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微波法艾蒿色素提取及抗菌性能研究

毛纺科技 2011年第2期39卷 17-19页

作者：孙福娟陈莉孙卫国西安工程大学陕西西安710048

文章旨在研究一种新型抗菌性能染料,对艾蒿植物染料的提取方法以及抗菌性能做了研究。采用微波法对艾蒿色素进行提取,利用单因素实验和正交试验优化出最佳提取工艺为:固液比1∶20,温度为中火(约500 W),时间为10 min。对毛织物进行直接... 详细信息

文章旨在研究一种新型抗菌性能染料,对艾蒿植物染料的提取方法以及抗菌性能做了研究。采用微波法对艾蒿色素进行提取,利用单因素实验和正交试验优化出最佳提取工艺为:固液比1∶20,温度为中火(约500 W),时间为10 min。对毛织物进行直接染色和后媒染色,之后根据GB/T 20944.1—2007标准测试毛织物的抑制大肠杆菌和葡萄球菌繁殖的性能。结果表明,微波法对艾蒿色素提取具有良好的抑菌效果。

关键词：艾蒿微波色素抗菌性

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LY12CZ铝合金激光焊接工艺

中国激光 2006年第2期33卷 273-277页

作者：孙福娟刘洪军张丹峰海军航空工程学院青岛分院山东青岛266041

通过对LY12CZ铝合金激光焊接焊缝的金相组织分析、显微硬度测试，研究了如何有效控制CO2连续激光器焊接LY12CZ铝合金的有关工艺参数，从而使焊缝达到较好的性能。研究结果表明，只要对材料采取适当的焊前预处理工艺，合理选择激光功率... 详细信息

通过对LY12CZ铝合金激光焊接焊缝的金相组织分析、显微硬度测试，研究了如何有效控制CO2连续激光器焊接LY12CZ铝合金的有关工艺参数，从而使焊缝达到较好的性能。研究结果表明，只要对材料采取适当的焊前预处理工艺，合理选择激光功率、激光扫描速度、保护气体流量等焊接工艺参数，就能够得到晶粒明显细化、中心等轴晶尺寸约为基体晶粒尺寸的1／10～1／15、无气孔和裂纹缺陷的焊缝。由于高温晶界氧化，焊缝晶界和基体晶界相比有所变粗，同时由于焊缝的退火效应、高温下镁的蒸发以及强化相析出等原因，焊缝的显微硬度和基体相比有所下降。

关键词：激光技术激光焊接硬铝合金金相硬度

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激光表面重熔对LY12CZ性能的影响

中国激光 2007年第8期34卷 1159-1162页

作者：孙福娟刘洪军胡芳友海军航空工程学院青岛分院山东青岛266041

通过控制CO2连续激光器的有关工艺参数,对LY12CZ铝合金进行了激光表面重熔,并对重熔后的试样进行了疲劳实验、疲劳断口分析、金相分析及显微硬度测试.研究结果表明,LY12CZ铝合金经过激光重熔后,疲劳寿命与未经激光处理试样相比无显著差... 详细信息

通过控制CO2连续激光器的有关工艺参数,对LY12CZ铝合金进行了激光表面重熔,并对重熔后的试样进行了疲劳实验、疲劳断口分析、金相分析及显微硬度测试.研究结果表明,LY12CZ铝合金经过激光重熔后,疲劳寿命与未经激光处理试样相比无显著差异,疲劳断口显示疲劳裂纹源区出现在重熔区的表层,疲劳裂纹沿着柱状晶的晶界扩展,在基材处瞬断.激光重熔后表层金相组织明显细化,使得材料表层的显微硬度比基体硬度提高了40%.

关键词：激光技术铝合金激光重熔疲劳寿命金相显微硬度

厦门城市化进程中的土地财政与政府经济行为研究

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重庆建筑 2007年第8期30卷 39-40页

作者：孙富娟厦门市土地开发总公司福建厦门361012

厦门征地拆迁城市化的特征是,表面上城市政府具有强制征收农民土地的权力,实际上城市政府-区政府-被征地农村间进行的是谈判和交易;土地利益自身,并不是地方政府选择土地财政的唯一理由,地方政府以一次性的经营性用地出让收益补贴工业... 详细信息

厦门征地拆迁城市化的特征是,表面上城市政府具有强制征收农民土地的权力,实际上城市政府-区政府-被征地农村间进行的是谈判和交易;土地利益自身,并不是地方政府选择土地财政的唯一理由,地方政府以一次性的经营性用地出让收益补贴工业化以换取经常性税收,主要是为了保证重大建设的财政支出;市、区各级政府间的组织关系,更像是母公司-子公司关系,既是垂直的行政权力关系,也是独立核算的相对自主的财务实体;厦门市政府对于征地不公的回应,没有尝试建立农地直接入市的路径,而是为其预留发展用地,这个发展用地产权属完整的经营性城市建设用地,从而使被征地农村成为土地财政链条上的"子公司"。

关键词：征地拆迁土地财政产权发展权

Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan Li Carl Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing sun Jie Lin Xiaoyu Fan Binbin Jia Mengdi Cai Linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

2A12CZ激光熔覆Al-Y的疲劳性能分析

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青岛大学学报（自然科学版） 2008年第2期21卷 32-35页

作者：孙福娟李晓崴海军航空工程学院青岛分院青岛266041 南开大学物理科学学院天津300071

以常用航空材料2A12CZ为基材,在其表面激光熔覆Al-Y(6%Y)合金粉末,进行疲劳性能测试实验。运用扫描电镜和金相显微镜分别对疲劳断口和金相组织进行了观察研究,并与2A12基材做了对比。结果表明,熔覆Al-Y(6%Y)合金试样的安全寿命达到了基... 详细信息

以常用航空材料2A12CZ为基材,在其表面激光熔覆Al-Y(6%Y)合金粉末,进行疲劳性能测试实验。运用扫描电镜和金相显微镜分别对疲劳断口和金相组织进行了观察研究,并与2A12基材做了对比。结果表明,熔覆Al-Y(6%Y)合金试样的安全寿命达到了基材对比试样安全寿命的65.1%,且熔覆层和基体结合得非常紧密,熔覆层内没有大的气孔和裂纹缺陷。

关键词：铝合金激光熔覆疲劳寿命疲劳断口稀土

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激光功率对2A12铝合金淬火组织的影响

现代制造工程 2009年第8期 81-82,93页

作者：孙福娟高峰王斌王永杰王兵海军航空工程学院青岛分院 94362部队

通过改变CO2连续激光器的功率,对2A12铝合金试样进行激光表面淬火热处理,并对淬火时效后的组织进行金相分析、显微硬度测试。研究结果表明,功率对2A12铝合金激光淬火组织的影响比较显著。由于2A12铝合金是过烧敏感性最大的硬铝合金,在... 详细信息

通过改变CO2连续激光器的功率,对2A12铝合金试样进行激光表面淬火热处理,并对淬火时效后的组织进行金相分析、显微硬度测试。研究结果表明,功率对2A12铝合金激光淬火组织的影响比较显著。由于2A12铝合金是过烧敏感性最大的硬铝合金,在激光扫描速度、保护气体流量等工艺参数一定的条件下,激光功率过大,得到的是过烧的淬火组织,晶界局部变粗,并出现共晶液相球。激光淬火后,显微组织和基材相比明显细化,显微硬度也明显提高。正常淬火表面的显微硬度明显高于过烧表面的显微硬度,比过烧表面的显微硬度高9%。

关键词：铝合金激光淬火金相组织显微硬度过烧