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Establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor

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Stem Cell Discovery 2011年第2期1卷 21-28页

作者： Pravin Potdar sachin Chaugule 不详

Breast cancer remains a leading cause of morbidity and mortality in women mainly because of the propensity of primary breast tumors to metastasize. It is composed of heterogeneous cell populations with different biological properties. Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24-/low cells, which display stem cell like properties. In the present study, we have isolated breast cancer stem cells from non-metastasis tumor tissue, which is presently at passage 18 and designated as human Breast Cancer Mesenchymal Stem Cells (hBCMSCs) line. These cells showed spindle shaped morphology and formed mammos-pheres as well as pluripotency clones indicating their stem cell nature. Molecular marker study confirmed mesenchymal nature as well as pluripotency, plasticity and oncogenicity of these cells. The hBCMSCs cell line may likely contain a heterogeneous population of malignant cells. Interestingly, we also found that these cells exhibit BRCA 2 mutation, which was found in Indian population. Overall, this study revealed that hBCMSCs cell line may represent a suitable in vitro model to study the mechanism of breast cancer which further leads to an identification of molecular targets for future breast cancer targeted therapy.

关键词： Breast Cancer Stem Cells Breast Cancer BRCA2 Mesenchymal Stem Cells Molecular Markers

Review：Mg and Its Alloy--Scope, Future Perspectives and Recent Advancements in Welding and Processing

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Journal of Harbin Institute of Technology(New Series) 2017年第6期24卷 1-37页

作者： sachin Kumar Chuansong WU Institute of Materials Joining Shandong University Jinan 250061 China

This review article aims to analyze and evaluate the advantages, shortcomings, technological advancements and hereafter prospects in welding and processing of magnesium and its alloys. Studies have accounted that replacing other metals with Mg alloys will bring about in monumental weight reduction with significant addition in strength that could lead to dramatic transformation of metallic era of 21st century and onwards. However,wide application of Mg and its alloys depends on the development of advanced welding &joining technologies. The current paradigm and progress in welding,joining and processing of magnesium and its alloys are reviewed,and research trend in this field is briefly discussed.

关键词： magnesium Mg alloy processing welding joining recent advancements

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

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Journal of Sport and Health Science 2016年第2期5卷 176-182页

作者： sachin Wankhede Vishwaraman Mohan Prasad Thakurdesai Department of Microbiology Smt.Kashibai Navale Medical College Department of Scientific Affairs Indus Biotech Private Limited

Purpose： To evaluate the efficacy and safety of the glycoside fraction of fenugreek （Trigonellafoenum-graecum） seeds （Fenu-FG） on physiologi- cal parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design. Methods： Sixty healthy male subjects were randomized to ingest capsules of Fenu-FG （1 capsule of 300 rag, twice per day） or the matching placebo at a 1：1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment （baseline） and at the end of the treatment （8 weeks）. The efficacy outcome included serum testosterone （total and free） levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity （serum creatinine and blood urea nitrogen）, and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed. Results： Fenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplemen- tation was found to be safe and well-tolerated. Conclusion： Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects.

关键词： Anabolic Androgenic Fenugreek seeds Glycosides Randomized controlled study Resistance training

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

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Chinese Chemical Letters 2013年第5期24卷 422-424页

作者： Santosh V.Goswami Prashant.B.Thorat Vijay N.Kadam sachin A.Khiste Sudhakar R.Bhusare Department of Chemistry Dnyanopasak College

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3- chlorophenylboronic acid as a catalyst under ambient temperature *** three-component reaction of indoles,aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent *** protocol presents some remarkable features such as mild reaction conditions,simple workup procedure and excellent yields.

关键词： 3-Aminoalkylaed indoles 3-Chlorophenylboronic acid Aromatic aldehyde N-Methylaniline Indoles

Borderline resectable pancreatic tumors:Is there a need for further refinement of this stage?

