed weigh.ed averaging(LWWA),were developed for MAP (R-boot = 0.89,RMSEP = 109 mm),MAT(R-boot = *** = 2.3℃),ALT(R-boot = 0.73, RMSEP = 597 m),h.h.R-boot = 0.82,RMSEP = 4.5%),and July mean precipitation(MP7)(R- boot = 0.87,RMSEP = 23 ram).Overall,our results confirm th.t pollen can provide reliable estimates of th. primary climatic *** application of th. LWWA model to th. fossil records of Ch.n Co Lake allowed q.antitative inferences to be made about h.locene climatic ch.nges in th. south.rn Tibetan Plateau,suggesting th.t LWWA is a robust calibration meth.d for q.antitative palaeo-environ-mental reconstruction based on pollen data in th. regions.

关键词： q.ngh.i-Tibetan plateau Vegetation Pollen Transfer functions h.locene Climatic ch.nges

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Ch.nese Ph.sics C 2013年第12期37卷 1-6页

作者：麦迪娜 M.N.Ach.sov O.Albayrak D.J.Ambrose 安芬芬安琪白景芝 R.Baldini Ferroli 班勇 J.Becker J.V.Bennett M.Bertani 边渐鸣 E.Boger O.Bondarenko I.Boyko S.Braun R.A.Briere V.Bytev 蔡浩蔡啸 O.Cakir A.Calcaterra 曹国富 S.A.Cetin 常劲帆 G.Ch.lkov 陈刚陈和生陈江川陈玛丽陈申见陈旭荣陈元柏程和平初元萍 D.Cronin-h.nnessy 代洪亮代建平 D.Dedovich.邓子艳 A.Denig I.Denysenko M.Destefanis 丁伟民丁勇董燎原董明义杜书先方建房双世 L.Fava 封常青 P.Friedel 傅成栋傅金林 O.Fuks 高原宁耿聪 K.Goetzen 龚文煊 W.Gradl M.Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭墩郭玉萍韩艳良 F.A.h.rris 何康林何苗何振亚 T.h.ld 衡月昆侯治龙胡深胡海明胡继峰胡涛黄光明黄光顺黄金书黄亮黄性涛黄勇 T.h.ssain 姬长胜纪全姬清平季晓斌季筱璐姜丽丽江晓山焦健斌焦铮金大鹏金山景繁凡 N.Kalantar-Nayestanaki M.Kavatsyuk B.Kloss B.Kopf M.Kornicer W.Kueh. 赖蔚 J.S.Lange M.Lara P.Larin M.Leyh. 李春花李澄李翠李德民李飞李刚李海波李家才李康李蕾李培荣李秋菊李卫东李卫国李晓玲李小男李学潜李秀荣李志兵梁昊梁勇飞梁羽铁廖广瑞 D.X.LinLin 刘北江 C.L.Liu 刘春秀刘福虎刘芳刘峰刘宏邦刘汇慧刘怀民刘觉平刘凯刘魁勇刘佩莲刘倩刘树彬刘翔刘玉斌刘振安刘志强刘智青 h.Loeh.er 娄辛丑鲁公儒吕海江吕军光吕晓睿卢云鹏罗成林罗民兴 T.Luo 罗小兰吕蒙马凤才马海龙马秋梅马斯马天马骁妍 F.E.Maas M.Maggiora q.A.Malik 冒亚军毛泽普 J.G.Messch.ndorp 阂建闵天觉 R.E.Mitch.ll 莫晓虎 h.Moeini C.Morales Morales K.Moriya N.Yu.Much.oi h.Muramatsu Y.Nefedov I.B.Nikolaev 宁哲 S.Nisar 马鹏欧阳群 S.Pacetti J.W.Park M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 R.Poling E.Prencipe 祁鸣钱森乔从丰秦丽清秦小帅秦瑶秦中华邱进发 K.h.Rash.d C.F.Redmer 荣刚阮向东 A.Sarantsev 邵明沈成平沈肖雁盛华义 M.R.Sh.ph.rd 宋维民宋新颖 S.Spataro B.Spruck 孙功星孙俊峰孙胜森孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 I.Tapan E.h.Th.rndike D.Toth.M.Ullrich.I.Uman G.S.Varner 王斌王东王大勇王科王亮亮王灵淑王萌王平王佩良王庆娟王思广王雄飞汪晓莲 Y.D.WangYadi 王贻芳王亚乾王铮王志刚王志宏王至勇魏代会韦江波 P.Weidenkaff 文群刚文硕频 M.Werner U.Wiedner 伍灵慧吴宁吴硕星吴蔚吴智夏力钢夏宇肖振军谢宇广修青磊许国发徐庆君徐庆年徐新平许志蕊薛镇严亮鄢文标闺文成颜永红杨洪勋杨迎杨永栩叶桦叶梅叶铭汉俞伯祥喻纯旭于海旺俞洁晟于帅鹏苑长征n 袁野 A.A.Zafar A.Zallo 臧石磊曾云张丙新张炳云张驰张长春张达华张宏浩章红宇张敬庆张家文张建勇张景芝张丽丽张书华张晓杰张学尧张瑶张银鸿张子平张振宇张正好赵光赵京伟赵雷赵玲赵明刚赵强赵书俊赵天池赵祥虎赵豫斌赵政国 A.Zh.mch.gov 郑波郑建平郑阳恒钟彬周莉周详周晓康周小蓉朱凯朱科军朱相雷朱莹春朱永生朱自安庄建邹冰松邹佳恒 Institute of h.gh.Energy Ph.sics Chinese Academy of Sciences G.I.Budker Institute of Nuclear Ph.sics SB RAS (BINP) Also at th. Novosibirsk State University Carnegie Mellon University Pittsburgh University of Roch.ster Rochester University of Science and Tech.ology of Ch.na INFN Laboratori Nazionali di Frascati Peking University Boch.m Ruh.-University Indiana University Bloomington University of Minnesota Minneapolis Joint Institute for Nuclear Research Also at th. Moscow Institute of Ph.sics and Tech.ology KVI University of Groningen Universitaet Giessen Wuh.n University Ankara University Dogol Caddesi Dogus University Nanjing University Lanzh.u University h.angsh.n College Joh.nnes Gutenberg University of Mainz University of Turin INFN Sh.ndong University Liaoning University Zh.ngzh.u University University of Eastern Piedmont Tsingh.a University GSI h.lmh.ltzcentre for h.avy Ion Research.Gmbh GuangXi University University of Ch.nese Academy of Sciences Nankai university Nanjing Normal University University of h.waii Central Ch.na Normal University h.nan Normal University University of th. Punjab h.lmh.ltz Institute Mainz h.ngzh.u Normal University Seoul National University Sun Yat-Sen University Sich.an University Sh.nxi University h.nan University of Science and Tech.ology Also at University of Texas at Dallas Zh.jiang University COMSATS Institute of Information Tech.ology INFN and University of Perugia University of Minnesota Also at th. PNPI Beih.ng University Uludag University Guangxi Normal University h.nan University Sooch.w University Ch.na Center of Advanced Science and Tech.ology University of South.Ch.na

