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Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2.Knockout Rat Model of Rett Syndrome

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Engineering 2022年第5期8卷 83-89页

作者： Yanhong sun Zhifang Chen Yi Xu Yuefang Zhang Zhilei Ge Chenglie Lin Yi Zhou fangfei Zhao Meiling Yan Xinyi Liu Ying Zhu Jimin Gao Hongyi Li Lihua Wang Jun Hu Zilong Qiu Chunhai fan Bioimaging Center Shanghai Synchrotron Radiation FacilityZhang Jiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China institute of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China Cardiology Department Beijing HospitalBeijing 100730China

Rett syndrome is a progressive neurodevelopmental disorder that lacks effective *** deep-brain stimulation can alleviate some symptoms in Rett model mice,this interventional manipula-tion requires deliberate surgical ***,we report that electro-acupuncture stimulation(EAS)can ameliorate symptoms of an Mecp2.knockout rat model of Rett syndrome from the remote acupoints Baihui(GV 2.),Yongquan(KI 1),and Shenmen(HT 7).We find that EAS not only prolongs the survival time of Rett rats,but also improves their behavior ability,including locomotion,motor coordination,and social *** activation was observed in the substantia nigra of the midbrain,corpus striatum,and cerebral cortex of wild-type and Rett model rats,as reflected by the increased expression of the c-Fos ***,EAS provides a potential promising therapeutic tool for treating neurodevel-opmental diseases.

关键词： Neurodevelopmental disorder Electro-acupuncture stimulation Rett syndrome Motor function Social interaction

Age-specific differences in non-cardiac comorbidities among elderly patients hospitalized with heart failure: a special focus on young-old, old-old, and oldest-old

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Chinese Medical Journal 2019年第24期132卷 2905-2913页

作者： Meng-Xi Yang Hui An Xue-Qiang fan Li-Yuan Tao Qiang Tu Li Qin Li-fang Zhang Dong-Ping Feng Yu Wang Li {2. Si Gao Wen-Zhuo Guan Jin-Gang Zheng Jing-Yi ren Department of Cardiology China-Japan Friendship HospitalBeijing 100029China Department of Cardiology Hebei General HospitalShijiazhuangHebei 050051China Department of Cardiovascular Surgery China-Japan Friendship HospitalBeijing 100029China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China State Key Laboratory for Molecular and Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100039China Department of Laboratory Medicine Peking University People's HospitalBeijing 100044China

Background:Despite the growing epidemic of heart failure(HF),there is limited data available to systematically compare noncardiac comorbidities in the young-old,old-old,and oldest-old patients hospitalized for *** precise differences will add valuable information for better management of HF in elderly ***:A total of 1053 patients aged 65 years or older hospitalized with HF were included in this *** were compared among three age groups:(1)young-old:65 to 74 years,(2.old-old:75 to 84 years,and(3)oldest-old:≥85 *** details of presentation,comorbidities,and prescribed medications were ***:The mean age was 76.7 years and 12.7%were 85 years or *** elderly patients with HF(97.5%)had at least one of the non-cardiac *** patterns of common non-cardiac comorbidities were different between the young-old and oldestold *** three most common non-cardiac comorbidities were anemia(53.6%),hyperlipidemia(45.9%),and diabetes(42.4%)in the young-old group,while anemia(73.1%),infection(58.2.),and chronic kidney disease(44.0%)in the oldest-old *** was observed in 93.0%elderly patients with ***,2..2.patients were diagnosed with infection,and 67.0%patients were prescribed ***,60.4%patients were diagnosed with anemia with only 8.9%of them receiving iron ***:Non-cardiac comorbidities are nearly universal in three groups but obviously differ by age,and inappropriate medications are very common in elderly patients with *** treatment strategies should be focused on providing optimal medications for age-specific non-cardiac conditions.

