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Traction Potential Analysis of Self-Propelled Seafloor Trencher Based on Mechanical Measurements in Bentonite Soil

Journal of Harbin Institute of Technology(New Series) 2017年第1期24卷 71-80页

作者： Meng Wang xuyang Wang Yuanhong sun Zhimin Gu School of Naval Architecture Ocean and Civil EngineeringShanghai Jiaotong UniversityShanghai 200240China North China Sea Marine Technical Support Centre State Oceanic AdministrationQingdao 266061ShandongChina

Shear stress-displacement relationship model of soil is very important to predict the tractive performance of tracked vehicle. Most shear stress-displacement models were proposed for terrestrial ***,they are not suit for soft seafloor with flow surface and high water content. Based on comprehensive analysis of seafloor soil shear deformation and track segment shear tests,a new empirical model of shear stressdisplacement relationship for saturated soft-plastic soil(SSP model) was proposed. To validate the SSP model and evaluate potential tractive force of self-propelled seafloor trencher,a test platform,where track segment shear test and drawbar pull test can be performed in seafloor soil substitute(bentonite water mixture),was built. Series of shear tests were carried out. Test results show that the SSP model can describe the mechanical behavior of track segment in seafloor soil substitute with good approximation. Through analyzing the main external forces,including environmental loads from seafloor soil and sea current applied to seafloor tracked trencher during the trenching process in a straight line,drawbar pull analysis model was deduced with the SSP model. A scale test model of seafloor tracked trencher was built,and the verification tests for drawbar pull analysis model were designed and carried out. Results of verification tests indicate that the drawbar pull analysis model was feasible and effective. The drawbar pull tests also indicated that the SSP model is valid from another side.

关键词： shear stress-displacement relationship SSP model tractive performance drawbar pull self-propelled seafloor trencher

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急诊部分脾栓塞术治疗食管胃静脉曲张破裂出血的初步研究

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胃肠病学和肝病学杂志 2018年第11期27卷 1261-1264页

作者：李丛勇刘江涛郭亮亮李超赵义名孙旭阳王淑芳孙刚中国人民解放军总医院消化内科北京100853 中国人民解放军总医院海南分院消化科海军总医院干部病房消化内科

目的探讨急诊部分脾栓塞术(partial splenic embolization,PSE)救治肝硬化食管胃静脉曲张破裂出血(esophageal and gastric variceal bleeding,EGVB)的可行性及近期疗效。方法对中国人民解放军总医院海南分院2016年3月至2017年6月连续... 详细信息

目的探讨急诊部分脾栓塞术(partial splenic embolization,PSE)救治肝硬化食管胃静脉曲张破裂出血(esophageal and gastric variceal bleeding,EGVB)的可行性及近期疗效。方法对中国人民解放军总医院海南分院2016年3月至2017年6月连续收治的9例肝硬化急性EGVB患者,24 h内进行肝静脉压力梯度(hepatic venous pressure gradient,HVPG)测定并采用急诊PSE治疗,以HVPG降低20%或低于12 mm Hg为目标,观察1周内再出血率及不良反应; 1周后序贯内镜治疗。结果 9例肝硬化急性EGVB的患者均成功接受PSE术,男7例,女2例,平均年龄(53. 78±13. 01)岁;脾脏栓塞体积40%~60%,HVPG由术前(14. 82±3. 93) mm Hg下降到(12. 11±3. 69) mm Hg(平均降低18. 62%)。术后1周再出血率为0,除一过性腹痛、发热以外,无严重并发症。结论通过HVPG测定指导下的急诊PSE对肝硬化急性EGVB的患者具备一定的可行性;通过降低HVPG到目标值,实现近期止血效果,为后续的内镜治疗创造机会。

关键词：食管胃静脉曲张破裂出血肝静脉压力梯度部分脾栓塞术可行性

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Region-aware neural graph collaborative filtering for personalized recommendation

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International Journal of Digital Earth 2022年第1期15卷 1446-1462页

