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TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu Linqi Zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu Li Shen Xiaochun Zhang aijun sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 *** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

面向国家需求的应急技术与管理专业人才培养体系研究

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中国安全科学学报 2024年第5期34卷 9-16页

作者：王丽陈文涛关文玲孙爱军天津理工大学环境科学与安全工程学院天津300384 应急管理部信息研究院北京100029 天津至上安全技术咨询服务有限公司天津300461

为推动高校应急技术及管理专业建设、加强应急救援人才培养,基于国家应急需求明确专业定位,从职业道德素养、理论知识体系、实践技术能力等方面,提出应急技术与管理专业人才培养模式。首先,参考《应急救援技术专业教学标准》和《应急救... 详细信息

为推动高校应急技术及管理专业建设、加强应急救援人才培养,基于国家应急需求明确专业定位,从职业道德素养、理论知识体系、实践技术能力等方面,提出应急技术与管理专业人才培养模式。首先,参考《应急救援技术专业教学标准》和《应急救援员国家职业技能标准》中的职业道德要求,确定专业职业素养;其次,从应急管理预防、准备、响应、恢复(PPRR)模型出发,构建覆盖应急管理全周期的专业核心课程体系;然后,提出学训结合、政产研融合,共同推进应急技能培养和实践创新能力提升;最后,从教材建设、师资队伍、培养质量监控、人才考核体系、持续改进机制等方面,构建人才培养质量保障体系。结果表明:结合应急技术与管理专业的公共服务和社会责任属性、全周期工作内容和全灾种、多主体实际应用,构建人才培养体系,可以建立专业人才培养与实务工作需求之间的紧密联系,为培养德才兼备、理论与实践并重的应急领域高层次应用型人才提供借鉴。

关键词：应急技术与管理专业人才培养专业素养课程体系应急技能实践创新能力

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手性分子构象分析装置圆二色光谱仪的加强与改造

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分析测试技术与仪器 2024年第3期30卷 139-146页

作者：孙爱君张云马宣中国科学院南海海洋研究所广东广州510301

圆二色光谱仪是对手性分子进行构象分析和理化性质表征的重要仪器.然而长期高强度的使用会产生光谱仪光学元件劣化、检测器灵敏度降低等问题.通过优化分光系统的光学元件提升光传输效率,升级具有更高量子效率的大面积雪崩硅光电二极管... 详细信息

圆二色光谱仪是对手性分子进行构象分析和理化性质表征的重要仪器.然而长期高强度的使用会产生光谱仪光学元件劣化、检测器灵敏度降低等问题.通过优化分光系统的光学元件提升光传输效率,升级具有更高量子效率的大面积雪崩硅光电二极管检测器,进而大幅提高仪器信噪比,同时将测量波长范围从175~900 nm扩展到175~1150 nm.在氙灯被点燃之前用氮气彻底净化仪器,把氧气排除在光谱仪之外是非常重要的操作步骤.安装具有监视、计划、流量设置、报警和辅助控制等功能的活性氮监测系统,可以实时监测控制仪器内部氮气吹扫情况.通过升级改造,既加强了仪器的性能,又节省了氮气消耗成本,同时仪器使用寿命将进一步延长.

关键词：手性光学元件检测器氮气吹扫管理系统圆二色光谱仪

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巨噬细胞在间充质干细胞治疗骨关节炎中的作用

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海军军医大学学报 2024年第6期45卷 764-769页

作者：张文博陈祖祥刘镇孙爱军单乐天赵东宝海军军医大学(第二军医大学)第一附属医院风湿免疫科上海200433 浙江省骨伤研究所杭州311400 海军军医大学(第二军医大学)基础医学院人体解剖学教研室上海200433

间充质干细胞(MSC)治疗骨关节炎是目前研究前沿与热点。研究证明,巨噬细胞在MSC治疗骨关节炎中起重要作用,MSC促进巨噬细胞向选择性活化巨噬细胞(M2表型)极化是其治疗骨关节炎的重要机制,这一机制涉及MSC分泌的一些蛋白和miRNA调控。此... 详细信息

间充质干细胞(MSC)治疗骨关节炎是目前研究前沿与热点。研究证明,巨噬细胞在MSC治疗骨关节炎中起重要作用,MSC促进巨噬细胞向选择性活化巨噬细胞(M2表型)极化是其治疗骨关节炎的重要机制,这一机制涉及MSC分泌的一些蛋白和miRNA调控。此外,MSC旁分泌物质(如外泌体)治疗骨关节炎展现出与MSC相似的疗效和机制。本文对巨噬细胞在骨关节炎发生、发展中的作用,MSC对巨噬细胞的影响,以及巨噬细胞在MSC治疗骨关节炎中的作用与机制进行综述,为临床积极开展MSC治疗骨关节炎奠定理论基础。