关键词： Heart failure Elderly Non-cardiac comorbidity Polypharmacy

Terahertz wave avalanche breakdown transistor for high-performance switching

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Photonics Research 2021年第3期9卷 370-378页

作者： Weijun WANG Liang-Hui Du Jiang Li Pei-ren Tang Changlin sun Songlin Chen Jun Wang Zhao-Hui Zhai Zhipeng Gao Ze-ren Li Jianquan Yao Furi Ling Li-Guo Zhu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Microsystem&Terahertz Research Center China Academy of Engineering PhysicsChengdu 610200China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityTianjin 300072China

There is still a lack of high-performance terahertz(THz) modulators with wide operation bandwidth and large modulation depth due to the underlying physics limitation behind existing approaches. Meanwhile, for many applications, simple compact THz modulators working straightforward in the transmission mode are also highly desired. Here, we demonstrate a THz modulator with a maximal transmission-amplitude modulation depth of 99.9%(switching ratio of 1000) based on a commonly used silica-on-silicon structure. Different from those reported graphene or metamaterials enhanced proposals, the device we proposed works within a reversible avalanche breakdown region of silicon that has not been studied yet and has the potential to modulate/switch THz waves efficiently. Further, we proved that the modulation depth exceeds 97% in the frequency range from 0.2.to 1 THz in the experiment. The simplicity and generality of this new type of near-perfect THz modulator will undoubtedly attract lots of attention of researchers in the near future due to its potential to be engineered into integrated devices.

关键词： breakdown modulator avalanche

Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference,and delays morphine extinction in rats

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Neuroscience Bulletin 2012年第5期28卷 567-576页

作者： Yaodong fan Haichen Niu Joshua D. Rizak Ling Li Guimei Wang Liqi Xu He ren Hao Lei Hualin Yu Department of Neurosurgery the Third Affiliated Hospital of Kunming Medical University Kunming 650118 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Math-ematics Chinese Academy of Sciences Wuhan 430071 China State Key Laboratory of Brain and Cognitive Sciences Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Department of Medical Imaging Kunming General Hospital of Chengdu Military Region People's Liberation Army Kunming 650032 China Minimally Invasive Neurosurgery Department the First Affiliated Hospital of Kunming Medical University Kunming 650032 China

Objective It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor （NMDAR）, play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 （GLT-1）（ceftriaxone） are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference （CPP） than either compound alone. Methods A morphine-paired CPP experiment was used to study the effects of low doses of MK-801, ceftriaxone and a combination of both on reward-related memory （acquisition, extinction, and reinstatement of morphine preference） in rats. Results A low dose of neither MK-801 （0.05 mg/kg, i.p.） nor ceftriaxone （2. mg/kg, i.p.） alone effectively impaired CPP behaviors. However, when applied in combination, they reduced the acquisition of morphine-induced CPP and completely prevented morphine reinstatement. Their combination also notably impaired the extinction of morphine-induced CPP. Conclusion The combined action of a low dose of an NMDAR antagonist （MK-801） and GLT-1 activation by ceftriaxone effectively changed different phases of CPP behavior.

关键词： ceftriaxone conditioned place preference morphine MK-801 glutamate transporter subtype-1

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分布式光纤传感技术研究和应用的现状及未来

光学学报 2024年第1期44卷 3-65页

作者：张旭苹张益昕王亮余贶琭刘波尹国路刘琨李璇李世念丁传奇汤玉泉尚盈王奕首王晨王峰樊昕昱孙琪真谢尚然吴慧娟吴昊王花平赵志勇南京大学智能光感知与调控技术教育部重点实验室江苏南京210023 华中科技大学光学与电子信息学院湖北武汉430074 北京交通大学信息科学研究所北京100044 之江实验室光纤传感研究中心浙江杭州311100 重庆大学光电技术及系统教育部重点实验室重庆400044 天津大学精密仪器与光电子工程学院天津300072 中国电力科学研究院有限公司北京100192 中国煤炭地质总局勘查研究总院北京100039 中油奥博(成都)科技有限公司四川成都611731 中国科学院合肥物质科学研究院安徽光学精密机械研究所光子器件与材料安徽省重点实验室安徽合肥230031 齐鲁工业大学(山东省科学院) 山东省科学院激光研究所山东济南250104 厦门大学航空航天学院福建厦门361005 上海交通大学电子信息与电气工程学院区域光纤通信网与新型光通信系统国家重点实验室上海200240 北京理工大学光电学院信息光子技术工信部重点实验室北京100081 电子科技大学光纤传感与通信教育部重点实验室四川成都611731 兰州大学土木工程与力学学院甘肃兰州730000

