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Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury?

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World Journal of Stem Cells 2023年第7期15卷 654-664页

作者： Long-Fei Pan Ze-qun Niu song Ren Hong-Hong Pei Yan-Xia Gao Hui Feng Jiang-Li sun Zheng-Liang Zhang Emergency Department The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Geriatric Digestive Surgery The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

Acute pancreatitis(AP)often leads to a high incidence of cardiac injury,posing significant challenges in the treatment of severe AP and contributing to increased mortality *** stem cells(MSCs)release bioactive molecules that participate in various inflammatory ***,extracellular vesicles(EVs)secreted by MSCs have garnered extensive attention due to their comparable anti-inflammatory effects to MSCs and their potential to avoid risks associated with cell ***,the therapeutic potential of MSCs-EVs in various inflammatory diseases,including sepsis and AP,has gained increasing *** preclinical research on the utilization of MSCs-EVs in AP-induced cardiac injury is limited,several studies have demonstrated the positive effects of MSCs-EVs in regulating inflammation and immunity in sepsis-induced cardiac injury and cardiovascular ***,clinical studies have been conducted on the therapeutic application of MSCs-EVs for some other diseases,wherein the contents of these EVs could be deliberately modified through prior modulation of ***,we hypothesize that MSCs-EVs hold promise as a potential therapy for AP-induced cardiac *** paper aims to discuss this ***,additional research is essential to comprehensively elucidate the underlying mechanisms of MSCs-EVs in treating AP-induced cardiac injury,as well as to ascertain their safety and efficacy.

关键词： Acute pancreatitis Cardiac injury Mesenchymal stem cells Extracellular vesicles Inflammation Therapeutic strategies

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Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity

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Chinese Journal of Natural Medicines 2021年第7期19卷 528-535页

作者： YAN Chen LONG qun ZHANG Yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei song Jing-Rui RAO Qing YI Ping sun Mao LI Yan-Mei Department of Pharmacy An Shun City People’s HospitalAnshun 561000China Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences Guiyang 550014China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Department of Medical Biochemistry Dr.ALM PGIBMSUniversity of MadrasTaramani CampusChennaiIndia

In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium *** structures were established by a combination of extensive NMR spectroscopic analysis,HR-ESIMS data,and ECD *** anti-leukemia activities of all compounds towards three cell lines(HEL,KG-1a,and K562)were evaluated in *** 1–3 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47μmol·L^(−1).Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 *** results suggest that compound 2 is a potential anti-leukemia agent.

关键词： Carpesium cernuum Germacranolides Anti-leukemia K562 MAPK

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基于舌象大数据的早期食管鳞癌中医证候转化规律分析

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中医肿瘤学杂志 2024年第1期6卷 57-62页

作者：于然娄彦妮陈冬梅宋国慧李军孙建荣贾立群解放军总医院第六医学中心北京100048 中日友好医院北京100029 河北省磁县肿瘤医院河北邯郸056500 四川省盐亭县肿瘤医院四川绵阳621600

目的将食管癌高发区舌象筛查与内镜筛查相结合,分析食管癌变过程中不同病理状态下舌象特征,探索食管癌前病变向早期食管鳞癌转化的舌象特征规律及中医病机特点。方法纳入河北磁县、四川盐亭、山西阳城地区2017年—2021年完成内镜筛查及... 详细信息

目的将食管癌高发区舌象筛查与内镜筛查相结合,分析食管癌变过程中不同病理状态下舌象特征,探索食管癌前病变向早期食管鳞癌转化的舌象特征规律及中医病机特点。方法纳入河北磁县、四川盐亭、山西阳城地区2017年—2021年完成内镜筛查及舌象筛查的18954例人群,使用道生舌诊仪(DS01-B)在统一标准的光源环境下提取12种舌象特征。使用SPSS 24.0软件进行数据分析,并通过多因素Logistic回归对多种混杂因素进行控制,比较食管癌前病变及早期食管癌与病理正常人群之间的舌象特征差异。结果舌象分布分析显示,紫舌在食管癌前病变及早期食管癌组的比例高于病理正常组,且其在早期食管癌组的比例高于食管癌前病变组,Logistic回归分析结果显示紫舌在食管癌前病变及早期食管癌组的OR值分别为1.82(95%CI:1.45~2.28,P<0.001)、2.14(95%CI:1.51~3.05,P<0.001);红舌与裂纹舌主要在癌前病变组占比较高,其在早期食管癌组的比例略低于癌前病变组,Logistic回归分析结果显示其OR值分别为1.44(95%CI:1.25~1.66,P=0.003)、1.49(95%CI:1.30~1.72,P<0.001)。将其他差异具有统计学意义的舌象特征纳入多因素Logistic回归分析后,结果与前面分析相一致。结论食管癌前病变组紫舌、红色与裂纹舌的比例均高于病理正常组,而早期食管癌组紫舌的比例高于食管癌前病变组,红色与裂纹舌的比例略低于食管癌前病变组,反映出食管癌变过程中由阴虚燥热向瘀血内阻转化的中医病机规律。

