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光致动态可调太赫兹超材料吸收器

Journal of Southeast University(English Edition) 2024年第2期40卷 148-154页

作者：刘宏微陈庆超孙美琪吕俊鹏南京师范大学物理科学与技术学院南京210023 东南大学物理学院南京211189

设计了一种具有偏振不敏感和广角吸收的光激发可切换单/双波段太赫兹超材料吸收器.通过调制嵌入谐振器中的光敏砷化镓的电导率实现功能切换,并提取不同砷化镓电导率下的表面电流,对超材料吸收器的吸收机理进行了物理解释.结果表明,该吸... 详细信息

设计了一种具有偏振不敏感和广角吸收的光激发可切换单/双波段太赫兹超材料吸收器.通过调制嵌入谐振器中的光敏砷化镓的电导率实现功能切换,并提取不同砷化镓电导率下的表面电流,对超材料吸收器的吸收机理进行了物理解释.结果表明,该吸收器可以实现从0.568和1.442 THz的双波段吸收(吸收率为99.08%和99.56%)到0.731 THz的单波段吸收(吸收率为95.43%)的切换.该器件强度调制深度为61.4%,频率调谐带宽为60.6%,可制作太赫兹频段的强度调制器和频率选择吸收器.此外,所提出的吸收器对横电(TE)和横磁(TM)偏振波都具有与偏振无关的广角吸收.可调谐超材料吸收器的实现为成熟的半导体技术以及有源太赫兹调制器和开关的潜在应用提供了机会.

关键词：太赫兹超材料吸收器光激发动态可调

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新时代背景下高校财务信息化建设研究

教育财会研究 2024年第2期35卷 56-62页

作者：魏巍李黎孙美琪周誉哈尔滨师范大学财务处黑龙江哈尔滨150025 河北师范大学财务处河北石家庄050024 南京师范大学财务处江苏南京211100

当前高校财务业务活动的多样性和复杂性对高校财务信息化建设提出了更高的要求和挑战,信息技术的迅速发展为解决这些要求和挑战提供了方式方法。高校财务信息化建设的重要性愈加凸显,它不仅能够提升高校财务管理的效率和准确性,还能为... 详细信息

当前高校财务业务活动的多样性和复杂性对高校财务信息化建设提出了更高的要求和挑战,信息技术的迅速发展为解决这些要求和挑战提供了方式方法。高校财务信息化建设的重要性愈加凸显,它不仅能够提升高校财务管理的效率和准确性,还能为决策提供重要的数据支持。在这一背景下,本文将进一步探讨高校财务信息化建设的必要性以及存在的问题,深入研究高校财务信息化建设在新时代的适应性,探索信息化建设的关键问题和路径,对推动高校财务的信息化进程,提高高校财务管理的效能和水平具有重要的理论和实践意义。

关键词：高校财务管理信息化建设

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头皮衰老与雄激素性脱发

皮肤科学通报 2024年第3期41卷 352-356页

作者：王鹏雨孙美琪赵月纯张宁馨宋坪中国中医科学院广安门医院皮肤科北京100053 中国中医科学院西苑医院皮肤科北京100091

雄激素性脱发(AGA)是脱发中最常见的类型之一,以渐进性毛囊微型化为主要特征。结合临床观察及现代医学理论,笔者认为雄激素性脱发患者存在头皮衰老现象,将其中医病机关键概括为肾虚精亏与痰瘀阻滞。本文遵循“补肾填精,活血化浊”的治... 详细信息

雄激素性脱发(AGA)是脱发中最常见的类型之一,以渐进性毛囊微型化为主要特征。结合临床观察及现代医学理论,笔者认为雄激素性脱发患者存在头皮衰老现象,将其中医病机关键概括为肾虚精亏与痰瘀阻滞。本文遵循“补肾填精,活血化浊”的治疗方法,根据不同病程时期特点,提出了初期侧重活血化浊以固脱,后期侧重补肾养血以生发的治疗角度。

关键词：雄激素性脱发衰老头皮中西医结合

NDUFS6蛋白生物信息学分析及过表达质粒的构建与鉴定

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宁夏医科大学学报 2024年第4期46卷 353-359页

作者：张瑜孙美琪徐方晶王洁方克宝王一帆何军宁夏医科大学第一临床医学院银川750004 宁夏医科大学附属银川市中医医院银川750000 宁夏医科大学总医院宁夏医科大学第一临床医学院银川750004

目的应用生物信息学方法分析线粒体呼吸链复合体Ⅰ结构亚基烟酰胺腺嘌呤二核苷酸脱氢酶(泛素)铁硫蛋白6(NDUFS6)的理化性质,构建pCV702-NDUFS6过表达质粒并进行鉴定,为进一步研究NDUFS6蛋白功能奠定基础。方法利用Expasy、UniProtKB、... 详细信息