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史... 详细信息

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史、现状以及典型应用原理和方案等的基础上,对其工作新机理、系统设计方案、研究发展方向等进行了阐述和讨论。

关键词：光纤光学分布式光纤传感技术光时域反射仪光频域反射仪干涉型分布式光纤传感

Suppression of AOM/DSS-induced colorectal cancer by scutellarin through downregulation of Wnt signaling pathway activity

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中国药理学与毒理学杂志 2021年第10期35卷 739-740页

作者： ZENG Sha ZHAO Hui CHEN Li sun Qiang ren Shan LIU Mao-lun YANG Han TANG Shun LU Jin-jian XU Hai-bo State Key Laboratory of Southwestern Chinese Medicine Resources Department of PharmacologyChengdu University of Traditional Chinese MedicineChengdu 611137China institute of Chinese Medical Sciences University of MacaoMacaoChina

OBJECTIVE To investigate the therapeutic effect of scutellarin on colitis-associated cancer(CAC)and its underlying mechanism based on Wnt/β-catenin signaling *** The mouse model of CAC was established by azomethane oxide(AOM)and sodium dextran sulfate(DSS),followed by scutellarin treatment,with recording the body weight,diarrhea and *** sacrificing the mice,the colorectal length and colorectal tumor were *** levels of pro-inflammatory factors TNF-αand IL-6 in mice′s sera were measured by the enzyme-linked immunosorbent assay(ELISA).The colorectal lesions were appraised by hematoxylin and eosin(H&E)***β-catenin level in CAC tissues was probed by immunofluorescent *** apoptosis-related genes Bax and Bcl-2.and Wnt signaling pathway-related genesβ-catenin,GSK-3β,TCF4,c-Myc and cyclin D1 were detected by real-time quantitative RT-PCR(RT-qPCR).Finally,Western blotting analysis(WB)was employed to examine the expressions of the apoptosis and Wnt signaling pathway-related *** Scutellarin significantly improved AOM/DSS-caused weight loss,colorectal length shortening,and tumor growth in mice(P1).Meanwhile,colorectal lesions could be substantially alleviated by *** results showed that the levels of pro-inflammatory factors TNF-αand IL-6 were drastically lessened(P1).Scutellarin also sharply inhibited the nuclear translocation ofβ-catenin,as evidenced by the reduction in the nuclear level ofβ-catenin *** addition,scutellarin attenuated the mRNA expression of Wnt signaling pathway-relatedβ-catenin,TCF4,c-Myc and cyclin D1,whereas it heightened GSK-3βmRNA *** results were consolidated by WB analysis,which indicated that scutellarin could mitigate the protein levels of phospho-GSK-3β,β-catenin,TCF4,c-Myc and cyclin D1,with the increase in GSK-3βprotein in CAC ***,scutellarin could induce the apoptosis of CAC,demonstrated by enhanced expression of Bax and diminished ex

关键词： scutellarin colorectal cancer Wnt signaling pathway AOM/DSS

异质信息网络中最大路径连通Steiner分量查询算法

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软件学报 2023年第2期34卷 655-675页

作者：李源范晓林孙晶赵会群杨森王国仁北方工业大学信息学院北京100144 北京理工大学计算机学院北京100081

异质信息网络(HINs)是包含多种类型对象(顶点)和链接(边)的有向图,能够表达丰富复杂的语义和结构信息.HINs中的稠密子图查询问题,即给定一个查询点q,在HINs中查询包含q的稠密子图,已成为该领域的热点和重点研究问题,并在活动策划、生物... 详细信息

异质信息网络(HINs)是包含多种类型对象(顶点)和链接(边)的有向图,能够表达丰富复杂的语义和结构信息.HINs中的稠密子图查询问题,即给定一个查询点q,在HINs中查询包含q的稠密子图,已成为该领域的热点和重点研究问题,并在活动策划、生物分析和商品推荐等领域具有广泛应用.但现有方法主要存在以下两个问题:(1)基于模体团和关系约束查询的稠密子图具有多种类型顶点,导致其不能解决仅关注某种特定类型顶点的场景;(2.基于元路径的方法虽然可查询到某种特定类型顶点的稠密子图,但其忽略了子图中顶点之间基于元路径的连通度.为此,首先在HINs中提出了基于元路径的边不相交路径的连通度,即路径连通度;然后,基于路径连通度提出了k-路径连通分量(k-PCC)模型,该模型要求子图的路径连通度至少为k;其次,基于k-PCC模型提出了最大路径连通Steiner分量(SMPCC)概念,其为包含q的具有最大路径连通度的k-PCC;最后,提出一种高效的基于图分解的k-PCC发现算法,并在此基础上提出了优化查询SMPCC算法.大量基于真实和合成HINs数据的实验结果验证了所提出模型和算法的有效性和高效性.

