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Post-dilatation improves stent apposition in patients with ST-segment elevation myocardial infarction receiving primary percutaneous intervention: A multicenter, randomized controlled trial using optical coherence tomography

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World Journal of Emergency Medicine 2020年第2期11卷 87-92页

作者： Jun jiang Nai-liang Tian Han-bin Cui Chang-ling li xian-bao liu liang dong yong sun Xiao-min Chen Shao-liang Chen bo Xu jian-an wang Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Cardiology Nanjing First HospitalNanjingChina Department of Cardiology Ningbo First HospitalNingboChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesBeijingChina

BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute ***: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset liant balloon was inflated to >16 atm *** apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month *** primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after ***: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation *** group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, Plinical *** identifier: NCT02121223).

关键词： ST-segment elevation myocardial infarction Post-dilatation Incomplete strut apposition Optical coherence tomography

Epigenetics in the modern era of crop improvements

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Science China life Sciences 2025年

作者： Yan Xue Xiaofeng Cao xiangsong Chen xian Deng Xingwang Deng yong Ding Aiwu dong Chengguo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng He Hang He Shengbo He Xinjian He Yan He Yuehui He Guifang Jia Danhua jiang jianjun jiang Jinsheng Lai Zhaobo Lang Chenlong li Qing li Xingwang li Bao liu Bing liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song xianwei Song Zhixi Tian Jiawei wang Yuan wang liang Wu Zhe Wu Rui Xia Jun Xiao lin Xu Zhengyi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing Zhang Yusheng Zhao Xuehua Zhong Daoxiu Zhou Ming Zhou Yue Zhou bo Zhu jiankang Zhu Qikun liu College of life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key Laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural Sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key Laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key Laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University State Key Laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Center for Crop Functional Genomics and Molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed Laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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Design and evaluation of prototype readout electronics for nuclide detector in Very Large Area Space Telescope

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Nuclear Science and Techniques 2022年第5期33卷 154-166页

作者： Hai-bo Yang xian-Qin li Yu-Hong Yu yong Chen Jie Kong yong-Jie Zhang Shu-Wen Tang jian-Hua Guo Bing Yang Feng-Jiao Su Wen-jian sun Jin-xiang wang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Harbin Institute of Technology Harbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210000China Harbin University of Science and Technology Harbin 150080China Northwest Normal University Harbin 150080China

China plans to develop the next generation dark matter particle explorer satellite,referred to as the Very Large Area Space Telescope(VLAST).As an essential step in this process,the prototype design of detectors and electronics for the VLAST is currently *** nuclide detector is a core detector in the *** mainly measures nuclides’charges and distinguishes high-energy gamma rays and *** paper will discuss the prototype readout electronics for the VLAST’s nuclide detector,which accurately measures the charge signal of the photomultiplier tubes using the VATA160 applicationspecific integrated circuit chip;furthermore,we consider a series of critical problems,including radiation-hardening and environment *** test results show that the system exhibits stable operation,good performance,and good technical ***,each electronic channel achieves a dynamic range of 0-12.5 pC,the random noise level exceeds 1.6 fC,and the integral nonlinearity exceeds 0.35%.

关键词： Dark matter VLAST Nuclidedetector Prototype readout electronics VATA160 Large dynamic range Irradiationtest Performance test

Analysis of combining ability for stem-related traits and its correlations with lodging resistance heterosis in hybrid wheat

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Journal of Integrative Agriculture 2022年第1期21卷 26-35页

作者： YANG Wei-bing QIN Zhi-lie sun Hui HOU Qi-ling GAO jian-gang CHEN xian-chao ZHANG li-ping wang yong-bo ZHAO Chang-ping ZHANG Feng-ting Beijing Engineering Research Center for Hybrid Wheat Beijing Academy of Agricultural and Forestry SciencesBeijing 100097P.R.China The Municipal Key Laboratory of Molecular Genetics of Hybrid Wheat Beijing 100097P.R.China

