Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis
作者机构：Department of Breast SurgeryRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Thyroid and Breast Oncological SurgeryXuzhou Medical College Affiliated Huaian HospitalHuai'anJiangsu 223001China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第1期
页 面：358-366页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：sponsored and funded by the Shanghai Sailing Program(China)(No.22YF1424500 to Xiaonan Sheng) the Science and Technology Commission of Huaian Municipality,Jiangsu,China(No.HAB202209 to Aijun Sun)
主 题：Breast cancer Cancer treatment Ferroptosis Lipid metabolism Mitochondria Oxidative phosphorylation
摘 要：Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid *** core organelle involved in ferroptosis is ***-chondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology,biochemistry,gene expression,and energy *** increasing number of studies have shown that mitochondria and their associated metabolic pathways mediate ferroptosis in the development and progression of breast *** this review,we discuss the relevant research about ferroptosis in breast cancer and provide a comprehensive summary of mitochondrial regulation in ferroptosis from the perspective of lipid metabolism,oxidative phosphorylation,ion metabolism,glycometabolism,and nucleotide *** also summarize the appli-cation of mitochondrial metabolism-related pathways as ferroptosis treatment *** we provide new insights into the relationship between mitochondria,ferroptosis,and breast cancertreatment.
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