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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： lan Yang Lai-yu Kwok Zhihong sun Heping Zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

北京再发黑热病利什曼原虫K26基因和ITS-1序列的多态性分析

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寄生虫与医学昆虫学报 2024年第1期31卷 1-5,52页

作者：孙玉兰王小梅吴文婷张代涛何战英北京市疾病预防控制中心北京100013

目的了解北京市再发黑热病病例的病原分子遗传背景。方法使用PCR方法分别扩增其亲水性酰化表面蛋白B(K26)和核糖体DNA内转录间隔区Ⅰ(ITS-1),然后克隆测序,分析其多态性,构建系统发育树以确定患者感染原虫的虫种类型及其遗传关系。结果... 详细信息

目的了解北京市再发黑热病病例的病原分子遗传背景。方法使用PCR方法分别扩增其亲水性酰化表面蛋白B(K26)和核糖体DNA内转录间隔区Ⅰ(ITS-1),然后克隆测序,分析其多态性,构建系统发育树以确定患者感染原虫的虫种类型及其遗传关系。结果K26基因扩增出626 bp大小片段,其长度与国内流行株差异明显,其氨基酸序列由14个氨基酸的基序重复排列组成,但个别位置发生氨基酸替代。K26序列的系统进化树分析显示,北京病例虫株与法国和西班牙的婴儿利什曼原虫相近,但与国内新疆、四川、河北等地的婴儿利什曼原虫虫株距离较远;ITS-1序列扩增出314 bp大小的片段,其系统发育分析显示与婴儿利什曼原虫Leishmania infantum属于同一分支。结论该病例感染的为婴儿利什曼原虫***,且与国内其他流行区的虫株有一定差异。

关键词：黑热病婴儿利什曼原虫多态性 K26 ITS-1 北京

CONVERGENCE OF MODIFIED TRUNCATED EULER-MARUYAMA METHOD FOR STOCHASTIC DIFFERENTIAL EQUATIONS WITH HOLDER DIFFUSION COEFFICIENTS

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Journal of Computational Mathematics 2024年第4期42卷 1109-1123页

作者： Guangqiang lan yu Jiang College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Convergence of modified truncated Euler-Maruyama(MTEM)method for stochastic differential equations(SDEs)with(1/2+α)-Holder continuous diffusion coefficients are investigated in this *** prove that the MTEM method for... 详细信息

关键词： Stochastic differential equations Modified truncated Euler-Maruyama method Strong convergence One-sided Lipschitz Holder continuous

Demonstration of high-dimensional controlled quantum teleportation for the first time

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 163-164页

作者： yu-Bo Sheng lan Zhou College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

Controlled quantum teleportation(CQT) [1] is the tripartite version of quantum teleportation and it allows the teleportation of an unknown quantum state under the control of a third party. Compared with low-dimensional counterparts,high-dimensional CQT can exhibit larger information transmission capacity and a higher control power [2,3].

关键词： quantum dimensional high

Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutrons uniting with D-T neutron activation and AMS techniques

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Nuclear Science and Techniques 2024年第6期35卷 78-89页

作者： Xian-Lin Yang Chang-Lin lan yu-Ting Wei Yi Zhang Gong Jiang Bo Xie yu Liu Hong-Tao Shen Xiao-Jun sun School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China

Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great *** address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion *** the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He ***^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of *** neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb *** measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature *** newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental *** obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

关键词： 14-MeV neutron ^(27)Al(n,2n)^(26)Al Cross section AMS

Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： lan Zhou yu Huang yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

Persistent Variations in the East Asian Trough from March to April and the Possible Mechanism

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Advances in Atmospheric Sciences 2024年第4期41卷 737-753,I0002-I0004页

作者： Shui yu Jianqi sun Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The East Asian trough(EAT)profoundly influences the East Asian spring *** this study,the relationship of the EATs among the three spring months is *** analysis shows that the variation in March EAT is closely related to that of April *** empirical orthogonal function(EEOF)analysis also confirms the co-variation of the March and April *** positive/negative EEOF1 features the persistent strengthened/weakened EAT from March to *** investigation indicates that the variations in EEOF1 are related to a dipole sea surface temperature(SST)pattern over the North Atlantic and the SST anomaly over the tropical Indian *** dipole SST pattern over the North Atlantic,with one center east of Newfoundland Island and another east of Bermuda,could trigger a Rossby wave train to influence the EAT in March−*** SST anomaly over the tropical Indian Ocean can change the Walker circulation and influence the atmospheric circulation over the tropical western Pacific,subsequently impacting the southern part of the EAT in March−*** the SST factors,the Northeast Asian snow cover could change the regional thermal conditions and lead to persistent EAT anomalies from March to *** three impact factors are generally independent of each other,jointly explaining large variations in the EAT ***,the signals of the three factors could be traced back to February,consequently providing a potential prediction source for the EAT variation in March and April.

关键词： spring East Asian trough sea surface temperature snow cover

Cooperative game penetration guidance for multiple hypersonic vehicles under safety critical framework

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Chinese Journal of Aeronautics 2024年第1期37卷 247-255页

作者： Jieqing CHEN Ruisheng sun yu LU School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China

The rapid development of the anti-missile weapon technology brings new challenges to the cooperative penetration strategy solution and the guidance law design for Hypersonic Vehicles(HVs).This paper studies the coordinated game penetration guidance problem for multiple hypersonic vehicles faced with space threat areas.A scheme for seeking cooperative game penetration guidance strategy under safety critical control framework is *** this scheme,a multiHV cooperative game model is proposed in a minimum optimization form which can simplify the solving process and accelerate the computing ***,a second-order control barrier function is developed to transform the implicit nonlinear constraints of the proposed model into linear *** order to obtain better performance of guidance strategy,a composite guidance law under the safety critical control framework is presented to allocate guidance strategies appropriately in the whole *** is shown that the proposed scheme can guarantee successful penetration while avoiding threat ***,a comparative simulation with a two-on-three game is conducted to verify the effectiveness of the proposed method.

关键词： Hypersonic vehicles Safety critical control Penetration game Space constraints Cooperative guidance

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： lan-lan Li yu Zhao Li-Jia Pan Jian-Bin Xu Yi Shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

Mechanisms of inclusion-induced pitting of stainless steels:A review

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Journal of Materials Science & Technology 2024年第1期168卷 143-156页

作者： Yangting sun Xin Tan Rulei lan Guoyong Ran Jin Li Yiming Jiang Department of Materials Science State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200438China

Pitting is a common type of localized corrosion in passive alloys that can cause rapid failure of material or *** the case of stainless steels,non-metallic inclusions have been identified as the most susceptible sites for pitting,and have therefore garnered significant *** review critically ex-amines the issue of how inclusions induce pitting,with a particular focus on three mechanisms:sponta-neous dissolution of inclusions,active dissolution of Cr-depleted regions,and propagation of microcracks at the inclusion-matrix *** researchers have made significant strides in understanding these mechanisms over the past few decades,many gaps and controversies *** such as the ini-tial driving force of inclusion dissolution and factors affecting Cr-depleted regions require further ***,some old concepts and methods need to be revised to arrive at more credible *** review aims to delve deeply into these important issues and provide inspiration for future research.

关键词： Pitting Inclusion Stainless steel Localized corrosion MnS