关键词：异质信息网络稠密子图查询 k-路径连通分量最大路径连通Steiner分量元路径

科研机构合作网络演化特征对创新绩效的影响——以中国科学院为例

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科技管理研究 2021年第18期41卷 131-139页

作者：孙中瑞樊杰孙勇中国科学院科技战略咨询研究院北京100190 中国科学院大学北京100049 中国科学院地理科学与资源研究所北京100101

基于中国科学院1985—2.19年合作专利数据构建专利合作网络,在对专利合作态势以及城市尺度下的合作网络进行演化分析的基础上,采用负二项回归模型检验度数中心度、中间中心度、接近中心度、结构洞及其二次项对创新合作网络节点创新绩效... 详细信息

基于中国科学院1985—2.19年合作专利数据构建专利合作网络,在对专利合作态势以及城市尺度下的合作网络进行演化分析的基础上,采用负二项回归模型检验度数中心度、中间中心度、接近中心度、结构洞及其二次项对创新合作网络节点创新绩效的影响。结果表明在研究期间:(1)中国科学院的专利合作保持快速增长态势,发展过程呈现三阶段特征,其中企业是最广泛的合作主体,合作领域从传统行业向高新技术行业转移趋势较为明显;(2.专利合作空间分布差异显著,主要集中分布在东中部地区,基本形成以长江中游城市群为中心,以京津冀、长三角、珠三角、成渝城市群为顶点的高强度专利合作菱形区域;(3)度数中心度、中间中心度、接近中心度与当期、滞后1期、滞后2.创新绩效均显著呈倒"U"型关系,而结构洞与当期、滞后1期、滞后2.创新绩效均显著呈"U"型关系。研究结论的主要启示为:中国科学院应继续加强与企业、高校、科研机构等主体间的创新合作,并加强跨地区合作、优化创新空间布局,且应注意避免因中心度过高而给创新带来负面影响。

关键词：专利合作网络中心度结构洞创新绩效

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利用立体观测降低太阳磁场测量误差

天文学报 2024年第5期65卷 121-130页

作者：曾柏予郭洋李川李臻尤伟黄帆张兰强杨金生南京大学天文与空间科学学院南京210023 上海卫星工程研究所上海200240 中国科学院光电技术研究所成都610209

塞曼效应是目前测量太阳磁场最主要的方法,但使用塞曼效应观测存在两个问题:测量到的矢量磁场中,垂直于视线方向的磁场(横场)方向存在180°不确定性;同时,横场的测量精度也要比沿视线方向的磁场(纵场)低一个量级.可以通过在不同的视线... 详细信息

塞曼效应是目前测量太阳磁场最主要的方法,但使用塞曼效应观测存在两个问题:测量到的矢量磁场中,垂直于视线方向的磁场(横场)方向存在180°不确定性;同时,横场的测量精度也要比沿视线方向的磁场(纵场)低一个量级.可以通过在不同的视线方向立体观测磁场去除180°不确定性并且提高太阳磁场横场的测量精度.重点讨论联合日地L5点和日地连线方向的观测提高横场测量精度的问题,同时通过模型建构与数据定量分析,得出横场误差的减小量.通过球面三角公式,求得地球和L5点磁场的坐标关系,由标准偏差传递公式得到修正后的地球处的测量误差;统计日震和磁场成像仪(Helioseismic and Magnetic Imager,HMI)观测到的太阳磁场误差的数据分布,模拟出两幅符合太阳磁场分布的数据,分别作为地球和L5点的误差图;结合地球和L5点数据,得出地球横场误差的修正数据并与原始横场数据进行对比,发现可以使地球处观测的黄道面上的横场误差降低为原来的17%左右.

关键词：航天器:仪器方法:统计太阳:磁场