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Modelling air change rate of naturally ventilated dairy buildings using response surface methodology and numerical simulation

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Building Simulation 2021年第3期14卷 827-839页

作者： Qianying Yi Guoqiang Zhang Barbara Amon sabrina Hempel David Janke Chayan Kumer Saha Thomas Amon Department of engineering Aarhus UniversitySkejby Nordlandsvej 3018200 AarhusDenmark Department of engineering for Livestock Management Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 70014469 PotsdamGermany Department of Technology Assessment and Substance Cycles Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 10014469 PotsdamGermany Faculty of Civil engineering Architecture and Environmental EngineeringUniversity ofZielona GoraLicealna 9/965-417 Zielona GoraPoland Department of Farm Power and Machinery Bangladesh Agricultural UniversityBAU Main Road2202 MymensinghBangladesh Institute of Animal Hygiene and environmental Health Department of Veterinary MedicineFree University BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany

The air change rate(ACR)of naturally ventilated dairy buildings(NVDBs)plays an important part in the design and control of the ventilation system,as well as in the estimation of the gaseous emission *** objectives of this research were to model the ACR based on a quantitative investigation of the relationship between the ACR and its potential influencing factors,including the opening ratio(r),the building length to width ratio(a),the wind speed(U),and the wind direction(0).The investigations were performed using the response surface methodology integrated with the Box-Behnken design and Computational Fluid Dynamics(CFD)*** response surface models of the ACR of NVDBs were established for three opening ratio ranges of 5%-42.5%,42.5%-80%,and 5%-80%,*** was found that the selection of the opening ratio range had almost no effect on the developed response surface *** results showed that the ACR of NVDBs was not influenced by a,but was significantly affected by r,U,6,and interaction effects between every two of the three *** highest ACR was 6.7 s^(-1),6.0 s^(-1),and 4.0 s^(-1)when 0,U,and r was at their respective medium value while the rest parameters were at the highest values,indicating that the r played an important role in the value of *** was concluded that in the prediction of the ACR of a building,the influences of both individual and interactional effects of 0,U,and r should be considered.

关键词： emission estimation computational fluid dynamics Box-Behnken design response surface model

A comparative study of Neogymnomyces virgineus,a new keratinolytic species from dung,and its relationships with the Onygenales

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Fungal Diversity 2012年第1期52卷 13-34页

作者： Francesco Doveri Susanna Pecchia Mariarosaria Vergara sabrina Sarrocco Giovanni Vannacci Department of Tree Science Entomology and Plant Pathology“G.Scaramuzzi”Section Plant PathologyUniversity of Pisavia del Borghetto 8056124 PisaItaly

Isolations of onygenalean fungi were made recently from different dung samples from Italy.A striking snowwhite species with gymnothecial ascomata,developed in damp chamber on dormouse dung collected in a cave,was subjected to keratinolytic tests and morphological,cultural,and phylogenetic *** keratinolytic ability of this species,associated with a Chrysosporium anamorph and a sexual state of appendiculate reticuloperidia and oblate ascospores,allows it to be accomodated in *** ascomata,blunt or subcapitate peridial appendages,pitted ascospores,and tuberculate conidia suggest it to be a new Neogymnomyces,and this was confirmed by parsimony analyses of LSU and ITS nrDNA *** recent phylogenetic analyses,the morphological and physiological features of order Onygenales and its families are re-examined and *** the introduction of a new species,Neogymnomyces is reviewed and compared with all other genera in *** Chrysosporium imperfect state of Neogymnomyces virgineus is described and compared to the anamorph of *** is also compared to the atypical Chrysosporium merdarium and to several other Chrysosporium species with echinulate to verrucose-tuberculate conidia,isolated from guano,dung,and nitrogen-rich soils in *** onygenalean fungi isolated from any kind of dung are discussed and their facultative coprophily ascribed to variable faecal contents of keratin or other degradable substances.A key to the families and genera of the Onygenales is provided.

关键词： Chrysosporium Coprophily Key Keratinolysis/keratinophily New Neogymnomyces Onygenalean fungi Phylogeny

A new hemostatic agent composed of Zn^(2+)-enriched Ca^(2+)alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo

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Bioactive Materials 2022年第12期7卷 368-382页

作者： Anne-Charlotte Ponsen Richard Proust sabrina Soave Françoise Mercier-Nom´e Isabelle Garcin Laurent Combettes Jean-Jacques Lataillade Georges Uzan INSeRM UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plateforme d’Histologie Immunopathologie de Clamart(PHIC) Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Universit´e Paris-Saclay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSeRM UMRS 1174 Universit´e Paris-SaclayOrsayFrance Centre de Transfusion Sanguine des Arm´ees ClamartFrance

