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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Adjusted Log-rank Test with Double Inverse Weighting under Dependent Censoring

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Acta Mathematica Sinica,English Series 2021年第10期37卷 1573-1585页

作者： yi Min guo Jie ZHOU Liu Quan sun Institute of Applied Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China School of Mathematics of Sciences Capital Normal UniversityBeijing 100048P.R.China

It is a common issue to compare treatment-specific survival and the weighted log-rank test is the most popular method for group comparison. However, in observational studies, treatments and censoring times are usually not independent, which invalidates the weighted log-rank tests. In this paper, we propose adjusted weighted log-rank tests in the presence of non-random treatment assignment and dependent censoring. A double-inverse weighted technique is developed to adjust the weighted log-rank tests. Specifically, inverse probabilities of treatment and censoring weighting are involved to balance the baseline treatment assignment and to overcome dependent censoring, respectively. We derive the asymptotic distribution of the proposed adjusted tests under the null hypothesis, and propose a method to obtain the critical values. Simulation studies show that the adjusted log-rank tests have correct sizes whereas the traditional weighted log-rank tests may fail in the presence of non-random treatment assignment and dependent censoring. An application to oropharyngeal carcinoma data from the Radiation Therapy Oncology Group is provided for illustration.

关键词： Adjusted log-rank test dependent censoring double inverse weighting survival data

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FOCAD基因复合杂合变异致儿童重型先天性肝病1例

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中华儿科杂志 2025年第1期63卷 90-91页

作者：李艺佩郭张妍王义西安交通大学附属儿童医院重症医学科西安

患儿, 女, 2月6日龄, 以"皮肤黄染10 d"入院。家系全外显组测序结果提示FOCAD基因存在NM001375567.1:c.4203C>G（***1401*）和c.2303dupC（***769Phefs*54）复合杂合变异。诊断为FOCAD基因变异致儿童重型先天性肝病。以保肝降酶对症支...

患儿, 女, 2月6日龄, 以"皮肤黄染10 d"入院。家系全外显组测序结果提示FOCAD基因存在NM001375567.1:c.4203C>G（***1401*）和c.2303dupC（***769Phefs*54）复合杂合变异。诊断为FOCAD基因变异致儿童重型先天性肝病。以保肝降酶对症支持治疗为主, 经治疗16 d, 好转出院, 出院后继续口服药物治疗。19 d后因凝血功能异常再次入院, 治疗4 d, 基因结果回报异常, 家属放弃治疗, 2个月后死亡。

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龙门加工中心的模糊自学习交叉耦合补偿控制

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沈阳工业大学学报 2004年第1期26卷 47-50页

作者：孙宜标郭庆鼎沈阳工业大学电气工程学院辽宁沈阳110023

以龙门加工中心的双轴同步传动机构为背景,研究两套永磁同步电动机(PMSM)伺服系统在具有一定动态指标和抗干扰性能前提下的同步控制问题.针对两套进给系统难以同步且易受干扰的特点,设计了一种基于模糊自学习方法的交叉耦合补偿器.仿真... 详细信息

以龙门加工中心的双轴同步传动机构为背景,研究两套永磁同步电动机(PMSM)伺服系统在具有一定动态指标和抗干扰性能前提下的同步控制问题.针对两套进给系统难以同步且易受干扰的特点,设计了一种基于模糊自学习方法的交叉耦合补偿器.仿真结果表明该系统对不平衡负载具有良好同步抗扰性能.

关键词：移动式龙门加工中心同步进给 IP控制交叉耦合补偿模糊自学习

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双直线电机动态同步进给鲁棒控制研究

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沈阳工业大学学报 2003年第5期25卷 408-411页

作者：孙宜标郭庆鼎沈阳工业大学电气工程学院辽宁沈阳110023

针对双直线伺服系统的两个位置环间的动态同步进给控制问题,子系统的速度和位置控制器的设计采用具有较强鲁棒性和跟踪特性的积分比例(IP)方法.并在分析双直线电动机同步进给伺服系统产生不同步现象原因的基础上,基于变结构控制理论设... 详细信息

针对双直线伺服系统的两个位置环间的动态同步进给控制问题,子系统的速度和位置控制器的设计采用具有较强鲁棒性和跟踪特性的积分比例(IP)方法.并在分析双直线电动机同步进给伺服系统产生不同步现象原因的基础上,基于变结构控制理论设计了滑模同步控制器,以解决双位置环系统输出端机械耦合、电机参数变化和其它扰动等不确定性因素对同步精度的影响.仿真结果表明该控制方案具有很强的鲁棒性,在不对称负载的条件下能实现动态同步进给.

