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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen lin Wen-Feng Fang Jui-Ning yeh john y Chiang Hsin-Ju Chiang Pei-lin Shao Pei-Hsun Sung Hon-Kan yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including l2 cells treated with lipopolysaccharide(lPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-l2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Plevels of inflammation[interleukin(Il)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TlR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(lPS)-treated l2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pls were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pl oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel leung Xiwei Wang Xiaofeng Mu yuet Chung Tsun Ming lau Manni Wang Wenyue Zhang yanmei Zhang Howard H.W.Wong leo C.H.Tsang Sara Chaothai Tsz Chun Kwan john K.C.li Karl C.K.Chan leo l.H.luk Jenson C.H.Ho Wing yan li Amos M.T.lee Jennifer H.y.lam Sau Man Chan Wilfred H.S.Wong Issan y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(Il-2)+CD4^(+),SNM-specific Il-2^(+)CD8^(+),S-specific Il-2^(+)CD8^(+),N-specific Il-2^(+)CD4^(+),N-specific Il-2^(+)CD8^(+)and M-specific Il-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific Il-2^(+)CD4^(+),interferon-γ+CD8^(+)and Il-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Effect of cinnamaldehyde on Rhizopus stolonifer and on the conservation of sweet potato

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Food Quality and Safety 2024年第1期8卷 212-225页

作者：陈晨薛智超 Penta Pristijono john B.Golding 陈刚李永新杨虎清 College of Food and Health Zhejiang A&F UniversityHangzhouChina Zhejiang Provincial Key laboratory of Resources Protection and Innovation of Traditional Chinese Medicine Zhejiang A&F UniversityHangzhouChina School of Environmental and life Sciences University of NewcastleOurimbahNSWAustralia NSW Department of Primary Industries OurimbahNSWAustralia

Objectives:Rhizopus stolonifer,which causes soft rot of sweet potato,has resulted in substantial loss of economy *** and Methods:The antifungal effect and mechanism of cinnamaldehyde(CIN)against *** were explored by biochemical analysis and RNA-sequencing in this research,and the edible quality of CIN-treated sweet potato was ***:The results showed that CIN inhibited the growth of *** and reduced the incidence of soft rot in sweet potato at a minimum inhibitory concentration of 1000μl/*** damage of the cell walls of *** by CIN was associated with the upregulation of *** leakage and malondialdehyde content increased following CIN-treatment,which was correlated with increased reactive oxygen species levels and decreased catalase *** of ERG genes and oxidative stress-related genes following CIN treatment was associated with impaired cell membrane *** mitochondrial structure of *** was damaged by CIN treatment resulting in decreased respiration rates and ATP production,which was correlated with lower expression levels of IDH1,COX4,and ***:Our research suggests that the inhibition of CIN on *** was related to the disruption of its normal gene expression network,and CIN maintained the nutritional and edible quality of sweet *** study provides valuable insights into the antifungal mechanism of CIN on *** and the maintenance of root quality,which contributes to the effcient use of CIN for controlling soft rot in sweet potato.

关键词： Ipomoea batatas soft rot cinnamaldehyde antifungal mechanism transcriptome

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Applying plant-based irrigation scheduling to assess water use efficiency of cotton following a high-biomass rye cover crop

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Journal of Cotton Research 2020年第2期3卷 134-145页

作者： MEEKS Calvin D snider john l.cul.epper stanl.y HAWKINS Gary Division of Plant Sciences University of MissouriPortagevilleMO 63873USA Department of Crop and Soil Sciences University of GeorgiaTiftonGA 31793USA Department of Crop and Soil Sciences University of GeorgiaWatkinsvilleGA 30677USA.

