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Chinese Journal of Natural Medicines 2022年第9期20卷 701-711页

作者： ZHANG Yi-Jie BAI Ming LI Jia-Yi QIN Shu-Yan LIU Yu-Yang HUANG Xiao-Xiao ZHENG jiang song shao-jiang Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Provincial Key Laboratory of PharmaceuticsGuizhou Medical UniversityGuiyang 550004China

Five undescribed sesquiterpenoids(1–5),and nine known sesquiterpenoids(6–14)were obtained from the fruits of Litsea lancilimba *** LC-MS/MS molecular networking *** A(1)possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of *** structures were elucidated by spectroscopic techniques including IR,UV,NMR,HR-ESI-MS,and their absolute configurations were assigned by ECD *** isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H_(2)O_(2)-induced injury in human neuroblastoma SH-SY5Y cells.

关键词： Litsea lancilimba Lauraceae Sesquiterpenoids Neuroprotective effect

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Discovery of alkaloids from the leaves of Isatis indigotica Fortune with neuroprotective activity

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Chinese Journal of Natural Medicines 2021年第9期19卷 680-685页

作者： XI Yu-Fei LOU Li-Li HAN Feng-Ying WANG Xiao-Bo HUANG Xiao-Xiao YAO Guo-Dong song shao-jiang Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Chinese People's Liberation Army Logistics Support Force No.967 Hospital Dalian 116000China

Seven alkaloids including five undescribed ones(1 a/1 b,2,3 and 5)were obtained from the leaves of Isatis indigotica *** structures were established by extensive spectroscopic *** absolute configurations of compounds 1 a,1 b,3 and 5 were determined by comparison of the experimental and calculated electronic circular dichroism(ECD)***,the neuroprotective effects of all the isolates against H_(2)O_(2)-induced injury in SH-SY5 Y cells were evaluated in vitro by MTT ***,Annexin V-FITC/PI double staining was performed,while the activities of antioxidant enzymes(SOD,CAT and GSH-Px)for compounds 1 a and 1 b were measured.

关键词： Isatis indigotica Alkaloids Neuroprotective effects Structure elucidation

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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HPLC法测定消瘿平亢颗粒中栀子苷含量

中国新药杂志 2006年第9期15卷 715-716页

作者：寇翔宋少江沈阳药科大学药学院沈阳110016 沈阳药科大学中药学院沈阳110016

目的:用HPLC法测定消瘿平亢颗粒中栀子苷含量。方法:色谱柱为ODS(Diamonsil,250 mm×4．6 mm, 5μm),流动相为乙腈-水(15:85),流速为0．8 mL·min^(-1),检测波长238 nm。结果:栀子苷在0．12～0．24μg进样量范围内栀子苷进样量与色谱峰... 详细信息

目的:用HPLC法测定消瘿平亢颗粒中栀子苷含量。方法:色谱柱为ODS(Diamonsil,250 mm×4．6 mm, 5μm),流动相为乙腈-水(15:85),流速为0．8 mL·min^(-1),检测波长238 nm。结果:栀子苷在0．12～0．24μg进样量范围内栀子苷进样量与色谱峰面积呈良好的线性关系(r=0．9992);平均回收率为96．79%(n=5),RSD为1．1%。结论:本法可以用于消瘿平亢颗粒中栀子苷含量的测定。

关键词：高效液相色谱消瘿平亢颗粒栀子苷

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朝鲜淫羊藿中的一个新黄酮苷

沈阳药科大学学报 2006年第8期23卷 505-506,517页

作者：李娜宋少江沈阳药科大学中药学院辽宁沈阳110016

目的对朝鲜淫羊藿提取物进行化学成分的研究。方法通过硅胶柱色谱、聚酰胺柱色谱、Sephadex LH 20和制备HPLC等手段分离,利用理化性质和光谱方法鉴定。结果得到化合物1,鉴定为3,5,7 trihydroxyl 4′methoxy 8(3″hydroxyisopentyl)flavo... 详细信息

目的对朝鲜淫羊藿提取物进行化学成分的研究。方法通过硅胶柱色谱、聚酰胺柱色谱、Sephadex LH 20和制备HPLC等手段分离,利用理化性质和光谱方法鉴定。结果得到化合物1,鉴定为3,5,7 trihydroxyl 4′methoxy 8(3″hydroxyisopentyl)flavone 7OβDglucopyranosyl 3OβDglucopyranosyl(1→3)αL(4 acetyl)rhamnopyranoside。结论该化合物为未见文献报道的新化合物,命名为朝藿苷F(Caohuoside F)。

关键词：朝鲜淫羊藿朝藿苷F 波谱分析结构鉴定

Terpenoids from Excoecaria cochinchinensis Lour.

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Terpenoids from Excoecaria cochinchinensis Lour.

