Polymer-virus core-shell structures prepared via co-assembly and template synthesis methods

作     者：SUTHIWANGCHAROEN Nisaraporn PREVELIGE Peter E.Jr 

作者机构：Department of Chemistry and Biochemistry and NanocenterUniversity of South CarolinaColumbiaSouth Carolina 29208USA Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamAL 35294USA 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2010年第53卷第1期

页      面：71-77页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：support from the US NSF CAREER program US DoD (W911NF-09-1-0236) the Alfred P. Sloan Scholarship  the Camille Dreyfus Teacher Scholar Award  DoD-BCRP and the W.M.Keck Foundation 

主　　题：core-shell structures bionanoparticles virus polymers co-assembly template synthesis layer-by-layer 

摘      要：Bionanoparticles(BNPs),consisting of virus and virus-like assemblies,have attracted much attention in the biomedical field for their applications such as imaging and targeted drug delivery,owing to their well-defined structures and well-controlled ***-based core-shell structures provide a unique system for the investigation of biological interactions such as protein-protein and protein-carbohydrate ***,it is still a challenge to prepare the BNPs-based core-shell ***,we describe(i) co-assembly method and(ii) template synthesis method in the development of polymer-BNPs core-shell *** two methods can be divided into three different *** system A,different polymers including poly(2-vinylpyridine)(P2VP),poly(4-vinylpyridine)(P4VP) and poly(ε-caprolactone)-block-poly(2-vinylpyridine)(PCL-b-P2VP) can form a raspberry-like structure with *** system B,polystyrene(PS) spheres end capped with free amine and BNPs can form a core-shell *** System C,layer-by-layer(LBL) method is used to prepare positive charged PS particles,which can be used as a template to form the core-shell structures with *** two methods may open a new way for preparing novel protein-based functional materials for potential applications in the biomedical field.