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X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun Zheng Lin Liu Yi’ang Li Rui Rong Liang Song Junpeng Shi Jing Teng xia sun Yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity bioimaging.Transition metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window emission.Here,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence emission.After excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 h.More importantly.LYGM can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence emission.In addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in mice.After LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be achieved.After the persistent luminescence decays,LYGM can be re-excited for repeated imaging.Therefore,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

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World Journal of Clinical Cases 2024年第7期12卷 1296-1304页

作者： Dan Wu Qiong Wang Shuai Yan xia sun Ya Qin Ming Yuan Nan-Yao Wang xian-Ting Huang Department of Oncology Jiangyin People's HospitalWuxi 214400Jiangsu ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more limited.Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer.Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune microenvironment.CASE SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 months.Patient 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 months.Moreover,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was observed.The patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)infection.The patient died in February 2023.Patient 2 also took two prior lines of chemotherapy and then local radiotherapy combined with S-1.After confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third line.After the patient had COVID-19 in December 2022,fruquintinib was discontinued.The patient died in January 2023 due to disease progression.CONCLUSION Both cases achieved a PFS benefit from later-line single-agent fruquintinib therapy.With its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

关键词： Pancreatic cancer Anti-vascular endothelial growth factor receptor Fruquintinib Case report

Spatial Distribution and Seasonal Variation of Hypoxic Zone in the Eastern Equatorial Indian Ocean

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Journal of Ocean University of China 2023年第4期22卷 918-929页

作者： XIE Linping WANG Baodong XIN Ming WANG Ying sun xia WEI Qinsheng LIU Lin YUAN Chao Key Laboratory of Marine Eco-Environmental Science and Technology First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

The spatial distribution and seasonal variations of the hypoxic zone in the eastern equatorial Indian Ocean were investigated using survey data collected from four cruises from 2013 to 2018.Results showed that hypoxic zone occurred all year round in the eastern equatorial Indian Ocean,and it spread southward in the shape of a double tongue at two depths with one at subsurface centered at a depth of 150 m and the other in intermediate water centered at a depth of 800 m.The southward expansion and maximum thickness of the hypoxic zone were greatest in the spring inter-monsoon and least in the summer monsoon.The hypoxic zone originated from the southward expansion of the hypoxic water in the Bay of Bengal and its spatial distribution was driven by southward output flux of mid-deep(100–1000 m)hypoxic water from the Bay of Bengal.The hypoxia southward expansion was blocked near the equator in the subsurface layer,because of mixing with multiple zonal circulations(e.g.,Wyrtki Jets and the equatorial undercurrent),which meant that the hypoxic zone extended over a smaller area than in the intermediate water.These new findings will contribute to an improved understanding of the hypoxic zone and will contribute to circulation research,particularly about intermediate circulation in the eastern equatorial Indian Ocean.

关键词： hypoxic zone spatial distribution vertical structure seasonal variation eastern equatorial Indian Ocean

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大尺寸三维超声振动系统的智能优化设计

物理学报 2024年第8期73卷 181-194页

作者：林基艳孙姣夏林书玉榆林学院榆林市大数据与智能决策重点实验室榆林719000 陕西师范大学陕西省超声学重点实验室西安710119

对大尺寸三维超声换能器系统的耦合振动进行有效控制,优化系统的性能,一直都是功率超声领域亟待解决的难题.研究发现,一些声子晶体槽、孔结构可以对大尺寸换能器系统的横向振动进行抑制,提高系统振幅分布均匀度,且可以通过改变声子晶体... 详细信息

对大尺寸三维超声换能器系统的耦合振动进行有效控制,优化系统的性能,一直都是功率超声领域亟待解决的难题.研究发现,一些声子晶体槽、孔结构可以对大尺寸换能器系统的横向振动进行抑制,提高系统振幅分布均匀度,且可以通过改变声子晶体结构的配置参数人为地实现对大尺寸三维超声振动系统性能的调控.但过多的设计参数必然会增加系统设计的复杂度,且目前大尺寸三维超声换能器系统的优化设计依赖于经验试错法,设计效率和成功率较低,性能也无法保证.研究引入同质位错、点缺陷结构对大尺寸三维超声振动系统进行优化设计,并利用数据分析技术评价了同质位错、点缺陷结构的配置对系统辐射面的纵向位移振幅、振幅分布均匀度、辐射声功率、工作带宽等的影响规律,建立了同质位错结构、近周期缺陷结构的结构参数——大尺寸超声换能器系统性能的预测模型,实现了对大尺寸功率超声换能器系统的智能设计,提高了设计效率和成功率,降低了设计成本.

