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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin Wu Yan sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Complex adaptive system theory,agent-based modeling,and simulation in dominant technology formation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 130-153页

作者： ZHANG Ruihan sun Bing Glorious sun School of Business and Management Donghua UniversityShanghai 200051China School of Economics and Management Harbin Engineering UniversityHarbin 150001China

Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and ***,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical *** results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and ***,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical *** is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different *** study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.

关键词： complex adaptive system theory agent-based modeling and simulation dominant technology socio-technical landscape adaptation-choice

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利用四重氢键和主客体作用构筑超分子共聚物

有机化学 2020年第4期40卷 944-949页

作者：肖唐鑫周玲魏小艳李正义孙小强常州大学石油化工学院江苏常州213164

合成了一种同时含有脲基嘧啶酮基团(UPy)和苯并21冠7基团(B21C7)的单体H以及一种同时含有两个二烷基铵盐单元的单体G.分子H和G中的功能基团均由短间隔基相连.H可以通过四重氢键形成二聚体,进而和G发生主客体组装形成线性超分子共聚物.... 详细信息

合成了一种同时含有脲基嘧啶酮基团(UPy)和苯并21冠7基团(B21C7)的单体H以及一种同时含有两个二烷基铵盐单元的单体G.分子H和G中的功能基团均由短间隔基相连.H可以通过四重氢键形成二聚体,进而和G发生主客体组装形成线性超分子共聚物.对该超分子共聚物进行了如下表征:随浓度变化1H NMR,粘度测试以及扫描电子显微镜(SEM)等.该结果将启发在更多领域中利用正交策略构筑各种超分子聚合物智能材料.

关键词：超分子化学四重氢键自组装超分子聚合物冠醚大环主客体作用

Study on Coded Permutation Entropy of Finite Length Gaussian White Noise Time Series

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Chinese Journal of Electronics 2024年第1期33卷 185-194页

作者： Huihui sun Xiaofeng ZHANG School of Physics and Information Technology Shaanxi Normal University

As an extension of permutation entropy(PE), coded permutation entropy(CPE) improves the performance of PE by making a secondary division for ordinal patterns defined in PE. In this study, we provide an exploration of the statistical properties of CPE using a finite length Gaussian white noise time series theoretically. By means of the Taylor series expansion, the approximate expressions of the expected value and variance of CPE are deduced and the Cramér-Rao low bound(CRLB) is obtained to evaluate the performance of the CPE estimator. The results indicate that CPE is a biased estimator, but the bias only depends on relevant parameters of CPE and it can be easily corrected for an arbitrary time series. The variance of CPE is related to the encoding patterns distribution,and the value converges to the CRLB of the CPE estimator when the time series length is large enough. For a finitelength Gaussian white noise time series model, the predicted values can match well with the actual values, which further validates the statistic theory of CPE. Using the theoretical expressions of CPE, it is possible to better understand the behavior of CPE for most of the time series.

关键词： Time series analysis White noise Predictive models Taylor series Entropy Encoding Time measurement

Multi-Sensor Fusion Adaptive Estimation for Nonlinear Under-observed System with Multiplicative Noise

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Chinese Journal of Electronics 2024年第1期33卷 282-292页

作者： Yongpeng CUI Xiaojun sun School of Electronic Engineering Heilongjiang University Key Laboratory of Information Fusion Estimation and Detection

The adaptive fusion estimation problem was studied for the multi-sensor nonlinear under-observed systems with multiplicative noise. A one-step predictor with state update equations was designed for the virtual state with virtual noise first of all. An extended incremental Kalman filter(EIKF) was then proposed for the nonlinear under-observed systems. Furthermore, an adaptive filtering method was given for optimization. The fusion adaptive incremental Kalman filter weighted by scalar was finally proposed. The comparison analysis was made to verify the optimization of the state estimation using adaptive filtering method in the filtering process.

关键词： Adaptive systems Information filters Matrices Adaptive estimation Kalman filters State estimation Nonlinear systems

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滚珠丝杠式惯容器非线性建模与参数辨识

振动．测试与诊断 2016年第2期36卷 329-334,404页

作者：孙晓强陈龙汪少华杨晓峰江苏大学汽车与交通工程学院镇江212013

针对滚珠丝杠式惯容器存在的非线性力学特征,首先,分析了滚珠丝杠式惯容器的工作原理,对惯容器的主要部件进行了非线性力学分析,建立了考虑摩擦、间隙以及丝杠弹性力的惯容器非线性力学模型;然后,在数控液压伺服激振试验台上进行了惯容... 详细信息

针对滚珠丝杠式惯容器存在的非线性力学特征,首先,分析了滚珠丝杠式惯容器的工作原理,对惯容器的主要部件进行了非线性力学分析,建立了考虑摩擦、间隙以及丝杠弹性力的惯容器非线性力学模型;然后,在数控液压伺服激振试验台上进行了惯容器的力学性能试验,得到了惯容器在不同惯容系数以及不同激振输入下的力学响应特性;最后,根据试验结果分析了摩擦和间隙对惯容器力学性能的影响,得到了便于参数辨识的惯容器力学模型结构,实现了惯容器输出力仿真与试验结果的分析和对比。结果显示,二者在一个周期内的均方根值误差不超过7%,非线性模型呈现出良好的拟合精度,证明了所述方法的可行性和有效性。

关键词：滚珠丝杠式惯容器非线性最小二乘法参数辨识

Organic thin-film transistors and related devices in life and health monitoring

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Nano Research 2024年第2期17卷 426-444页

作者： Chenfang sun Tie Wang Tianjin Key Laboratory of Drug Targeting and Bioimaging Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

The early determination of disease-related biomarkers can significantly improve the survival rate of ***,a series of explorations for new diagnosis technologies,such as optical and electrochemical methods,have been devoted to life and health *** thin-film transistor(OTFT),as a state-of-the-art nano-sensing technology,has attracted significant attention from construction to application owing to the merits of being label-free,low-cost,facial,and rapid detection with multi-parameter ***,interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas,so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity,selectivity,and ***,we overviewed the composition,mechanism,and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled *** results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.