Data sets were collected with.th. BESⅢ detector at th. BEPCⅡ collider at th. center-of-mass energy of √s=3.650 GeV during May 2009 and at √s=3.773 GeV from January 2010 to May 2011. By analyzing th. large angle Bh.bh. scattering events, th. integrated luminosities of th. two data sets are measured to be （44.49±0.02±0.44） pb-1 and （2916.94±0.18±29.17） pb-1, respectively, wh.re th. first error is statistical and th. second error is systematic.

关键词： Bh.bh. scattering events integrated luminosity cross section

因5q.5-q.2染色体缺失导致家族性腺瘤性息肉病与智力发育迟缓的病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 19-19页

作者： Finch.R. Moore h.G. Lindor N. J.G. Guillem 张欣 1275 York Avenue New York NY 10021 United States Dr.

Familial adenomatous polyposis, caused by mutations in th. adenomatous polyposis coli gene located at ch.omosome 5q.1, is an autosomal dominant syndrome ch.racterized by polyposis of th. colon and rectum and nearly 100 percent progression to colorectal cancer. We report a case of familial adenomatous polyposis and mental retardation caused by a ch.omosomal deletion at 5q.5-q.2. Ch.omosomal analysis is considered part of th. evaluation of ch.ldren with.mental retardation and developmental delay. Th. resulting karyotypes from h.gh.resolution ch.omosomal analysis can h.lp ch.racterize large deletions, some of wh.ch.involve known tumor suppressor genes. Because familial adenomatous polyposis may arise from de novo ch.omosomal deletions involving th. adenomatous polyposis coli gene locus, individuals with.ch.omosomal deletions involving 5q.1 sh.uld be considered at-risk for familial adenomatous polyposis and offered standard screening with.flexible sigmoidoscopy by 10 to 12 years of age.

关键词：家族性腺瘤性息肉病智力发育迟缓染色体缺失病例报道结肠直肠癌染色体分析常染色体显性肿瘤抑制基因肠息肉病染色体组型