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二氢麦角碱治疗脑小血管病性认知障碍对患者神经功能、认知功能及炎症因子水平的影响

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中国医学创新 2024年第24期21卷 60-64页

作者：孙文强王洪亮南通市第六人民医院神经内科江苏南通226011

目的:探讨二氢麦角碱治疗脑小血管病性认知障碍的效果及对炎症因子的影响。方法:选择2022年4月—2023年7月南通市第六人民医院收治的脑小血管病性认知障碍患者73例,按照随机数字表法分为观察组(n=37)、对照组(n=36)。两组患者均应用标... 详细信息

目的:探讨二氢麦角碱治疗脑小血管病性认知障碍的效果及对炎症因子的影响。方法:选择2022年4月—2023年7月南通市第六人民医院收治的脑小血管病性认知障碍患者73例,按照随机数字表法分为观察组(n=37)、对照组(n=36)。两组患者均应用标准的脑小血管病治疗方案,对照组给予盐酸多奈哌齐片,观察组给予甲磺酸二氢麦角碱缓释片。对比两组治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)]、简易智力状态检查量表(MMSE)评分、日常生活活动能力量表(ADL)评分、炎症因子,评估两组治疗效果及不良反应发生率。结果:治疗90 d后,两组NIHSS均降低,观察组低于对照组,MMSE、ADL评分均升高,观察组均高于对照组,差异均有统计学意义(P0.05)。结论:对于脑小血管病性认知障碍,采用二氢麦角碱治疗的效果满意,可显著改善患者神经功能及认知功能,提高日常生活能力,降低血清炎症因子水平,且安全性高。

关键词：脑小血管病认知障碍二氢麦角碱超敏C反应蛋白

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球团回转窑煤粉供入量预测

冶金能源 2024年第2期43卷 30-35页

作者：刘新民路明刘旭刘书含孙文强东北大学冶金学院鞍钢集团矿业有限公司大孤山球团厂国家环境保护生态工业重点实验室辽宁省流程工业节能与绿色低碳技术工程研究中心

球团回转窑煤粉供入量的预测对回转窑精准控制和建设智能工厂都至关重要。然而,煤粉供入量与众多因素有关,只依据煤粉的历史数据建立模型进行预测,效果难以满足实际生产需求。因此,建立了基于XGBoost的煤粉消耗量预测模型,对影响煤粉消... 详细信息

球团回转窑煤粉供入量的预测对回转窑精准控制和建设智能工厂都至关重要。然而,煤粉供入量与众多因素有关,只依据煤粉的历史数据建立模型进行预测,效果难以满足实际生产需求。因此,建立了基于XGBoost的煤粉消耗量预测模型,对影响煤粉消耗量的众多因素进行筛选,确定影响煤粉消耗量的关键影响因素。以某球团厂为应用案例,开展了煤粉供入量预测研究。煤粉消耗量预测结果的平均相对误差为7.22%,生产状态平稳时的预测平均相对误差为6.1%,生产波动较大时的预测平均相对误差为8.9%,预测结果精度较高。

关键词：回转窑球团矿 XGBoost算法煤粉

Decomposition analysis of energy-related carbon dioxide emissions in the iron and steel industry in China

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Frontiers of Environmental Science & Engineering 2012年第2期6卷 265-270页

作者： wenqiang sun Jiuju CAI Hai YU Lei DAI SEP Key Laboratory of Eco-industry Institute of Thermal and Environmental EngineeringNortheastern UniversityShenyang 110819China

This work aims to identify the main factors influencing the energy-related carbon dioxide （CO2） emissions from the iron and steel industry in China during the period of 1995-2007. The logarithmic mean divisia index （LMDI） technique was applied with period-wise analysis and time-series analysis. Changes in energy- related CO2 emissions were decomposed into four factors： emission factor effect, energy structure effect, energy consumption effect, and the steel production effect. The results show that steel production is the major factor responsible for the rise in CO2 emissions during the sampling period; on the other hand the energy consump- tion is the largest contributor to the decrease in C02 emissions. To a lesser extent, the emission factor and energy structure effects have both negative and positive contributions to C02 emissions, respectively. Policy implications are provided regarding the reduction of C02 emissions from the iron and steel industry in China, such as controlling the overgrowth of steel production, improving energy-saving technologies, and introducing low-carbon energy sources into the iron and steel industry.

关键词： carbon dioxide (C02) emissions decomposi-tion analysis logarithmic mean divisia index (LMDI)technique time-series analysis

加减归脾汤联合胃复春治疗脾胃虚弱型慢性萎缩性胃炎伴焦虑临床观察

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中医药临床杂志 2024年第4期36卷 754-758页

作者：孙雯蔷杨辉刘丽丽安徽中医药大学安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

目的:观察加减归脾汤联合胃复春治疗脾胃虚弱型慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)伴焦虑的临床疗效。探求该药的临床价值及潜在的作用机制,为临床治疗提供一种参考。方法:观察符合纳入要求的CAG伴焦虑患者,共80例,随机地... 详细信息