Background:This study addressed the potential of combining a high biomass rye winter cover crop with predawn leaf water potential(ΨPD)irrigation thresholds to increase agricultural water use efficiency(WUE)in *** this end,a study was conducted near Tifton,Georgia under a manually-controlled,variable-rate lateral irrigation system using a Scholander pressure chamber approach to measure leaf water potential and impose varying irrigation scheduling treatments during the growing season.ΨPDthresholds were-0.4 MPa(T1),-0.5 MPa(T2),and-0.7 MPa(T3).A winter rye cover crop or conventional tillage were utilized for T1-T3 as ***:Reductions in irrigation of up to 10%were noted in this study for the driest threshold(-0.7 MPa)with no reduction in lint yield relative to the-0.4 MPa and-0.5 MPa *** conditions during flowering(2014)limited plant growth and node production,hastened cutout,and decreased yield and WUE relative to ***:We conclude thatΨPDirrigation thresholds between-0.5 MPa and-0.7 MPa appear to be viable for use in aΨPDscheduling system with adequate yield and WUE for cotton production in the southeastern *** cover positively impacted water potential at certain points throughout the growing season but not yield or WUE indicating the potential for rye cover crops to improve water use efficiency should be tested under longer-term production scenarios.

关键词： Cotton Irrigation management Water use efficiency Cover crops Cotton sustainability

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Ameliorative effects of potassium on drought-induced decreases in fiber length of cotton(Gossypium hirsutum l.) are associated with osmolyte dynamics during fiber development

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The Crop Journal 2019年第5期7卷 619-634页

作者： Wenqing Zhao Haoran Dong Rizwan Zahoor Zhiguo Zhou john l.snider yinglong Chen Kadambot H.M.Siddique youhua Wang Key laboratory of Crop Ecophysiology and Management of Ministry of Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina Jiangsu Collaborative Innovation Center for Modern Crop Production(JCIC-MCP) Nanjing Agricultural UniversityNanjing 210095JiangsuChina The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6001Australia The Department of Crop and Soil Sciences University of GeorgiaTiftonGA 31794USA State Key laboratory of Soil Erosion and Dryland Farming on the loess Plateau Northwest A&F UniversityYangling 712100ShannxiChina University of the Agriculture Faisalabad Sub-campus DepalpurOkaraPakistan

Fiber length of cotton(Gossypium hirsutum l.)decreases under drought stress,potassium(K)could diminish the decreased caused by drought,but the mechanism associated with this alleviation effect is not *** evaluated the effect of K on fiber elongation using two cotton cultivars,Simian 3 and Siza 3,grown in well-watered and drought-stressed *** fertilizer(K2O)was applied 0,150,or 300 kg ha?1 in each growing *** stress reduced the final fiber length due to a decline in the maximum rate of rapid elongation(Vmax,mmday?1).The application of K alleviated the droughtinduced fiber length reduction by increasing *** 10 and 15 days post-anthesis(DPA),drought significantly reduced osmotic potential(OP)and increased K+and malate contents at all K rates,relative to well-watered conditions,which was associated with increased activities of phosphoenolpyruvate carboxylase(PEPC),V-ATPase,PPase,and PM H+-ATPase in cotton ***,the relative contribution of K+and malate to OP declined under drought in comparison with well-watered *** with control without K,K application decreased OP and increased the accumulation of osmolytes(K+,malate and soluble sugar)as well as the activities of related enzymes in fiber irrespective of water ***,K application increased osmotic adjustment during drought,and improved the contribution of K+and malate to OP,especially under drought *** study showed that drought decreased fiber length by reducing Vmax,and K application ameliorates the decline in fiber elongation due to drought by enhancing osmolytes accumulation and their contribution to OP in fiber cells.

关键词： Cotton(Gossypium hirsutum) Fiber length Drought stress Potassium application Osmolyte

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Circadian rhythms in liver metabolism and disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： Jessica M.Ferrell john y.l.Chiang Department of Integrative Medical Sciences Northeast Ohio Medical University

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and ***, these associations are reviewed with respect to liver metabolism and disease.

