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Atypical Weight Loss in Two Patients with Schizophrenia Treated with Clozapine: A Case Report

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Open Journal of Applied Sciences 2024年第9期14卷 2544-2558页

作者： a.el Kamal Mohammed Ghaday saad Almutairi Abdulsalam Abdullah Almreef Psychiatry Department Mental Health Hospital Hafr al-Batin Saudi Arabia College of Medicine Qassim University Unizah Saudi Arabia

Clozapine is widely recognized as an effective antipsychotic medication for treatment-resistant schizophrenia, but it is typically associated with significant weight gain. This case report presents two unusual cases of patients with schizophrenia who experienced substantial weight loss while on long-term clozapine therapy. The first case involves a 35-year-old male who lost 21.3% of his initial body weight, and the second case describes a 54-year-old female who lost 30.2% of her initial weight, despite having comorbid hypothyroidism. Both patients showed improvement in psychiatric symptoms concurrent with the weight loss. Comprehensive investigations did not reveal other clear etiologies for the weight reduction. These cases challenge the conventional understanding of clozapine’s metabolic effects and highlight the potential for atypical responses in some individuals. The report discusses possible mechanisms for this unusual phenomenon, including genetic factors and altered pharmacokinetics. It also emphasizes the need for individualized monitoring and management strategies in clozapine therapy. These findings contribute to the growing body of evidence suggesting that metabolic responses to clozapine may be more complex and varied than previously thought, underscoring the importance of personalized approaches in schizophrenia treatment.

关键词： Schizophrenia Clozapine Weight Loss Treatment-Resistant Atypical Antipsychotics Metabolic Effects Case Report

Biological silicon nanoparticles improve Phaseolus vulgaris L. yield and minimize its contaminant contents on a heavy metals-contaminated saline soil

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Journal of Environmental Sciences 2021年第8期33卷 1-14页

作者： Mohamed T.el-saadony el-sayed M.Desoky Ahmed M.saad Rania S.M.Eid Eman Selem Ahmed S.elrys Department of Agricultural Microbiology Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Botany Department Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Biochemistry Department Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Agricultural Botany Department Faculty of AgricultureBenha University13736Egypt Botany and Microbiology Department Faculty of ScienceZagazig University44511Egypt Soil Science Department Faculty of AgricultureZagazig University44511ZagazigEgypt

The synthesis of biological silicon nano-particles(Bio-Si-NPs)is an eco-friendly and lowcost *** is no study focusing on the effect of Bio-Si-NPs on the plants grown on saline soil contaminated with heavy *** this study,an attempt was made to synthesis Bio-Si-NPs using potassium silica florid substrate,and the identified Aspergillus tubingensis AM11 isolate that separated from distribution systems of the potable water.A twoyear field trial was conducted to compare the protective effects of Bio-Si-NPs(2.5 and 5.0 mmol/L)and potassium silicate(10 mmol/L)as a foliar spray on the antioxidant defense system,physio-biochemical components,and the contaminants contents of Phaseolus vulgaris *** on saline soil contaminated with heavy *** findings showed that all treatments of Bio-Si-NPs and potassium silicate significantly improved plant growth and production,chlorophylls,carotenoids,transpiration rate,net photosynthetic rate,stomatal conductance,membrane stability index,relative water content,free proline,total soluble sugars,N,P,K,Ca2+,K+/Na+,and the activities of peroxidase,catalase,ascorbic peroxidase and superoxide oxide *** of Bio-Si-NPs and potassium silicate significantly decreased electrolyte leakage,malondialdehyde,H2 O2,O2·-,Na+,Pb,Cd,and Ni in leaves and pods of Phaseolus vulgaris *** to ***-Si-NPs were more effective compared to potassium *** of Bio-Si-NPs at the rate of 5 mmol/L was the recommended treatment to enhance the performance and reduce heavy metals content on plants grown on contaminated saline soils.

