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Genitourinary melanoma:An overview for the clinician

Asian Journal of Urology 2022年第4期9卷 407-422页

作者： Danielle K.DePalo Kelly M.Elleson Michael J.carr Philippe E.Spiess Jonathan S.Zager Department of Cutaneous Oncology Moffitt Cancer CenterTampaFLUSA Department of Surgery University of LouisvilleLouisvilleKYUSA Department of Genitourinary Oncology Moffitt Cancer CenterTampaFLUSA

Genitourinary (GU) melanoma is a rare presentation of melanoma accounting for approximately 0.5% of all *** melanomas include primary melanomas of the vulva,vagina,uterine cervix,ovary,penis,scrotum,urethra,bladder,ureter,and *** melanomas are often diagnosed in advanced stages and stigma is thought to contribute to delays in *** the likely diagnosing provider,it is imperative that dermatologists,urologists,and gynecologists are aware of these uncommon sites of *** there have been major advances in the treatment of melanomas as a whole in the last 10 years,their applications to GU melanomas have often been *** melanomas have not been included in many of the major phase II clinical trials which brought contemporary advanced treatments to market and the prognoses for GU melanomas remain *** to the rarity of GU melanomas,much of the literature provides gener alized recommendations across multiple different organs affected by GU melanomas or omits certain topics,making it difficult to appreciate the funda-mentals of the individual *** review aimed to provide background information on the pathogenesis and epidemiology of the different sites of GU melanomas and categorize data specific to the presentation,staging,treatment,and prognosis of each type of GU melanoma to guide the *** was also meant to encourage a multidisciplinary approach to the management of these patients as it spans the expertise of surgical oncologists,medical oncologists,radiation oncologist,dermatologists,urologists,and gynecologists.

关键词： Genitalia Female Male Melanoma Rare diseases Staging Treatment Urinary tract

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Physical and chemical changes of rapeseed meal proteins during toasting and their effects on in vitro digestibility

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Journal of Animal Science and Biotechnology 2017年第2期8卷 417-427页

作者： Sergio Salazar-Villanea Erik M.A.M.Bruininx Harry Gruppen Wouter H.Hendriks Patrick carré Alain Quinsac Antonius F.B.van der Poel Wageningen Livestock Research P.O.Box 3386700 AH WageningenThe Netherlands Animal Nutrition Group Wageningen University&ResearchP.O.Box 3386700 AH WageningenThe Netherlands Agfifirm Innovation Center Royal Dutch Agrifirm GroupP.O.Box 200187302 HA ApeldoornThe Netherlands Laboratory of Food Chemistry Wageningen University&ResearchP.O.Box 176700 AA WageningenThe Netherlands CREOL/OLEAD 11 rue MongeParc Industriel33600 PessacFrance Terres Inovia 11 rue MongeParc Industriel33600 PessacFrance

Background： Toasting during the production of rapeseed meal（RSM） decreases ileal crude protein（CP） and amino acid（AA） digestibility. The mechanisms that determine the decrease in digestibility have not been fully elucidated. A high protein quality, low-denatured, RSM was produced and toasted up to 120 min, with samples taken every 20 min. The aim of this study was to characterize secondary structure and chemical changes of proteins and glucosinolates occurring during toasting of RSM and the effects on its in vitro CP ***： The decrease in protein solubility and the increase of intermolecular β-sheets with increasing toasting time were indications of protein aggregation. The contents of NDF and ADIN increased with increasing toasting *** of arginine, lysine and O-methylisourea reactive lysine（OMIU-RL） linearly decreased with increasing toasting time, with a larger decrease of OMIU-RL than lysine. First-order reactions calculated from the measured parameters show that glucosinolates were degraded faster than lysine, OMIU-RL and arginine and that physical changes to proteins seem to occur before chemical changes during toasting. Despite the drastic physical and chemical changes noticed on the proteins, the coefficient of in vitro CP digestibility ranged from 0.776 to 0.750 and there were no effects on the extent of protein hydrolysis after 120 min. In contrast, the rate of protein hydrolysis linearly decreased with increasing toasting time, which was largely correlated to the decrease in protein solubility, lysine and OMIU-RL observed. Rate of protein hydrolysis was more than 2-fold higher for the untoasted RSM compared to the 120 min toasted ***： Increasing the toasting time for the production of RSM causes physical and chemical changes to the proteins that decrease the rate of protein hydrolysis. The observed decrease in the rate of protein hydrolysis could impact protein digestion and utilization.

