Effect and Safety of Acupuncture for Type 2 Diabetes Mellitus:A Systematic Review and Meta-analysis of 21 Randomised Controlled Trials

作     者：LI Shu-qing CHEN Jian-rong LIU Mei-lu WANG Yan-ping ZHOU Xu SUN Xin 

作者机构：Evidence-Based Medicine Research CentreJiangxi University of Traditional Chinese MedicineNanchang(330004)China Department of Endocrinologythe First Affiliated Hospital of Nanchang UniversityNanchang(330006)China Department of Integrated Chinese and Western MedicineWest China HospitalSichuan UniversityChengdu(610041)China Chinese Evidence-Based Medicine CentreWest China HospitalSichuan UniversityChengdu(610041)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2022年第28卷第5期

页      面：463-471页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by the Teaching Reform Project of Colleges and Universities in Jiangxi Province(No.JXJG-19-12-14) Education Science"13th Five-Year Plan"Project of Jiangxi Province(No.20YB148) Jiangxi University of Traditional Chinese Medicine 1050 Youth Talent Project(No.5142001011) 

主　　题：acupuncture type 2 diabetes mellitus systematic review meta-analysis 

摘      要：Objective:To evaluate the effects of acupuncture on hypoglycaemic outcomes in type 2 diabetes mellitus(T2 DM).Methods:Pub Med,Embase,Cochrane Library,and Clinical *** were searched from inception up to July 2020,to identify randomised controlled trials(RCTs)that enrolled patients with T2 DM and compared acupuncture combined with antidiabetic drugs to antidiabetic drugs *** primary outcomes were haemoglobin A1 c(Hb A1 c)and fasting blood glucose(FBG).The secondary outcomes included 2-h blood glucose(2 h BG),fasting insulin(FINS),homeostatic model assessment for insulin resistance(HOMA-IR),and acupuncture-related adverse *** difference(MD)and 95%confidence interval(CI)were used as the effect measure in the *** quality of evidence was assessed using the Grading of Recommendations Assessment,Development and Evaluation ***:Twenty-one RCTs(n=1,188)were *** meta-analytic results showed that the acupuncture group had greater reductions in FBG(MD-6.46 mg/d L,95%CI-11.95 to-0.98;moderate-quality evidence)and HOMA-IR(MD-1.23,95%CI-2.16 to-0.31;low-quality evidence),but comparable changes in Hb A1 c(MD-0.39%,95%CI-0.84 to 1.61;very-low-quality evidence),2 h BG(MD-4.99 mg/d L,95%CI-20.74 to 10.76;low-quality evidence),and FINS(MD-1.32μIU/m L,95%CI-3.76 to 1.12;low-quality evidence).No data on the incidence of diabetic complications were *** acupuncture-related adverse events reported were ***:The current evidence suggests that acupuncture,as a complementary therapy to antidiabetic drugs,has a small but statistically significant effect on decreasing FBG and improving insulin *** effects of acupuncture on Hb A1 c,2 h BG,and FINS remain *** is generally safe in patients with mild *** evidence for the long-term effects of acupuncture on T2 DM is needed.(Registration ***42018115639)