关键词：动态同步进给直线电机 IP控制滑模控制

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Synthesis of ultrathin semicircle-shaped copper nanowires in ethanol solution for low haze flexible transparent conductors

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Nano Research 2018年第7期11卷 3899-3910页

作者： Ye Zhan~ Jiangna guo Dan Xu yi sun Feng Yan Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Copper nanowires （CuNWs） are becoming an indispensable item for next- generation transparent optical devices due to their excellent conductivity and transparency. In this work, ultrathin semicircle-shaped copper nanowires （SCuNWs） with a diameter of - 15 nm and a length of - 30 μm （aspect ratio of -2,000） were synthesized in ethanol solution. The mechanism and factors that affect the morphology and dispersity of the SCuNWs were investigated. The prepared SCuNWs were coated on polyethylene terephthalate （PET） or polyd- imethylsiloxane （PDMS） substrate to fabricate flexible transparent conductors （FTCs）. The fabricated FTCs exhibited excellent optoelectrical performance and low haze. In addition, the fabricated FTCs showed high mechanical stability during stretching and bending, indicating their great potential in flexible optical devices.

关键词： copper nanowires semicircle-shaped ultrathin low haze flexible transparent conductors

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Efficient electrocatalytic reduction of nitrate to ammonia at low concentration by copper-cobalt oxide nanowires with shell-core structure

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Nano Research 2024年第6期17卷 5087-5094页

作者： Chenhao Xiao Yaxiao guo Jiayuan sun Tao guo Xinyuan Jia Shinuo guo Guancheng Wu Yue sun Zhaoyang Yao yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China Key Laboratory of Functional Polymer Materials College of ChemistryNankai UniversityTianjin 300071China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Electrocatalytic nitrate reduction to ammonia(NO3−RR)for removing nitrate from wastewater is a promising but challengeable technology that is increasingly ***,we developed an efficient CuO_(x)and CoCuO_(x)composed hybrid catalyst(CoCuO_(x)@CuO_(x)/copper foam(CF)),characteristic of distinctive shell-core nanowires grown on CF substrate with CuO_(x)core and CoCuO_(x)*** built-in electric field formed at the interface of the CoO/Cu_(2)O heterostructure promotes NO3−adsorption by modulating the charge distribution at the interface,which greatly improves the ammonia yield rate and Faradaic ***−0.2 V *** hydrogen electrode(RHE),CoCuO_(x)@CuO_(x)/CF achieves not only an excellent ammonia yield rate of up to 519.1μg·h^(−1)·cm^(−2)and Faradaic efficiency of 99.83%at 1 mM NO3−concentration,but also excellent mechanical *** study provides a novel pathway to design electrocatalyst for the removal of nitrate from dilute nitric acid solutions(≤2 mM).

关键词： CoCuO_(x)@CuO_(x)/copper foam(CF) shell-core nanowires heterostructure low concentration nitrate electroreduction to ammonia

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长角血蜱、草原革蜱经期传播莱姆病螺旋体的实验研究(英文)

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寄生虫与医学昆虫学报 2003年第3期10卷 174-180页

作者：孙毅许荣满郭天宇张泮河曹务春军事医学科学院微生物流行病研究所北京100071

为了明确长角血蜱、草原革蜱在我国北方莱姆病传播中的地位和作用 ,以全沟硬蜱为对照 ,在实验室内对它们经期传播莱姆病螺旋体的可能性进行了研究。结果表明 ,全沟硬蜱可保持活的螺旋体到下一发育阶段 ,并且其体内的莱姆病螺旋体具备感... 详细信息

为了明确长角血蜱、草原革蜱在我国北方莱姆病传播中的地位和作用 ,以全沟硬蜱为对照 ,在实验室内对它们经期传播莱姆病螺旋体的可能性进行了研究。结果表明 ,全沟硬蜱可保持活的螺旋体到下一发育阶段 ,并且其体内的莱姆病螺旋体具备感染敏感KM鼠的能力。长角血蜱和草原革蜱虽然可以通过吸血获得莱姆病螺旋体 ,但它们对莱姆病螺旋体的保持期较短 ,不能跨越蜕皮阶段 ,因而不具备经期携带、传播的能力。所以它们作为莱姆病媒介的可能性不大。

关键词：长角血蜱草原革蜱莱姆病螺旋体经期传播

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人力资源会计有关问题的探讨

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沈阳工业大学学报 2000年第S1期22卷 107-108页

作者：刘春孙奕驰郭慧敏沈阳工业大学经济管理学院辽宁沈阳110023

就人力资源会计模式等问题进行论述，在阐述早期的人力资源会计模式的优缺点的基础上，着重对劳动者权益模式的会计核算进行探讨．

关键词：人力资源资本会计

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