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A progressive compression model of thoracic spinal cord injury in mice： function assessment and pathological changes in spinal cord

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Neural Regeneration Research 2017年第8期12卷 1365-1374页

作者： Guo-dong sun yan Chen Zhi-gang Zhou Shu-xian yang Cheng Zhong Zhi-zhong Li Department of Orthopedics First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Jinan UniversityGuangzhouGuangdong ProvinceChina Department Of Traumatology and-Plastic Surgery The Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan UniversityJiangmenGuangdong ProvinceChina Department of Orthopedics Heyuan People's Hospital(Heyuan Affiliated Hospital of Jinan University)HeyuanGuangdong ProvinceChina

Non-traumatic injury accounts for approximately half of clinical spinal cord injury, including chronic spinal cord compression. However, previous rodent spinal cord compression models are mainly designed for rats, few are available for mice. Our aim is to develop a thoracic progressive compression mice model of spinal cord injury. In this study, adult wild-type C57BL/6 mice were divided into two groups： in the surgery group, a screw was inserted at T9 lamina to compress the spinal cord, and the compression was increased by turning it further into the canal（0.2 mm） post-surgery every 2 weeks up to 8 weeks. In the control group, a hole was drilled into the lamina without inserting a screw. The results showed that Basso Mouse Scale scores were lower and gait worsened. In addition, the degree of hindlimb dysfunction in mice was consistent with the degree of spinal cord compression. The number of motor neurons in the anterior horn of the spinal cord was reduced in all groups of mice, whereas astrocytes and microglia were gradually activated and proliferated. In conclusion, this progressive compression of thoracic spinal cord injury in mice is a preferable model for chronic progressive spinal cord compression injury.

关键词： nerve regeneration progressive spinal cord compression injury pathological changes Basso Mouse Scale scores gait motor evokedpotentials astrocytes microglia motor neurons hindlimb dysfunction neural regeneration

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浙江省部分地区鸡球虫感染情况调查分析

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畜牧兽医学报 2024年第6期55卷 2629-2640页

作者：周思含李天恩邓金华孙洪超闫文朝石团员王天奇河南科技大学动物科技学院洛阳471023 浙江省农业科学院畜牧兽医研究所杭州310000 塔里木大学动物科学与技术学院阿拉尔843300

为了解浙江省部分地区鸡球虫感染情况,以及对致病性新种:拉坦艾美耳球虫(Eimeria latan)、纳甘比艾美耳球虫(Eimeria nagambie)和扎利亚艾美耳球虫(Eimeria zaria)进行鉴定,从杭州、丽水、嘉兴3个地区7个养殖场采集新鲜鸡粪便349份。使... 详细信息

为了解浙江省部分地区鸡球虫感染情况,以及对致病性新种:拉坦艾美耳球虫(Eimeria latan)、纳甘比艾美耳球虫(Eimeria nagambie)和扎利亚艾美耳球虫(Eimeria zaria)进行鉴定,从杭州、丽水、嘉兴3个地区7个养殖场采集新鲜鸡粪便349份。使用麦克马斯特计数法检查并计数每克粪便中球虫卵囊数,用显微观察法确定阳性样品中球虫种类,并进行PCR鉴定。随后,按地区来源、养殖方式、用途和日龄不同对鸡球虫的感染情况进行差异分析。结果显示,所调查地区鸡球虫的总感染率为72.78%(254/349),共检出七种传统鸡艾美耳球虫和纳甘比艾美耳球虫。其中优势种为堆型艾美耳球虫,7个养殖场均为混合感染。PCR及序列分析结果表明在7个场中4个存在疑似纳甘比艾美耳球虫的感染,其中A场纳甘比艾美耳球虫与澳大利亚株LR877717.1 COI基因序列亲缘关系最近,相似性为99.99%,聚成一支。调查研究结果表明,浙江地区鸡球虫总体感染率较高,其中堆型艾美耳球虫田间感染尤其严重。所调查的浙江省部分地区部分鸡场已出现疑似纳甘比艾美耳球虫的感染。

