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SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep k.Dabla Dharmsheel Shrivastav Swapan Gupta Manisha Yadav subhash Yadav Bidhan Chandra k.ner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACk.ROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytok.ne response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleuk.n(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk.of drug resistance *** biomark.rs IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be link.d to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory mark.rs response in drug resistance *** SCN1A genotypes AA and AT are link.d to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytok.nes Genetic factors

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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh k.Mittal Nirak.r Sahoo Tripti Saini Francesco Giorgianni Mohammad Sik.nder Andrew E.Massey Bilal B.Hafeez Manish k.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema k.an subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remark.ble properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-lik. phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively block.d oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini subhash k.nase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed k.ang-Soon Ahn Jun-Seok.Ha Uk.Sim Hyeyoung Shin Soon Hyung k.ng Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a k.y point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M k.CO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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Alignment Techniques in Total k.ee Arthroplasty:Where do We Stand Today?

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Chinese Medical Sciences Journal 2024年第3期39卷 224-233页

作者： Hemanta Dhungana subhash Jangid Meghal Goyal Department of Orthopedics Fortis HospitalGurgaonHaryanaIndia

Achieving optimal alignment in total k.ee arthroplasty(Tk.)is a critical factor in ensuring optimal outcomes and long-term implant ***,mechanical alignment has been favored to achieve neutral post-operative joint ***,contemporary approaches,such as k.nematic alignments and hybrid techniques including adjusted mechanical,restricted k.nematic,inverse k.nematic,and functional alignments,are gaining attention for their ability to restore native joint k.nematics and anatomical alignment,potentially leading to enhanced functional outcomes and greater patient *** ongoing debate on optimal alignment strategies considers the following factors:long-term implant durability,functional improvement,and resolution of individual anatomical ***,advancements of computer-navigated and robotic-assisted surgery has augmented the precision in implant positioning and objective measurements of soft tissue *** ongoing debates on balancing implant longevity and functional outcomes,there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical *** review evaluates the spectrum of various alignment techniques in Tk.,including mechanical alignment,patient-specific k.nematic approaches,and emerging hybrid *** technique is scrutinized based on its fundamental principles,procedural techniques,inherent advantages,and potential limitations,while identifying significant clinical gaps that underscore the need for further investigation.

关键词： total k.ee arthroplasty hybrid alignment functional alignment k.nematic alignment alignment axes anatomical alignment mechanical alignment

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冷弯带肋薄壁不锈钢管再生混凝土短柱轴压力学性能研究

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工程力学 2024年

作者：潘爽廖飞宇张伟杰 Pantha subhash 福建农林大学交通与土木工程学院福建农林大学数字福建智能交通技术物联网实验室

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承... 详细信息

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承载力和延性的影响规律。采用ABAQUS建立了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压性能的有限元分析模型，计算结果与试验结果吻合良好，利用有限元模型，进行了典型构件的荷载-应变曲线、荷载分配比例、不锈钢管和核心再生混凝土的纵向应力分布及其相互作用的分析。通过参数分析，研究了不锈钢屈服强度、核心再生混凝土强度、加劲肋宽度、再生骨料替代率和钢管宽厚比等参数对构件轴压受力性能的影响。最后，提出了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压承载力的简化计算公式，可为实际工程设计提供参考。

关键词：冷弯薄壁不锈钢再生骨料混凝土轴压试验有限元分析简化计算公式

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Enhancement of Urinary Elimination of 3-Bromobenzanthrone Metabolites by Oral Supplementation of Ascorbic Acid in Guinea Pigs

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Biomedical and Environmental Sciences 2004年第4期17卷 390-396页

作者： RAVINDRA P. SINGH RAJ k.anna subhash k. k.anna MUk.L DAS Department of Biochemistry Lucknow University Lucknow-226001Department of Biochemistry Lucknow University Lucknow-226001Food Toxicology Laboratory Industrial Toxicology Research Centre Postal Box No. 80 M. G. Marg Lucknow-226 001 IndiaFood Toxicology Laboratory Industrial Toxicology Research Centre Postal Box No. 80 M. G. Marg Lucknow-226 001 India

Objective 3-Bromobenzanthrone (3-BBA), an anthraquinone intermediate dye, is extensively used in textile industry. Since, our prior studies have shown that 3-BBA caused significant depletion of ascorbic acid (AsA) levels, the effect of exogenous supplementation of AsA on the urinary elimination of 3-BBA metabolites was investigated. Method Guinea pigs were treated with single oral dose of 3-BBA (50 mg/k. b. wt.) in groundnut oil while another group was treated with single oral dose of 3-BBA (50 mg/k. b. wt.) along with 3 day prior and post oral supplementation of AsA. Control groups were either treated with groundnut oil or AsA alone. Urine from individual animals was collected, extracted and analysed on HPTLC. Results The highest elimination of 3-BBA (75 mg) was found to be in 0-24 h urine fraction which decreased to 18 mg and 5 mg in the two subsequent 24 hourly fractions of urine. Exogenous supplementation of AsA increased the total urinary elimination of 3-BBA by almost 77%. A total of 10 fluorescent metabolites excluding the parent compound were eliminated in the urine of guinea pigs treated with 3-BBA. Densitometric scanning of chromatogram showed different peak. at Rf 0.18, 0.22, 0.27, 0.34, 0.40, 0.48, 0.56, 0.66, 0.72, 0.80, and 0.95 which were eliminated and mark.d as urinary metabolite 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 respectively. AsA not only significantly enhanced the elimination of 3-BBA metabolites but also modified the pattern of metabolites drastically in 0-6 h, 6-24 h and 24-48 h urine fractions. Conclusion These results indicate that AsA may be useful in protecting the toxicity of 3-BBA by fascilitating the urinary metabolite(s) excretion of 3-BBA.