目的应用生物信息学方法分析线粒体呼吸链复合体Ⅰ结构亚基烟酰胺腺嘌呤二核苷酸脱氢酶(泛素)铁硫蛋白6(NDUFS6)的理化性质,构建pCV702-NDUFS6过表达质粒并进行鉴定,为进一步研究NDUFS6蛋白功能奠定基础。方法利用Expasy、UniProtKB、NCBI、SOPMA等生物信息学工具分析NDUFS6蛋白的理化性质、二级结构等;根据NDUFS6 cDNA序列构建携带NDUFS6基因的过表达质粒pCV702-NDUFS6,转染大鼠心肌细胞H9C2,并设置阴性对照(NC)组和相应空载体CON520作为阳性对照(PC)组,经嘌呤霉素筛选后,采用RT-qPCR和Western blot检测NDUFS6 mRNA和蛋白表达水平。结果 NDUFS6蛋白由116个氨基酸组成,理论等电点pI为9.37。蛋白二级结构以无规则卷曲(占50%)为主。酶切鉴定和基因测序结果显示,pCV702-NDUFS6表达质粒构建成功。RT-qPCR和Western blot结果显示,相较于NC组和PC组,过表达组NDUFS6表达水平均上调(P均<0.05)。结论成功构建了能在心肌细胞H9C2中有效过表达NDUFS6基因的过表达质粒。

关键词：烟酰胺腺嘌呤二核苷酸脱氢酶(泛素)铁硫蛋白6 生物信息学分析心肌细胞质粒构建

泛素连接酶MuRF2通过抑制线粒体自噬减轻心肌细胞缺氧损伤

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宁夏医科大学学报 2024年第4期46卷 338-344,359页

作者：孙美琪张瑜徐方晶方克宝王一帆朱力何军宁夏医科大学第一临床医学院银川750004 银川市中医医院银川750004 宁夏医科大学总医院宁夏医科大学第一临床医学院银川750004

目的探讨泛素连接酶肌肉环指状蛋白2(muscle ring finger protein 2,MuRF2)对缺氧心肌细胞活力和自噬的调控作用。方法构建大鼠源MuRF2基因过表达和敲减慢病毒载体,分别感染大鼠心肌细胞H9C2。将H9C2细胞分为阴性对照组(NC)、阳性对照组... 详细信息

目的探讨泛素连接酶肌肉环指状蛋白2(muscle ring finger protein 2,MuRF2)对缺氧心肌细胞活力和自噬的调控作用。方法构建大鼠源MuRF2基因过表达和敲减慢病毒载体,分别感染大鼠心肌细胞H9C2。将H9C2细胞分为阴性对照组(NC)、阳性对照组[MuRF2过表达空载体组(LV-Vector)、MuRF2敲减空载体组(LV-RNAi-Vector)]、Mu RF2过表达组(LV-MuRF2)和MuRF2敲减组(LV-RNAi-MuRF2),缺氧培养(5%CO_(2)、1%O_(2)、94%N_(2))后,采用CCK-8法和ELISA法检测心肌细胞损伤水平,利用透射电子显微镜检测心肌细胞超微结构和自噬水平变化,采用Western blot测定自噬相关蛋白LC3-Ⅱ和P62的表达水平。结果与对照组相比,缺氧组心肌细胞间隙增大、细胞皱缩、多见漂浮的死亡细胞和细胞碎片,心肌细胞活力下降、肌钙蛋白Ⅰ(cTnⅠ)含量增加(P均<0.05);电子显微镜下可观察到部分线粒体发生肿胀,并存在嵴断裂、嵴溶解现象,自噬小体散在胞质内;缺氧组LC3-Ⅱ蛋白表达水平升高,P62蛋白表达水平降低(P均<0.05)。缺氧培养后,与NC组和LV-Vector组相比,LV-MuRF2组细胞活力增加,偶见自噬小体,LC3-Ⅱ蛋白表达水平降低、P62蛋白表达水平增高(P均<0.05);与NC组和LV-RNAi-Vector组相比,LV-RNAi-MuRF2组细胞活力降低,可见大量自噬小体,LC3-Ⅱ蛋白表达水平升高、P62蛋白表达水平降低(P均<0.05)。结论泛素连接酶MuRF2可减轻缺氧所致的心肌细胞损伤,其机制可能与抑制心肌细胞线粒体自噬有关。

关键词：泛素连接酶肌肉环指状蛋白2 心肌细胞缺氧线粒体自噬

Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019

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General Psychiatry 2024年第1期37卷 122-132页

作者： Yunxi Zhong Yifan Chen Xiaoying Su meiqi Wang Qixiu Li Ziming Shao Long sun Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandongChina National Health Commission of China(NHC)Key Laboratory of Health Economics and Policy Research Shandong UniversityJinanShandongChina nstitute of Health and Elderly Care Shandong UniversityJinanShandongChina

Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young *** The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to *** The data analysed in this study were from the Global Burden of Diseases *** numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 *** trends by age,sex and Social Development Index(SDI)were further *** Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and *** largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest ***,the largest increase in incidence was observed in southern Latin *** the national level,the most pronounced increase in the incidence was in *** The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.

