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复合应用利多卡因对鞘内注射布比卡因时效的影响

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麻醉与镇痛 2010年第1期6卷 16-19页

作者： Sung-Jin Lee Sun-Joon Bai Jong-Seok Lee Won-Ok Kim Yang-sik Shin Ki-Young Lee 邹蓉(译) 崔苏扬(校) Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Korea 不详

背景由于阻滞持续时间较长，布比卡因蛛网膜下腔阻滞技术在门诊手术中使用受限。近期动物研究结果证实复合利多卡因后能缩短布比卡因蛛网膜下腔阻滞的持续时间。我们的研究旨在证实人类蛛网膜下腔阻滞时布比卡因复合利多卡因是否如同动... 详细信息

背景由于阻滞持续时间较长，布比卡因蛛网膜下腔阻滞技术在门诊手术中使用受限。近期动物研究结果证实复合利多卡因后能缩短布比卡因蛛网膜下腔阻滞的持续时间。我们的研究旨在证实人类蛛网膜下腔阻滞时布比卡因复合利多卡因是否如同动物实验结果一样能够缩短其阻滞时间。方法采用随机双盲的方法将90例纳入本项研究的经尿道行膀胱肿瘤切除或前列腺切除的患者分为3组。每组均鞘内注射0．5％布比卡因重比重液1．5ml及下述溶液0．6ml：组Ⅰ（30例，对照组）生理盐水，组Ⅱ（30例）1％利多卡因，组Ⅲ（30侧）2％利多卡因。记录感觉阻滞最高平面、达到感觉阻滞最高平面的时间、从感觉阻滞最高平面到消退两个节段以及消退至L1和S2平面的时间、在感觉阻滞最高平面时和平面消退至L1和S2时的运动阻滞评分及在麻醉恢复室（PACU）的留观时间。结果3组患者达到感觉阻滞最高平面的时间相似。组Ⅱ患者的感觉阻滞最高平面消退两个节段和消退至L1和S2水平的时间，以及PACU内留观时间均较组Ⅰ患者显著缩短。组Ⅲ患者的感觉阻滞最高平面消退至L1和S2水平的时间，以及PACU内留观时间均显著延长。结论复合使用利多卡因（6mg）能够缩短布比卡因（7．5mg）的蛛网膜下腔阻滞时间，阻滞后患者恢复程度较单独使用相同剂量布比卡因（7．5mg）的脊髓麻醉更加迅速。

关键词： 1%利多卡因布比卡因复合应用鞘内注射蛛网膜下腔阻滞感觉阻滞时效膀胱肿瘤切除

Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

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Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

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World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

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金黄色葡萄球菌蛋白酶FtsH底物的鉴定

金黄色葡萄球菌蛋白酶FtsH底物的鉴定

Erratum to:Tyrosine-mediated analog resistive switching for artificial neural networks

中国化学会第二届全国质谱分析学术报告会

作者：刘倩胡墨 Lei He Won-sik Yeo Hoonsik Cho Tianming Li Yuanjun Zhu 亚楠刘小云李敏 Taeok Bae 上海交通大学仁济医院检验科北京大学化学与分子工程学院分析化学研究所和合成与功能分子中心 Department of Microbiology and Immunology Indiana University School of Medicine-Northwest

金黄色葡萄球菌属于革兰氏阳性菌,可引起从皮肤和软组织感染到败血症,肺炎,心内膜炎,和中毒性休克综合征等危及生命的感染,是一种重要的人类病原细菌[1]。Fts H家族是ATP依赖的金属蛋白酶[2],在金黄色葡萄球菌中,Fts H与细菌在氨基酸或... 详细信息

金黄色葡萄球菌属于革兰氏阳性菌,可引起从皮肤和软组织感染到败血症,肺炎,心内膜炎,和中毒性休克综合征等危及生命的感染,是一种重要的人类病原细菌[1]。Fts H家族是ATP依赖的金属蛋白酶[2],在金黄色葡萄球菌中,Fts H与细菌在氨基酸或磷酸缺乏时的生长有关[3],但这一蛋白酶的底物至今仍然未知。这一工作中,我们采用定量蛋白质组学系统鉴定金黄色葡萄球菌的两个菌株（Newman与USA300）中蛋白酶Fts H的底物（图1）。与野生型相比,Fts H突变体在NM/USA300两个菌株中分别有189和154个蛋白的丰度发生了显著变化,但其中只有33个蛋白在两个菌株中都发生了变化。通过对这些蛋白转录水平的分析,我们筛选出转录水平恒定,而蛋白丰度在Fts H存在时显著降低的11个蛋白为FtsH的潜在底物。对这些底物进一步的验证与研究表明,FtsH在不同菌株中的作用不同:在Newman中,Fts H通过Sae RS二元调控系统调节Eap蛋白的丰度,影响金黄色葡萄球菌的自聚集;在USA300中,Fts H则调控甲氧西林感受与信号转导蛋白Mec R1的丰度,影响金黄色葡萄球菌对抗生素的耐受性。在小鼠感染模型中,两个菌株的Fts H突变体都表现出更弱的毒性。我们的研究表明,尽管Fts H的直接底物数量有限,但它可通过这些底物调控细胞内150-200个蛋白的丰度,从而影响金黄色葡萄球菌的诸多生命过程。这一方法有望应用于研究更多蛋白酶的底物及功能。