关键词：浙江鸡球虫流行病学调查纳甘比艾美耳球虫堆型艾美耳球虫

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Hashtag Recommendation Using LSTM Networks with Self-Attention

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Computers, Materials & Continua 2019年第9期61卷 1261-1269页

作者： Yatian Shen yan Li Jun sun Wenke Ding Xianjin Shi Lei Zhang Xiajiong Shen Jing He School of Computer and Information Engineering Henan UniversityKaifeng475000China The Corporate and Investment Bank TechnologyCanary WharfLondonE145JPUK

On Twitter,people often use hashtags to mark the subject of a *** have specific themes or content that are easy for people to *** the increase in the number of tweets,how to automatically recommend hashtags for tweets has received wide *** previous hashtag recommendation methods were to convert the task into a multi-class classification ***,these methods can only recommend hashtags that appeared in historical information,and cannot recommend the new *** this work,we extend the self-attention mechanism to turn the hashtag recommendation task into a sequence labeling *** train and evaluate the proposed method,we used the real tweet data which is collected from *** results show that the proposed method can be significantly better than the most advanced *** with the state-of-the-art methods,the accuracy of our method has been increased 4%.

关键词： Hashtags recommendation self-attention neural networks sequence labeling

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Random sperm DNA fragmentation index is not associated with clinical outcomes in day-3 frozen embryo transfer

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Asian Journal of Andrology 2022年第1期24卷 109-115页

作者： Qing-Xin Wang Xia Wang Min-yan Yu Hua sun Di Wang Shu-Ping Zhong Feng Guo Center of Reproductive Medicine The Affiliated Hospital of Nantong UniversityNantong 226001China

Damage to sperm DNA was proposed to play an important role in embryonic *** studies focused on outcomes after fresh embryo transfer,whereas this study investigated the influence of sperm DNA fragmentation index(DFI)on laboratory and clinical outcomes after frozen embryo transfer(FET).This retrospective study examined 381 couples using cleavage-stage *** used for intracytoplasmic sperm injection(ICSI)or in vitro fertilization(IVF)underwent density gradient centrifugation and swim up *** DFI had a negative correlation with sperm motility(r=−0.640,P<0.01),sperm concentration(r=−0.289,P<0.01),and fertilization rate of IVF cycles(r=−0.247,P<0.01).Sperm DFI examined before and after density gradient centrifugation/swim up processing was markedly decreased after processing(17.1%vs 2.4%,P<0.01;65 randomly picked couples).Sperm progressive motility was significantly reduced in high DFI group compared with low DFI group for both IVF and ICSI(IVF:46.9%±12.4%vs 38.5%±12.6%,respectively;ICSI:37.6%±14.1%vs 22.3%±17.8%,respectively;both P<0.01).The fertilization rate was significantly lower in high(≥25%)DFI group compared with low(<25%)DFI group using IVF(73.3%±23.9%vs 53.2%±33.6%,respectively;P<0.01)but was equivalent in high and low DFI groups using *** development and clinical outcomes after FET were equivalent for low and high DFI groups using ICSI or *** this study,sperm DFI did not provide sufficient information regarding embryo development or clinical outcomes for infertile couples using FET.

关键词： embryo quality frozen embryo transfer in vitro fertilization intracytoplasmic sperm injection pregnancy semen parameters sperm DNA fragmentation index

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Dosimetry Comparison between Volumetric Modulated Arc Therapy with RapidArc and Fixed Field Dynamic IMRT for Local-Regionally Advanced Nasopharyngeal Carcinoma

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Chinese Journal of Cancer Research 2011年第4期23卷 259-264页

作者： Bao-min Zheng Xiao-xia Dong Hao Wu You-jia Duan Shu-kui Han yan sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of RadiotherapyPeking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China