关键词：早期食管癌癌前病变舌象中医病机大数据

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Therapeutic effects of potassium sodium hydrogen citrate on melamine-induced urinary calculi in China

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Chinese Medical Journal 2010年第9期123卷 1112-1116页

作者： GAO Jie SHEN Ying sun Ning JIA Li-qun PAN Yue-song sun Qiang Department of Nephrology Beijing Children's Hospital Affiliated to Capital Medical UniversityBeijing 100045China

Background In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beijing Children＇s Hospital. This study examined the therapeutic efficacy of potassium sodium hydrogen citrate （PSHC） used to treat melamine-induced urinary stones in Chinese children who consumed melamine-containing infant formula. Methods Seventy-two infants and children （average age （18.2±7.7） months） who were diagnosed with urinary calculi were icuidomly divided into three treatment groups using the SAS Plan program. Group 1 was given a low dose （1 g/d） of PSHC, group 2 was given high dose of PSHC （2 g/d） and group 3 was given no PSHC （control group）. The dose of drug was adjusted according to the baseline urinary pH. This study analyzed the influence of the dose of PSHC, the age of patients, stone size and position, and urinary pH on the level of efficacy of PSHC （cured, effectively treated or not cured）.Results After 1-6 months of therapy, 19 patients from group 1, five patients from group 2 and six patients from group 3 were cured. Five patients from group 1, five patients from group 2 and four patients from group 3 were effectively treated. There were significant differences in therapeutic efficacy between the two treatment doses after 3 and 6 months as measured by the increase in the successful expulsion rate and time of melamine-induced urinary calculi. After 6 months the mean time of expulsion of urinary calculi in groups 1 and 2 was significantly shorter than in the control group. Conclusions PSHC can significantly increase the successful expulsion rate and time of melamine-induced urinary calculi. The therapeutic efficacy is affected by PSHC dose, treatment duration, calculi position, and urinary pH. There is no relationship between the therapeutic efficacy and the stone size or patient age.

关键词： melamine potassium sodium hydrogen citrate urinary calculi

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PCR成型机带束防拉伸改造及效果分析

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橡塑技术与装备 2024年第5期50卷 72-75页

作者：孙明武杜金宝宋曰福刘海波崔富亮王海伟刘春亮谢清汝山东万达宝通轮胎有限公司山东东营257500

主要介绍了一种新型的轮胎厂防止带束层拉伸的设备改造方案。该方案采用了一种新型的拉伸控制系统和自动化控制技术,可以有效地防止轮胎生产中带束层的过度拉伸现象,提高了轮胎生产的质量和效率。

关键词：带束层拉伸控制系统自动化控制技术设备改造

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Progress in nanoparticle-based regulation of immune cells

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Medical Review 2023年第2期3卷 152-179页

作者： Ya-Nan Fan Gui Zhao Yue Zhang Qian-Ni Ye Yi-qun sun song Shen Yang Liu Cong-Fei Xu Jun Wang School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong ProvinceChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong ProvinceChina Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Biomedical Engineering Wake Forest School of MedicineWinston-SalemNCUSA School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442Guangdong ProvinceChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina

Immune cells are indispensable defenders of the human body,clearing exogenous pathogens and toxicities or endogenous malignant and aging *** cell dysfunction can cause an inability to recognize,react,and remove these hazards,resulting in cancers,inflammatory diseases,autoimmune diseases,and *** cells regulation has shown great promise in treating disease,and immune agonists are usually used to treat cancers and infections caused by immune *** contrast,immunosuppressants are used to treat inflammatory and autoimmune ***,the key to maintaining health is to restore balance to the immune system,as excessive activation or inhibition of immune cells is a common complication of *** are efficient drug delivery systems widely used to deliver small molecule inhibitors,nucleic acid,and *** nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell *** this review,we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.

关键词： biomaterial drug delivery immune cell immunotherapy nanoparticle

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Protective effect of luteolin-7-O-β-D-glucuronide against oxygenglucose deprivation-induced H9C2 cardiomyocytes injury

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中国药理学与毒理学杂志 2018年第4期32卷 332-333页

作者： Hai-feng ZHANG Lu LI Sheng-qun HOU Li-hui LU Xian-chu HAN Zhen-zhen song Ying sun Fang WANG Life Science and Biopharmaceutics School Faculty of functional food and wine Shenyang Pharmaceutical University Shenyang 110016 China Engineering Research Center for Research and Development of Plant Polyphenols of Liaoning Province Shenyang