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 319-324页

作者： Shailesh V Shrikhande Supreeta Arya Savio George Barreto sachin Ingle Melroy A D'Souza Rohini Hawaldar Parul J Shukla Department of Hepato-Pancreato-Biliary Surgical Oncology Department of Radiology Tata Memorial Hospital Department of Surgery Royal Adelaide Hospital Clinical Research Secretariat

BACKGROUND:The ideal treatment of patients with 'borderline resectable pancreatic tumors (BRTs)' needs to be *** protocols advise neoadjuvant chemo(radio)therapy,although some patients may appear to have BRT on preoperative imaging and a complete resection may be achieved without the need for vascular *** aim of the present study was to identify specific findings on preoperative imaging that could help predict in which patients with BRT a complete resection,with or without vascular resection (VR),could be ***:Twelve patients with BRTs were *** location,maximum degree of circumferential contact (CC),length of contact of the tumor with major vessels (LC),and luminal narrowing of vessels at the point of contact with the tumor (venous deformity,VD) were graded on preoperatively acquired multidetector computed tomography (MDCT) images and then compared with the intraoperative findings and need for ***:A complete resection (R0) was achieved in 10 patients with 2 having microscopic positive margins (R1) on histopathology at the uncinate *** of the 10 patients required VR (40%).In 3 of the 4 patients whose tumors required VRs,CC was ≥grade III and VD was grade *** did not influence the need for ***:It is possible to achieve a complete resection at the first instance in patients found to have BRTs on preoperative *** MDCT-based grading systems and our proposed criteria may help identify such patients,thus avoiding any delay in curative resections in such patients.

关键词： pancreatic head carcinoma pancreatic cancer pancreatic neoplasms resection

Optimization of AWJM Process Parameters on 3D-Printed Onyx-Glass Fiber Hybrid Composite

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哈尔滨工业大学学报:英文版 2023年第2期30卷 84-98页

作者： Dharmalingam G Arun Prasad M Deepak Panghal sachin Salunkhe Siva kumar M Rathinasuriyan C Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyAvadiChennai-600062Tamil NaduIndia Department of Fashion Technology National Institute of Fashion TechnologyNew Delhi-11016India

Compared with conventional manufacturing methods, the additive manufacturing technique enhances mechanical properties. The present investigation of additive manufacturing technique is focused on delamination studies of Onyx-Glass Fiber Hybrid Polymer Composite(OGFHPC) along with surface roughness properties during machining(drilling) of composites through abrasive water jet machining(AWJM). However, delamination is a major issue during machining of OGFHPC. In order to overcome these drawbacks, the fabrication of OGFHPC was carried out using fused deposition modeling(FDM) technology which is an additive manufacturing method with Mark forged Mark Two 3D-composite printer. The machinability studies were conducted for drilling operation through AWJM process with different abrasive mass flow rates, drilling diameters and traverse speeds. These drilling machinability process parameters were optimized through the design of experiments-Taguchi analysis followed by the analysis of variance(ANOVA) and validated through the Harmony Search Algorithm(HSA), Whale Optimization Algorithm(WOA) and Grey Wolf Optimization Algorithm(GWO). It was observed that minimum delamination and surface roughness of OGFHPC were optimized for AWJM at abrasive mass flow rates(450 g/min), drilling diameters(12 mm) and traverse speed rate(30 mm/min).

关键词： Onyx-Glass composite fused deposition modeling AWJM delamination surface roughness Taguchi analysis

On global behavior for complex soliton solutions of the perturbed nonlinear Schrödinger equation in nonlinear optical fibers

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Journal of Ocean Engineering and Science 2022年第5期7卷 431-443页

作者： M.S.Osman Hassan Almusawa Kalim U.Tariq Sadia Anwar sachin Kumar Muhammad Younis Wen-Xiu Ma Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt Department of Mathematics Faculty of Applied ScienceUmm Alqurah UniversityMakkah 21955Saudi Arabia Department of Mathematics College of SciencesJazan UniversityJazan 45142Saudi Arabia Department of Mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi 110007India Centre for Undergraduate Studies University of the PunjabLahore 54590Pakistan Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina Department of Mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics and Statistics University of South FloridaTampaFL 33620USA School of Mathematical and Statistical Sciences North-West UniversityMafikeng CampusPrivate Bag X2046Mmabatho 2735South Africa

In this research article,the perturbed nonlinear Schrödinger equation(P-NLSE)is examined by utilizing two analytical methods,namely the extended modified auxiliary equation mapping and the generalized Riccati equation mapping ***,we establish several sorts of new families of complex soliton wave solutions such as hyperbolic functions,trigonometric functions,dark and bright solitons,periodic solitons,singular solitons,and kink-type solitons wave solutions of the *** the mentioned methods,the results are displayed in 3D and 2D contours for specific values of the open *** obtained findings demonstrate that the implemented techniques are capable of identifying the exact solutions of the other complex nonlinear evolution equations(C-NLEEs)that arise in a range of applied disciplines.