关键词： Hydrolysis rate In vitro protein digestibility Rapeseed meal Reactive lysine Secondary structure

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Comparing outcomes from the two most recognized acupuncturist workforce surveys

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Journal of Integrative Medicine 2017年第1期15卷 37-43页

作者： Steven H. Stumpf Kory Ward-Cook Clifford R. carr Health Administration Program California State University at NorthridgeNorthridgeCalifornia 91330USA National Certification Commission of Acupuncture and Oriental Medicine JacksonvilleFlorida 32202USA Clifford R.carr 1743 PenmarAvenue#3VeniceCalifornia 90291USA

OBJECTIVE： To determine the informational consistency produced by the two most recent independent surveys and draw a conclusion whether the data would be sufficient for the National Center for Health Workforce Analysis and Bureau of Labor and Statistics consideration. METHODS： This paper compares workforce outcomes collected by the two most prominent acupuncture entities that have produced the most useful acupuncturist workforce data （California Acupuncture Board 2015 Occupational Analysis and the National Certification Commission of Acupuncture and Oriental Medicine^2013 Job Analysis） at national and state levels. RESULTS： Findings based upon the most compatible survey questions showed the following： more than 70% of acupuncturists work fewer than 40 hours weekly; approximately 76% work in solo practice or in shared space with other acupuncturists; more than 70% of the national sample have been in practice 15 years or less; and median income is between $40 000 and $50 000. A preponderance of acupuncturists is less than 50 years of age, and fewer than 15% of all respondents have been in practice more than 20 years. CONCLUSION： Basic workforce information is a necessary precursor for conducting workforce projections. It is useful to track the expansion or contraction of any given profession. Tracking influences subsequent planning for the profession based upon reliable and valid information about its growth. The ability of the profession to collect its own workforce data is paramount to workforce projection models. Any future survey should be a shared project that follows guidelines supported by the National Center for Health Workforce Analysis.

关键词： acupuncture workforce survey outcome assessment (health care) income

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Differential Relationships among Facets of Alexithymia and BDNF- and Dopamine-Related Polymorphisms

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Neuroscience & Medicine 2012年第1期3卷 7-13页

作者： Nancy S. Koven Leah H. carr Program in Neuroscience Bates College Lewiston Maine USA

Alexithymia refers to a cluster of emotion-related deficits such as difficulty attending to and identifying one’s feelings. Although not a diagnosable psychiatric condition, alexithymia is considered a personality risk factor for multiple pathologies, including somatoform, substance use, eating, and mood disorders. Evidence suggests heritability, but few studies have examined the influence of specific genes on alexithymic traits. Candidate genes explored thus far include those involved in modulation of brain-derived neurotrophic factor (BDNF) and dopamine, two neurotransmitters whose functions have been implicated in human emotion processing. This study investigated the relationship between the C270T polymorphism of the BDNF gene, facets of alexithymia, and possible interactions with the COMT, DAT1, and ANKK1 genes in a sample of 130 healthy adults. Given the multidimensionality of the alexithymia construct and its overlap with the related constructs of emotional intelligence and mood awareness, we used principal components analysis to derive Clarity of Emotion and Attention to Emotion as specific facets of alexithymia. Results showed that the C270T C/C genotype group had lower Clarity of Emotion scores relative to the C/T genotype group, even after covarying for COMT, DAT1, and ANKK1 genotypes. Dopamine-related genes had no association with alexithymia dimensions, nor did they interact with the C270T polymorphism to predict Clarity of Emotion. Although the molecular mechanisms by which this polymorphism influences BDNF are unknown, this study suggests a role for BDNF in modulating aspects of alexithymia. We discuss these results in the context of BDNF’s trophic effects in the nervous system.