关键词： Circadian rhythm liver Metabolic syndrome Type 2 diabetes

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The gut's feeling on bile acid signaling in NAFlD

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Hepatobiliary Surgery and Nutrition 2018年第2期7卷 151-153页

作者： john y.l.Chiang Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA

The gut to live axis plays a critical role in regulation of hepatic bile acid synthesis and metabolic homeostasis(1).Non-alcoholic fatty liver disease(NAFlD)is the most common chronic liver disease with a high prevalence of^35%in *** can progress from simple steatosis to non-alcoholic steatohepatitis(NASH),cirrhosis and hepatocellular *** is associated with insulin resistance,obesity and type 2 *** acid-activated farnesoid X receptor(FXR)and G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5)have been shown to regulate lipid,glucose and energy metabolism and activation of FXR by agonists have been shown to improve hepatic metabolism and metabolic disorder in several mouse models of NASH(2).However,the role of bile acid signaling in pathogenesis and treatment of NASH is not clear.

关键词： NAFlD metabolism bile

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Bile acid metabolism and signaling in liver disease and therapy

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liver Research 2017年第1期1卷 3-9页

作者： john y.l.Chiang Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA

Bile acids play a critical role in the regulation of glucose,lipid,and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor(FXR)and membrane G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5).Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes,obesity,and non-alcoholic fatty liver disease(NAFlD).Bile acids have both pro-and anti-inflammatory actions through FXR and TGR5 in the intestine and *** the intestine,bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 *** and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases,such as diabetes and NAFlD.

关键词： Bile acid metabolism Cholestatic liver diseases Metabolic diseases

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Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic Iiver disease

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 152-169页

作者： Tiangang li john y.l.Chiang Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Bile acids are synthesized from cholesterol only in *** acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in small *** acids are signaling molecules that activate nuclear receptor farnesoid X receptor(FXR)and cell surface G protein-coupled receptor *** critically regulates bile acid homeostasis by mediating bile acid feedback inhibition of hepatic bile acid *** addition,bile acid-activated cellular signaling pathways regulate metabolic homeostasis,immunity,and cell proliferation in various metabolically active *** the small and large intestine,gut bacterial enzymes modify primary bile acids to generate secondary bile acids to help shape the bile acid pool composition and subsequent biological *** turn,bile acids exhibit anti-microbial properties and modulate gut microbiota to influence host metabolism and ***,bile acid-based therapies including systemic and intestine-restricted FXR agonists,TGR5 agonists,fibroblast growth factor 19 analogue,intestine FXR antagonists,and intestine apical sodium-bile acid transporter(ASBT)inhibitors have been developed as promising treatments for non-alcoholic steatohepatitis(NASH).These pharmacological agents improved metabolic and inflammatory disorders via distinct mechanisms of action that are subjects of extensive research *** recently,human and experimental alcoholic liver disease(AlD)has been associated with disrupted bile acid *** additional,new findings showed that targeting bile acid metabolism and signaling may be promising therapeutic approaches for treating AlD.

关键词： Bile acid farnesoid X receptor(FXR) microbiota non-alcoholic steatohepatitis(NASH) alcoholic liver disease(AlD)

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Bile acid receptors and signaling crosstalk in the liver, gut and brain

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liver Research 2021年第3期5卷 105-118页

作者： Jessica M.Ferrell john y.l.Chiang Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient ab-sorption,and they play roles in glucose,lipid,and energy metabolism and in gut microbiome and metabolic *** acids mediate crosstalk between the liver and gut through bactericidal modulation of the gut microbiome,while gut microbes influence the composition of the circulating bile acid *** research indicates bile acids may also be important mediators of neurological disease by acting as peripheral signaling molecules that activate bile acid receptors in the blood-brain barrier and in the brain *** review highlights the role of bile acids in maintaining liver and gut microbe homeostasis,as well as their function as mediators of cellular signaling in the liver-gut-brain axis.

关键词： Bile acid metabolism Farnesoid X receptor(FXR) Gut-brain axis Microbiome Neurodegenerative disease Takeda G protein-coupled receptor(TGR5)

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