检索结果-南通市图书馆

Hydroxychloroquine in SARS-CoV-2 infection:Understanding the misadventure

在线全文

学校读者我要写书评

暂无评论

Journal of Acute Disease 2024年第2期13卷 45-52页

作者： david Banji Otilia J f Banji Department of Pharmacology&Toxicology College of PharmacyJazan UniversitySaudi Arabia Department of Clinical Pharmacy College of PharmacyJazan UniversitySaudi Arabia

The widespread outbreak of SARS-CoV-2 was declared a public health emergency by the World Health Organization and various governments *** prompted the implementation of stringent infection control measures to curb the spread of the *** this,the medical community faced the challenge of treating the virus without specific therapies or a vaccine,leading to reliance on empirical treatment *** this context,hydroxychloroquine,an antimalarial and antirheumatic drug,gained attention as a potential treatment *** its theoretical benefits,such as inhibiting viral entry,reducing inflammation,and modulating immune responses,empirical studies yielded inconsistent *** indicated a potential for symptom relief,while others showed no significant improvement in patient *** initial enthusiasm waned as the lack of substantial evidence led to revoking its Emergency Use Authorization,and several clinical trials were prematurely *** review in question critically examines the factors contributing to the ineffectiveness of hydroxychloroquine in treating SARS-CoV-2 infection,highlighting the complexities of drug repurposing during a rapidly evolving pandemic.

关键词： SARS-CoV-2 Hydroxychloroquine Pharmacogenomics TLR signaling Cardiotoxicity

Association between baseline levels of muscular strength and risk of stroke in later life:The Cooper Center Longitudinal Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第5期13卷 642-649页

作者： Stephen W.farrell david Leonard Qing Li Carolyn E.Barlow Kerem Shuval Jarett D.Berry Andjelka Pavlovic Laura f.Defina Research Division The Cooper InstituteDallasTX 75230USA Department of Internal Medicine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular strength is an important component of physical *** evaluated the relationship between baseline muscular strength and risk of stroke among adults who were aged≥65 years during ***:We included 7627 healthy adults(mean age=43.9 years,86.0%male)underwent a baseline physical examination between 1980 and *** strength was determined by 1-repetition maximum measures for bench press and leg press and categorized into age-and sex-specific tertiles for each *** fitness(CRf)was assessed via a maximal treadmill exercise *** enrolled in fee-for-service Medicare from 1999 to 2019 were included in the *** between baseline strength and stroke outcomes were estimated using a modified Cox proportional hazards *** a secondary analysis,we examined stroke risk by categories of CRf where Quintile 1=low,Quintiles 2-3=moderate,and Quintiles 4-5=high CRf based on age and ***:After 70,072 person-years of Medicare follow-up,there were 1211 earliest indications of incident *** multivariable analyses,the hazard ratio(95%confidence interval(95%CI))for stroke across bench press categories were 1.0(referent),0.96(0.83-1.11),and 0.89(0.77-1.04),respectively(p trend=0.14).The trend across categories of leg press was also non-significant(p trend=0.79).Adjusted hazard ratio(95%CI)for stroke across ordered CRf categories were 1.0(referent),0.90(0.71-1.13),and 0.72(0.57-0.92)(p trendfor muscular strengthening activities is likely to improve muscular strength as well as many health outcomes in older adults,performing such activities may not be helpful in preventing ***,meeting guidelines for aerobic activity is likely to improve CRf and lower stroke risk.

关键词： Cardiorespiratory fitness Medicare Muscular strength Stroke

Role of climatic variability in shaping intraspecific variation of thermal tolerance in Mediterranean water beetles

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 285-298页

作者： Susana Pallarés david Garoffolo Belén Rodríguez david Sánchez-fernández Department of Zoology University of SevilleSevilleSpain faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothesis(CVH)predicts that organisms in more thermally variable environments have wider thermal breadths and higher thermal plasticity than those from more stable ***,due to evolutionary trade-offs,taxa with greater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).The CVH assumes that climatic variability is the ultimate driver of thermal tolerance variation across latitudinal and altitudinal gradients,but average temperature also varies along such *** explored intraspecific variation of thermal tolerance in three typical Mediterranean saline water beetles(families Hydrophilidae and Dytiscidae).for each species,we compared two populations where the species coexist,with similar annual mean temperature but contrasting thermal variability(continental *** population).We estimated thermal limits of adults from each population,previously acclimated at 17,20,or 25℃.We found species-specific patterns but overall,our results agree with the CVH regarding thermal ranges,which were wider in the continental(more variable)*** the two hydrophilid species,this came at the cost of losing plasticity of the upper thermal limit in this population,supporting the trade-off hypothesis,but not in the dytiscid *** results support the role of local adaptation to thermal variability and trade-offs between basal tolerance and physiological plasticity in shaping thermal tolerance in aquatic ectotherms,but also suggest that intraspecific variation of thermal tolerance does not fit a general pattern among aquatic *** such intraspecific variation could lead to inaccurate predictions of the vulnerability of aquatic insects to global warming.

