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X-ray diagnosis of synchronous multiple primary carcinoma in the upper gastrointestinal tract

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World Journal of Gastroenterology 2011年第14期17卷 1817-1824页

作者： Zhi-Hao Yang Jian-Bo Gao song-wei Yue hua Guo Xue-hua Yang Department of Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

AIM:To analyze the radiological features of multiple primary carcinoma (MPC) in the upper gastrointestinal (GI) tract,study its biological characteristics and evaluate X-ray examination in its diagnosis. METHODS:Hypotonic double-contrast GI radiography was performed in 59 multiple primary carcinoma cases,pathologically proved by surgery or endoscopy biopsy. Radiological findings were analyzed. RESULTS:Of the 59 cases,esophageal MPC (EMPC) was seen in 24,esophageal and gastric MPC (EGMPC) in 27 and gastric MPC (GMPC) in 8. Of the 49 lesions found in 24 EMPC,hyperplastic type was seen in 23,medullary type in 9. The lesions were located at the upper (n = 17),middle (n = 19) or lower (n = 13) segment of the esophagus. In 27 EGMPC,the esophageal lesions were located at the middle (n = 16) or lower (n = 11) segment of the esophagus,while the gastric le-sions were located at the gastric cardia (n = 16),fundus (n = 1),body (n = 3) and antrum (n = 7). The esophageal lesions were mainly of the hyperplastic type (n = 12) or medullary type (n = 7),while the gastric lesions were mainly of the hyperplastic type (n = 18). A total of 119 lesions in the 59 patients with synchronous multiple carcinoma were proved by surgery or endoscopy biopsy,and preoperative upper radiographic examination detected 100 of them (84.03% sensitivity). Eighteen (52.94%) of the T1 lesions were found during preoperative diagnosis by radiographic examination. Moreover,only 3 (3.53%) of the T2-4 lesions were misdiagnosed. CONCLUSION:Hypotonic double-contrast upper gastrointestinal examination,providing accurate information about lesion morphology,location and size,can serve as a sensitive technique for the preoperative diagnosis of MPC.

关键词： Multiple primary carcinoma Upper gastrointestinal tract Radiography

Primary mixed germ cell tumor of the liver with sarcomatous components

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World Journal of Gastroenterology 2010年第5期16卷 652-656页

作者： Xu, Ai-Min Gong, Shao-Juan song, wei-hua Li, Xiao-wei Pan, Chun-hua Zhu, Jun-Jun Wu, Meng-Chao Second Mil Med Univ Dept Intervent Radiotherapy 3 Eastern Hepatobiliary Surg Hosp Shanghai 200438 Peoples R China

Germ cell tumor(GCT)of the liver is extremely rare. Here,we describe a case of hepatic mixed GCT with significant sarcomatous components and elevated serum α-fetoprotein(AFP)in a 34-year-old ***,the tumor was composed of two GCTs components:yolk sac tumor and immature *** predominant components of immature teratoma consisted of several types of tissue that represented different germinal layers(endoderm,mesoderm and ectoderm) and showed varying degrees of differentiation with significant sarcomatous *** yolk sac component showed positivity for AFP and cytokeratin(AE1/ AE3).The immature teratoma components showed positivity for varying differentiation *** cytogenetic analysis revealed that the yolk sac tumor and immature teratoma were positive for i(12p)and 12p *** particular,the rhabdomyoblastic components also showed typical i(12p)and 12p *** suggested that sarcomatous components may be associated with dedifferentiation or malignant transformation of certain mesenchymal components within teratoma.

关键词： Germ cell tumor Teratoma Sarcoma Liver neoplasms

Arabidopsis Di 19 Functions as a Transcription Factor and Modulates PR1, PR2, and PR5 Expression in Response to Drought Stress

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Molecular Plant 2013年第5期6卷 1487-1502页

作者： Wen-Xin Liu Fei-Cui Zhang Wen-Zheng Zhang Lian-Fen song wei-hua Wu Yi-Fang Chen State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University National Plant Gene Research Centre (Beijing) #2 West Yuan Ming Yuan Rd Beijing 100193 China