关键词：巨噬细胞骨关节炎间充质干细胞微RNA 外泌体

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The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

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Genes & Diseases 2022年第4期9卷 959-972页

作者： Xiaokai Zhang Yang Zhang aijun sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032PR China Institute of Biomedical Sciences Fudan UniversityShanghai 200032PR China

Recently, cardiovascular diseases (CVDs) were identified as the leading cause of mortality, imposing a heavy burden on health care systems and the social economy. Nicotinamide adenine dinucleotide (NAD+), as a pivotal co-substrate for a range of different enzymes, is involved in many signal transduction pathways activated in CVDs. Emerging evidence has shown that NAD+ can exert remediating effects on CVDs by regulating metabolism, maintaining redox homeostasis and modulating the immune response. In fact, NAD+ might delay ageing through sirtuin and non-sirtuin pathways and thus contribute to interventions for age-related diseases such as CVDs. Considering that robust clinical studies of NAD+ are ongoing, we discuss current challenges and the future translational potential of NAD+ based on existing studies and our understanding. Despite some remaining gaps in its clinical application, NAD+ has been shown to have broad prospects and pan-effects, making it a suitable prophylactic drug for CVDs.

关键词： Ageing Cardiovascular disease Metabolism Nicotinamide adenine dinucleotide Sirtuin

末次冰消期以来黄河首曲流域气候变化与地表过程相互关系

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中国沙漠 2024年第2期44卷 121-132页

作者：葛健辉刘冰徐宇杰孙爱军汪克奇李冬雪赵晖中国科学院西北生态环境资源研究院中国科学院沙漠与沙漠化重点实验室甘肃兰州730000 中国科学院大学北京100049 兰州大学资源环境学院西部环境教育部重点实验室甘肃兰州730000

黄河首曲是世界高海拔地区生物多样性丰富和生态变化敏感的地区,其环境演变过程如何响应区域气候变化具有重要的科学意义。针对该区末次冰消期以来气候环境重建结果的分歧,以目前已发表的多载体记录为基础,独立集成区域气候变化的框架... 详细信息

黄河首曲是世界高海拔地区生物多样性丰富和生态变化敏感的地区,其环境演变过程如何响应区域气候变化具有重要的科学意义。针对该区末次冰消期以来气候环境重建结果的分歧,以目前已发表的多载体记录为基础,独立集成区域气候变化的框架性过程和地表环境演变历史,进而探讨两者的相互关系。结果表明:(1)该区在13~6 ka气温和湿度持续增加,10~6 ka为气候最优期,6 ka以后气温和湿度逐渐下降,气候变冷变干。(2)18~11 ka地表过程以河湖相过程为主,风沙活动非常弱;11~8 ka河湖沉积过程减弱,风沙活动增强;8~3 ka古土壤大规模发育;3 ka以来广泛发育草甸土。(3)区域地表环境变化过程与气候变化之间存在非同步变化,6 ka以前气候变化对区域地表过程呈正向驱动,6 ka以后对区域地表过程呈负向驱动。基于现代和晚全新世草甸土壤粒度的比较,发现草甸土壤的发育是气候变冷变干背景下风成物质不断加积的产物,进一步暗示区域土壤发育与气候变化间的复杂关系。

关键词：末次冰消期黄河首曲气候变化地表过程相互关系

Serum metabolomic profiling reveals potential biomarkers in assessing the management of women with polycystic ovary syndrome:a randomized controlled trial

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Chinese Medical Journal 2022年第1期135卷 79-85页

作者： Xuesong Ding Yan Deng Yanfang Wang Wei Xue Shiyang Zhu Xiao Ma Ruilin Ma aijun sun Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Background: As one of the most common endocrinal disorders for women at childbearing age, the diagnostic criteria of polycystic ovary syndrome (PCOS) have been defined differently among different international health organizations. Phenotypic heterogeneity of PCOS also brings about difficulties for its diagnosis and management assessment. Therefore, more efficient biomarkers representing the progression of PCOS are expected to be integrated into the monitoring of management process using metabolomic ***: In this prospective randomized controlled trial, 117 PCOS patients were enrolled from December 2016 to September 2017. Classical diagnostic parameters, blood glucose, and metabolome were measured in these patients before and at 2 months and 3 months of different medical interventions. The receiver operating characteristic (ROC) curves were built based on multivariate statistical analysis using data at baseline and 3 months’ management, and combinational biomarkers with appreciable sensitivity and specificity were selected, which then validated with data collected at 2 ***: A set of metabolites including glutamic acid, aspartic acid, 1-methylnicotinamide, acetylcarnitine, glycerophosphocholine, and oleamide were filtered out with high performance in representing the improvement through 3-month management of PCOS with high sensitivity and specificity in ROC analysis and validation with other two groups showed an appreciable area under the curve over ***: The six metabolites were representative of the remission of PCOS through medical intervention, making them a set of potential biomarkers for assessing the outcome of PCOS *** Registration: ***, NCT03264638.