目的:观察加减归脾汤联合胃复春治疗脾胃虚弱型慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)伴焦虑的临床疗效。探求该药的临床价值及潜在的作用机制,为临床治疗提供一种参考。方法:观察符合纳入要求的CAG伴焦虑患者,共80例,随机地分为对照组和治疗组各40例,对照组予胃复春治疗,治疗组予加减归脾汤联合胃复春,两组以8周为疗程。治疗8周后观察两组中医证候积分、中医证候疗效、汉密尔顿焦虑量表(HAMA)评分、胃镜症候评分、病理评分、血清中胃泌素17(G-17)、胃蛋白酶原I(PGI)、胃蛋白酶原I/II比值(PGR)以及安全性评价。结果:中医症候疗效:相比对照组的总有效率为75.00%,治疗组总有效率92.50%显示较对照组更佳(P<0.05)。中医症候积分:治疗8周后,两组中医证候积分均较前有所下降,对比治疗前后中医症候积分变化情况,治疗组更为明显(P<0.05)。病理积分:将炎症、萎缩、肠化、异型增生的有无,按程度分为分为无、轻、中、重四个轻重等级,记为0、1、2、3分,两组治疗后记录各项目总积分,表明两组治疗均是有效的(P<0.05),且治疗组治疗效果明显高于对照组(P<0.05)。血清G-17、PGI、PGR水平:经治疗两组患者G-17、PGI、PGR较前均上升(P<0.05),且治疗组升幅大于对照组(P<0.05)。汉密尔顿焦虑量表(HAMA)评分:治疗后两组患者焦虑量表评分均较治疗前降低(P<0.05),治疗后两组间比较,差异具有统计学意义(P<0.05)。表示治疗组较对照组更能改善焦虑。结论:加减归脾汤联合胃复春治疗脾胃虚弱型CAG伴有焦虑的患者时可以显著改善患者的中医症候、心理状态、胃黏膜状态及病理积分,有效调节血清G-17、PGI、PGR水平,对比对照组疗效更佳,且治疗安全,无不良事件发生。

关键词：加减归脾汤慢性萎缩性胃炎伴焦虑脾胃虚弱型

血清吲哚胺2,3-双加氧酶和犬尿喹啉酸在支气管肺发育不良早产儿中的变化

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中华围产医学杂志 2024年第3期27卷 215-219页

作者：陈慧娟孙文强李梦曌杨紫浩朱雪萍苏州大学附属儿童医院新生儿科苏州215025

目的探讨血清吲哚胺2,3-双加氧酶(indoleamine 2,3-dioxygenase,IDO)及犬尿喹啉酸(kynurenic acid,KYNA)在支气管肺发育不良(bronchopulmonary dysplasia,BPD)早产儿中的变化。方法采用巢式病例对照研究。建立早产儿队列,纳入2021年12月1日至2022年12月31日生后24 h内收住苏州大学附属儿童医院新生儿科的胎龄<32周的早产儿。诊断BPD者作为BPD组(n=35),按1∶1比例选取与BPD组胎龄相差<1周、出生体重相差<150 g的非BPD早产儿作为对照组(n=35)。检测患儿生后第1、7、14、28天血清IDO及KYNA水平。分析BPD组与对照组间、轻度BPD与中-重度BPD患儿间血清IDO及KYNA水平的差异,以及血清IDO及KYNA水平与BPD严重程度的关系。采用两独立样本t检验和Spearman相关分析进行统计学分析。结果与对照组患儿相比,BPD组患儿生后第7、14、28天血清IDO水平[分别为(60.68±9.37)与(50.66±10.46)、(57.81±11.07)与(44.45±8.20)、(50.62±10.77)与(41.31±7.74)pg/ml,t值分别为4.21、5.73和4.15]及第14、28天血清KYNA水平均升高[(439.31±41.22)与(368.99±68.79)、(376.97±45.74)与(325.50±60.07)μmol/L,t值分别为5.18和4.03],差异均有统计学意义(P值均<0.05)。生后第7、14、28天血清IDO水平与BPD严重程度均呈正相关(r值分别为0.546、0.495和0.502,P值均<0.05),生后第14、28天血清KYNA水平与BPD严重程度也呈正相关(r值分别为0.536和0.458,P值均<0.05)。结论BPD患儿血清IDO及KYNA水平升高,提示IDO和KYNA可能在BPD发生和发展中发挥一定作用。

关键词：支气管肺发育不良色氨酸吲哚胺2,3-双加氧酶犬尿喹啉酸

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基于激光自混合干涉的磁场测量方法研究

激光杂志 2024年第3期45卷 106-110页

作者：赵岩李康达林茂华孙文强张正阳天津理工大学电气工程与自动化学院天津市复杂系统控制理论及应用重点实验室天津300384

针对光纤磁流体磁场传感器易受环境干扰及磁流体薄膜制作工艺复杂的问题,激光自混合干涉具有抗干扰能力强、稳定性好的特点,提出一种基于空间光的水平偏振激光自混合干涉的磁场测量方法,在外部磁场的作用下,水平偏振自混合干涉信号幅值... 详细信息

