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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

Matter and radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix rosenthal sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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Prevalence, Maternal and Perinatal Prognosis of Breech Delivery Compared to That of the Vertex in 242 Cases for 484 Controls at Ségou Hospital in Malti

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1414-1421页

作者： Tidiani Traoré Famakan Kané Abdoulaye Kassogué Seydou Traoré Seydou Z. Dao Balilé Harber sabré Koné Kassoum Sidibé Brahima Donigolo Babou Traoré Adama Coulibaly Abdrhamane Diarisso Alima Sidibé Mamadou Sima Augustin Théra Youssouf Traoré Ibrahima Teguété Niani Mounkoro Ministry of Health in Bamako Nianakoro Fomba Hospital Segou Mali regional Health Department of Segou District Hospital Bla Mali regional Health Department of Koutiala Reference Health Center Koutiala Mali regional Health Department of Bamako Reference Health Center Commune II Bamako Mali Ministry of Health in Bamako Fousseyni Daou Hospital Kayes Mali Ministry of Health in Bamako Point G University Hospital Center Bamako Mali Ministry of Health in Bamako Gabriel Toure University Hospital Center Bamako Mali

Introduction: Breech birth has always been a subject of great interest because of its risks of perinatal morbidity and mortality. Aim: The aim of our study was to compare the maternal and perinatal prognosis of breech delivery with that of vertex delivery. Patients and Method: This was a retrospective case-control analytical study carried out in the obstetrics and gynaecology department of Ségou hospital over a 2-year period from 1 January 2020 to 31 December 2021, involving 242 breech deliveries compared with 484 top deliveries with a live single foetus without foetal malformation of gestational age ≥ 35 sa. The statistical tests used were: chi² (p results: The frequency of breech delivery was 3.3%, with a predominance of caesarean section for breech presentation (64.88%) compared with 32.85% for vertex (P: 0.00;CI: (0.191 - 0.367). The perinatal prognosis of fetuses with breech presentations was marked by a higher rate of neonatal asphyxia (Apgar score Conclusion: Breech birth is relatively rare in our department. It carries a higher risk of maternal morbidity and neonatal morbidity than breech delivery. However, the vital prognosis for the mother was identical in both groups.

关键词： Delivery Breech Vertex Prognosis Mali

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獐牙菜苦苷、灵仙新苷组分配伍对ra模型大鼠血清学指标及踝关节COX-2的影响

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时珍国医国药 2024年第5期35卷 1034-1040页

作者：郝倩莹高慧琴吴国泰李飒王丽明甘肃中医药大学甘肃兰州730101 中国人民解放军96604部队医院甘肃兰州730031

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(rheumatoid arthritis,ra)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis... 详细信息

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(rheumatoid arthritis,ra)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis,CIA)大鼠模型。将造模成功的30只大鼠按随机数字表法分为模型组、阳性药(正清风痛宁)组、獐牙菜苦苷组、灵仙新苷组、獐牙菜苦苷配伍灵仙新苷组(以下简称“獐-灵配伍组”),每组6只。给药组分别给予相应药液灌胃,模型组和空白组给予等量生理盐水灌胃,连续灌胃10 d。实验中对各组大鼠进行一般状态观察记录、关节炎评分(AI),苏木素-伊红(HE)染色法观察大鼠踝关节组织病理变化;酶联免疫吸附测定法(ELIsa)检测大鼠血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、类风湿因子(rF)、C反应蛋白(CrP)、抗环瓜氨酸肽抗体(anti-CCP Ab)及前列腺素E2(PGE2)含量;免疫组织化学法(Immunohistochemistry)及蛋白免疫印迹法(Western blot)检测大鼠踝关节环氧化酶-2(COX-2)蛋白表达;实时荧光定量聚合酶链式反应法(real-time PCr)检测大鼠踝关节COX-2基因表达。结果与空白组比较,模型组大鼠一般状态较差,大鼠左后足趾AI评分及血清中TNF-α、IL-1β、rF、CrP、anti-CCP Ab、PGE2含量显著高于其他组(PrF、CrP、anti-CCP、PGE2含量明显降低(PrF、CrP、anti-CCP、PGE2作用最为突出;獐牙菜苦苷在抑制IL-1β作用最突出。踝关节组织病理状态均有不同程度改善;IHC及WB检测结果显示獐-灵配伍组降低踝关节COX-2蛋白表达水平最为显著(Pr检测结果显示獐牙菜苦苷组降低踝关节COX-2基因表达最为显著(Pra模型大鼠能起到良好的治疗作用,其中獐-灵配伍组的治疗效果明显优于各单体给药组;獐牙菜苦苷与灵仙新苷具有明显的协同增效作用,其作用机制可能是通过降低炎性细胞因子的分泌,抑制COX-2蛋白活性而发挥作用。

关键词：獐牙菜苦苷灵仙新苷组分配伍类风湿关节炎 COX-2

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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： Maira T.Teixeira Livia L.sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso ricardo N.Marreto Mariana Landin Marcilio Cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,Ludipressr,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity Mass variation Mass loss Friability Hardness