With the application of hybrid wheat, lodging is becoming one of the major factors limiting high yield in its production. However,few studies have focused on combining ability and heterosis analysis of stem-related traits. In this study, 24 crosses were made according to NCII genetic design, using the three(photo-sensitive male sterile lines)×eight(restorer lines) incomplete diallel crosses. The length of basal second internode(LBSI) and breaking strength of basal second internode(BSBSI)as well as other stem-related traits were used to perform the principal component analysis(PCA), combining ability and heterosis analysis. The PCA results showed that the variables could be classified into two main factors, which were named as the positive factor(factor 1) and the negative factor(factor 2), and accounted for 52.3 and 33.2%, respectively, of the total variance in different variables, combined with the analysis for index weight indicated that the factor 1-related traits play positive roles in lodging resistance formation of hybrids. Combining ability variance analysis indicated that its genetic performance was mainly dominated by additive gene effects, and the hybrid combinations with higher lodging resistance can be selected by using of 14 GF6085(R1), 14 GF6343-2(R4), 14 GF6937(R6), 14 GF7433-1(R7), and BS1086(M3),which are with the features with lower general combining ability(GCA) effects of factor 2-related traits whereas higher GCA effects of factor 1-related traits. The heterosis analysis showed that the wide range of heterosis varied with the traits and combinations, and GCA or specific combining ability(SCA) effects of factor 1-related traits except wall thickness of basal second internode(WTBSI) were positively and closely related to the heterosis of lodging resistance. Generally, the correlation coefficients of heterosis to GCA effects of sterile lines(GCAm) of factor 1-related traits are significantly higher than that to GCA of restorer lines(GCAr) and SCA,

关键词： lodging resistance stem-related traits general combining ability specific combining ability heterosis

Chinese Herbal Medicine Combined with Entecavir for HBeAg Positive Chronic Hepatitis B:Study Protocol for a Multi-Center,Double-Blind Randomized-Controlled Trial

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Chinese Journal of Integrative Medicine 2018年第9期24卷 653-660页

作者： YE yong-an li Xiao-ke ZHOU Da-qiao CHI Xiao-ling li Qin wang li LU Bing-jiu MAO De-wen WU Qi-kai wang xian-bo ZHANG Ming-xiang XUE Jing-dong li yong LU Wei GUO jian-chun jianG Feng ZHANG Xin-wei DU Hong-bo YANG xian-zhao GUO Hui GAN Da-nan li Zhi-guo Institute of liver Diseases Beijing University of Chinese MedicineDongzhimen Hospital affiliated to Beijing University of Chinese Medicine Department of Hepatology Shenzhen Traditional Chinese Medicine Hospital Department of Hepatology Guangdong Hospital of Traditional Chinese Medicine Department of Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical University Department of Hepatology Public Health Clinical Center of Chengdu Department of Hepatology Liaoning Hospital of Traditional Chinese Medicine Department of Hepatology the First Affiliated Hospital of Guangxi University of Chinese Medicine Department of Hepatology the Third People's Hospital of Shenzhen Department of Hepatology Beijing Ditan Hospital Department of Hepatology the Sixth People's Hospital of Shenyang Department of Hepatology Shaanxi Hospital of Traditional Chinese Medicine Department of Hepatology Shandong Hospital of Traditional Chinese Medicine Department of Hepatology the Second People's Hospital of Tianjin Department of Hepatology Xixi Hospital of Hangzhou Department of Hepatology 302 Military Hospital of China Department of Hepatology the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Background： The domestic prevalence of chronic hepatitis B （CHB） in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot（s）ide analogues （NUCs） anti-hepatitis B virus （HBV） therapies are widely applied despite the relatively low rate of seroconversion and high risk of drug-resistant mutation. More effective treatments for CHB deserve further explorations. Combined therapy of NUCs plus Chinese herbal medicine （CHM） is widely accepted in China, which is recognized as a prospective alternative approach. The study was primarily designed to confirm the hypothesis that Tiaogan-Yipi Granule （调肝益脾颗粒, TGYP） or Tiaogan-jianpi-Jiedu Granule （调肝健脾解毒颗粒, TGJPJD） plus entecavir tablet （ETV） was superior over ETV monotherapy in enhancing HBeAg loss rate. Methods： The study was a nationwide, large-scale, multi-center, double-blind, randomized, placebo-controlled trial with a designed duration of 108 weeks. A total of 16 hospitals and 596 eligible Chinese HBeAg positive CHB patients were enrolled from November 2012 to September 2013 and randomly allocated into 2 groups in 1：1 ratio via central randomization system： experimental group （EG） and control group （CG）. Subjects in EG received CM formulae （TGYP or TGJPJD, 50 g per dose, twice daily） plus ETV tablet （or ETV placebo） 0.5 mg per day in the first 24 weeks （stage 1）, and CHM granule plus ETV tablet （0.5 mg per day） from week 25 to 108 （stage 2）. Subjects in CG received CHM Granule placebo plus E＇IV tablet （0.5 mg per day） for 108 weeks throughout the trial. The assessments of primary outcomes （HBV serum markers and HBV-DNA） were conducted by a third-party College of American Pathologists （CAP） qualified laboratory. Adverse effects were observed in the hospitals of recruitment. Discussion： The study was designed to compare the curative effect of CM plus E＇IV and ETV monotherapy in respect of HBeAg loss, which is recognized by the European Association for the Study of the liver as ＂a valuable endpoint＂. We be