作者： Shengwen Li Renyao Chen Chenpeng sun Hong Yao xuyang Cheng Zhuoru Li Tailong Li Xiaojun Kang State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhanPeople’s Republic of China School of Computer Science China University of GeosciencesWuhanPeople’s Republic of China School of Future Technology China University of GeosciencesWuhanPeople’s Republic of China National Engineering Research Center of Geographic Information System China University of GeosciencesWuhanPeople’s Republic of China

Personalized recommender systems have been widely deployed in various scenarios to enhance user experience in response to the challenge of information ***,personalized recommendation models based on graph structure have advanced greatly in predicting user ***,geographical region entities that reflect the geographical context of the items is not being utilized in previous works,leaving room for the improvement of personalized *** study proposes a region-aware neural graph collaborative filtering(RA-NGCF)model,which introduces the geographical regions for improving the prediction of user *** approach first characterizes the relationships between items and users with a user-item-region ***,a neural network model for the region-aware graph is derived to capture the higher-order interaction among users,items,and ***,the model fuses region and item vectors to infer user *** on real-world dataset results show that introducing region entities improves the accuracy of personalized *** study provides a new approach for optimizing personalized recommendation as well as a methodological reference for facilitating geographical regions for optimizing spatial applications.

关键词： Collaborative filtering neural graph collaborative filtering geographical region personalized recommendation graph convolution networks

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裂解性噬菌体内溶酶和穿孔素抗革兰阴性菌的研究进展

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畜牧兽医杂志 2023年第4期42卷 37-40,43页

作者：荣睿璠曾君郭志良左君豪赵瑞利郭海悦孙旭阳天津农学院动物科学与动物医学学院/天津市农业动物繁育与健康养殖重点实验室天津300392

随着细菌耐药情况的日益严重,人们开始寻找抗生素的代替物,噬菌体内溶酶(endolysin)和穿孔素(holin)受到了关注。其中内溶酶展现了良好的抑菌潜力,与抗生素和噬菌体制剂相比有着一定的优点。而内溶酶的作用特点决定了其在抑制革兰阴性... 详细信息

随着细菌耐药情况的日益严重,人们开始寻找抗生素的代替物,噬菌体内溶酶(endolysin)和穿孔素(holin)受到了关注。其中内溶酶展现了良好的抑菌潜力,与抗生素和噬菌体制剂相比有着一定的优点。而内溶酶的作用特点决定了其在抑制革兰阴性菌时需要穿孔素的协同,因此有研究利用基因工程把内溶酶和穿孔素进行重组来解决这一问题。此外,在噬菌体-细菌相互作用的研究中,已有研究表明噬菌体基因参与调控细菌间的通讯系统,内溶酶和穿孔素正是其中重要的调控因素。本文通过对噬菌体与噬菌体制剂的研究进展、内溶酶和穿孔素抗革兰阴性菌的研究进展及其应用进行了综述,以期为未来有关噬菌体裂解酶的研究提供思路。

关键词：裂解性噬菌体革兰阴性菌内溶酶穿孔素

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1例梅花鹿异位生鹿茸样组织的结构分析

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经济动物学报 2022年第2期26卷 113-115+120页

作者：李可可邬慧慧荆焕松孙旭阳顾晓莹彭静娜熊家军华中农业大学动物科学技术学院

在湖北鄂州一梅花鹿养殖场中发现1头雄性梅花鹿的左眼下部长出一块疑似鹿茸角的组织，将该组织取下，分离消化培养细胞，并对细胞进行茜素红、阿利新蓝、番红固绿、TRAP染色鉴定。将取下的该组织各部位制成切片进行HE染色，在光镜下观... 详细信息

在湖北鄂州一梅花鹿养殖场中发现1头雄性梅花鹿的左眼下部长出一块疑似鹿茸角的组织，将该组织取下，分离消化培养细胞，并对细胞进行茜素红、阿利新蓝、番红固绿、TRAP染色鉴定。将取下的该组织各部位制成切片进行HE染色，在光镜下观察各部位组织的病理组织学变化。结果表明：该组织外形与鹿茸角相似，表面光滑，无分叉，内部组织分层界限明显，分层情况及特征与正常鹿茸顶端组织结构相似，但组织已经骨化，可能与取样较晚有关。