Objective: A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC). Methods: The CT scan data sets of 20 patients of locally advanced NPC were selected randomly. The plans were managed using volumetric modulated arc with RapidArc and fixed nine-field coplanar dynamic intensity-modulated radiotherapy (IMRT) for these patients. The dosimetry of the planning target volumes (PTV), the organs at risk (OARs) and the healthy tissue were evaluated. The dose prescription was set to 70 Gy to the primary tumor and 60 Gy to the clinical target volumes (CTV) in 33 fractions. Each fraction applied daily, five fractions per week. The monitor unit (MU) values and the delivery time were scored to evaluate the expected treatment efficiency. Results: Both techniques had reached clinical treatment’s requirement. The mean dose (Dmean), maximum dose (Dmax) and minimum dose (Dmin) in RapidArc and fixed field IMRT for PTV were 68.4±0.6 Gy, 74.8±0.9 Gy and 56.8±1.1 Gy; and 67.6±0.6 Gy, 73.8±0.4 Gy and 57.5±0.6 Gy (P0.05). Compared to IMRT, RapidArc allowed a reduction of Dmean to the brain stem, mandible and optic nerves of 14.1% (P<0.05), 5.6% (P<0.05) and 12.2% (P<0.05), respectively. For the healthy tissue and the whole absorbed dose, Dmean of RapidArc was reduced by 3.6% (P<0.05), and 3.7% (P<0.05), respectively. The Dmean to the parotids, the spinal cord and the lens had no statistical difference among them. The mean MU values of RapidArc and IMRT were 550 and 1,379. The mean treatment time of RapidArc and IMRT was 165 s and 447 s. Compared to IMRT, the delivery time and the MU values of RapidArc were reduced by 63% and 60%, respectively. Conclusion: For locally advanced NPC, both RapidArc and IMRT reached the c

关键词： Volumetric modulated arc therapy Intensity-modulated radiotherapy Dosimetry Target volume Nasopharyngeal carcinoma

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α-fetoprotein involvement during glucocorticoid-induced precocious maturation in rat colon

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World Journal of Gastroenterology 2011年第24期17卷 2933-2940页

作者： Min Chen Peng sun Xiao-yan Liu Dan Dong Jun Du Luo Gu Ying-Bin Ge Lian Yun Gang Higher Vocational Technical College of Traditional Chinese Medicine Lianyungang 222006 Jiangsu Province China Department of Physiology Nanjing Medical University Nanjing 210029 Jiangsu Province China The Laboratory Center for Basic Medical Sciences Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： TO investigate the role of a-fetoprotein （AFP）, a cancer-associated fetal glycoprotein, in glucocorticoidinduced precocious maturation in rat colon. METHODS： Colons from suckling Sprague-Dawley rats were used in this study. Corticosterone acetate at a dose of 100 μg/g body weight was given to normal pups on days 7, 9 and 11 after birth to induce hypercorticoidism. Control animals were injected with identical volumes of normal saline. Some rats receiving corticosterone 7 d after birth were also treated with mifepristone （RU38486）, a glucocorticoid cytoplasm receptor antagonist to investigate the effects of glucocorticoids （GCs）. The morphological changes of the crypt depth and villous height of the villous zone in colon were observed as indicesof colon maturation. Expression levels of AFP in colons were detected by reverse transcriptase polymerase chain reaction and Western blotting. To identify the cellular lo- calization of AFP in developing rat colons, double-immu- nofluorescent staining was performed using antibodies to specific mesenchymal cell marker and AFP. RESULTS： Corticosterone increased the crypt depth and villous height in the colon of 8- and 10-d-old rats with hypercorticoidism compared with that in the control ani- mals （120% in 8-d-old rats and 118% in 10-d-old rats in villous height, P = 0.021; 145% in 8-d-old rats and 124% in 10-d-old rats in crypt depth, P = 0.017）. These increases were accompanied by an increase of AFP ex- pression in both mRNA and protein （2.5-folds in 8-d- old and 2.5-folds in 10-d-old rats higher than in control animals, P = 0.035; 1.8-folds in 8-d-old and 1.3-folds in 10-d-old rats higher than in control animals, P = 0.023）. Increased crypt depth and villous height and increased expression of AFP in the colon of rats with hypercorti- coidism were blocked by mifepristone. Both had positive staining for AFP or vimentin, and overlapped in mesen- chymal cells at each tested colon. CONCLUSION： GCs promote the development of ra

