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Polymer-virus core-shell structures prepared via co-assembly and template synthesis methods

Science China Chemistry 2010年第1期53卷 71-77页

作者： suthiwangcharoen nisaraporn PREVELIGE Peter E.Jr Department of Chemistry and Biochemistry and Nanocenter University of South CarolinaColumbiaSouth Carolina 29208USA Department of Microbiology University of Alabama at BirminghamBirminghamAL 35294USA

Bionanoparticles(BNPs),consisting of virus and virus-like assemblies,have attracted much attention in the biomedical field for their applications such as imaging and targeted drug delivery,owing to their well-defined structures and well-controlled ***-based core-shell structures provide a unique system for the investigation of biological interactions such as protein-protein and protein-carbohydrate ***,it is still a challenge to prepare the BNPs-based core-shell ***,we describe(i) co-assembly method and(ii) template synthesis method in the development of polymer-BNPs core-shell *** two methods can be divided into three different *** system A,different polymers including poly(2-vinylpyridine)(P2VP),poly(4-vinylpyridine)(P4VP) and poly(ε-caprolactone)-block-poly(2-vinylpyridine)(PCL-b-P2VP) can form a raspberry-like structure with *** system B,polystyrene(PS) spheres end capped with free amine and BNPs can form a core-shell *** System C,layer-by-layer(LBL) method is used to prepare positive charged PS particles,which can be used as a template to form the core-shell structures with *** two methods may open a new way for preparing novel protein-based functional materials for potential applications in the biomedical field.

关键词： core-shell structures bionanoparticles virus polymers co-assembly template synthesis layer-by-layer

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Tuning the optical properties of BODIPY dye through Cu(Ⅰ) catalyzed azide-alkyne cycloaddition(CuAAC) reaction

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Science China Chemistry 2012年第1期55卷 125-130页

作者： WANG Chao XIE Fang suthiwangcharoen nisaraporn SUN Jian WANG Qian Natural Products Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208USA

Borondipyrromethenes(BODIPY) are a class of fluorescent dyes whose fluorescence quantum yields are generally high and independent of the *** this paper,we report the synthesis of a new type of BODIPY compound that carries an azido group on the 3-position of the pyrrole *** azido group quenches the fluorescence of the dye due to its weak electron-donating *** fluorescence of the BODIPY dye can be switched on after reacting with alkynes via a Cu(Ⅰ) catalyzed azide-alkyne cycloaddition(CuAAC) *** further demonstrate that this azido-BODIPY compound can be used in the cell imaging applications.

关键词： CuAAC reaction fluorogenic BODIPY dye cell imaging fluorescent probe

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M13 Bacteriophage-Polymer Nanoassemblies as Drug Delivery Vehicles

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Nano Research 2011年第5期4卷 483-493页

作者： nisaraporn suthiwangcharoen Tao Li Kai Li Preston Thompson Shaojin You Qian Wang Department of Chemistry and Biochemistry and Nanocenter University of South Carolina Columbia SC 29208 USA Histo-Pathology Core Atlanta VA Medical Center 1670 Clairmont Road Decatur GA 30033 USA

Poly（caprolactone-b-2-vinylpyridine）（PCL-P2VP） coated with folate-conjugated M13 （FA-M13） provides a nanosized delivery system which is capable of encapsulating hydrophobic antitumor drugs such as doxorubicin （DOX）. The DOXqoaded FA-M13-PCL-P2VP assemblies had an average diameter of approximately 200 nm and their structure was characterized using transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. The particles were stable at physiological pH but could be degraded at a lower pH. The release of DOX from the nanoassemblies under acidic conditions was shown to be significantly faster than that observed at physiological pH. In addition, the DOX-loaded FA-M13-PCL-P2VP particles showed a distinctly greater cellular uptake and cytotoxicity against folate-receptor-positive cancer cells than folate-receptor-negative cells, indicating that the receptor facilitates folate uptake via receptor-mediated endocytosis. Furthermore, the DOX-loaded particles also had a significantly higher tumor uptake and selectivity compared to free DOX. This study therefore offers a new way to fabricate nanosized drug delivery vehicles.

关键词： Bacteriophage M13 nanoassemblies doxorubicin drug delivery polymer

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Tuning the optical properties of BODIPY dye through Cu(I) catalyzed azide-alkyne cycloaddition(CuAAC) reaction

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中国科学：化学 2012年第2期42卷 231-232页

Borondipyrromethenes(BODIPY) are a class of fluorescent dyes whose fluorescence quantum yields are generally high and independent of the *** this paper,we report the synthesis of a new type of BODIPY compound that carries an azido group on the 3-position of the pyrrole *** azido group quenches the fluorescence of the dye due to its weak electron-donating *** fluorescence of the BODIPY dye can be switched on after reacting with alkynes via a Cu(I) catalyzed azide-alkyne cycloaddition(CuAAC) *** further demonstrate that this azido-BODIPY compound can be used in the cell imaging applications.

关键词：环加成反应肾上腺素荧光染料叠氮光学特性铜(I) 催化荧光量子产率

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