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Strong attenuation of SArS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

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Signal Transduction and Targeted Therapy 2023年第1期8卷 10-12页

作者： rayhane Nchioua Federica Diofano sabrina Noettger Pascal von Maltitz Steffen Stenger Fabian Zech jan Münch Konstantin M.J.Sparrer Steffen Just Frank Kirchhoff Institute of Molecular Virology Ulm University Medical CenterUlmGermany Molecular Cardiology Department of Internal Medicine IIUlm UniversityUlmGermany Institute of Medical Microbiology and Hygiene Ulm University Medical CenterUlmGermany

Dear Editor,Since its first description in South Africa in November 2021,the SArS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta *** is the fifth variant of concern(VOC).It contains an unusually high number of mutations compared to previous VOCs,especially in the viral Spike protein,and shows high transmissibility and efficient escape of neutralizing antibodies.

关键词： Strong neutral Omi

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Printed microelectrode arrays on soft materials:from PDMS to hydrogels

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npj Flexible Electronics 2018年第1期2卷 111-119页

作者： Nouran Adly sabrina Weidlich Silke Seyock Fabian Brings Alexey Yakushenko Andreas Offenhausser Bernhard Wolfrum Institute of Bioelectronics(ICS-8)and JArA-Fundamentals of Future Information Technology Forschungszentrum JulichJulich 52425Germany Neuroelectronics-Munich School of Bioengineering Department of Electrical and Computer EngineeringTechnical University of MunichBoltzmannstrase 11D-85749 GarchingGermany

Microelectrode arrays(MEAs)provide promising opportunities to study electrical signals in neuronal and cardiac cell networks,restore sensory function,or treat disorders of the nervous ***,most of the currently investigated devices rely on silicon or polymer materials,which neither physically mimic nor mechanically match the structure of living tissue,causing inflammatory response or loss of ***,we present a new method for developing soft MEAs as bioelectronic *** functional structures are directly deposited on PDMS-,agarose-,and gelatin-based substrates using ink-jet printing as a patterning *** demonstrate the versatility of this approach by printing high-resolution carbon MEAs on PDMS and *** soft MEAs are used for in vitro extracellular recording of action potentials from cardiomyocyte-like HL-1 *** results represent an important step toward the design of next-generation bioelectronic interfaces in a rapid prototyping approach.

关键词： PDMS printing arrays

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Implantable cardiac defibrillators in octogenarians

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Journal of Geriatric Cardiology 2023年第1期20卷 23-31页

作者： Maarten Pauwelyn Sebastian Ingelaere ruben Hoffmann Johan Vijgen Georges H.Mairesse Ivan Blankoff Yves Vandekerckhove Jean-Benoit le Polain de Waroux Bert Vandenberk rik Willems University Hospitals Leuven CardiologyLeuvenBelgium KU Leuven Department of Cardiovascular SciencesLeuvenBelgium UZA Department of CardiologyAntwerpBelgium Jessa Ziekenhuis Department of CardiologyHasseltBelgium Cliniques du Sud Luxembourg Department of CardiologyArlonBelgium CHU Charleroi Department of CardiologyCharleroiBelgium AZ Sint-jan Department of CardiologyBruggeBelgium University of Calgary Libin Cardiovascular InstituteCalgaryCanada

OBJECTIVE Implantable cardiac defibrillators(ICD)implantation in the very elderly remains *** aimed to describe the experience and outcome of patients over 80 years old implanted with an ICD in *** Data were extracted from the national QErMID-ICD *** implantations performed in octogenarians between February 2010 and March 2019 were *** on baseline patient characteristics,type of prevention,device configuration and all-cause mortality were *** determine predictors of mortality,multivariable Cox proportional hazard regression modelling was *** Nationwide,704 primo ICD implantations were performed in octogenarians(median age 82,IQr 81-83 years;83% male and 45% secondary prevention).During a mean follow-up of 3.1±2.3 years,249(35%)patients died,of which 76(11%)within the first year after *** multivariable Cox regression analysis age(Hr=1.15,P=0.004),oncological history(Hr=2.43,P=0.027)and secondary prevention(Hr=2.23,P=0.001)were independently associated with 1-year mortality.A better preserved left ventricular ejection fraction(LVEF)was associated with a better outcome(Hr=0.97,P=0.002).regarding overall mortality multivariable analysis withheld age,history of atrial fibrillation,centre volume and oncological history as significant *** LVEF was again protective(Hr=0.99,P=0.008).CONCLUSIONS Primary ICD implantation in octogenarians is not often performed in *** this population,11%died within the first year after ICD *** age,oncological history,secondary prevention and a lower LVEF were associated with an increased one-year ***,low LVEF,atrial fibrillation,centre volume and oncological history were indicative of higher overall mortality.

关键词： prevention implantation protective

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Long noncoding rNA MALAT1-derived mascrNA is involved in cardiovascular innate immunity

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Journal of Molecular Cell Biology 2016年第2期8卷 178-181页