关键词： Brain-Derived Neurotrophic Factor Alexithymia Dopamine Polymorphism

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地震学小史

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地球物理学进展 1991年第2期6卷 130-134页

作者： Duncan carr Agnew 谢小碧

虽然对地震产生的原因和影响进行学究式的研究可以追溯到中世纪之前(Needham,1959;Adams,1938),但迟至19世纪末地震学才逐渐成为一门独立的科学,许多进行了深入研究的分枝则起步更晚,有些甚至是20世纪60年代才开始的。本文回顾了地震学... 详细信息

虽然对地震产生的原因和影响进行学究式的研究可以追溯到中世纪之前(Needham,1959;Adams,1938),但迟至19世纪末地震学才逐渐成为一门独立的科学,许多进行了深入研究的分枝则起步更晚,有些甚至是20世纪60年代才开始的。本文回顾了地震学中不同分枝的发展,同时试图阐明它们是如何以及为什么发展成今天这样的。我们不准备讨论地震学中的所有重要结果,也不想考证谁对特定的概念做了最初的陈述;对此Stoneley(1967)已进行过类似的考察。

关键词：地震学家地震大小地震图仪器记录地球结构地震仪器等震线图小史弹性回跳理论地方震

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Convective high-speed flow and field-aligned high-speed flows explored by TC-1

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Chinese Science Bulletin 2008年第15期53卷 2371-2375页

作者： ZHANG LingQian LIU ZhenXing MA ZhiWei W. BAUMJOHANN M.W. DUNLOP WANG GuangJun WANG Xiao H. REME C. carr Centre for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Institute for Fusion Theory and Simulation Zhejiang University Hangzhou 310027 China Space Research Institute Austrian Academy of Sciences 68042 Graz Austria Space Sciences Division Rutherford Appleton Laboratory Chilton Didcot Oxfordshire OX11 0QX United Kingdom Centre d'Etude Spatiale des Rayonnements F-78140 Toulouse Codex France Imperial College London SW7 2BZ United Kingdom

From June 1, 2004 to October 31, 2006, a total 465 high-speed flow events are observed by the TC-1 satellite in the near-Earth region (?13 RE < x < ?9 RE, |Y |<10 RE, |Z|<5 RE). Based on the angle between the flow and the magnetic field, the high-speed flow events are further divided into two types, that is, field-aligned high-speed flow (FAHF) in the plasma sheet boundary and convective bursty bulk flow (BBF) in the center plasma sheet. Among the total 465 high-speed flow events, there are 371 FAHFs, and 94 BBFs. The CHF are mainly concentrated in the plasma sheet, the intersection angle between the flow and the magnetic field is larger, the magnetic field intensity is relatively weak. The FHF are mainly distributed near the boundary layer of the plasma sheet, the intersection angle between the flow and magnetic field is smaller, and the magnetic field intensity is relatively strong. The convective BBFs have an important effect on the substorm.

关键词：高速流对流磁场地球科学

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The management of telecommunications :business solutions to business problems enabled by voice and data communications 2nd ed. 2nd ed.

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2003年

作者： Houston H. carr Charles A. Snyder

来源：畅想之星图书光盘版（南... 评论

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中山文库和平之条件

中山文库和平之条件

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1944年

作者： Edward Hallett carr 王之珍译

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A Precoding Real-Time Buffer Based Self-Healing Solution for 5G Networks

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Journal of Computer and Communications 2021年第6期9卷 1-23页

作者： Tamer Omar Thomas Ketseoglou Omar Naffaa Asatur Marzvanyan Connor carr Department of Electrical and Computer Engineering California State Polytechnic University Pomona USA

In order to meet key requirements imposed by transitioning to a 5G network, new network management techniques must be employed in order to increase network reliability and efficiency. Most notably, it is important that a Self-Organizing Network (SON) is able to recover autonomously from network failure or congestion through Self-Healing procedures (i.e. autonomous detection, diagnosis, and correction). This paper aims to develop a self-healing algorithm that can effectively “heal” a 5G network by testing a proposed self-healing algorithm within a network simulator that adheres to current 5G standards. The simulator developed in this paper aims to model a network of small cells that can inherit one of multiple states (healthy, congested, and failing) to validate the effectiveness of a programmed self-healing algorithm in recovering a simulated network. Results show that the application of a self-healing in a network is able to resolve issues related to Quality of Service (QoS) and reduced network data rates in portions of a network that are in a partially congested or failing state.

关键词： Self-Healing MIMO-Beamforming Millimeter Wavelength Base Station Latency

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各阶导数都只有整根的多项式

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数学译林 1991年第4期10卷 351-352页

作者： carr.,CE 陈培德

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