关键词： Bean Silicon Nano-silicon Aspergillus tubingensis AM11 Salinity Heavy metals

Security Monitoring and Management for the Network Services in the Orchestration of SDN-NFV Environment Using Machine Learning Techniques

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Computer Systems Science & Engineering 2024年第2期48卷 363-394页

作者： Nasser Alshammari Shumaila Shahzadi saad Awadh Alanazi Shahid Naseem Muhammad Anwar Madallah Alruwaili Muhammad Rizwan Abid Omar Alruwaili Ahmed Alsayat Fahad Ahmad Department of Computer Science College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72341Saudi Arabia Department of Computer Sciences Kinnaird College forWomenLahorePunjab54700Pakistan Department of Information Sciences Division of Sciences and TechnologyUniversity of EducationLahore54770Pakistan Department of Computer Engineering and Networks College of Computer and Information SciencesJouf UniversitySakaka72341Saudi Arabia Computer Science Florida Polytechnic UniversityLakelandFlorida33805USA Delta3T LahorePunjab54700Pakistan Department of Basic Sciences Common First YearJouf UniversitySakaka72341Saudi Arabia

Software Defined Network(SDN)and Network Function Virtualization(NFV)technology promote several benefits to network operators,including reduced maintenance costs,increased network operational performance,simplified network lifecycle,and policies *** vulnerabilities try to modify services provided by Network Function Virtualization MANagement and Orchestration(NFV MANO),and malicious attacks in different scenarios disrupt the NFV Orchestrator(NFVO)and Virtualized Infrastructure Manager(VIM)lifecycle management related to network services or individual Virtualized Network Function(VNF).This paper proposes an anomaly detection mechanism that monitors threats in NFV MANO and manages promptly and adaptively to implement and handle security functions in order to enhance the quality of experience for end *** anomaly detector investigates these identified risks and provides secure network *** enables virtual network security functions and identifies anomalies in Kubernetes(a cloud-based platform).For training and testing purpose of the proposed approach,an intrusion-containing dataset is used that hold multiple malicious activities like a Smurf,Neptune,Teardrop,Pod,Land,IPsweep,etc.,categorized as Probing(Prob),Denial of Service(DoS),User to Root(U2R),and Remote to User(R2L)*** anomaly detector is anticipated with the capabilities of a Machine Learning(ML)technique,making use of supervised learning techniques like Logistic Regression(LR),Support Vector Machine(SVM),Random Forest(RF),Naïve Bayes(NB),and Extreme Gradient Boosting(XGBoost).The proposed framework has been evaluated by deploying the identified ML algorithm on a Jupyter notebook in Kubeflow to simulate Kubernetes for validation *** classifier has shown better outcomes(99.90%accuracy)than other classifiers in detecting anomalies/intrusions in the containerized environment.

关键词： Software defined network network function virtualization network function virtualization management and orchestration virtual infrastructure manager virtual network function Kubernetes Kubectl artificial intelligence machine learning

The Impact of Social Media on Dietary Behaviors and Body Image of College Students: A Qualitative Approach

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Food and Nutrition Sciences 2024年第8期15卷 711-726页

作者： Basem Azmy saad Boutros Tabbetha D. Lopez Valencia Browning-Keen Department of Human Sciences Sam Houston State University Huntsville TX USA

Background: The use of social media platforms for health and nutrition information has become popular among college students. Although social media made information readily accessible in different formats, nutritional misinformation promoted by influencers and non-experts caused negative impact on diet behavior and perception of body image. Previous research indicated that extensive use of social media was positively linked to disordered eating behaviors. Social media platforms like Facebook and Instagram that allow users to follow celebrities intensified exposure to influencers’ messages and images and resulted in negative moods and body dissatisfaction. Objective: This paper aims to explore the impact of social media on college students’ dietary behaviors and body image. Participants: 18 undergraduate students from a public university in the Southern United States were recruited through a mass email. Methods: A cross-sectional qualitative study of three focus groups was conducted. The focus groups were based on guiding open-ended questions. *** was used to code and analyze the data using inductive and deductive codes. Results: Three main themes were identified. The conditions theme included elements that explain why and how social media influences the participants’ actions. The actions theme included eating behavior, physical activity, and dietary supplement intake. The consequences theme describes anticipated or actual outcomes of actions such as body image and ideal weight. Conclusions: Social media has had a negative influence on diet behaviors and a positive influence on physical activity. Evidence-based nutrition and weight management information is needed to thwart potential misinformation.

