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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： maira T.Teixeira Livia L.sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso Ricardo N.marreto mariana Landin marcilio Cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity mass variation mass loss Friability Hardness

Anomalous bond-length behaviors of solid halogens under pressure

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Chinese Physics B 2021年第7期30卷 420-424页

作者： Min Wu Ye-Feng Wu Yi ma College of materials Science and Engineering Zhejiang University of TechnologyHangzhou310014China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China

The three halogen solids(Cl_(2),br_(2),and I_(2))have the isostructural diatomic molecular phaseⅠwith a space group of Cmca at ambient *** high pressure,they all go through an intermediate phaseⅤwith incommensurate structures before eventually dissociating into the monatomic phaseⅡ.However,a new structural transition between phaseⅠandⅤwith anomalous bond-length behavior was observed in bromine under pressure,which,so far,has not been confirmed in iodine and ***,we perform first-principles calculations for iodine and *** new structural transition was predicted to be common to all three halogens under *** transition pressures might be systematically underestimated by the imperfect van der Waals correction method,but they follow the order Cl_(2)>br_(2)>I_(2),which is consistent with other pressure-induced structural transitions such as metallization and the molecular-to-monatomic transition.

关键词： high pressure structural transition halogen first-principles calculation

Corrosion resistance and anti-soiling performance of micro-arc oxidation/graphene oxide/stearic acid superhydrophobic composite coating on magnesium alloys

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International Journal of Minerals,Metallurgy and materials 2023年第6期30卷 1128-1139页

作者： Dong Wang Chen ma Jinyu Liu Weidong Li Wei Shang Ning Peng Yuqing Wen Guangxi Key Laboratory of Electrochemical and magnetochemical Function materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China

magnesium(Mg)alloys,the lightest metal construction material used in industry,play a vital role in future ***,the poor corrosion resistance of Mg alloys in corrosion environments largely limits their potential wide ***,a micro-arc oxidation/graphene oxide/stearic acid(maO/go/sa)superhydrophobic composite coating with superior corrosion resistance was fabricated on a Mg alloy AZ91D through micro-arc oxidation(maO)technology,electrodeposition technique,and self-assembly *** composition and microstructure of the coating were characterized by scanning electron microscopy,X-ray diffraction,energy dispersive spectroscopy,and Raman *** effective protection of the maO/go/sa composite coating applied to a substrate was evaluated using potentiodynamic polarization,electrochemical impedance spectroscopy tests,and salt spray *** results showed that the maO/go/sa composite coating with a petal spherical structure had the best superhydrophobicity,and it attained a contact angle of 159.53°±2°.The maO/go/sa composite coating exhibited high resistance to corrosion,according to electrochemical and salt spray tests.

关键词： magnesium alloy composite coating superhydrophobic corrosion resistance anti-soiling performance

不同成熟度鲜食嫩南瓜种子活力及生理生化特性研究

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中国瓜菜 2024年第3期37卷 103-111页

作者：赵夏云瞿飞杨静马关鹏周麟笔蒋芳芳文林宏贵州省农业科学院园艺研究所贵阳550025 麻江县经济作物技术推广站贵州麻江557600

为了探究鲜食嫩南瓜种子成熟过程中种子活力及生理生化特性的变化趋势,以自育品种为试验材料,对不同成熟度采收的种子活力指标和生理生化指标进行测定,分析他们之间的相关性。结果表明,随着种子的成熟,种子逐渐发育饱满,种皮木质化明显... 详细信息