关键词：耦合振动大尺寸三维超声振动系统同质位错点缺陷智能化设计

迈向新有机团结:旅游发展驱动各民族“三交”

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中央民族大学学报（哲学社会科学版） 2024年第2期51卷 5-14页

作者：孙九霞周明中山大学旅游学院广东珠海519082 中山大学粤港澳发展研究院广东广州510275

促进各民族交往交流交融的战略实践中,面临着经济文化交往不足、族际交流不充分、少数民族发展融入有限等困境。旅游业的高质量发展有望成为解决以上困境的有效路径,实现各民族在空间、文化、经济、社会和心理等方面的全方位嵌入。本文... 详细信息

促进各民族交往交流交融的战略实践中,面临着经济文化交往不足、族际交流不充分、少数民族发展融入有限等困境。旅游业的高质量发展有望成为解决以上困境的有效路径,实现各民族在空间、文化、经济、社会和心理等方面的全方位嵌入。本文借鉴有机团结理论,在旅游流动带来的空间互嵌基础上,从文化、经济、社会和心理维度分析旅游与各民族“三交”之间的融合性。研究发现,旅游作为一种现代化的力量,是民族地区在原有社会结构、交往历史、文化传统等基础上谋求新发展的重要手段。在民族旅游目的地,机械团结和有机团结并存,继而形成新的有机团结,共同影响着民族嵌入机制和民族团结格局。迈向新有机团结,意味着在旅游情境下实现个体—族群—多民族—国家的多元多层主体间循环互动,并依托旅游发展加强文化—经济—社会—心理的多维整合,以实现各民族交往交流交融的新平衡。本文为旅游促进各民族“三交”提供分析框架,旨在为各民族“三交”注入新内涵。

关键词：有机团结旅游交往交流交融民族互嵌

Adsorptive Recovery of Uranium from Nuclear Fuel Industrial Wastewater by Titanium Loaded Collagen Fiber

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Chinese Journal of Chemical Engineering 2011年第4期19卷 592-597页

作者： CHENG YuanMei sun xia LIAO Xuepin Sill Bi School of Chemical Engineering Sichuan University Chengdu 610065 China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu 610065 China

Effective recovery of UO2+2 from wastewater is essential for nuclear fuel industry and related industries.In this study,a novel adsorbent was prepared by loading titanium(Ti4+) onto collagen fiber(TICF),and its physical and chemical properties as well as adsorption to UO2+2 in nuclear fuel industrial wastewater were investigated.It is found that TICF can effectively recover UO2+2 from the wastewater with excellent adsorption capacity.The adsorption capacity is 0.62 mmol·g-1 at 303 K and pH 5.0 when the initial concentration of UO2+2 is 1.50 mmol·L-1.The adsorption isotherms can be described by the Langmuir equation and the adsorption capacity increases with temperature.The effect of co-existed F on the adsorption capacity for UO2+2 is significant,which can be eliminated by adding aluminum ions as complexing agent,while the other co-existed ions in the solutions,including HCO-3,Cl-,NO-3,Ca2+,Mg2+ and Cu2+,have little effect on the adsorption capacity for UO2+2.The saturated TICF after UO2+2 adsorption can be regenerated by using 0.2 mol·L-1 nitrate(HNO-3) as desorption agent,and the TICF can be reused at least three times.Thus the TICF is a new and effective adsorbent for the recovery of UO2+2 from the wastewater.

关键词：二氧化铀吸附回收工业废水胶原纤维核燃料 Langmuir方程吸附能力钛

儿童保育与革命事业:互助变工托儿所的历史实践(1943-1949)

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长治学院学报 2024年第2期41卷 17-22页

作者：孙霞吕梁学院历史文化系山西离石033000

革命战争年代,为了解决照料子女的私人家庭劳动和进行生产工作的公共社会劳动之间的矛盾,女干部和家属们依托供给制,在政府帮助下创办了互助变工托儿所。基于集体互助和情感信任组建托儿所的集体保育既是家庭劳动也是社会工作,将照料子... 详细信息