关键词：梅花鹿鹿茸样组织异位组织

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rGO aerogel embedded with organic–inorganic hybrid perovskite for lightweight broadband electromagnetic wave absorption

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Nano Research 2024年第11期17卷 10196-10207页

作者： Xueying Zhao Xiaohui sun Wei Wu Peng Tang JiaWei Du xuyang Zhang Haining Qian Ruihui Peng Xiangwei Wang Yaohong Zhang Guohua Wu College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China Qingdao Innovation and Development Center Harbin Engineering University Qingdao 266000 China School of Physics Northwest University Xi’an 710127 China The Key Laboratory of Functional Molecular Solids Ministry of Education Wuhu 241002 China

Organic–inorganic hybrid perovskites are quite promising candidates in the field of electromagnetic wave (EMW) absorption due to their unique physicochemical properties. However, it is still a considerable challenge to satisfy the light weight, broad bandwidth, and strong absorption properties simultaneously. Herein, the solution of methylammonium lead iodide (MAPbI3) perovskites was infiltrated into the pores of reduced graphene oxide (rGO) aerogels. After drying, a series of MAPbI3/rGO composite aerogel (MGA) materials were synthesized by anchoring the MAPbI3 perovskite nanoparticles to rGO sheets with the assistance of rGO templates. Through the adjustment of component ratios, excellent EMW absorption properties are obtained with the synergistic effects of polarization loss, conduction loss, and multiple reflection and scattering of MAPbI3 and rGO. The porous structure of the aerogel and the suitable group distribution ratio allowed the MGA-4 samples to obtain excellent impedance matching and ultra-low density of ∼ 7.69 mg·cm−3. At a low filling ratio of 15 wt.%, the MGA-4 sample simultaneously achieves highly efficient and broadband EMW absorption performance at a thin thickness. The MGA-4 sample obtained a minimum reflection loss value of −64.35 dB and the effective absorption bandwidth (EAB) value of 5.4 GHz at a thickness of 2.08 mm and a maximum EAB (EABmax) value of 6.2 GHz under 2.22 mm. The MGA-5 sample obtained a maximum EAB value of 6.4 GHz with the thinckness of 2.16 mm. Furthermore, the simulation results of the radar cross-section (RCS) verified the component-optimized composites are capable of achieving excellent EMW attenuation. This paper provides a new approach and valuable reference for the development of hybrid perovskite-based microwave absorption materials with lightweight, ultra-broadband, and strong absorption properties.

关键词： broadband absorption electromagnetic wave absorption lightweight methylammonium lead iodide(MAPbI3) reduced graphene oxide(rGO)aerogel

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Review on piezoelectric actuators:materials,classifications,applications,and recent trends

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Frontiers of Mechanical Engineering 2024年第1期19卷 5-33页

作者： xuyang ZHOU Shuang WU Xiaoxu WANG Zhenshan WANG Qixuan ZHU Jinshuai sun Panfeng HUANG Xuewen WANG Wei HUANG Qianbo LU Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical *** types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural *** paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric ***,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several *** addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind *** rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.

关键词： piezoelectric actuator piezoelectric effect amplified piezoelectric actuator ultrasonic actuator stepping actuator piezoelectric polymer

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Cloned pigs derived from somatic cell nuclear transferembryos cultured in vitro atlow oxygen tension

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Chinese Science Bulletin 2006年第7期51卷 839-844页

作者： PAN Dengke ZHANG Yunhai sun Xiuzhu ZHANG Jian LI xuyang LI Yan GU Zhiliang DA Yunping WU Changxin LI Ning State Key Laboratory for Agrobiotechnology China Agricultural University Beijing 100094 China College of Animal Science and Technology China Agricultural Uni versity Beijing 100094 China Animal Clinical Hospital China Agricultural University Beijing 100094 China Hebei Minghui Group of Pigs Breeding Sanhe 065200 China

