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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata S Y Yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Commentary on:“Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation”

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Neural Regeneration Research 2025年第10期20卷 3040-3040页

作者： Kwok-Fai so Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Mitochondrial function is fundamental to neuroregeneration,particularly in neurons,where high energy demands are essential for repair and recovery(Patrón and Zinsmaier,2016;Beckervordersandforth et al.,2017;Iwata et al.,2023).Mitochondrial dysfunction,characterized by an imbalance in ATP levels and excessive production of mitochondrial reactive oxygen species,is a key factor that impedes neural regeneration in neurodegenerative diseases and after neuronal injury(Han et al.,2016,2020;Zheng et al.,2016;Zong et al.,2024).

关键词： neural Becker Human

Optimal Design of Splitters Attached to Turbo Blower Impeller by RSM

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Journal of Thermal Science 2012年第3期21卷 215-222页

作者： Choon-man Jang ka-Ram Choi Environmental Engineering Research Division Korea Institute of Construction Technology

This paper describes the optimization of the impeller having splitters for a turbo *** design variables,chord of splitter and pitch of splitter,are introduced to enhance the blower *** pressure and ef-ficiency are selected as an object function,and the optimization of the blower impeller is performed by a response surface method (RSM).Three-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of the object function for each *** the shape optimization of the splitters attached to the impeller in the turbo blower,pressure and efficiency at the design flow condition are suc-cessively increased by 5.9 percent and 17.9 percent respectively based on the reference *** higher blower efficiency obtained by optimization of impeller having splitters is mainly caused by reducing the number of im-peller blades and optimal design of splitters in the blade passage while pressure increase keeps almost the same with the reference *** the object function of pressure,pressure increase is obtained at the design and off-design conditions while efficiency keeps higher compared to the reference *** enhancement of blow-er performance is due to the reduction of reverse and circulation flows in the blade passage.

关键词： Turbo Blower Splitter Numerical Simulation Optimal Design Pressure Response Surface Method

Martin boundary and exit space on the Sierpinski gasket

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Science China Mathematics 2012年第3期55卷 475-494页

作者： LAU ka-Sing NGAI Sze-man Department of Mathematics The Chinese University of Hong Kong Department of Mathematical Sciences Georgia Southern University

We define a new Markov chain on the symbolic space representing the Sierpinski gasket (SG),and show that the corresponding Martin boundary is homeomorphic to the SG while the minimal Martin boundary is the three vertices of the *** addition,the harmonic structure induced by the Markov chain coincides with the canonical one on the *** suggests another approach to consider the existence of Laplacians on those self-similar sets for which the problem is still not settled.

关键词： Martin boundary Markov chain Green function harmonic function fractal Sierpinski gasket

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang ka Lu Ju-song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Electromagnetic wave propagation of wireless capsule endoscopy in human body

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Journal of Central south University 2013年第10期20卷 2650-2656页

作者： LIM Eng-Gee 王炤陈瑾慧 TILLO Tammam man ka-lok Department of Electronic and Electrical Engineering Xi’an Jiaotong-Liverpool University

Wireless capsule endoscopy(WCE) is a promising technique which has overcome some limitations of traditional diagnosing tools, such as the comfortlessness of the cables and the inability of examining small intestine section. However, this technique is still far from mature and asks for the feasible improvements. For example, the relatively low transmission data rate and the absence of the real-time localization information of the capsule are all important issues. The studies of them rely on the understanding of the electromagnetic wave propagation in human body. Investigation of performance of WCE communication system was carried out by studying electromagnetic(EM) wave propagation of the wireless capsule endoscopy transmission channel. Starting with a pair of antennas working in a human body mimic environment, the signal transmissions and attenuations were examined. The relationship between the signal attenuation and the capsule(transmitter) position, and direction was also evaluated. These results provide important information for real-time localization of the capsule. Moreover, the pair of antennas and the human body were treated as a transmission channel, on which the binary amplitude shift keying(BASK) modulation scheme was used. The relationship between the modulation scheme, data rate and bit error rate was also determined in the case of BASK. With the obtained studies, it make possible to provide valuable information for further studies on the selection of the modulation scheme and the real-time localization of the capsules.