The Arabidopsis Di19 （Drought-induced） gene family encodes seven Cys2/His2-type zinc-finger proteins, most with unknown functions. Here, we report that Di19 functioned as a transcriptional regulator and was involved in Arabidopsis responses to drought stress through up-regulation of pathogenesis-related PR1, PR2, and PR5 gene expres- sions. The Di19 T-DNA insertion mutant di19 was much more sensitive to drought stress, whereas the Di19-overexpressing lines were much more tolerant to drought stress compared with wild-type plants. Di19 exhibited transactivation activity in our yeast assay, and its transactivation activity was further confirmed in vivo. DNA-binding analysis revealed that Di19 could bind to the TACA（A/G）T element and chromatin immunoprecipitation （CHIP） assays demonstrated that Di19 could bind to the TACA（A/G）T element within the PR1, PR2, and PR5 promoters, qRT-PCR results showed that Di19 promoted the expressions of PR1, PR2, and PRS, and these heightened expressions were enhanced by CPK11, which interacted with Di19 in the nucleus. Similarly to the Di19-overexpressing line, PRI-, PR2-, and PRS-overexpressing lines also showed the drought-tolerant phenotype. The pre-treatment with salicylic acid analogs INA can enhance plants＇ drought tolerance. Taken together, these data demonstrate that Di19, a new type of transcription factor, directly up-regulates the expres- sions of PR1, PR2, and PR5 in response to drought stress, and its transactivation activity is enhanced by CPK11.

关键词： Arabidopsis Di19 transcription factor drought stress PRll PR2 PR5.

Questioned on Andre Lefevere＇s ＂Chinese and Western thinking on translation＂

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Sino-US English Teaching 2008年第2期5卷 77-81页

作者： song wei-hua School of Foreign Languages Shaoguan University Shaoguan 512005 China

In Andre Lefevere＇s ＂Chinese and Western thinking on translation＂, he has compared the Chinese translation tradition with the tradition of the Western translation. Historically and culturally, he views the similarities and the differences between these two traditions, which has shed much light on extending the horizons of translation studies in China. However, some of his points put forward in the article need a further consideration. The author has a few doubts about the essay and offers her own different opinions.

关键词： translation tradition Chinese and Western thinking translations of Buddhist scriptures

A POLAROGRAPHIC CATALYTIC WAVE OF OXYGEN INDUCED BY DIPHENYLAMINE COMPOUNDS

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Chinese Chemical Letters 1992年第1期3卷 67-68页

作者： Jun Feng song wei GUO Yin hua HU Department of Chemistry,Northwest University,Xi’an 710069

It is reported in this paper a polarographic catalytic double wave of oxygen reduction caused by diphenylamine compounds(diphs).The electrochemical process of the wave includes the polarographic generation of the supe... 详细信息

关键词： A POLAROGRAPHIC CATALYTIC WAVE OF OXYGEN INDUCED BY DIPHENYLAMINE COMPOUNDS

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGhua song hua LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第1期68卷 337-349页

作者： Meiyun Xu song Gu Fulong Chen Zhe Zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

关键词： quaternized polymer networks adsorption pertechnetate iodide liquid radioactive streams

基于网格搜索-支持向量机的采场顶板稳定性预测

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中国安全科学学报 2014年第8期24卷 31-36页

作者：郭超宋卫华魏威辽宁工程技术大学矿业学院辽宁阜新123000 中南大学资源与安全工程学院湖南长沙410083

为准确、快速地预测采场顶板稳定性(SRS),建立基于支持向量机(SVM)理论的SRS评价法。考虑煤-岩石介质与环境条件和工程因素,研究岩石单轴抗压强度、岩石质量指标(RQD)、煤体抗压强度、顶板水文状况和工作面月推进速度对SRS的影响。建立... 详细信息

为准确、快速地预测采场顶板稳定性(SRS),建立基于支持向量机(SVM)理论的SRS评价法。考虑煤-岩石介质与环境条件和工程因素,研究岩石单轴抗压强度、岩石质量指标(RQD)、煤体抗压强度、顶板水文状况和工作面月推进速度对SRS的影响。建立SRS识别的SVM模型。为提高预测模型的泛化能力和预测精度,利用网格搜索法(GSM)及10折交叉确认寻优方法对SVM模型的参数进行优化。用该模型对5组待判工程实例进行判别。研究结果表明,模型训练样本10折交叉确认准确率达91.3%,对测试样本识别正确率为80%,识别结果与实际较吻合。

关键词：采场顶板稳定性(SRS) 支持向量机(SVM) 网格搜索法(GSM) 10折交叉确认预测