关键词： chronic hepatitis B Chinese herbal medicine Tiaogan-jianpi-Jiedu Granule Tiaogan-Yipi Granule protocol randomized-controlled trial

Effect of antioxidants on the efficiency of jet milling and the powder characteristics of Sm2Co17 permanent magnets

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Chinese Physics B 2024年第9期33卷 615-620页

作者： Da-Shuai Xu Lei liu jian-Hui Yuan bo Zhou Chuang-Hui dong Feng-Qing wang yong Ding Ying-li sun A-Ru Yan School of Materials Science and Engineering Shanghai University of Engineering ScienceShanghai 201620China CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets CAS Key Laboratory of Magnetic Materials and DevicesZhejiang Province Key Laboratory of Magnetic Materials and Application TechnologyNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

This study investigated the effect of antioxidants on the grinding efficiency,magnetic powder characteristics,microstructure,and magnetic properties of 2:17 type SmCo permanent magnet *** results show that adding antioxidants helps improve the dispersion among magnetic powders,leading to a 33.3%decrease in jet milling time and a 15.8%increase in magnet powder production ***,adding antioxidants enhances the oxidation resistance of the magnetic *** being stored in a constant temperature air environment at 25C for 48 h,the O content in the powder decreased by 33%compared to samples without *** in the magnet body,the O content decreased from 0.21 wt.%to 0.14 wt.%,which helps increase the effective Sm content and domain wall pinning uniformity in the *** magnetic properties were obtained in the magnet with added antioxidants:B_(r)=11.6 kGs,SF=79.6%,H_(cj)=16.8 kOe,and(BH)_(max)=32.5 MGOe.

关键词： antioxidant SmCo permanent magnet oxidation resistance grinding efficiency

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Journal of Integrative Agriculture 2020年第10期19卷 2407-2418页

作者： YANG Wei-bing QIN Zhi-lie sun Hui liAO xiang-zheng GAO jian-gang wang yong-bo HOU Qi-ling CHEN xian-chao TIAN li-ping ZHANG li-ping MA Jin-xiu CHEN Zhao-bo ZHANG Feng-ting ZHAO Chang-ping Beijing Engineering Research Center for Hybrid Wheat Beijing Academy of Agricultural and Forestry SciencesBeijing 100097P.R.China

Because of the yield increase of 3.5-15%compared to conventional wheat,hybrid wheat is considered to be one of the main ways to greatly improve the wheat yield in the *** this study,we performed a principal component analysis(PCA)on two-line hybrids wheat and their parents using the grain weight(GW),the length of spike(LS),the kernel number of spike(KSN),and spike number(SPN)as *** results showed that the variables could be classifed into three main factors,the weight factor(factor 1),the quantity factor 1(factor 2)and the quantity factor 2(factor 3),which accounted for 37.1,22.6 and 18.5%,respectively of the total variance in different agronomic variables,suggesting that the GW is an important indicator for evaluating hybrid combinations,and the grain weight of restorer line(RGW)could be used as a reference for parents *** hybrid combination with a higher score in factor 1 direction and larger mid-parent heterosis(MPH)of the GW and its parents were used to carry out the analysis of grain fling,1-aminocylopropane-1-carboxylicacid(ACC)and polyamine synthesis related *** results suggested that the GW of superior grain was significantly higher than that of inferior grains in BS1453xJS1(H)and its *** grain types showed a weight of H between BS 1453(M)and JS1(R),and a larger MPH,which may be caused by their differences in the active fling stage and the grain fling *** ADP-glucose pyrophosphorylase(AGPase),granule bound starch synthase I(GBSS/),starch synthaseⅡ(SSS),and starch branching enzyme-Ⅰ(SBE-1)expression levels of H were intermediated between M and R,which might be closely related to MPH formation of the *** with R and H,the GW of M at maturity was the *** expression levels of spermidine synthase 2(Spd2),ornithine decarboxylase(ODC)and S adenosylmethionine decarboxylase(SAMDC)had significantly positive correlations with the grain flig rate(1=0.77,0.51,0.59"),suggesting their major roles in the grain flli