关键词： wireless capsule electromagnetic wave propagation transmission channel

Transfusion-transmitted hepatitis E:What we know so far?

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World Journal of Gastroenterology 2022年第1期28卷 47-75页

作者： Carmen ka man Cheung Sunny Hei Wong Alvin Wing Hin Law man Fai Law Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China Institute of Digestive Disease and Department of Medicine and Therapeutics the Chinese University of Hong KongHong Kong 852China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore West Island School Hong Kong 852China

Hepatitis E virus(HEV)is a major cause of viral hepatitis *** is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health *** can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even *** 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin *** is infectious even at very low blood concentrations of the *** patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as *** interferon can be considered in those who are refractory or intolerant to ***,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not ***,rescue treatment remains an unmet *** need for HEV screening of all blood donations remains *** screening has been adopted in some countries after consideration of risk and resource *** pathogen reduction methods have also been proposed to reduce the risk of *** studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis.

关键词： Hepatitis E virus Acute and chronic hepatitis Immunosuppression Blood transfusion Transplantation

Weather Information Acquisition and Health Significance during Extreme Cold Weather in a Subtropical City:A Crosssectional Survey in Hong Kong

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International Journal of Disaster Risk Science 2017年第2期8卷 134-144页

作者： Emily Ying Yang Chan Zhe Huang Carman ka man Mark Chunlan Guo Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford Franois-Xavier Bagnoud Center for Health and Human Rights Harvard University

Health and disaster risk reduction are important and necessary components in building a smart city,especially when climate change may increase the frequency of extreme temperatures and the health risks of urban ***,limited knowledge is available about the best way to disseminate weather warnings and health protection *** study explores the weather information acquisition patterns of the Hong Kong public and examines the sociodemographic predictors of these patterns to establish the potential public health implications of smart city development.A population-based,stratified crosssectional,random digit dialing telephone survey was conducted among the Cantonese-speaking population aged over 15 years in Hong Kong in early *** were conducted based on 1017 valid samples,with a response rate of 63.6%.Cold Weather Warnings were well disseminated in Hong Kong,with 95.7% of the respondents reporting awareness of the public *** and smartphone apps were the two most important channels for weather information *** and education level are the main social-demographic variables associated with the current utilization and future preference of smartphone *** those who were not using a preferredchannel to acquire weather information,61.3% considered switching to a smartphone ***,the patterns of individual health protection measures and self-reported health impacts were significantly different between smartphone app users and *** information dissemination should be tailored to the sociodemographic characteristics of the users.

关键词： Cold weather warnings Public health emergencies Smart cities Subtropical city Weather information dissemination systems

Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 139-144页

作者： Rui Guo Emily C Liong Kwok Fai so man-Lung Fung George L Tipoe Departments of Anatomy Li ka Shing Faculty of Medicine The University of Hong Kong Physiology Li Ka Shing Faculty of MedicineThe University of Hong Kong

BACKGROUND：Non-alcoholic fatty liver disease（NAFLD）refers to any fatty liver disease that is not due to excessive use of *** probably results from abnormal hepatic lipid metabolism and insulin *** exercise is shown to improve *** review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on *** soURCE：We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub ***： The mechanisms of chronic aerobic exercise in regulating the outcome of NAFLD include：（i） reducing in- trahepatic fat content by down-regulating sterol regulatory element-binding protein-lc and up-regulating peroxisome proliferator-activated receptor y expression levels; （ii） decreas- ing hepatic oxidative stress through modulating the reactive oxygen species, and enhancing antioxidant enzymes such as catalase and glutathione peroxidase; （iii） ameliorating hepatic inflammation via the inhibition of pro-inflammatory media- tors such as tumor necrosis factor-alpha and interleukin-1 beta; （iv） attenuating mitochondrial dependent apoptosis by reducing cytochrome C released from the mitochondria to the cytosol; and （v） inducing hepato-protective autophagy. CONCLUSION： Aerobic exercise, via different mechanisms, significantly decreases the fat content of the liver and improves the outcomes of patients with NAFLD.

关键词： non-alcoholic fatty liver disease chronic aerobic exercise oxidative stress inflammation apoptosis autophagy