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Clinical assessment for three routes of hysterectomy

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Chinese Medical Journal 2009年第4期122卷 377-380页

作者： ZHU Lan LANG jing-he LIU Chun-yan SHI Hong-hui sun Zhi-jing fan Rong Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background Hysterectomy is a very common surgery in gynecology. Ideal surgery for hysterectomy is microinvasive with few complications. There are three major routes of hysterectomy that are currently used. The aim of this study was to identify the differences of peri-operative outcome among the patients who underwent the three different approaches.Methods One hundred and one women undergoing hysterectomy for myoma had the procedure performed by laparoscopic assisted vaginal hysterectomy （LAVH）, total vaginal hysterectomy （TVH） or total abdominal hysterectomy （TAH） in a randomized study. We compared the course of peri-operative and post-operative outcome for the three different approaches. Results were evaluated by linear regression analysis, Fisher＇s exact test and Student＇s t test for independent samples. Results The operation time among the three procedures was not significantly different （P 〉0.05）. The amount of blood loss in the TVH group was less than in the LAVH and TAH groups （P 〈0.05）. The pain score 3 hours after operation in the LAVH group was significantly lower than in the TAH and TVH groups （P 〈0.001）. The pain scores in the LAVH and TVH groups were lower than in the TAH group at 24 and 48 hours after operation （P 〈0.01）. The women who underwent LAVH and TVH had a shorter hospitalization stay （P 〈0.001）. The highest body temperature after operation in the TAH group was higher than that in LAVH and TVH groups （P 〈0.001）. Conclusions LAVH and TVH are better procedures for women requiring hysterectomy. The peri-operative and post-operative courses of TVH are better than LAVH, excluding the pain score 3 hours after operation. Vaginal hysterectomy is the most cost-effective approach but the final choice for the route of hysterectomy can depend on many factors such as gynecological disease, patients＇ health status and experiences of the gynecologist.

关键词： hysterectomy route outcome

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao fangqing Zhao jing-Dong J.Han Qi Liu Xiaohui fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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环境公共治理政策的效果评价与优化组合研究

统计研究 2017年第3期34卷 3-15页

作者：张同斌孙静范庆泉东北财经大学经济学院首都经济贸易大学财政税务学院

本文构建了包含环境治理体系的动态一般均衡模型,基于模型的研究发现,在经济增长方面生产者补贴较为有效;而技术研发补贴在技术进步中的作用十分显著,其通过"研发投入→绿色技术提升→降低污染物排放"的路径可以实现环境质量的改善。此... 详细信息

本文构建了包含环境治理体系的动态一般均衡模型,基于模型的研究发现,在经济增长方面生产者补贴较为有效;而技术研发补贴在技术进步中的作用十分显著,其通过"研发投入→绿色技术提升→降低污染物排放"的路径可以实现环境质量的改善。此外,本文还模拟了生产者补贴和技术研发补贴的政策组合对社会福利和污染排放的影响,结果显示,政府可以采用生产者价格补贴或技术研发补贴促进产出水平增长进而提高社会福利水平,同时增大生产者价格补贴和技术研发补贴的幅度则能够通过提高技术水平促使污染水平不断下降。最后,本文给出了社会福利增进与环境质量改善双重目标下生产补贴和技术研发补贴政策的可行性区域,进行了环境公共治理政策的优化组合研究。

关键词：环境规制政策环境质量社会福利动态一般均衡模型

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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现场演出扩声系统中的阻抗匹配

演艺科技 2018年第11期 15-19,23页

作者：孙璟璠冀翔中国传媒大学北京100024

以最基本的音频信号流为线索,探讨现场演出扩声系统中与阻抗匹配相关的问题,对扩声系统各级设备间的阻抗匹配问题进行分析和梳理。

关键词：阻抗匹配扩声系统现场演出

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多无人机协同规划研究综述

计算机工程与应用 2025年第01期61卷 42-58页

作者：宁聪范菁孙书魁云南民族大学电气信息工程学院云南民族大学云南省高校信息与通信安全灾备重点实验室云南民族大学云南省无人自主系统重点实验室

无人机在各行各业中发挥重要作用，多无人机之间的合作已成为研究热点。针对任务分配与路径规划两个核心问题，整理和分析了多无人机协同规划两个关键问题之间的复杂性，以及子问题间的信息耦合因素，并重点探讨了解耦策略；从数学模型... 详细信息

无人机在各行各业中发挥重要作用，多无人机之间的合作已成为研究热点。针对任务分配与路径规划两个核心问题，整理和分析了多无人机协同规划两个关键问题之间的复杂性，以及子问题间的信息耦合因素，并重点探讨了解耦策略；从数学模型方面对多无人机协同规划问题的通用模型进行描述，整理归纳出常见环境建模方法和多目标优化求解的约束条件；综述了基于集中式控制和分布式控制的任务规划方法，以及启发式算法在多无人机协同规划中的应用和研究进展，并重点介绍了多无人机协同规划问题面临实时性要求下的协同规划方法；结合典型研究，讨论了多无人机协同规划问题的未来研究方法与挑战，展望多无人机协同规划的发展。

关键词：无人机解耦策略智能算法任务分配路径规划

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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分光光度法测定蒙药橡子中的微量铁

光谱实验室 2009年第5期26卷 1267-1269页

作者：袁宏志张程马帅赵玉英孙景繁内蒙古通辽市产品质量计量检验所内蒙古民族大学分析测试中心

采用浓硝酸和高氯酸的混合消解法处理橡子样品,盐酸羟氨将三价铁还原成二价铁,在pH为5-6的条件下,用分光度法测定铁含量,校准曲线回归方程为y=0.0031002+0.2145x(r=0.9999)。用灰化法和微波消解法分别得橡子中铁含量为86.90μg/g和87.6... 详细信息

采用浓硝酸和高氯酸的混合消解法处理橡子样品,盐酸羟氨将三价铁还原成二价铁,在pH为5-6的条件下,用分光度法测定铁含量,校准曲线回归方程为y=0.0031002+0.2145x(r=0.9999)。用灰化法和微波消解法分别得橡子中铁含量为86.90μg/g和87.6μg/g。回收率为99.8%—102%,RSD为0.78%,该方法操作简单,重现性好,测量方法准确。

关键词：橡子分光光度法微量铁