To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a negative impact on tissue repair in the resected organ. To avoid complications and obtain a hemostatic agent that promotes tissue repair, a zinc-supplemented calcium alginate compress was developed: HeMO-IONIC®. This compress is non-absorbable and is therefore removed once hemostasis has been achieved. After demonstrating the hemostatic efficacy and stability of the blood clot obtained with HeMO-IONIC, the impact of Surgicel, TachoSil, and HeMO-IONIC on cell activation and tissue repair were compared (i) in vitro on endothelial cells, which are essential to tissue repair, and (ii) in vivo in a mouse skin excision model. In vitro, only HeMO-IONIC maintained the phenotypic and functional properties of endothelial cells and induced their migration. In comparison, Surgicel was found to be highly cytotoxic, and TachoSil inhibited endothelial cell migration. In vivo, only HeMO-IONIC increased angiogenesis, the recruitment of cells essential to tissue repair (macrophages, fibroblasts, and epithelial cells), and accelerated maturation of the extracellular matrix. These results demonstrate that a zinc-supplemented calcium alginate, HeMO-IONIC, applied for 10 min at the end of surgery and then removed has a long-term positive effect on all phases of tissue repair.

关键词： Hemostatic agent Alginate Surgery Hemostasis endothelial cells Tissue repair

extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

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Neural Regeneration Research 2020年第4期15卷 573-585页

作者： Deepak Jain sabrina Mattiassi eyleen L.Goh evelyn K.F.Yim Department of Chemical engineering University of WaterlooWaterlooOntarioCanada Neuroscience Academic Clinical Programme Duke-NUS Medical SchoolSingapore

extracellular matrix(eCM)influences cell differentiation through its structural and biochemical *** nervous system,neuronal behavior is influenced by these eCMs structures which are present in a meshwork,fibrous,or tubular forms encompassing specific molecular *** addition to contact guidance,eCM composition and structures also exert its effect on neuronal *** short report reviewed the native eCM structure and composition in central nervous system and peripheral nervous system,and their impact on neural regeneration and neuronal *** topographies,stem cells have been differentiated to ***,focussing on engineered biomimicking topographies,we highlighted the role of anisotropic topographies in stem cell differentiation to neurons and its recent temporal application for efficient neuronal differentiation.

关键词： biomimetic platforms biophysical cues contact guidance extracellular matrix neuronal development neural regeneration neural stem cell niche neuronal differentiation neuronal maturation stem cell topography

A novel microcosm to identify inherently competitive microorganisms with the ability to mineralize phytate in solum

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Soil ecology Letters 2021年第4期3卷 367-382页

作者： sabrina M.Pittroff Stefan Olsson Ashlea Doolette Ralf Greiner Alan e.Richardson Mette Haubjerg Nicolaisen Microbial ecology and Biotechnology Department of Plant and Environmental SciencesFaculty of ScienceUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark State Key Laboratory for ecological Pest Control of Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002China CSIRO Agriculture and Food PO Box 1700CanberraACT2601Australia Department of Food Technology and Bioprocess engineering Max Rubner InstitutKarlsruheGerman School of Agriculture Food and WineWaite Research InstituteThe University of AdelaideWaite Campus UrrbraeSA5064 Australia Plant Immunity Center Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou 350002China

Fertilizer phosphorus(P)is a finite resource,necessitating the development of innovative solutions for P fertilizer efficiency in agricultural ***-inositol hexakisphosphate(phytate)constitutes the majority of identified organic P in many soil types and is poorly available to *** phytase-producing biofertilizers into soil presents a viable and environmentally acceptable way of utilizing P from phytate,while reducing the need for mineral P application.A deeper understanding of the microbial ecology in relation to degradation of phytate under natural soil conditions is however needed to obtain successful biofertilizer candidates able to compete in complex soil *** we present the development of a microcosm for studying microbial communities able to colonize and utilize Ca-phytate hotspots in *** results provide evidence that the recruited microbial population mineralizes ***,quantification of bacterial genes associated with organic P cycling in alkaline soils indicated that the phosphatases PhoX and PhoD may play a larger role in phytate mineralization in soil than previously *** sequencing and BioLog®catabolism studies show that hotspots containing Ca-phytate,recruited a different set of microorganisms when compared to those containing an addition of C source alone,with the genus Streptomyces specifically *** propose that Streptomyces represents an hitherto unexplored resource as P biofertilizer with competitive advantage for utilizing CaPhy in an inherently competitive soil *** further conclude that the use of our newly designed microcosm presents an innovative approach for isolating soil microorganisms with the potential to degrade precipitated phytate in solum.