关键词： hybrid wheat agronomic traits ethylene polyamines grain illing heterosis

Chinese expert consensus on quantitatively monitoring and assessing immune cell function status and its clinical application(2024 edition)

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 551-558页

作者： lin Zhou Ji-Qiao Zhu jian-Tao Kou Wen-li Xu Shao-Cheng Lyu Guo-Sheng Du Hong-Wei Yang jian-Feng wang Xiao-Peng Hu Chun-Zhao Yu Chun-Hui Yuan dong-dong Han Cui-Qin Sang bo li Jie Gao Hai-Zhi Qi li-Ming wang ling Lyu Hao liu jian-yong Wu Ren Lang Qiang He xian-liang li Department of Hepatobiliary and Pancreatic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Beijing Organ Transplant Center Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Organ Transplantation Center General Hospital of Northern Theater CommandShenyang 110010China Department of Interventional Therapy Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Urology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of General Surgery Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China Department of General Surgery Peking University Third HospitalBeijing 100191China liver Transplantation Department China-Japan Friendship HospitalBeijing 100029China Department of Obstetrics and Gynecology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatobiliary Surgery West China Hospital of Sichuan UniversityChengdu 610041China Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100871China Department of General Surgery/Organ Transplant Center The Second Xiangya Hospital of Central South UnivercityChangsha 410011China Organ Transplant Center The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027China Department of General Surgery Jiangsu Provincial People’s HospitalNanjing 210029China Department of Hepatobiliary Surgery The First Affiliated Hospital of China Medical UniversityShenyang 110001China Kidney Transplant Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction The immune system is the cornerstone of human health,with most diseases and health conditions closely related to immune ***,immune status management is a core health *** recent years,significant research breakthroughs in immunosuppressants,immune cell therapy,and immune checkpoint inhibitors have enabled clinical experts and researchers to effectively modulate immune status and regulate immunity more *** questions in the field of immunology include:How can immune function be visually assessed?What constitutes normal immune cell function status?How can immune cell function status be quantitatively evaluated?How can a standardized system for assessing immune cell function status be established?Currently,there is no consensus on these issues *** August 28,2023,the National Natural Science Foundation of China announced the National Major Research Plan:Immune Power Digital Decoding *** research models have failed to systematically reveal the generation and evolution of immune power.

关键词： assessing clinical immunity

Experimental Study of p-^(11)B Reaction Related to the Clean Fusion Fuel

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Chinese Physics Letters 1998年第11期15卷 796-798页

作者： liN Erh-kang wang Chang-wan YUAN jian liU Xiao-dong li Cheng-bo sun Zu-xun ZHANG Pei-hua CHEN Jin-xiang YANG Qi-xiang wang jian-yong Gong ling-hua Institute of Physics Academia SinicaTaipei 11529 China Institute of Atomic Energy Beijing 102413 Graduate School Chinese Academy of SciencesBeijing 100039 Institute of Heavy Ion Physics Peking UniversityBeijing 100871

Whole continuous a spectra of the p-^(11)B three-body sequential decay reaction have been measured by using a charge particle time-of-flight(TOF)spectrometer with the high-resolution passivated implanted planar silicon detector.A characteristic shape of the saddle-type distribution was *** Monte Carlo calculations show that observed a spectra can be interpreted by anisotropy sequential decay process of the intermediate nucleus ^(8)Be(1)for the p-^(11)B *** the measurement,angular distributions were obtained for proton energies at 667 and 1370keV,*** cross-sections for the ^(11)B(p,α)^(8)Be(2α)reaction related to the clean fusion fuel were also reported at two bombarding energies.

关键词： reaction. decay saddle