为了探究鲜食嫩南瓜种子成熟过程中种子活力及生理生化特性的变化趋势,以自育品种为试验材料,对不同成熟度采收的种子活力指标和生理生化指标进行测定,分析他们之间的相关性。结果表明,随着种子的成熟,种子逐渐发育饱满,种皮木质化明显;授粉后45 d时种子已具有萌发能力,授粉后70 d种子活力最高;贮藏物质在授粉后35~50 d基本完成积累,脂肪、蛋白质、淀粉大量形成,而可溶性总糖和可溶性还原糖含量同期持续减少。吸胀8 h的南瓜种子中SOD、CAT、POD活性受MDA含量变化影响,随着成熟度的增加,呈先升高后降低再升高的变化趋势;各内源激素含量变化波动不同,其中sa与br含量整体上呈显著增长趋势且高于其他激素,GA_(3)与ABA含量变化趋势相反,ETH含量授粉后35 d最高。相关性分析表明,种子活力指标与SOD、POD活性以及淀粉、粗脂肪、CTK、GA_(3)、IAA、br、sa含量呈正相关,而与可溶性总糖、可溶性还原糖、蛋白质、MDA、ABA、ETH含量呈负相关。综上,不同成熟度对鲜食嫩南瓜种子质量和种子活力有显著影响。鲜食嫩南瓜种子发育过程中的生理生化过程复杂,伴随着贮藏物质的大量积累,抗氧化酶活性与MDA、内源激素含量不断变化。

关键词：鲜食嫩南瓜种子活力生理生化特性成熟度

Comparative phosphoproteomic analysis of br-defective mutant reveals a key role of GhSK13 in regulating cotton fiber development

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Science China(Life Sciences) 2020年第12期63卷 1905-1917页

作者： Lingling Wang Han Cheng Fangjie Xiong Shuya ma Lei Zheng Yun Song Kexuan Deng Huanhuan Wu Fuguang Li Zuoren Yang Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang 455000China Key Laboratory for Ecology of Tropical Islands Ministry of EducationCollege of Life SciencesHainan Normal UniversityHaikou 571158China School of Life Sciences Chongqing UniversityChongqing 401331China

brassinosteroid(br), a steroid phytohormone, whose signaling transduction pathways include a series of phosphorylation and dephosphorylation events, and GSK3 s are the main negative regulator kinases. brs have been shown to play vital roles in cotton fiber elongation. However, the underlying mechanism is still elusive. In this study, fibers of a br-defective mutant Pagoda 1(pag1), and its corresponding wild-type(ZM24) were selected for a comparative global phosphoproteome analysis at critical developmental time points: fast-growing stage(10 days after pollination(DPA)) and secondary cell wall synthesis stage(20DPA). Based on the substrate characteristics of GSK3, 900 potential substrates were identified. Their go and KEGG annotation results suggest that br functions in fiber development by regulating GhSKs(GSK3s of gossypium hirsutum L.) involved microtubule cytoskeleton organization, and pathways of glucose, sucrose and lipid metabolism. Further experimental results revealed that among the GhSK members identified, GhSK13 not only plays a role in br signaling pathway, but also functions in developing fiber by respectively interacting with an AP2-like ethylene-responsive factor GhAP2L, a nuclear transcription factor GhDNFYB19, and a homeodomain zipper member GhHDZ5. Overall, our phosphoproteomic research advances the understanding of fiber development controlled by br signal pathways especially through GhSKs, and also offers numbers of target proteins for improving cotton fiber quality.

关键词： phosphoproteome brassinosteroid GSK3 GhSK13 cotton fiber development

基于QsaR机器学习模型结合“久病致瘀”理论对丹参治疗慢性疼痛的分子机制研究

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上海中医药大学学报 2024年第2期38卷 71-82页

作者：杨紫媛李晨红唐晔翎梁鹏晨雷璇子常庆马杰上海理工大学健康科学与工程学院上海200093 上海健康医学院附属嘉定区中心医院临床科研中心上海201800 上海中医药大学研究生院上海201203 上海大学微电子学院上海201800 上海交通大学医学院附属瑞金医院消化外科研究所上海200025 上海中医药大学针灸推拿学院上海201203

目的:运用定量结构-活性关系(QsaR)机器学习模型和分子对接技术预测丹参治疗慢性疼痛相关的活性成分,并结合“久病致瘀”理论以及网络药理学探讨丹参治疗慢性疼痛的分子机制。方法:首先通过中药系统药理学数据库与分析平台(TCMSP)和人... 详细信息

