Toward innovative veterinary nanoparticle vaccines
作者机构：Institute of Preventive Veterinary MedicineCollege of Animal Sciences of Zhejiang University866 Yuhangtang RoadHangzhou 310058China Zhejiang Provincial Key Laboratory of Preventive Veterinary MedicineHangzhou 310058China ZJU-Xinchang Joint Innovation Centre(TianMu Laboratory)Gaochuang Hi‑Tech ParkXinchang 312500ZhejiangChina Department of CardiologyCardiovascular Key Lab of Zhejiang ProvinceThe Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina
出 版 物：《Animal Diseases》 (动物疾病（英文）)
年 卷 期：2024年第4卷第2期
页 面：78-97页
主 题：Nanoparticles Veterinary vaccine Self-assembling protein nanoparticles(SAPNs) Virus-like nanoparticles(VLPs) Immune responses Animal infectious diseases Optimization strategies
摘 要：Nanoparticles are significant for veterinary vaccine development because they are safer and more effective than conventional *** promising area of research involves self-assembled protein nanoparticles(SAPNs),which have shown potential for enhancing antigen-presenting cell uptake,B-cell activation,and lymph node *** nanovaccines have been utilized in veterinary medicine,including natural self-assembled protein nanoparticles,rationally designed self-assembled protein nanoparticles,animal virus-derived nanoparticles,bacteriophagederived nanoparticles,and plant-derived nanoparticles,which will be discussed in this *** vaccines can produce robust cellular and humoral immune responses and have been shown to protect against various animal infectious *** article attempts to summarize these diverse nanovaccine types and their recent research progress in the field of veterinary ***,this paper highlights their disadvantages and methods for improving their immunogenicity.
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