关键词： P-NLSE Optical solitons The AEM method The REM method

Investigation on Effect of Radial and Extended Fins in PCM Heat Sink for LED Cooling

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哈尔滨工业大学学报:英文版 2023年第5期30卷 89-98页

作者： Thangamani Ramesh Ayyappan Susila Praveen Praveen Bhaskaran Pillai sachin Salunkhe J.Paulo Davim Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai600062Tamil NaduIndia Department of Mechanical Engineering Kalasalingam Academy of Research and EducationKrishnankoil626126Tamil NaduIndia Department of Mechanical and Aeronautical Engineering Clean Energy Research GroupUniversity of PretoriaPretoria0002South Africa Department of Mechanical Engineering University of AveiroCampus SantiagoAveiro 3810-193Portuga

This work focuses on the efficiency of the LED acting as the heat sink containing Phase Change Material(PCM). Three different heat sink configurations(H-1, H-2, and H-3) are used in this study. Input power and the number of fins are altered to find their effect on junction temperatures, luminous flux, and thermal resistance. The junction temperature of heat sink H-3 with PCM decreased by 3.1 % when compared with heat sink devoid of PCM at 10 W. The thermal resistance of the heat sink H-3 is reduced by 18.2 % when compared to its counterpart devoid of PCM at 10 W. The luminous flux of the PCM filled heat sink H-3 is found to increase by 12.15 % against the PCM not filled heat sink H-1 at 10 W. The H-3 heat sink with PCM showed superior performance because of the enhanced natural convection and conduction in bulk PCM with fins, and with added high latent heat capacity of PCM.

关键词： LED phase change material thermal resistance junction temperature luminous flux

Hyperparameter Tuning Bidirectional Gated Recurrent Unit Model for Oral Cancer Classification

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Computers, Materials & Continua 2022年第12期73卷 4541-4557页

作者： K.Shankar E.Laxmi Lydia sachin Kumar Ali S.Abosinne Ahmed alkhayyat A.H.Abbas Sarmad Nozad Mahmood Department of Computer Science South Ural State UniversityChelyabinsk454080Russia Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Computer Technical Engineering Department College of Technical Engineeringthe Islamic UniversityNajaf54001Iraq College of Technical Engineering the Islamic UniversityNajafIraq College of Information Technology Imam Ja’afar Al-Sadiq UniversityAl-Muthanna66002Iraq Computer Technology Engineering College of Engineering TechnologyAl-Kitab UniversityIraq

Oral Squamous Cell Carcinoma(OSCC)is a type of Head and Neck Squamous Cell Carcinoma(HNSCC)and it should be diagnosed at early stages to accomplish efficient treatment,increase the survival rate,and reduce death *** imaging is a wide-spread standard used for OSCC ***,it is a cumbersome process and demands expert’s ***,there is a need exists for automated detection ofOSCC using Artificial Intelligence(AI)and Computer Vision(CV)*** this background,the current research article introduces Improved Slime Mould Algorithm with Artificial Intelligence Driven Oral Cancer Classification(ISMA-AIOCC)model on Histopathological images(HIs).The presented ISMA-AIOCC model is aimed at identification and categorization of oral cancer using *** the initial stage,linear smoothing filter is applied to eradicate the noise from ***,MobileNet model is employed to generate a useful set of feature ***,Bidirectional Gated Recurrent Unit(BGRU)model is exploited for classification *** the end,ISMA algorithm is utilized to fine tune the parameters involved in BGRU ***,ISMA algorithm is created by integrating traditional SMA and ChaoticOppositional Based Learning(COBL).The proposed ISMA-AIOCC model was validated for performance using benchmark dataset and the results pointed out the supremacy of ISMA-AIOCC model over other recent approaches.

关键词： Computer aided diagnosis deep learning BGRU biomedical imaging oral cancer histopathological images