关键词： organic thin-film transistors biosensors biomarkers organic bioelectronics organic semiconductors healthcare

Turbulence Statistics of Thermo-Buoyancy Supercritical Fuel Flow in a Regenerative Cooling Channel

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Journal of Thermal Science 2024年第1期33卷 126-137页

作者： sun Feng XIE Gongnan School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Department of Thermal Engineering Tsinghua UniversityBeijing 100084China

Active regenerative cooling with supercritical hydrocarbon fuel is considered as the most promising thermal protection *** existence of buoyancy force would lead to strongly anisotropic flow and thermal transport *** is closely related to the cooling performance of the *** elucidate the mechanisms of turbulent transport,the large eddy simulation(LES) was performed to assess turbulence statistics within different turbulence *** results indicated that the buoyancy and inertial force together dominated the change of turbulent ***,the spatial thermal buoyancy effect significantly suppressed the vertical velocity *** is due to the laminar motion caused by the buoyancy force,thereby weakening the thermal *** the statistics of velocity fluctuation,it was found that the buoyancy force and inertial force greatly weaken the vertical and streamwise velocity fluctuation,*** the statistics of thermal transport,the results pointed out that the near-wall heat transport characteristics need to be paid more *** thickness of the temperature mixing boundary layer led to the attenuation of vertical heat flux,which inhibited vertical temperature diffusion and predisposed to extreme conditions of heat transfer *** results can enhance the academic understanding of the heat transfer mechanism of supercritical fluids,and give guidance for further applications of thermal protection.

关键词： active regenerative cooling large eddy simulation(LES) buoyancy force turbulence statistics

基于动力吸振理论的车辆ISD悬架设计与性能分析

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汽车工程 2014年第10期36卷 1262-1266,1277页

作者：杨晓峰沈钰杰陈龙汪若尘孙晓强江苏大学汽车与交通工程学院镇江212013

ISD（inerter-spring-damper）悬架是由惯容器、弹簧和阻尼器构成的一种新型车辆被动悬架。本文中基于动力吸振器在振动控制中的作用,利用惯容器动力学特性,建立了ISD悬架的单轮模型,设计出含有动力吸振器结构的ISD悬架,并对其进行仿真... 详细信息

ISD（inerter-spring-damper）悬架是由惯容器、弹簧和阻尼器构成的一种新型车辆被动悬架。本文中基于动力吸振器在振动控制中的作用,利用惯容器动力学特性,建立了ISD悬架的单轮模型,设计出含有动力吸振器结构的ISD悬架,并对其进行仿真,用多目标遗传算法确定元件参数,分析ISD悬架的主频率特性和各性能指标（车身加速度、悬架动行程和轮胎动载荷）的振动传递特性。仿真结果表明,在0-15Hz低频段,与等刚度的传统被动悬架相比,ISD悬架改善了各性能指标的振动传递幅频特性,降低了各性能指标在共振频率1Hz附近的功率谱密度峰值。

关键词：车辆悬架动力吸振器惯容器设计性能分析

基于可拓博弈的智能汽车轨迹跟踪协调控制方法研究

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机械工程学报 2022年第8期58卷 181-194页

作者：臧勇蔡英凤孙晓强徐兴陈龙王海江苏大学汽车与交通工程学院镇江212000 江苏大学汽车工程研究院镇江212000

针对智能汽车在高速过弯工况下,轨迹跟踪误差大、横向稳定性无法保障的问题,提出一种可拓博弈轨迹跟踪协调控制方法,通过可拓划区域切换控制和博弈协调相结合,突破单一控制策略的工况适应性和多策略切换的抖动问题。所提方法基于分层控... 详细信息

针对智能汽车在高速过弯工况下,轨迹跟踪误差大、横向稳定性无法保障的问题,提出一种可拓博弈轨迹跟踪协调控制方法,通过可拓划区域切换控制和博弈协调相结合,突破单一控制策略的工况适应性和多策略切换的抖动问题。所提方法基于分层控制体系,将轨迹跟踪控制分解为上层测度模式识别层和下层博弈协调层。上层基于可拓理论,提出并联可拓测度模式识别策略,将车-路系统实时状态映射至对应的可拓控制架构中经典域、可拓域和非域三种测度模式。下层针对不同测度模式对应设计三种控制策略,根据上层测度模式识别结果进行实时策略切换,引入博弈协调方法对并联可拓权重进行协调控制,有效避免了模式切换带来的抖动问题。通过Simulink/Carsim建立联合仿真模型,在双移线和“8字”形时变曲率高速工况开展算法对比验证,所提方法相较于比例-积分-微分(Proportion-integral-derivative,PID)控制方法,平均跟踪误差精度提升45.08%,尤其在大曲率突变的恶劣工况下,车辆稳定性提升44%。最后利用智能汽车试验平台进行了对比验证,对设计智能汽车高速轨迹跟踪控制策略具有极强的指导意义和参考价值。

关键词：智能汽车并联可拓控制关联函数博弈协调控制纳什均衡解