关键词： Glucocorticoids a-fetoprotein Precociousmaturation Colon Rat

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Influence of the biological carbon pump effect on the sources and deposition of organic matter in Fuxian Lake, a deep oligotrophic lake in southwest China

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Acta Geochimica 2019年第5期38卷 613-626页

作者： Haibo He Zaihua Liu Chongying Chen Yu Wei Qian Bao Hailong sun Yundi Hu Hao yan State Key Laboratory of Environmental Geochemistry Institute of GeochemistryCASGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Quaternary Science and Global Change Guiyang 550081China

Biological carbon pumping(BCP)is a key process in which dissolved inorganic carbon in terrestrial aquatic ecosystems is utilized by aquatic autotrophs for photosynthesis and transformed into autochthonous organic matter(AOC).However,the mechanisms underlying BCP and the amount of generated AOC deposited effectively,are still poorly ***,we conducted a systematic study combining modern hydrochemical monitoring and a sediment trap experiment in Fuxian Lake(Yunnan,SW China),the second-deepest plateau,oligotrophic freshwater lake in ***,pH,EC(electrical conductivity),DO(dissolved O2),[HCO3^-],[Ca^2+],SIc,partial CO2(pCO2)pressure,and carbon isotopic compositions of HCO3^-(δ^13CDIc)in water from Fuxian Lake all displayed distinct seasonal and vertical *** was especially apparent in an inverse correlation between pCO2 and DO,indicating that variations of hydrochemistry in the lake water were mainly controlled by the metabolism of the aquatic ***,the lowest C/N ratios and highestδ^13Corg were recorded in the trap *** of the C/N ratio demonstrated that the proportions of AOC ranged from 30%to 100%of all OC,indicating that AOC was an important contributor to sedimentary organic matter(OC).It was calculated that the AOC flux in Fuxian Lake was 20.43 t C km^-2 in ***,AOC produced by carbonate weathering and aquatic photosynthesis could potentially be a significant carbon sink and may have an important contribution to solving the lack of carbon sinks in the global carbon cycle.

关键词： Carbonate weathering Hydrochemical variation Biological carbon pump effect Sediment trap Autochthonous organic carbon Carbon sink

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Characterization and expression analysis of a novel RING-HC gene,ZmRHCP1,involved in brace root development and abiotic stress responses in maize

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Journal of Integrative Agriculture 2017年第9期16卷 1892-1899页

作者： LI Wen-lan sun Qi LI Wen-cai YU yan-li ZHAO Meng MENG Zhao-dong Maize Research Institute Shandong Academy of Agricultural Sciences~National Engineering Laboratory of Wheat and Maize/Key Laboratory of Biology and Genetic Improvement of Maize in Northern Yellow-Huai River PlainMinistry of AgricultureJinan 250100.P.R.China

RING is a really interesting new gene which plays important regulatory roles in many developmental processes as well as in plant-environment interactions. In the present report, the Zm RHCP1 gene encoding a putative RING-HC protein was isolated from maize and characterized. The Zm RHCP1 protein contained 310 amino acid residues with a conserved RINGHC zinc-finger motif and two transmembrane（TM） domains. Zm RHCP1 was expressed ubiquitously in various organs（root, stem, leaf, seedling, immature ear, and tassel）, but its transcript levels were higher in vegetative organs than in reproductive organs. Moreover, the expression pattern of Zm RHCP1 in brace roots indicated that Zm RHCP1 functions in brace root initiation. In addition, Zm RHCP1 expression was regulated by abiotic stresses. The expression results suggested that Zm RHCP1 plays important roles in brace root development and abiotic stress responses. The findings of the present study provide important information to help us understand the function of Zm RHCP1 in maize.