目的:运用定量结构-活性关系(QsaR)机器学习模型和分子对接技术预测丹参治疗慢性疼痛相关的活性成分,并结合“久病致瘀”理论以及网络药理学探讨丹参治疗慢性疼痛的分子机制。方法:首先通过中药系统药理学数据库与分析平台(TCMSP)和人类基因组数据库(GeneCards)收集丹参化学成分和慢性疼痛作用靶点,筛选核心靶标,通过STRING数据库进行蛋白质相互作用(PPI)网络分析;然后对交集靶标进行基因本体(go)富集分析和京都基因与基因组百科全书(KEGG)通路富集分析;最后运用QsaR机器学习模型以及分子对接技术筛选丹参治疗慢性疼痛的活性成分和核心靶点。结果:(1)筛选获得丹参与慢性疼痛的交集靶标55个、潜在活性成分55个,通过PPI分析发现丝氨酸/苏氨酸激酶1(AKT1)、表皮生长因子受体(EGFR)、白介素(IL)-6等核心靶标;(2)通过功能富集分析得到细胞组成45个,分子功能87个,生物过程1 450个,信号通路140条,涉及磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K/AKT)、IL-17、缺氧诱导因子1(HIF-1)、环磷腺苷(cAMP)、丝裂原活化蛋白激酶(maPK)等信号通路;(3)通过QsaR模型和分子对接发现丹参中的鼠尾草呋萘嵌苯、表丹参螺缩酮内脂、salvianan A、异丹参酮Ⅱ和丹酚酸C是治疗慢性疼痛的活性成分。结论:丹参治疗慢性疼痛的活性成分为二萜类化合物,其作用机制可能与调节AKT1介导的信号通路密切相关。

关键词：慢性疼痛丹参定量构效关系机器学习网络药理学

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玉米抗禾谷镰刀菌的转录组分析

作物学报 2016年第8期42卷 1122-1133页

作者：刘永杰马传禹马雪娜徐明良中国农业大学国家玉米改良中心北京100193

赤霉菌茎腐病是由禾谷镰刀菌(Fusarium graminearum,有性态,Gibberella zeae)引起的一类土传性病害,严重危害玉米的产量和品质。本研究依据玉米第10和第1染色体上的2个抗茎腐病QTL,q Rfg1和q Rfg2、培育近等基因系NIL-R(2个QTL位点均为... 详细信息

赤霉菌茎腐病是由禾谷镰刀菌(Fusarium graminearum,有性态,Gibberella zeae)引起的一类土传性病害,严重危害玉米的产量和品质。本研究依据玉米第10和第1染色体上的2个抗茎腐病QTL,q Rfg1和q Rfg2、培育近等基因系NIL-R(2个QTL位点均为抗病等位基因)和NIL-S(2个QTL位点均为感病等位基因)。在成株期和幼苗期接种禾谷镰刀菌,两近等基因系的抗性差异均显著。用2个近等基因系的幼根接种禾谷镰刀菌,进行转录组分析研究。结果表明,与NIL-S相比,NIL-R在接种禾谷镰刀菌后,乙烯(ethylene,ET)合成、信号途径基因,病程相关蛋白、脱氧雪腐镰刀菌烯醇毒素(deoxynivalenol,DON)解毒基因等呈现特异上调表达。与NIL-S相比,有1170个基因在NIL-R对照组中表达量较高,其中水杨酸(salicylic acid,sa)、茉莉酸(jasmonic acid,JA)和乙烯合成和信号介导途径以及苯丙烷合成途径中的基因显著富集;接种禾谷镰刀菌6 h或18 h后,病程相关蛋白、激素JA和ET合成基因、DON解毒基因在NIL-R中表达量较高。