Pig cloning has great potential to human xenotransplantation. The present study was designed to establish a more efficient system for producing cloned pigs by somatic cell nuclear transfer (SCNT). Our approach was as follows: SCNT embryos were reconstructed by using fetal fibroblasts of Chinese miniature pig as donors and in vitro matured oocytes of prepubertal gilts as recipients. Reconstructed em- bryos were induced by electrical fusion/activation and cultured in BSA-containing North Carolina State University 23 medium (NCSU-23) or Porcine Zygote Medium (PZM-3) at the gas condition of 5% CO2, 7% O2, 88% N2. A total of 230 cloned embryos were transferred to three surrogate sows, producing three piglets. One of them is apparently healthy. The clonal provenance of the piglet was indicated by its coat color and confirmed by DNA microsatellite analysis. These results indicate that the use of in vitro matured oocytes from prepubertal gilts as recipient, combined with cloned embryos cultured at low oxygen tension is an effective way to produce cloned pigs.

关键词：卵母细胞体外发育无性繁殖猪体细胞克隆迁移晶胚

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The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemia

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Acta Pharmaceutica Sinica B 2023年第2期13卷 648-661页

作者： Jian Lu xuyang Shang Bingyi Yao Dongyi sun Jie Liu Yuanjin Zhang He Wang Jingru Shi Huaqing Chen Tieliu Shi Mingyao Liu Xin Wang Changning Maternity and Infant Health Hospital and School of Life Sciences Shanghai Key Laboratory of Regulatory BiologyEast China Normal UniversityShanghai 200241China

Cholesterol is an important precursor of many endogenous *** of cholesterol homeostasis can cause many pathological changes,leading to liver and cardiovascular ***1A is widely involved in cholesterol metabolic network,but its exact function has not been fully ***,we aim to explore how CYP1A regulates cholesterol *** data showed that CYP1A1/2 knockout(KO)rats presented cholesterol deposition in blood and *** serum levels of low-density lipoprotein cholesterol,high-density lipoprotein cholesterol and total cholesterol were significantly increased in KO *** studies found that the lipogenesis pathway(LXRa-SREBP1-SCD1)of KO rats was activated,and the key protein of cholesterol ester hydrolysis(CES1)was ***,lansoprazole can significantly alleviate rat hepatic lipid deposition in hypercholesterolemia models by inducing *** findings reveal the role of CYP1A as a potential regulator of cholesterol homeostasis and provide a new perspective for the treatment of hypercholesterolemia.

关键词： Hyperlipidemia Hypercholesteremia Cholesterol CYP1A Lipidosis LXR CES1 Lansoprazole

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Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1322-1338页

作者： Fengfeng Li Man Jiang Minghui Ma xuyang Chen Yidan Zhang Yixin Zhang Yuanyuan Yu Yunfeng Cui Jiahui Chen Hui Zhao Zhijie sun Deli Dong Department of Pharmacology(the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150086China Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150086China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China

Lipid metabolism disorders contribute to hyperlipidemia and hepatic *** is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic *** is an FDA-approved oral antiprotozoal drug with excellent pharmacokinetic and safety *** found that nitazoxanide and its metabolite tizoxanide induced mild mitochondrial uncoupling and subsequently activated AMPK in Hep G2 *** administration of nitazoxanide inhibited high-fat diet(HFD)-induced increases of liver weight,blood and liver lipids,and ameliorated HFD-induced renal lipid accumulation in *** significantly improved HFD-induced histopathologic changes of hamster *** the hamsters with pre-existing hyperlipidemia and hepatic steatosis,nitazoxanide also showed therapeutic *** administration of nitazoxanide improved HFD-induced hepatic steatosis in C57BL/6J mice and western diet(WD)-induced hepatic steatosis in Apoe-/-*** present study suggests that repurposing nitazoxanide as a drug for hyperlipidemia and hepatic steatosis treatment is promising.

关键词： Nitazoxanide Tizoxanide Hyperlipidemia Hepatic steatosis AMPK Autophagy SQSTM1/P62 Mitochondrial uncoupling

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