关键词： Polycystic ovary syndrome Metabolomic approach Management evaluation Serum metabolomic

Interfacial growth of N,S-codoped mesoporous carbon onto biomass-derived carbon for superior potassium-ion storage

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Nano Research 2024年第4期17卷 2619-2627页

作者： Na Huang Cheng Tang Hao Jiang Jie sun aijun Du Haijiao Zhang Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneQLD 4001Australia Shanghai Engineering Research Center of Hierarchical Nanomaterials Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Carbonaceous materials have been recognized as one of the most promising anode materials for potassium-ion batteries(PIBs)due to their abundant raw materials,controllable structure,superior conductivity,and good chemical ***,the large radius of K ions and the low potassium content of intercalation compounds result in the sluggish storage kinetics and low reversible capacity of carbon *** this work,we present a unique heteroatom-doped carbon composite(denoted as NS-MC/SC)through a facile interfacial assembly route and simple heat-treatment process,where NS-MC is well grafted onto the biomass-derived spore carbon(SC).This unique structural design endows it with abundant mesoporous channels,expanded layer spacing,and highly doped N and *** these merits,the NS-MC/SC anode in PIBs exhibits a high reversible capacity of 350.4 mAh·g^(-1) at 100 mA·g^(-1) after 300 cycles,and an outstanding cycling ***,in-situ Raman spectra further verify the high reversibility of K ions insertion/***,theoretical simulations also reveal that the N,S dual-doping is an efficient approach for improving the potassium-ion storage performance of NS-MC/SC.

关键词： mesoporous carbon(MC) biomass-derived carbon(BC) N S co-doping interfacial assembly potassium-ion batteries(PIBs)

阿司匹林改善缺血性心脏病小鼠模型的心肌纤维化

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上海医学 2024年第3期47卷 145-149页

作者：史嘉然杨坤高日峰葛均波孙爱军上海心血管病研究所复旦大学附属中山医院心内科上海200032 宁波大学附属李惠利医院心内科

目的探讨阿司匹林对左前降支动脉结扎术诱导的缺血性心脏病小鼠心肌纤维化的作用。方法选用C57BL/6小鼠24只,均行左前降支结扎术。术后第4周,采用随机数表法将小鼠分为对照组和阿司匹林组,每组12只;阿司匹林组小鼠每日予20 mg/kg阿司匹... 详细信息

目的探讨阿司匹林对左前降支动脉结扎术诱导的缺血性心脏病小鼠心肌纤维化的作用。方法选用C57BL/6小鼠24只,均行左前降支结扎术。术后第4周,采用随机数表法将小鼠分为对照组和阿司匹林组,每组12只;阿司匹林组小鼠每日予20 mg/kg阿司匹林灌胃,对照组小鼠予等剂量0.9%氯化钠溶液灌胃,均干预4周。术后第4周(干预前)和第8周(干预后),经超声心动图检查记录心功能指标(左室射血分数、左室舒张末内径),采用Masson染色评估心肌纤维化程度(心肌瘢痕相对长度、心肌纤维化比例)。术后第8周,采用Western blot检测小鼠心肌组织中环氧合酶1(Cox-1)、α-平滑肌肌动蛋白(α-SMA)、α1-Ⅰ型胶原(Col1α1)蛋白质相对表达量。结果术后第4周,两组间小鼠的左室射血分数和左室舒张末内径的差异均无统计学意义(P值均>0.05);术后第8周,阿司匹林组小鼠左室射血分数显著高于对照组(P=0.0015),左室舒张末内径显著低于对照组(P=0.0001)。Masson染色结果显示,术后第4周,两组间小鼠心肌瘢痕长度和纤维化比例的差异均无统计学意义(P值均>0.05);术后第8周,阿司匹林组小鼠心肌瘢痕长度和纤维化比例均显著低于对照组(P值均<0.01)。术后第8周,阿司匹林组小鼠心肌组织中Cox-1、α-SMA、Col1α1的蛋白质表达量均显著低于对照组(P值均<0.05)。结论阿司匹林可改善缺血性心脏病小鼠模型的心功能障碍及心肌纤维化。

关键词：阿司匹林环氧化酶1 心肌纤维化缺血性心脏病