关键词： adolescent bipolar young

Symmetry dependent activation and reactivity of peroxysulfates on FeS_(2)(001)surface

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Science Bulletin 2024年第2期69卷 154-158页

作者： Cancan Ling meiqi Li Hao Li Xiufan Liu Guangming Zhan Hongwei sun Chuan Liang Yaling Li Bing Zhou Jincai Zhao Lizhi Zhang School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Institute of Environmental&Applied ChemistryCentral China Normal UniversityWuhan 430079China

Heterogeneous peroxysulfates-based advanced oxidation processes(AOPs)have garnered significant attention for purifying organic wastewater since they offer many advantages like low cost,safe storage,facile activation and reactive species participation[1].Nonradical and radical pathways have been proposed to be involved in peroxysulfates activation.

关键词： activation radical reactivity

Protective eff ect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection

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World Journal of Emergency Medicine 2024年第1期15卷 28-34页

作者： Yangyang Guo Yaqi sun Hongxia Wu Jian Lu Yuan Lin Jiaqing Zhu Meihong Lai meiqi Zhang Jun Wang Jungang Zheng Department of Intensive Care Medicine Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China National Children’s Regional Medical Center National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Spleen and Stomach Diseases Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China Department of Ultrasonic Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Zhejiang University School of Medicine Hangzhou 310058China The First People’s Hospital of Yuexi County Yuexi 616650China

BACKGROUND:Streptococcus pneumoniae(***)is a common pathogen that causes bacterial ***,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat *** *** with a 14-carbon saturated fatty acid(ND-C14)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide ***,it is unclear whether ND-C14 is effective against lung infections caused by ***:In vitro,three groups were established,including the control group,and the HD5 and ND-C14 treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C14 against *** morphological changes of *** treated with HD5 or ND-C14 were observed by scanning electron *** vivo,mice were divided into sham,vehicle,and ND-C14 treatment *** in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C14 treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×108 CFU/mL(total bacterial count:5×10^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C14(including 20μg or 50μg),*** rates were evaluated in the vehicle and ND-C14 treatment *** burden in the blood and bronchoalveolar lavage fluid were *** lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C14 against ***:Compared with HD5,ND-C14 had a better bactericidal eff ect against *** because of its stronger ability to destroy the membrane structure of *** in *** vivo,ND-C14 significantly delayed the death time and improved the survival rate of mice infected with ***-C14 reduced bacterial burden and lung tissue ***,ND-C14 had a membrane per

关键词： Streptococcus pneumoniae Antimicrobial peptides Humanα-defensin 5 Infection

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

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Quantitative Biology 2024年第1期12卷 100-116页

作者： Keran sun Jingyuan Ning Keqi Jia Xiaoqing Fan Hongru Li Jize Ma meiqi Meng Cuiqing Ma Lin Wei Department of Immunology Immunology Department of Hebei Medical UniversityShijiazhuangChina Department of Pathology Pathology Department of the Fourth Hospital of Hebei Medical UniversityShijiazhuangChina

To investigate the impact of hyperglycemia on the prognosis of patients with gastric cancer and identify key molecules associated with high glucose levels in gastric cancer development,RNA sequencing data and clinical features of gastric cancer patients were obtained from The Cancer Genome Atlas(TCGA)*** glucose-related genes strongly associated with gastric cancer were identified using weighted gene co-expression network and differential analyses.A gastric cancer prognosis signature was constructed based on these genes and patients were categorized into high-and low-risk *** immune statuses of the two patient groups were *** citrate lyase(ACLY),a gene significantly related to the prognosis,was found to be upregulated upon high-glucose *** and molecular analyses confirmed high ACLY expression in gastric cancer tissues and *** Set Enrichment Analysis(GSEA)revealed the involvement of ACLY in cell cycle and DNA replication *** of ACLY affected the proliferation and migration of gastric cancer cells induced by high glucose *** findings suggest that ACLY,as a high glucose-related gene,plays a critical role in gastric cancer progression.

关键词： ACLY gastric cancer high glucose immune microenvironment