OBJECTIVE To investigate the protective effect and mechanisms of luteolin-7-O-β-dglucuronide(LGU) on oxygen glucose deprivation(OGD)-induced H9C2 cardiomyocytes *** The protective effect of LGU on OGD-induced H9C2 cardiomyocytes death were investigated by MTT *** microfilament change of H9C2 cardiomyocytes was detected by phalloidin staining and the lactate dehydrogenase(LDH) leakage rate was also detected by LDH *** order to explore the possible mechanisms of LGU,ATP content,intracellular Ca^(2+) fluorescent intensity and ***,mitochondrial membrane potential(MMP)and the expressions of apoptosis-related proteins were detected by ATP kit,CLSM(Fluo-3/AM probe),Ca^(2+) kit,CLSM(JC-1 probe) and western blotting ***,*** The inhibition of H9C2 cardiomyocyte survival rate inducedby OGD was improvedby pretreated with LGU in a concentrationdependent *** microfilaments injury as well as the increase of LDH leakage rate were also improvedby pretreated with *** ATP content was significantly decreased,intracellular Ca^(2+) fluorescent intensity and concentration were significantly increased and the MMP was significantly decreased 4 hafter *** significantly reversed the *** of intracellular ATP content,the increase of Ca^(2+) fluorescent intensity and concentration and the decrease of *** release of cytochrome C,the expressionsof caspase-9 and caspase-3 in H9C2 cardiomyocytes were increased 16 h after *** inhibited the changes of these ***-related *** LGU has a significant protective effect against OGD-induced H9C2 cardiomyocytes injury through inhibiting calcium overload,increasing ATP content,improving *** function and inhibiting apoptosis.

关键词：心肌细胞保护作用治疗方法肿瘤

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Screening of SARS-CoV-2 in 299 Hospitalized Children with Hematooncological Diseases:A Multicenter Survey in Hubei,China

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Current Medical Science 2020年第4期40卷 642-645页

作者： song-mi WANG Fang TAO Yan HOU Ai ZHANG Hao XIONG Jun-jie sun Xiao-ping LUO Yan HAO Jian-xin LI qun HU Ai-guo LIU Department of Peditrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatric Hematology&Cncology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Pediatrics Xiangyang Central HospitalAfiliated Hospital of Hubei University ofArt and ScienceXiangyang 441021China

Summary:The SARS-CoV-2 infection status of hospitalized children was surveyed in the department of pediatric hematology and oncology in three different hospitals of epidemic areas in Hubei,China.A cross-sectional study was performed to investigate the clinical characteristics,lung CT scan,SARS CoV-2 nucleic acid test and serum antibodics of hospitalized children with hemato-oncological diseases from January 23 to April 24,2020.299 children were enrolled in this study,including 176 males(58.9%)and 123 females(41.1%),aged from 2 months to 16 years.255 cases(85.3%)received chemotherapy or other immunosuppressive therapies,and there were 44 cases(14.7%)of other benign *** acid test was performed on 258 children(86.3%)and one case was positive.163 cases(54.5%)were tested for serum antibodies,and all of them were *** CT scan was performed on 247 children(82.6%),and 107 of them showed infectious *** one case(0.33%)of COVID-19 was diagnosed in the *** prevalence rate of COVID-19 in enrolled children with hemato-oncological diseases in Hubei was 0.33%.Immunosuppressed patients are not prone to produce related *** protective measures and ward management can reduce the risk of SARS-CoV-2 infection in the group patients.

关键词： children COVID-19 hemato-oncological diseases SARS-CoV-2

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Engineering nano-clustered multivalent agonists to cross-link TNF receptors for cancer therapy

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Aggregate 2023年第6期4卷 209-220页

作者： Yue Zhang Gui Zhao Yi-Fang Chen Shi-Kun Zhou Yue Wang Yi-qun sun song Shen Cong-Fei Xu Jun Wang School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouP.R.China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouP.R.China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhouP.R.China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouP.R.China

Tumor necrosis factor receptors(TNFRs)are promising targets for cancer ***,activating their downstream signaling requires cross-linking of ***,to devise strong agonists of TNFRs,ligands targeting TNFRs,such as OX40L and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL),were fused with a multivalent protein scaffold(MV)to prepare multivalent agonists for cross-linking *** nano-clustered multivalent-OX40L(MV-OX40L)and MV-TRAIL could promote T cell activation and directly induce tumor cell ***,to develop a universal nano-adaptor for the rapid preparation of multivalent agonists of different TNFRs,the Fc receptor that could immobilize antibodies was fused with MV to prepare MV-FcR,which could multimerize commercial agonist antibodies targeting TNFRs,such as anti-OX40 antibody(αOX40).Simply incubatingαOX40 with MV-FcR could prepare MV-αOX40 to enhance its antitumor *** addition,MV-FcR could multimerize with other therapeutic antibodies,such as anti-PD-L1 antibody,to enhance their *** study provides a promising strategy for engineering multivalent antitumor protein drugs.

关键词： antibody cancer therapy drug delivery nanoparticle TNFR

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Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

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Protein & Cell 2019年第4期10卷 249-271页

作者： Chen Ling Zunpeng Liu Moshi song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui sun Lina Fu qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China Department of Neurology Peking University First HospitalBeijing 100034China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Institute for Stem cell and Regeneration CASBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 ***,the underlying cellular and molecular mechanisms remain ***,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell *** comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients ***,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for ***,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease.

关键词： CADASIL iPSC NOTCH NF-kB vascular smooth muscle

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