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Characterization and Utilization of Starches Extracted from Florencia and Waxy Maize Hybrids for Tablet Formulation: Compaction Behaviour and Tablet Properties

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American Journal of Plant Sciences 2014年第6期5卷 787-798页

作者： Anikó Szepes Piroska Szabó-révész János Bajdik Péter Kása Jr. Miklós Neményi roland Pap Attila József Kovács Klára Pintye-Hódi Martin Luther University Halle-Wittenberg Center for Engineering Thermal Process Technology Halle (Saale) Germany Department of Pharmaceutical Technology University of Szeged Szeged Hungary Faculty for Agricultural and Food Sciences Institut of Biosystems Engineering University of West Hungary Mosonmagyaróvár Hungary

The aim of this work is to analyze the particle characteristics, such as shape, roundness and size, of starches extracted from Florencia and waxy maize hybrids. The micromeritics and structural properties of the samples were examined. The evaluation of flow properties, densification and compression behaviour of the powders was carried out. Physical parameters and swelling characteristics of tablets containing Florencia and waxy maize starch were also studied. Starch samples were compared with respect to their applicability as excipients in tablet formulation. The samples exhibited identical structure and similar particle characteristics. Maize starch extracted from the Florencia dent hybrid showed better flowability and compressibility in tableting experiments, which resulted in better mechanical tablet properties. With regard to utilization as a disintegrant, Florencia starch indicated rapid and intensive swelling and proved to act more effectively in the swelling process than waxy maize starch.

关键词： Maize Starch Micromeritics X-ray Diffraction Compression Behaviour Tablets

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Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease

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World Journal of Gastroenterology 2012年第25期18卷 3254-3259页

作者： Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres First Department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary research Group for Pediatrics and Nephrology Semmelweis University and Hungarian Academy of SciencesH-1083 BudapestHungary SE-MTA "Lendulet" Diabetes research Group H-1083 BudapestHungary Second Department of Pathology Semmelweis UniversityH-1091 BudapestHungary First Department of Medicine Semmelweis UniversityH-1083 BudapestHungary Second Department of Medicine University of Debrecen H-4032 Debrecen Hungary

AIM： To investigate intestinal alkaline phosphatase （iAP） in the intestinal mucosa of children with inflammatory bowel disease （IBD）. METHODS： Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls. In IBD patients, specimens were obtainedboth from inflamed and non-inflamed areas. The lAP mrNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis, respectively. Tissue localiza- tion of lAP and Toll-like receptor （TLr） 4 was investi- gated by immunofluorescent staining. rESULTS： The lAP protein level in the inflamed muco- sa of children with Crohn＇s disease （CD） and ulcerative colitis （UC） was significantly decreased when compared with controls （both P 〈 0.05）. Similarly, we found a significantly decreased level of lAP protein in the in- flamed mucosa in CD compared with non-inflamed mucosa in CD （P 〈 0.05）. In addition, the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD （P 〈 0.05）. lAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls, lAP mrNA expression in inflamed colonic mucosa of children with CD and UC was not significant- ly different from that in non-inflamed colonic mucosa with CD. Expression of lAP mrNA in patients with non- inflamed mucosa and in controls were similar. Co-local- ization of lAP with TLr4 showed intense staining with a dotted-like pattern, lAP was present in the inflamed and non-inflamed mucosa of patients with CD, UC, and in control biopsy specimens, irrespective of whether it was present in the terminal ileum or in the colon. However, the fluorescent signal of TLr4 was more pro- nounced in the colon compared with the terminal ileum in all groups studied. CONCLUSION： Lower than normal lAP protein levels in inflamed mucosa of IBD patients may indicate a role for lAP in inflammatory lesions in IBD. Based on our r

关键词： Intestinal alkaline phosphatase Toll-like recep-tor Colonic biopsy Children Inflammatory bowel disease

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The membrane-associated E3 ubiquitin ligase MArCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis

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Cellular & Molecular Immunology 2021年第12期18卷 2648-2659页

作者： Heng Lin Lu Feng Kai-sa Cui Lin-Wen Zeng Deng Gao Long-Xiang Zhang Wen-Hua Xu Yu-Hao Sun Hong-Bing Shu Shu Li Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityMedical Research InstituteFrontier Science Center for Immunology and MetabolismResearch Unit of Innate Immune and Inflammatory DiseasesChinese Academy of Medical SciencesWuhan UniversityWuhan430071China Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi214062JiangsuChina

The IL-6-STAT3 axis is critically involved in inflammation-associated carcinogenesis(IAC).How this axis is regulated to modulate IAC remains ***,we show that the plasma membrane-associated E3 ubiquitin ligase MArCH3 negatively regulates STAT3 activation triggered by IL-6,as well as another IL-6 subfamily member,Oncostatin M(OSM).MArCH3 is associated with the IL-6 receptorα-chain(IL-6rα)and its coreceptor *** experiments indicated that MArCH3 mediates the polyubiquitination of IL-6rαat K401 and gp130 at K849 following IL-6 stimulation,leading to their translocation to and degradation in ***3 deficiency increases IL-6-and OSM-triggered activation of STAT3 and induction of downstream effector genes in various cell ***3 deficiency enhances dextran sulfate sodium(DSS)-induced STAT3 activation,increases the expression of inflammatory cytokines,and exacerbates colitis,as well as azoxymethane(AOM)/DSS-induced colitis-associated cancer in *** addition,MArCH3 is downregulated in human colorectal cancer tissues and associated with poor survival across different cancer *** findings suggest that MArCH3 is a pivotal negative regulator of IL-6-induced STAT3 activation,inflammation,and inflammation-associated carcinogenesis.