关键词： RING-HC zinc-finger brace root expression abiotic stresses maize

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Research on End-force Output of 8-cable Driven Parallel Manipulator

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International Journal of Automation and computing 2020年第3期17卷 378-389页

作者： Sen-Hao Hou Xiao-Qiang Tang Ling Cao Zhi-Wei Cui Hai-Ning sun Ying-Wei yan State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipments and Control Tsinghua UniversityBeijing 100084China Postal Scientific Research and Planning Academy Beijing 100096China

The return capsule needs to be launched to the moon and return back to earth in the third stage of the Chinese lunar exploration ***,it is necessary to perform simulations on the *** paper presents an 8-cable-driven parallel manipulator to achieve end-force output in a low-gravity ***-force output refers to the vector sum of the external force on the end-effector.A model of end-force output is established based on a kinematics model,a dynamic model,and a force analysis of an 8-cable driven parallel *** obtain end-force output in a low-gravity environment,the cable force has to be controlled to counteract *** addition,a force-position mix control strategy is proposed to proactively control the cable force according to the force optimal distribution given by the closed-form force distribution ***,a suitable choice for an end-force output is obtained by modeling the effect of cable force on end-force *** results show that the actual cable force agrees well with the calculated force distribution,indicating that it is feasible to realize end-force output in a low gravity environment.

关键词： Cable driven parallel manipulators low gravity environment end force output cable force control mix control strategy

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Effect and Safety of Acupuncture for Type 2 Diabetes Mellitus:A Systematic Review and Meta-analysis of 21 Randomised Controlled Trials

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Chinese Journal of Integrative Medicine 2022年第5期28卷 463-471页

作者： LI Shu-qing CHEN Jian-rong LIU Mei-lu WANG yan-ping ZHOU Xu sun Xin Evidence-Based Medicine Research Centre Jiangxi University of Traditional Chinese MedicineNanchang(330004)China Department of Endocrinology the First Affiliated Hospital of Nanchang UniversityNanchang(330006)China Department of Integrated Chinese and Western Medicine West China HospitalSichuan UniversityChengdu(610041)China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu(610041)China

Objective:To evaluate the effects of acupuncture on hypoglycaemic outcomes in type 2 diabetes mellitus(T2 DM).Methods:Pub Med,Embase,Cochrane Library,and Clinical *** were searched from inception up to July 2020,to identify randomised controlled trials(RCTs)that enrolled patients with T2 DM and compared acupuncture combined with antidiabetic drugs to antidiabetic drugs *** primary outcomes were haemoglobin A1 c(Hb A1 c)and fasting blood glucose(FBG).The secondary outcomes included 2-h blood glucose(2 h BG),fasting insulin(FINS),homeostatic model assessment for insulin resistance(HOMA-IR),and acupuncture-related adverse *** difference(MD)and 95%confidence interval(CI)were used as the effect measure in the *** quality of evidence was assessed using the Grading of Recommendations Assessment,Development and Evaluation ***:Twenty-one RCTs(n=1,188)were *** meta-analytic results showed that the acupuncture group had greater reductions in FBG(MD-6.46 mg/d L,95%CI-11.95 to-0.98;moderate-quality evidence)and HOMA-IR(MD-1.23,95%CI-2.16 to-0.31;low-quality evidence),but comparable changes in Hb A1 c(MD-0.39%,95%CI-0.84 to 1.61;very-low-quality evidence),2 h BG(MD-4.99 mg/d L,95%CI-20.74 to 10.76;low-quality evidence),and FINS(MD-1.32μIU/m L,95%CI-3.76 to 1.12;low-quality evidence).No data on the incidence of diabetic complications were *** acupuncture-related adverse events reported were ***:The current evidence suggests that acupuncture,as a complementary therapy to antidiabetic drugs,has a small but statistically significant effect on decreasing FBG and improving insulin *** effects of acupuncture on Hb A1 c,2 h BG,and FINS remain *** is generally safe in patients with mild *** evidence for the long-term effects of acupuncture on T2 DM is needed.(Registration ***42018115639)

关键词： acupuncture type 2 diabetes mellitus systematic review meta-analysis

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