革命战争年代,为了解决照料子女的私人家庭劳动和进行生产工作的公共社会劳动之间的矛盾,女干部和家属们依托供给制,在政府帮助下创办了互助变工托儿所。基于集体互助和情感信任组建托儿所的集体保育既是家庭劳动也是社会工作,将照料子女的事情由家庭私领域扩展到公共领域,由国家、集体和家庭共同来承担。互助变工托儿所呈现出家国一体、公私协力、互助变工的特点。中国共产党将儿童托育塑造为具有政治属性的革命事业,实现了革命愿景中的儿童公育,并辅助其走向社会主义道路,收两利之便。小型互助托儿所的创办为新中国成立后更深层次动员妇女参加社会劳动提供了借鉴。

关键词：互助变工托儿所女干部集体保育革命事业

旅游资源开发和社区异质化的双向驱动机制——以云南省环洱海地区为例

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自然资源学报 2024年第7期39卷 1531-1547页

作者：王思雅孙九霞中山大学旅游学院广州510275 中山大学旅游休闲与社会发展研究中心广州510275 中山大学大湾区人文共同体重点实验室广州510275

现有旅游资源开发研究集中关注资源的经济属性及其对产品或产业的经济转化效应,较少关注资源的社会属性和社会效应。对云南省环洱海地区中具有不同旅游介入度的三个乡村社区进行比较研究,探讨旅游资源开发的社区异质化效应,以及旅游资... 详细信息

现有旅游资源开发研究集中关注资源的经济属性及其对产品或产业的经济转化效应,较少关注资源的社会属性和社会效应。对云南省环洱海地区中具有不同旅游介入度的三个乡村社区进行比较研究,探讨旅游资源开发的社区异质化效应,以及旅游资源开发和社区异质化的双向驱动机制。研究发现:第一,区别于其他乡村资源开发模式,旅游资源开发使得同质性的村落共同体产生纵向上的经济异质化和横向上的群体异质化。第二,旅游资源开发和社区异质化产生双向驱动机制。一方面,旅游资源开发带来了资源价值的转化,从而形成“自然资源-社会资源”链接,带来了物质财富和人口群体的吸附。另一方面,社区异质化带来了资源利用主体的内部张力,形成了多元化和系统化的资源利用方式,从而促使资源类型整合和资源范畴拓展。在外部市场驱动和内部社区驱动的双重作用下旅游资源得以开发和再开发,呈现出价值转化效应和范畴拓展效应。

关键词：乡村旅游社区异质化资源链接资源利用社会效应

辅助放电下刷状空气等离子体羽的放电特性和参数诊断

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物理学报 2024年第8期73卷 209-217页

作者：张雪雪贾鹏英冉俊霞李金懋孙换霞李雪辰河北大学物理科学与技术学院保定071002 黑龙江工业学院电气与信息工程学院鸡西158100

大气压等离子体射流(APPJ)能产生富含活性粒子的等离子体羽,在众多领域具有广泛的应用前景.从应用角度考虑,如何产生大尺度弥散等离子体羽是APPJ研究的热点之一.目前,利用惰性气体APPJ已经能产生令人满意的大尺度等离子体羽,但从经济性... 详细信息

大气压等离子体射流(APPJ)能产生富含活性粒子的等离子体羽,在众多领域具有广泛的应用前景.从应用角度考虑,如何产生大尺度弥散等离子体羽是APPJ研究的热点之一.目前,利用惰性气体APPJ已经能产生令人满意的大尺度等离子体羽,但从经济性上考虑,如何产生大尺度空气等离子体羽更具有应用价值.针对于此,本工作设计了一个具有辅助放电的APPJ,产生了大尺度刷形空气等离子体羽.结果表明,刷状空气等离子体羽可以在一定电压峰值(Vp)内产生,并且随着Vp增大等离子体羽的长度和发光强度都增大.电压和发光信号波形表明,每半个电压周期最多会有一次放电.每半个电压周期的放电概率和光脉冲的强度都随着Vp增大而增大,但放电起始时刻的电压值会随着Vp增大而降低.高速影像研究表明弥散刷形空气等离子体羽和小尺度空气等离子体羽的产生机制类似,均源于分叉正流光的时间叠加.此外,采集了刷形空气等离子体羽的发射光谱,并利用其对放电的电子温度、电子密度、分子振动温度和气体温度进行了研究.结果表明,等离子体羽的气体温度较低,且基本不随Vp变化.然而电子密度、电子温度和分子振动温度均随着Vp增大而升高.利用激光诱导荧光光谱技术研究了等离子体羽的OH浓度,发现OH分布较为均匀,且其浓度随着Vp增大而增大.最后,对这些变化规律进行定性分析.

关键词：等离子体射流空气等离子体羽发射光谱等离子体参数