关键词： MArCH3 IL-6 IL-6ra colitis-associated carcinogenesis polyubiquitination

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弹性腔流激耦合共振及声辐射机理研究

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船舶力学 2016年第8期20卷 1036-1044页

作者：高岩沈琪俞孟萨中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082 中国船舶科学研究中心江苏省绿色船舶技术重点实验室江苏无锡214082

利用Elder空腔声学模型,分析了典型空腔腔口剪切振荡和刚性壁腔体声模态的频率特征。采用模态法建立了弹性壁腔体模态声阻抗计算模型,并计算分析了腔口剪切振荡与弹性腔体耦合的归一化声辐射函数。研究表明弹性壁提供的附加压缩性,降低... 详细信息

利用Elder空腔声学模型,分析了典型空腔腔口剪切振荡和刚性壁腔体声模态的频率特征。采用模态法建立了弹性壁腔体模态声阻抗计算模型,并计算分析了腔口剪切振荡与弹性腔体耦合的归一化声辐射函数。研究表明弹性壁提供的附加压缩性,降低了空腔模态频率,增大了腔口剪切振荡与空腔模态耦合共振及强声辐射的可能性,并由试验验证了计算结果。

关键词：空腔剪切振荡腔体声模态耦合共振声辐射

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Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

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Oncology research 2023年第3期31卷 361-374页

作者： FraNCISCO raÚL BOrZONE MArÍA BELÉN GIOrELLO LEANDrO MArCELO MArTINEZ MArÍA CECILIA saNMArTIN LEONArDO FELDMAN FEDErICO DIMASE EMILIO BATAGELJ GUSTAVO YANNArELLI NOrMA ALEJANDra CHASSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality *** this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MSCs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal *** work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(rOS)levels,and senescence-associatedβ‑galactosidase(sa‑β‑gal)staining of BMderived MSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TErT,as well as telomere length,were *** levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,M-CAM,rUNX-2,BMP-2,CCL-2,M-CSF,and IL-6)were also *** results showed that MSCs from BCPs had reduced,self-renewal and proliferation *** cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened ***,there was an increase in rOS and senescence levels and a decrease in the functional capacity of TErT to preserve telomere *** also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene *** conclude that these changes could be responsible for the abnormal functional profile that MSCs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

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Alternancy Study on rambutan(Nephelium lappaceum L.)Tree in Mexico

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American Journal of Plant Sciences 2017年第1期8卷 40-52页

作者： rubén Joo-Pérez Carlos Hugo Avenda?o-Arrazate Alfredo sandoval-Esquivez saúl Espinoza-Zaragoza Moisés Alonso-Báez José Luís Moreno-Martínez rafael Ariza-Flores Carlos raúl Morales-Nieto Faculty of Agricultural Sciences Autonomous University of ChiapasHuehuetanMexico National Forestry Crops and Livestock Research Institute(INIFAP)Experimental Station Rosario IzapaTuxtla ChicoMexico Autonomous University of Chiapas HuehuetanMexico INIFAP Experimental Station IgualaGuereroMexico Autonomous University of Chihuahua ChihuahuaMexico

rambutan growing in the state of Chiapas has brought about a demand for new plantations;however, this species has several biotic and abiotic factors that limit its production. These factors include phytosanitary problems, deficient agronomical handling, and production alternancy. Because of this, the objective of the present study was to evaluate the effect of the application of agronomical practices such as pruning, ringing, water stress, and their interaction on the rambutan alternancy. The experiment was carried out in the “La Chinita” commercial orchard located on KM. 4.5 the Huehuetan Station, municipality of Huehuetan, Chiapas, Mexico. We used 48 rambutan trees in production with an age of 14 years. Two production cycles were evaluated. The experiment was established under a divided plot experimental design in random complete blocks with a factorial arrangement and six replicates;each tree being a replicate. The study factors were: water stress, pruning, girdling, irrigation (control), and their combinations, resulting in eight treatments. The evaluation was done during flowering, fruit set, and harvest. In flowering, the treatments with permanent irrigation in both evaluated cycles (2010-2011 and 2011-2012) manifested a production alternancy behavior, with an average 36.4% flowering in the first evaluation cycle and increased to 82.1% in the second cycle. The treatments with water stress kept a proportional flowering during the first and second cycles of 97.9% and 95.3%, respectively. The water stress influenced the bunch weight (Pr) variable fruit set with bigger fruits and higher bunch weight than the irrigated treatments. In production, pruning and girdling together with water deficit had no alternancy in both production cycles.

关键词： Nephelium lappaceum L. Water Stress Pruning Girdling Irrigation

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