关键词： acclimation capacity aquatic insects climate change heat coma temperature supercooling point thermal plasticity

Degradation Rate Assessment of Biodegradable Magnesium Alloys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Sciences and Applications 2024年第8期15卷 245-252页

作者： Bianmei Cao Limei Cao david f. Kallmes Department of Radiology Mayo Clinic Rochester MN USA National Institutes for food and Drug Control Beijing China

Biodegradable magnesium alloys have been widely used in medical implants. But safety concerns were put forward for the high degradation rate of biodegradable magnesium alloy. The optimal biodegradable magnesium alloys that give rise to the desired degradation rate hasn’t yet to be defined. Assessing the degradation rate of biodegradable magnesium alloys involves in vitro testing, in vivo testing, numerical modeling, understanding the factors influencing their degradation in physiological environments, biocompatibility testing, and clinical studies. It is important to standardize analytical tools aimed at assessing the degradation rate of biodegradable magnesium alloys. It is advisable to identify the threshold for safe degradation rate of biodegradable magnesium alloys in biomedical applications.

关键词： Magnesium Alloys Biomedical Application Biodegradation Degradation Rate Biocompatibility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

from the editors

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 I0002-I0002页

作者： Qi Xiaozhai George C.Lee Billie f.spencer IEM UB UIUC

Dear Members of the Editorial Board, Contributors and friends of the journal,This issue of Earthquake Engineering and Engineering Vibration(Vol. 23, No. 2) includes five papers in a special section entitled “Wave-Based Nondestructive Testing and Evaluation Methods in Civil Engineering”. The special section aims to present recent developments and applications of wave-based nondestructive testing and evaluation research. We thank the guest editors, Prof. Nenad Gucunski of Rutgers University, USA, Prof. Lin Shibin of Jianghan University, China and Prof. Chen Hongbing, University of Science and Technology Beijing, China, for their hard work and dedication.

关键词： Earthquake journal section

Progressive meristem and single-cell transcriptomes reveal the regulatory mechanisms underlying maize inflorescence development and sex differentiation

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2024年第7期17卷 1019-1037页

作者： Yonghao Sun Liang Dong Lu Kang Wanshun Zhong david Jackson fang Yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA School of Agriculture Sun Yat-Sen UniversityShenzhen 518107China

Maize develops separate ear and tassel inflorescences with initially similar morphology but ultimately different architecture and *** detailed regulatory mechanisms underlying these changes still remain largely *** this study,through analyzing the time-course meristem transcriptomes and floret single-cell transcriptomes of ear and tassel,we revealed the regulatory dynamics and pathways underlying inflorescence development and sex *** identified 16 diverse gene clusters with differential spatiotemporal expression patterns and revealed biased regulation of redox,programmed cell death,and hormone signals during meristem differentiation between ear and ***,based on their dynamic expression patterns,we revealed the roles of two RNA-binding proteins in regulating inflorescence meristem activity and axillary meristem ***,using the transcriptional profiles of 53910 single cells,we uncovered the cellular heterogeneity between ear and tassel *** found that multiple signals associatedwith either enhancedcell death or reduced growth are responsiblefortassel pistil suppression,while part of the gibberellic acid signal may act non-cell-autonomously to regulate ear stamen arrest during sex *** further showed that the pistil-protection gene SILKLESS 1(SK1)functions antagonistically to the known pistil-suppression genes through regulating common molecular pathways,and constructed a regulatory network for pistil-fate ***,our study provides a deep understanding of the regulatory mechanisms underlying inflorescence development and sex differentiation in maize,laying the foundation for identifying new regulators and pathways for maize hybrid breeding and improvement.

关键词： maize inflorescence floral organ sex differentiation single-cell RNA sequencing RNA-binding protein

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth V.fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt david Gopurenko Matt N.Krosch francesca Strutt Karen f.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic ***

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第2期15卷 749-764页

作者： Kwangwook Kim Cynthia Jinno Xunde Li david Bravo Eric Cox Peng Ji Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Department of Animal Science Michigan State UniversityEast LansingMI 48824USA Cedars-Sinai Medical Center Los AngelesCA 90084USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma|ADM 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Department of Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic ***(ETEC)f18 in a manner similar to *** objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC *** Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and *** relative abundance of metabolic markers of immune responses and nutrient metabolisms,such as amino acids and carbohydrates,were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups(qfold change>2.0).In addition,pigs in antibiotic had a reduced(Pf Lachnospiraceae and Lactobacillaceae,whereas had greater(Pf oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood,and further exploration is ***,current research suggest that various mechanisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.

关键词： Carbadox Colon microbiota Enterotoxigenic E.coli f18 Metabolomics Oligosaccharide-based polymer Weaned pigs

Damper placement for seismic control of super-long-span suspension bridges based on the first-order optimization method

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2010年第7期53卷 2008-2014页

作者： Billie f spencer Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign

To ensure the anti-earthquake performances of super-long-span suspension bridges, effective devices should be employed to control the seismic response of key sections. In this paper, four kinds of assessment functions for seismic response control effect are formulated based on the mechanism of seismic response control with dampers and the seismic response characteristics of long-span suspension bridges. A new optimal placement method of dampers using penalty function and first-order optimization theory is then proposed. Runyang suspension bridge (RSB) with a main span of 1490 m is then taken as an example. After seismic response time-history analyses on RSB using different placements of dampers, the analysis results are optimized by employing the optimal placement method and the optimal placements of dampers with the four assessment functions are then achieved respectively. Comparison of the four optimal control effects show that different assessment functions can lead to different optimal placements when the number of dampers is certain, but all placements of dampers can reduce the seismic response of RSB significantly. The selection of assessment functions and damper optimal placement should be determined by the structural characteristics and by what is considered in the structures. Results also show that the first-order optimization is an effective method on determining the optimal placement of dampers.

关键词： suspension bridge seismic control damper placement control effect assessment first-order optimization method