关键词： Social Media Nutrition Information Dietary Behavior Body Image College Students

Bullous Pemphigoid Induced by Doxycycline: Case Report and Literature Review

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Case Reports in Clinical Medicine 2024年第5期13卷 187-192页

作者： Mishal Al Mebayadh Rahaf Aldawish Sohail A. Butt Abdulrahman saad Aljahhan Dermatology Department Imam Abdulrahman Bin Faisal University-National Guard Hospital Dammam Saudi Arabia Dermatology Department Al Rass General Hospital Al-Qassim Saudi Arabia Pathology Department Dammam Regional Laboratory & Blood Bank MOH Dammam Saudi Arabia Clinical Documentation Improvement (CDI) Dammam Health Network Dammam Saudi Arabia

Bullous pemphigoid (BP) is the most prevalent autoimmune sub-epidermal blistering disease that affects mainly the elderly and could lead to serious morbidity. It has numerous risk factors and triggers, including an aging population with several comorbidities and drug exposure. In the published paper, we reported a case about a 32 years old male patient with unknown medical conditions who presented with erythematous patches and plaques on the scalp, face, and trunk with scattered blisters two weeks after initiating doxycycline treatment for folliculitis. The exact pathogenesis of the drug-reaction in drug- associated bullous pemphigoid (DABP) remains controversial. In conclusion, it is crucial for clinicians to be aware of DABP when prescribing doxycycline. The purpose of this case report is to raise awareness of the possible association between bullous pemphigoid and doxycycline.

关键词： Bullous Pemphigoid Doxycycline Drug-Associated Bullous Pemphigoid

Genetic investigation of the ubiquitin-protein ligase E3A gene as putative target in Angelman syndrome

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World Journal of Clinical Cases 2024年第3期12卷 503-516页

作者： Wiem Manoubi Marwa Mahdouani Dorra Hmida Ameni Kdissa Aida Rouissi Ilhem Turki Neji Gueddiche Najla Soyah Ali saad Christian Bouwkamp Ype elgersma Soumaya Mougou-Zerelli Moez Gribaa Laboratory of Human Cytogenetics Molecular Genetics and Reproductive BiologyFarhat Hached University HospitalSousse 4000Tunisia Higher Institute of Biotechnology of Monastir University of MonastirMonastir 3000Tunisia Department of Neuropediatry La Rabta HospitalTunis 2000Tunisia Department of Pediatric Farhat Hached University HospitalSousse 4000Tunisia Department of Neuroscience Erasmus MCthe NetherlandsRotterdam 3112 tdNetherlands

BACKGROUND Angelman syndrome(AS)is caused by maternal chromosomal deletions,imprinting defects,paternal uniparental disomy involving chromosome 15 and the ubiquitin-protein ligase UBE3A gene *** the genetic basis remains unclear for several *** To investigate the involvement of UBE3A gene in AS and identifying new potential genes using exome *** We established a cohort study in 50 patients referred to Farhat Hached University Hospital between 2006 and 2021,with a strong suspicion of AS and absence of chromosomal *** UBE3A gene was screened for mutation *** unrelated patients issued from consanguineous families were subjected to exome *** We describe seven UBE3A variants among them 3 none previously described including intronic variants c.2220+14T>C(intron14),c.2507+43T>A(Exon15)and insertion in Exon7:c.30-47_*** exome sequencing revealed 22 potential genes that could be involved in AS-like syndromes that should be investigated *** Screening for UBE3A mutations in AS patients has been proven to be useful to confirm the *** exome findings could rise to new potential alternative target genes for genetic counseling.