关键词： Ascorbic acid 3-Bromobenzanthrone Metabolites High performance thin layer chromatography

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以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性

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电化学（中英文） 2024年第1期30卷 46-54页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江宁波315201 浙江启明电力集团有限公司浙江舟山316099 浙江大学舟山海洋研究中心浙江舟山316021 丹麦技术大学能源转换与储存系川麦哥本哈根

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·k.^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·k.^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2)和0.249Ω·cm^(2),但电堆中两个电池的电压反而分别增加了3.38 m V·k.^(-1)和3.78 m V·k.^(-1)。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr CrO_(4)物质,两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明,以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

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Crop productivity,soil health,and energy dynamics of Indian Himalayan intensified organic maize-based systems

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International Soil and Water Conservation Research 2021年第2期9卷 260-270页

作者： Raghavendra Singh subhash Babu R.k.Avasthe Gulab Singh Yadav Anup Das k.P.Mohapatra Amit k.mar Vinod k.Singh Puran Chandra ICAR-National Organic Farming Research Institute GangtokSikkim737102India Division of Agronomy ICAR-Indian Agricultural Research InstituteNew Delhi110012India ICAR Research Complex for NEH Region Tripura CentreLembucherraTripura799210India ICAR-National Bureau of Plant Genetic Resources New Delhi110012India

The sustainability of prevailing maize-fallow system in rainfed ecosystems of the Eastern Himalayan region(EHR)of India is often questioned due to poor economic return and negative impact on soil ***,the six cropping systems,maize-fallow(M-F),maize t cowpea-rapeseed(M t C-Rs),maize t cowpea-buck.heat(M t C-Bw),maize t cowpea-barley(M t CeB),maize t cowpea-garden pea(M t C-GP)and maize t cowpeaerajmash(M t C-R)in the main plot and three soil moisture conservation measures,no-mulch(NM),maize stover mulch(MSM)and maize stover t weed biomass mulch(MSM t WBM)in sub-plot were evaluated for four consecutive years(2014-18)at a Research Farm in fixed plot *** indicated that cowpea co-culture with maize and inclusion of winter crop increased maize yield by 6.2e23.5%over *** the systems,the M t C-GP recorded the highest crop *** residual effect of MSM t WBM increased maize grain yield by 19.1%over *** of maize t cowpea-winter crops significantly improved the available N(3.2e12.9%),P(3.6 e12.7%),k.1.9e26.3%),organic carbon(9.2e16.8%),microbial biomass carbon-MBC(15.2e43.9%)and dehydrogenases-DHA(17.2e42.3%)in soil at 0e15 cm depth as compared to *** M t C-GP also recorded maximum net return(US$2460 ha1),benefit:cost(B:C)ratio(2.86)and energy use efficiency(7.9%).The MSM t WBM recorded higher net return(US$1680 ha1)and B:C ratio(2.46)over ***,cowpea t maize-garden pea(M t C-GP)along with the application of MSM t WBM is a sustainable production practice to intensify the organically managed maize-fallow system in rainfed regions of the EHR of India and other similar ecosystems.

关键词： Crop intensification Energy productivity Gross return Soil health Water productivity

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以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性（英文）

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电化学(中英文) 2024年第1期 49-57页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江启明电力集团有限公司浙江大学舟山海洋研究中心丹麦技术大学能源转换与储存系

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%k.–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.24... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%k.–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.249Ω·cm2，但电堆中两个电池的电压反而分别增加了3.38 m V·k.–1和3.78 m V·k.–1。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr Cr O4物质，两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明，以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

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Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease

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World Journal of Gastroenterology 2006年第37期12卷 6017-6020页

作者： Vik.s G Pai Nitin V Pai Hemant P Thack.r Jaisingh k.Shinde Vijay P Mandora subhash S Erram Pai Clinic Pune India Thack.r’s Clinic Sukh Sagar 4th Floor NS Patkar Marg Mumbai India Surya Hospital Pune India Inlak. & Budhrani Hospital Pune India Sharada Clinic Karad India

AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P k.reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk.reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of ***: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equa

关键词： Gastro-esophageal reflux disease Pantoprazole Efficacy Tolerability

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