抱茎苦荬菜药材中木犀草素-7-O-β-D-吡喃葡萄糖苷的分离与含量测定

中国化学会第十届全国天然有机化学学术会议

作者： Yun-song Wang shao-song jiang Rui Wu Yu Wang Zhen Deng Jing-Hua Yang Key Laboratory of Medicinal Chemistry for Natural Resources Ministry of Education School of Chemical Science and TechnologyYunnan University

＜正＞The genus Excoecaria（Euphorbiaceae）comprises of nearly 40 species,distributed throughout tropical,Asia and northwest *** species are found in China,of which ***,*** and *** are commonly known.A large number of...

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沈阳药科大学学报 2006年第8期23卷 518-520页

作者：彭缨张梅宋少江沈阳药科大学药学院辽宁沈阳110016 沈阳药科大学中药学院辽宁沈阳110016

目的建立分离、测定抱茎苦荬菜药材中木犀草素-7-O-β-D-葡萄糖苷的方法。方法采用醇提取、氯仿萃取与硅胶柱分离等手段来分离木犀草素-7-O-β-D-葡萄糖苷；采用RP-HPLC法进行含量测定，色谱条件为：Diamonsin C18（250mm×4．6mm，5μ... 详细信息

目的建立分离、测定抱茎苦荬菜药材中木犀草素-7-O-β-D-葡萄糖苷的方法。方法采用醇提取、氯仿萃取与硅胶柱分离等手段来分离木犀草素-7-O-β-D-葡萄糖苷；采用RP-HPLC法进行含量测定，色谱条件为：Diamonsin C18（250mm×4．6mm，5μm）色谱柱，以质量分数为0．2％的磷酸溶液-甲醇（体积比为67：33）为流动相，检测波长为260nm，流速为0．8mL·min^-1。结果木犀草素-7-O-β-D-葡萄糖苷质量浓度在4．80-24．0mg·L^-1内线性关系良好（r=0．9997，n=5），平均回收率为99．4％，相对标准差（RSD）为0．97％。结论本法适合测定抱茎苦荬菜药材中木犀草素-7-O-β-D-葡萄糖苷的含量。

关键词：抱茎苦荬菜木犀草素-7-O-β-D-吡喃葡萄糖苷高效液相色谱法含量测定

Daphne-type diterpenes from Daphne linn and their anti-tumor activity

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中国药理学与毒理学杂志 2019年第10期 891-891页

作者： YAO Guo-dong HOU Zi-lin SHANG Xin-yue song shao-jiang School of Traditional Chinese Materia Medica Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development

In China, there are 44 kinds of plants belong to Daphne linn, which mainly distributed in southwest and northwest, they play noteworthy roles in traditional Chinese system of application. Daphne-type diterpenes are the active ingredients of Daphne linn. This review aims to give a systematic summary of this type compounds derived from Daphne linn regarding their chemical structures, anti-tumor activities as well as related molecular mechanisms. At the same time, the structure-activity relationship is also discussed briefly. The information related to compound structures, anti-tumor activities and its molecular mechanisms systematically collect from the scientific literature databases. There are about 100 Daphnane-type diterpenes in this genus, which can be divided into five different structural subtypes in accordance with the feature of their structure. In addition, some compounds with no typical structural features are categorized as a separate class. These compounds mainly show different degrees of inhibitory effect on various cancer cells, such as A549, HepG2, HCT116, MCF-7 and HL60. Furthermore, we find the inhibitory activities against human cancer cells is closely associated with their structure. In addition,we also summarize the molecular mechanisms of some representative compounds, such as Yuanhuacine, Yuanhuadine and Genkwadaphnin. We find that these compounds exert their anti-tumor effects mainly by inducing apoptosis,inhibiting invasion and migration, and reversing multidrug resistance. The potent molecular mechanisms by them might be associated with modulation of different cell-signaling pathways. These plants of Daphne linn have prominent medicinal properties, and the anti-tumor activity of Daphnane-type diterpenes is worthy of attention. In order to maximize its application, it is necessary to conduct in depth research. Collectively, we summarize this review and try to make marginal contributions to the further exploration of this type diterpenes.

关键词： Daphne linn Daphnane-type diterpenes compound structure anti-tumor effect molecular mechanism

Effects of rolling parameters of snake hot rolling on strain distribution of aluminum alloy 7075

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2150-2156页

作者：张涛吴运新龚海郑细昭蒋绍松中南大学机电工程学院长沙410083 中南大学高性能复杂制造国家重点实验室长沙410083

The realization way of snake rolling was introduced. Flow velocity, strain and stress distribution of 7075 aluminum alloy plate during snake rolling and symmetrical rolling were analyzed in Deform 3D. Effects of velocity ratio, offset distance between two rolls and pass reduction on the distribution of equivalent strain and shear strain were analyzed. The results show that flow velocity and equivalent strain on the lower layer of the plate are larger than those of the upper layer because of the larger velocity of the lower roll and the gap is increased with the increase of velocity ratio and pass reduction. The shear strain of roiling direction in the center point is almost zero during symmetrical rolling, while it is much larger during snake rolling because of the existence of rub zone. The shear strain is increased with the increase of velocity ratio, offset distance and pass reduction. This additional shear strain is beneficial to improve the in_homogeneous strain distribution.

关键词： finite simulation 7075 aluminum alloy snake rolling shear strain velocity ratio offset distance pass reduction