针对光纤磁流体磁场传感器易受环境干扰及磁流体薄膜制作工艺复杂的问题,激光自混合干涉具有抗干扰能力强、稳定性好的特点,提出一种基于空间光的水平偏振激光自混合干涉的磁场测量方法,在外部磁场的作用下,水平偏振自混合干涉信号幅值发生变化,在一定范围内,磁场与信号幅值变化成正比,通过用施加磁场前后信号幅值的均值比与磁场的变化关系实现对磁场的传感检测。经过实验验证,信号的幅值在1%浓度的磁流体中衰减明显,薄膜厚度为0.5 mm,减小了薄膜的制作难度。在实验结果中对5.02 mt到19.112 mt磁场强度范围内的均值比进行线性拟合,相对误差最小为0.17%。

关键词：自混合干涉磁场测量水平偏振磁流体薄膜

A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

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Virologica Sinica 2022年第5期37卷 746-757页

作者： Lihong He wenqiang sun Limin Yang Wenjun Liu Jing Li CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Institute of Microbiology Center for Biosafety Mega-ScienceChinese Academy of SciencesBeijing100101China

Dengue virus(DENV)is a mosquito-borne virus with a rapid spread to humans,causing mild to potentially fatal illness in hundreds of millions of people each *** to the large number of serotypes of the virus,there remains an unmet need to develop protective vaccines for a broad spectrum of the ***,we constructed a modified mRNA vaccine containing envelope domain III(E-DIII)and non-structural protein 1(NS1)coated with lipid *** multi-target vaccine induced a robust antiviral immune response and increased neutralizing antibody titers that blocked all four types of DENV infection in vitro without significant antibodydependent enhancement(ADE).In addition,there was more bias for Th1 than Th2 in the exact E-DIII and NS1-specific T cell responses after a single ***,intramuscular immunization limited DENV transmission in vivo and eliminated vascular *** findings highlight that chimeric allogeneic structural and non-structural proteins can be effective targets for DENV vaccine and that they can prevent the further development of congenital DENV syndrome.

关键词： Dengue virus(DENV) mRNA vaccine Envelope domain III(E-DIII) Non-structural protein 1(NS1) Multi-serotype Immune response

Dissection of heterotic loci for grain yield using interconnected chromosome segment substitution lines in rice

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The Crop Journal 2022年第2期10卷 323-331页

作者： Chaopu Zhang Yongjian sun Dianwen Wang wenqiang sun Yuye Yu Zhongli Hu Sibin Yu National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina State Key Laboratory of Hybrid Rice College of Life ScienceWuhan UniversityWuhan 430072HubeiChina

Heterosis contributes greatly to crop production, but the genetic basis of heterosis is not fully *** identify heterotic loci(HLs) for grain yield, 12 yield traits were evaluated in four rice(Oryza sativa L.)mapping populations: one parental population of chromosome segment substitution lines derived from a cross between the japonica cultivar Nipponbare and indica cultivar 9311 and three connected test populations in either a homozygous 9311 genetic background or a heterozygous background. A total of 390 HLs were detected for the measured traits in two environments. The genetic bases of heterosis differed between the backcross and testcross populations. At least 10 HLs were confirmed in F1 hybrids between9311 and near-isogenic lines, each of which carried a heterotic locus of interest in the same 9311 background. All 10 showed overdominant or dominant effects on grain yield and yield components. Among them, three were verified as being associated with yield heterosis and colocalized in the same regions as those containing previously reported heterosis-associated genes. Five HLs were identified to be promising candidate loci that could be used to achieve more than 15% yield heterosis in several commercial rice hybrids. These findings suggest the potential of indica or japonica introgression for increasing yield in hybrid rice breeding programs.

关键词： Rice Heterotic loci Grain yield Overdominance Commercial hybrids

Influence of CNN Structure Parameters on Blind Equalization of Shortwave Channels

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Wuhan University Journal of Natural Sciences 2021年第1期26卷 102-106页

作者： LIU Qi sun wenqiang RU Guobao GAN Liangcai School of Electronic and Information Wuhan UniversityWuhan 430072HubeiChina

Aiming at the severe inter-symbol interference and high bit error rate in short-wave fast time-varying channels,this paper designs a short-wave channel blind equalizer based on Convolution Neural Network(CNN),and analyzes the influence of parameters in CNN structure on channel equalization,such as the number of convolution layers,the depth of convolution layer and the size of the convolution kernel *** simulating two typical short-wave time-varying channel,Rayleigh flat fading and frequency selective fading channels,we have the following results:1)Compared with the Recurrent Neural Network(RNN)structure equalizer,the CNN has higher accuracy during the training process,the convergence speed is faster,and the stability after convergence is higher.2)Under the condition of simulation,the CNN-based short-wave channel blind equalizer designed in this paper can effectively extract input signal when using 2×3×3 convolution kernel size and 2-layer convolutional *** characteristics of the classification layer improve the equalization performance while reducing the complexity of CNN structure.3)For the short-wave channel,the error rate of Convolution Neural Network Equalizer(CNNE)is lower than that of Recurrent Neural Network Equalizer(RNNE)under the same SNR.

关键词： channel equalization short-wave fast time-varying channel Convolution Neural Network(CNN)