关键词：蛋白质组学质谱金黄色葡萄球菌 FtsH 底物

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Nano Research 2023年第8期16卷 11543-11543页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

关键词： artificial neural network neuromorphic computing artificial synapse proton conductor peptide materials

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Timeto B咖啡厅&酒馆

现代装饰 2023年第2期 16-23页

作者： Shin Jung-bae Park Jji-hoon Ham So yeon Park Ye-il Yeo In-seong Lee Yu-jin Park Ji-hoon Kim Woo-sik 范嘉苑(编译) 不详

本案位于韩国龙仁市郊区的光桥山附近,其地理位置及店铺奉行的“无外带”以及“无插座、无Wi-Fi”理念可能会给一些顾客带来不便,但设计者仍希望鼓励顾客在此享受时光,暂时远离数字设备,在大自然中完全地“休息”和“放松”。

关键词：数字设备咖啡厅地理位置 Wi-Fi 顾客

A Study on the Optimal Offset Distance Between a Welding Torch and the Infrared Thermometers

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Fluid Dynamics & Materials Processing 2019年第1期15卷 1-14页

作者： Tae-Jong Yun Won-Bin Oh Bo-Ram Lee Joon-sik Son Ill-soo Kim Department of Mechanical Engineering Mokpo National University1666 Yeongsan-roCheonggyemyeonMuan-gunJeollanam-do58554South Korea Research Institute of Medium&Small Shipbuilding 55Daebuljugeo 3-roSamho-eupYeongam-gunJeollanam-do58457South Korea

Detection of weld defects using real-time monitoring and controlling algorithm is of the significant task in manufacturing industries due to the increased production and liability costs that result when weld defects are not identified early in the production *** and controlling for robotic arc welding process employed should be reliable,flexible and cost-effective in non-clean,high-volume production ***,the robotic welding system has been utilized a complex jigging and mechanical devices to move the workpiece which related to the stationary welding head for getting higher efficiency and lower *** develop the fully robotic welding system,people make use of their senses of sound and/or sight to collect welding information,and take the necessary corrective measurements to ensure the weld quality after processing is ***,it is really required that the monitoring and controlling algorithm of sensors for increasing effectiveness in the robotic welding process has been *** this paper,bead-on-plate welding using an infrared thermography in the robotic GMA(Gas Metal Arc)welding process has been performed to study the effects of welding parameters on thermal profile characteristics and find the optimal offset distance which applied for monitoring and controlling of welding quality such as bead *** analysis for correlation between temperature distributions at three offset distance and bead height which based on the regression analysis such as Standard Error of Estimate(SEE),the coefficient of correlation(R)and coefficient of determination(R2)and(Predictive Ability of Model)has been *** infra-red sensor is useful for monitoring the isotherm radii that arise during the robotic welding process and identifying bead height as welding quality.

关键词： GMA welding adaptive control bead-on-plate joint infrared thermometers bead height

5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer

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5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（...

2000全国肿瘤学术大会

作者： Kazuo Kinoshita Yutaka Yonemura Toshiharu Sawa Tatsukazu Miyata Hiroshi Sakuma Nobuo Matsuki Sigehiro Tanaka Sachio Fushida Takashi Fujimura Young Jae Mok Byung sik Kim Jong In Lee Dong Wook Choi Young Jin Song Doo Hyun Yang Sung Joon Kwon Itsuo Miyazaki Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicine Kanazawa University13-1 Takara-machiKanazawaJapan M.D.

＜正＞Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.

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继旧开新——城市住宅设计

建筑师 2021年第2期 13-19页

作者： [瑞士]米洛斯拉夫·锡克程博(译) 张峰(校) 苏黎世联邦理工大学米洛斯拉夫·锡克设计事务所丘建筑设计事务所瑞士工程师与建筑师协会上海重峰建筑设计咨询有限公司

在阿尔多·罗西短暂的瑞士教学后,他的学生们对其思想和设计方法论进行了演绎发展。其中法比奥·莱茵哈特和米洛斯拉夫·锡克从20世纪80年代起所创立的"类比建筑"(Analoge Architektur)教学与实践方法论最为系统化。本文是锡克基于他过... 详细信息

在阿尔多·罗西短暂的瑞士教学后,他的学生们对其思想和设计方法论进行了演绎发展。其中法比奥·莱茵哈特和米洛斯拉夫·锡克从20世纪80年代起所创立的"类比建筑"(Analoge Architektur)教学与实践方法论最为系统化。本文是锡克基于他过去四十年教学与实践,对欧洲城市住宅的类型研究与设计思考。对罗西和他所影响的瑞士建筑师而言,类型学是生动而具体的,是对建筑如何回应历史和社会条件的基本理解,也是建筑设计中得以与古为新的基本工具,这在本文中得到了非常详尽的诠释。

关键词：类比建筑类型学居住建筑城市氛围