关键词：玉米茎腐病转录组抗性 JA/ET 苯丙烷

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溴代磺酸偶氮Ⅲ分光光度法测定微量钯

理化检验（化学分册） 2006年第5期42卷 366-367,371页

作者：袁莉马明广任小娜西北师范大学化学化工学院兰州730070

研究了在邻苯二甲酸氢钾-盐酸缓冲溶液中,3,6-双(4-溴-2-磺基-苯偶氮)-4,5-二羟基- 2,7-萘二磺酸与钯(Ⅱ)的显色反应。结果表明,钯(Ⅱ)与溴代磺酸偶氮Ⅲ形成1:1的蓝色络合物,其最大吸收波长为623．7 nm,表观摩尔吸光系数ε=6．375×104L... 详细信息

研究了在邻苯二甲酸氢钾-盐酸缓冲溶液中,3,6-双(4-溴-2-磺基-苯偶氮)-4,5-二羟基- 2,7-萘二磺酸与钯(Ⅱ)的显色反应。结果表明,钯(Ⅱ)与溴代磺酸偶氮Ⅲ形成1:1的蓝色络合物,其最大吸收波长为623．7 nm,表观摩尔吸光系数ε=6．375×104L·cm-1·mol-1,钯含量在0～32μg／25 mL范围内符合比耳定律,检出限为2．13μg·L-1。用于钯催化剂中微量钯的测定,结果与AAS法测定值相符。

关键词：分光光度法溴代磺酸偶氮Ⅲ 钯

水杨酸诱导下朱砂根转录组分析及三萜皂苷生物合成途径关键酶基因挖掘

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华北农学报 2023年第2期38卷 106-119页

作者：路艳马明东曹慧李媛媛四川农业大学风景园林学院四川成都611130 潍坊学院种子与设施农业工程学院山东潍坊261061

朱砂根是紫金牛科中药植物,主要活性成分为齐墩果烷型三萜类化合物朱砂根皂苷。为探索朱砂根三萜皂苷生物合成的分子基础,采用Illunima HiseqTM 4000对无菌水、2 mmol/L sa处理的3年生朱砂根植株进行转录组测序,基于Blast完成Unigene分... 详细信息

朱砂根是紫金牛科中药植物,主要活性成分为齐墩果烷型三萜类化合物朱砂根皂苷。为探索朱砂根三萜皂苷生物合成的分子基础,采用Illunima HiseqTM 4000对无菌水、2 mmol/L sa处理的3年生朱砂根植株进行转录组测序,基于Blast完成Unigene分类、功能注释、代谢通路分析、蛋白功能注释、差异表达基因分析、代谢途径关键基因挖掘等。共获得41.63 Gb数据,拼接组装获得102491条Unigenes,平均长度831 bp,注释率50.21%。筛选出3417个sa应答差异表达基因,其中2725个基因上调,692个基因下调。差异表达基因显著富集于次生代谢物生物合成、代谢途径、氨基糖和核苷酸糖代谢、糖酵解/糖异生、碳代谢等通路。与朱砂根三萜皂苷相关的代谢通路,包括萜类骨架生物合成(ko00900)和倍半萜与三萜生物合成(ko00909),共筛选出8个关键酶、11条差异表达Unigenes。sa处理后萜类骨架生物合成MVA途径HMGR、HMGS、MVK、GGPS、SS、SQE基因差异表达显著,MEP途径DXS、DXR、MCT、CMK、MDS、HDR基因差异表达不显著。催化生成齐墩果烷型五环三萜前体的关键酶β-香树素合成酶基因(β-AS)表达量下调,后修饰基因CYP450s(CYP72A67)表达量也下调。荧光定量qPCR值与RNA-seq表达量FPKM值变化趋势一致。推测sa通过诱导MVA途径的关键酶基因表达影响朱砂根三萜皂苷的积累,MEP途径中的酶基因可能参与其他支路次生代谢产物的合成。

关键词：朱砂根三萜皂苷转录组水杨酸差异表达 qPCR