关键词： Myo-inositol hexakisphosphate(phytate) Soil microcosm Soil microbial ecology Biofertilizers Alkaline phosphatase β-propeller phytase(BPP)

B cell development is critically dependent on NFATc1 activity

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Cellular & Molecular Immunology 2019年第5期16卷 508-520页

作者： sabrina Giampaolo Gabriela Wojcik Stefan Klein-Hessling edgar Serfling Amiya K.Patra Department of Molecular Pathology Institute of PathologyUniversity of WürzburgJosef Schneider-Str.297080 WürzburgGermany Institute of Translational and Stratified Medicine Faculty of Medicine and DentistryUniversity of PlymouthPlymouth PL68BUUK Comprehensive Cancer Center Mainfranken University of WürzburgJosef Schneider-Str.697080 WürzburgGermany

B cell development in bone marrow is a precisely regulated complex *** successive stages of differentiation,which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors,the common lymphoid progenitors ultimately give rise to mature B *** to early thymocyte development in the thymus,early B cell development in bone marrow is critically dependent on IL-7 *** this IL-7-dependent stage of differentiation,several transcription factors,such as e2A,eBF1,and Pax5,among others,play indispensable roles in B lineage specification and *** recent studies have implicated several other transcription factors in B cell development,the role of NFATc1 in early B cell developmental stages is not ***,using multiple gene-manipulated mouse models and applying various experimental methods,we show that NFATc1 activity is vital for early B cell *** of NFATc1 activity in pro-B cells suppresses eBF1 expression,impairs immunoglobulin gene rearrangement,and thereby preBCR formation,resulting in defective B cell ***,deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage,leading to severe B cell *** findings suggest that,along with other transcription factors,NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.

关键词： Differentiation eBF1 NFATc1 Pro-B Pre-B

Nitrate induction triggers different transcriptional changes in a high and a low nitrogen use efficiency maize inbred line

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Journal of Integrative Plant Biology 2014年第11期56卷 1080-1094页

作者： Anita Zamboni Stefania Astolfi sabrina Zuchi Youry Pii Katia Guardini Paola Tononi Zeno Varanini Department of Biotechnology University of Verona37134VeronaItaly Department of Agriculture ForestsNature and Energy (DAFNE)University of Tuscia01100ViterboItaly Faculty of Science and Technology (FaST) Free University of Bozen-Bolzano39100BolzanoItaly

In higher plants, NO3 can induce its own uptake and the magnitude of this induction is positively related to the external anion concentration. This phenomenon has been characterized in both herbaceous and woody plants. Here,different adaptation strategies of roots from two maize（Zea mays L., ZmAGOs） inbred lines differing in nitrogen use efficiency（NUe） and exhibiting different timing of induction were discussed by investigating NO3 ‐induced changes in their transcriptome. Lo5 line（high NUe） showing the maximum rate of NO3 uptake 4 h after the provision of 200 mmol/L NO3 treatment modulated a higher number of transcripts relative to T250（low NUe） that peaked after 12 h. The two inbred lines share only 368 transcripts that are modulated by the treatment with NO3 and behaved differently when transcripts involved in anion uptake and assimilation were analyzed. T250 line responded to the NO3 induction modulating this group of Researchgenes as reported for several plant species. On the contrary,the Lo5 line did not exhibit during the induction changes in this set of genes. Obtained data suggest the importance of exploring the physiological and molecular variations among different maize genotypes in response to environmental clues like NO3 provision, in order to understand mechanisms underlying NUe.

关键词： Maize NO3- induction microarray

First report of polymicrobial necrotizing fasciitis caused by eggerthia catenaformis and Finegoldia magna

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World Journal of emergency Medicine 2022年第4期13卷 326-329页

作者： Claudius Illg Jonas Kolbenschlag Ruth Christine Schäfer Adrien Daigeler sabrina Krauss Department of Hand Plastic and Reconstructive SurgeryBG Unfallklinik TuebingenEberhard Karls UniversityTuebingen 72076Germany

Dear editor,Necrotizing fasciitis is a relatively rare,rapidly advancing,infectious disease with high lethality.[1]It is characterized by subcutaneous and fascial tissue necrosis and can even extend to involve skin and muscle.[2]The initial spread along fascial planes with little visual evidence impedes the crucial early *** often report minor or major trauma preceding the infection,yet in some cases,the disease develops idiopathically.[3]Risk factors,including older age,diabetes,chronic renal failure,and obesity,predispose to impaired immunity and loss of physiological barriers.[2]

关键词： impaired immunity fas

Documented outbreaks of botulism:the impact of foodborne transmission

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 71-75页

作者： Victoria Rebagliati sabrina Chianelli Mariela Tornese Laura Rossi Alcides Troncoso Department of Microbiology and Parasitology School of NutritionBuenos Aires Medical SchoolBuenos AiresArgentina

Botulism is a severe neuroparalytic disease caused by Clostridium botulinums *** the disease is uncommon,causes great concern due to its high rate of mortality;foodbome outbreaks of botulism occur worldwide and require immediate public health and acute care *** study had a review of outstanding outbreaks published;Journals articles related to the *** the outbreaks analysis we found the most involved food products were;fermented fish products in Alaska;home canning food,oil preservation and restaurant sauce in London and USA;home canned vegetables,food airtight packed with inappropriate refrigeration and aerosols in *** conclusion,the diagnosis is based only on clinical findings matching the disease and previous exposure to suspicious *** must be immediately identified as one case suggests an epidemic and should be treated as a public health *** the purpose of the following review is to recognize the associated risks with the consumption of potentially dangerous foods,to help work our way on prevention for every public health professional to be aware of the dangers of this potentially lethal disease.

关键词： foodborne botulism Clostridium botulinum