关键词： Angelman syndrome Ubiquitin-protein ligase E3A Exome Consanguinity Polymorphism

PIF4 interacts with ABI4 to serve as a transcriptional activator complex to promote seed dormancy by enhancing ABA biosynthesis and signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 909-927页

作者： Xiaofeng Luo Yujia Dai Baoshan Xian Jiahui Xu Ranran Zhang Muhammad saad Rehmani Chuan Zheng Xiaoting Zhao Kaitao Mao Xiaotong Ren Shaowei Wei Lei Wang Juan He Weiming Tan Junbo Du Weiguo Liu Shu Yuan Kai Shu Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'an 710129China Research&Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen 518057China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China

Transcriptional regulation plays a key role in the control of seed dormancy,and many transcription factors(TFs)have been ***,the mechanisms underlying the interactions between different TFs within a transcriptional complex regulating seed dormancy remain largely ***,we showed that TF PHYTOCHROME-INTERACTING FACTOR4(PIF4)physically interacted with the abscisic acid(ABA)signaling responsive TF ABSCISIC ACID INSENSITIVE4(ABI4)to act as a transcriptional complex to promote ABA biosynthesis and signaling,finally deepening primary seed *** pif4 and abi4 single mutants exhibited a decreased primary seed dormancy phenotype,with a synergistic effect in the pif4/abi4 double ***4 binds to ABI4 to form a heterodimer,and ABI4 stabilizes PIF4 at the protein level,whereas PIF4 does not affect the protein stabilization of ***,both TFs independently and synergistically promoted the expression of ABI4 and NCED6,a key gene for ABA *** genetic evidence is also consistent with the phenotypic,physiological and biochemical analysis ***,this study revealed a transcriptional regulatory cascade in which the PIF4–ABI4 transcriptional activator complex synergistically enhanced seed dormancy by facilitating ABA biosynthesis and signaling.

关键词： ABA ABI4 PIF4 seed dormancy and germination transcriptional complex

A Methodology to Reduce Thermal Gradients Due to the Exothermic Reactions in Resin Transfer Molding Applications

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Fluid Dynamics & Materials Processing 2023年第1期19卷 95-103页

作者： Aouatif saad Mohammed el Ganaoui Advanced Systems Engineering Laboratory National School of Applied SciencesIbn Tofail UniversityKenitra242Morocco LERMAB/IUT Longwy Institut CarnotNancy186France

Resin transfer molding(RTM)is among the most used manufacturing processes for composite ***,the resin cure is initiated by heat supply to the *** supplementary heat generated during the reaction can cause thermal gradients in the composite,potentially leading to undesired residual stresses which can cause shrinkage and *** the present numerical study of these processes,a one-dimensional finite difference method is used to predict the temperature evolution and the degree of cure in the course of the resin polymerization;the effect of some parameters on the thermal gradient is then analyzed,na.ely:the fiber nature,the use of multiple layers of reinforcement with different thermal properties and also the temperature cycle *** validity of this numerical model is tested by comparison with experimental and numerical results in the existing literature.

关键词： Cure RTM finite difference method thermal gradients residual stresses

Hybrid-integer algorithm for a multi-objective optimal home energy management system

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Clean Energy 2023年第2期7卷 375-388页

作者： saad Gheouany Hamid Ouadi Saida.el Bakali ERERA National School of Arts and CraftsMohammed V UniversityRabatMorocco

Most of the energy produced in the world is consumed by commercial and residential *** the growth in the global economy and world demographics,this energy demand has become increasingly *** has led to higher unit electricity prices,frequent stresses on the main electricity grid and carbon emissions due to inefficient energy *** paper presents an energy-consumption management system based on time-shifting of loads according to the dynamic day-ahead electricity *** simultaneously reduces the electricity bill and the peaks,while maintaining user comfort in terms of the operating waiting time of *** proposed optimization problem is formulated mathematically in terms of multi-objective integer non-linear programming,which involves constraints and consumer *** optimal scheduling,the management problem is solved using the hybridization of the particle swarm optimization algorithm and the branch-and-bound *** techniques are proposed to manage the trade-off between the conflicting *** first technique is the Pareto-optimal solutions classification using supervised learning *** second technique is called the lexicographic *** simulations were performed based on residential building energy consumption,time-of-use pricing(TOU)and critical peak pricing(CPP).The algorithms were implemented in *** results of the current work show that the proposed approach is effective and can reduce the electricity bill and the peak-to-average ratio(PAR)by 28% and 49.32%,respectively,for the TOU tariff rate,and 48.91% and 47.87% for the CPP tariff rate by taking into account the consumer’s comfort level.

关键词： home energy management system smart building coordination of home appliances metaheuristic algorithm day-ahead scheduling multi-objective binary non-linear constraint problem