作者： Martina Gast Blanche Schroen Antje Voigt jan Haas Uwe Kuehl Dirk Lassner Carsten Skurk Felicitas Escher Xiaomin Wang Adelheid Kratzer Katharina Michalik Anna Papageorgiou Tim Peters Madlen Loebel sabrina Wilk Nadine Althof Kannanganattu VPrasanth Hugo Katus Benjamin Meder Shinichi Nakagawa Carmen Scheibenbogen Heinz-Peter Schultheiss Ulf Landmesser Stefanie Dimmeler Stephane Heymans Wolfgang Poller Department of Cardiology and Pneumology Campus Benjamin FranklinCharite–Universitatsmedizin BerlinBerlinGermany Center for Heart Failure research Cardiovascular Research Institute Maastricht(CARIM)Maastricht UniversityMaastrichtNetherlands Institute of Biochemistry Campus Charite MitteCharite–Universitatsmedizin BerlinBerlinGermany Otto-Meyerhof-Centrum University of HeidelbergHeidelbergGermany Medizinische Klinik University of HeidelbergHeidelbergGermany Institute for Cardiac Diagnostics and Therapy(IKDT) BerlinGermany Institute for Cardiovascular regeneration Goethe University FrankfurtFrankfurtGermany Institute for Medical Immunology Campus Virchow KlinikumCharite–Universitatsmedizin BerlinBerlinGermany Berlin Center forregenerative Therapies(BCrT) Charite–Universitatsmedizin BerlinBerlinGermany Department of CellandDevelopmental Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA rNA Biology Laboratory RIKEN Advanced Research InstituteWakoSaitama 351-0198Japan German Center for Cardiovascular research(DZHK) Site BerlinGermany DZHK Site Rhein-MainGermany

Dear Editor,Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding *** is estimated that.30000 long noncoding rNAs(lncrNAs)are expressed in humans,but their functions are largely unknown(Suckau et al.,2009;rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncrNAs.

关键词： MALAT1 immunity

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欧洲中央银行（ECB）

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城市环境设计 2020年第4期 162-173页

作者：沃尔夫·狄·普瑞克斯 Magdalena Baczkowska Markus Baumann Michael Beckert Johannes Behrens Hilde Benda Marcelo Bernardi Nico Boyer jan Brosch Timo Carl Anna rita Cedroni Jasmin Dieterle sabrina dlugosch.jan ruben fisch.r Brigitte Fuchs Sergio Gonzales Gesine G?rlich Martin Gruber Guthu Hallstein Sebastian Haffner Simone Hainz Sascha Hempel rob Henderson Emanuele Iacono Martin Jelinek rashmi Krishna Jois Ivana Jug Frank Pascal Kaul Matt Kirkham Daniela Kr?hnert Bernward Krone Christian Labud Anke Lammert Monika Lyzyczka Steven M Christian Maeder Dimitra Mamou Ariane Marx Christoph Maurer Matthias Niemeyer Martin Oberascher ross Olson renate Ott Gerhard Pfeiler Ellen Pietrzyk James Pike robert Pippan Jakob Przybylo Anna Ptaszynska Stephanie rathgeber Carmen renz Salome reves Donna riedel Akvile rimantaite Pete rose Penelope rüttimann Stefan rutzinger Oliver Sachse Kristina Schinegger Benjamin Schmidt Marita Schnepper Thomas Siegl Ebru Simsek-Lenk Denise Sokolowski Augustin Solorzano Anja Sorger Andrea St?llenwerk Ernst Stockinger Crystal K.H Tang Jürgen Tiltmann Markus Tritthart Josef Tr?ster Günther Weber Andreas Weissenbach Clemens Werb Judith Werkh?user Markus Wings Eva Wolf Barbara Zeleny Thomas Zengger Zeyneb Badur Fabien Barthelemey Oliver Cassik Alejandro Corena Alexander Daxb?ck Mario Dign?ss Helmut Fr?tscher Annegret Haider Christian Halm Gregor Kassl Gernot K?fer Alexander Laber Anita Lischka rangel Malinov Oliver Martinz Philipp Munz Barbara roller Nicole rumpler Wolfgang ruthensteiner Stefan Salchinger Stefan Schadenb?ck Thomas Schwed Hannes Schwed Eckart Schwerdtfeger Sylvia Spernbauer Christoph Treberspurg Johannes Weigl Paul raftery European Central Bank/robertMetsch Markus Pillhofer

项目大事记/CHrONOLOGY竞赛/Competition:第一阶段/Phase 1:2003;第二阶段/Phase 2:2003-2004;修改阶段/revision Phase:2004;优化阶段/Optimization Phase:2005规划设计起始时间/Start of Planning:2005前期工程/Preliminary Site Works:2008主体施工/Main Construction Works:2010竣工/Completion:2014项目参数/PrOJECT DATA用地面积/Site Area:120 000m2建筑毛面积/Gross Floor Area:185 000m2

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音乐屋——奥尔堡创意中心

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城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 Marcelo Bernardi Jesper Bork Bo Stjerne Hansen roberta Jiraschek Daniel Krüger Carsten Laursen Martin Oberascher Florian Pfeifer robert Pippan Marita Schnepper Sigrid Svensson Eva Wolf Carola B?ker Moa Carlson Isak Foged Annina G?hwiler Patricia Gola robin Heather Per Kruse Win Man ruth Mandl Aline Müller Tenna Olsen Anke Pasolt Annemarie Pedersen Eva ravnborg Carolin Schmitz-remberg Tim Seidl Guro Sollid Michele Zanella jan-ruben fisch.r Markus Pillhofer Markus Baumann robin Heather Anja Sorger Bo Stjerne Thomsen Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozminsky Hannes Walzl Morten Grau Jensen Stephanie Neufeld Tyler Bornstein Laura Githa Julia G?rtner Jenny Draxlbauer Duccio Malagamba Martin Schubert

项目大事记/CHrONOLOGY竞赛（第一名）/Competition （1st Place）:2003一期规划设计/Layout Planning Ho M I:2003—2005项目延期/Postponement of the Project:2006—2007二期规划设计/Start of Layout Planning Ho M II:2008二期动工/Start of Construction Ho M II:2010二期竣工/Completion Ho M II:2014项目参数/PrOJECT DATA建筑净面积/Net Floor Area:17 637m2建筑毛面积/Gross Floor Area:20 257m2音乐厅/Concert Hall:1 298座/1 289 Seats

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