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DNA methylation signature predicts cancer response to demethylation agents from profiling diverse cancer cell lines

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Cancer Communications 2022年第8期42卷 789-792页

作者： Zhifu Sun Xuewei Wang pete Vedell Jean-Pierre Kocher Division of Computational Biology Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905USA

Dear Editor,Abnormal DNA methylation,a process whereby tumor suppressors tend to be hypermethylated and silenced,is a hallmark of cancer cells[1].Removing the methylation by demethylation agents such as azacitidine and decitabine is one of the strategies to treat cancers and has been successfully used to treat certain hematological and solid tumors[2].However,there are no established DNA methylation markers or signatures that can accurately predict patients’response to treatment[2];thus,the identification of reliable predictive biomarkers for effective therapy remains a critical need in clinical practice.

关键词： cancer signature suppressor

Analysis of hourly generation patterns at large coal-fired units and implications of transitioning from baseload to load-following electricity supplier

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Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 468-474页

作者： Robert Kennedy smith U.S. Department of Energy Office of Fossil Energy

Several factors have led to the decline of electricity generation from coal over the past decade, and projections forecast high rates of growth for wind and solar technologies in coming years. This analysis uses hourly generation data from large coal-fired power stations to determine how operations have been modified in recent years and describes the implications of these changes for plant equipment and unit reliability. The data shows increasing variability in intraday generation output that affects nearly all of the units in the sample, but the magnitude of increase varies widely among plants. Outage patterns were examined as was the relationship between renewable energy growth in a region and the changes in coal plant operations. Aggregate direct and indirect costs associated with running coal plants as load-following units have not yet been quantified in large-scale studies on a sector-wide basis, largely due to differences in how specific equipment responds to output fluctuations. Due to findings from the hourly generation data analysis and the high degree of potential impact on coal plant equipment, the study suggests the development of a new modeling tool that will represent the costs of running coal-fired power plants at lower capacity factors.

关键词： Coal generation Emission intensity Baseload power Capacity factor

花岗质岩浆和矿化之间的关系:重要概念和关键特征

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岩石学报 2017年第5期33卷 1541-1553页

作者： ZUREVINSKI Shannon HOLLINGS pete 周涛发王世伟湖首大学合肥工业大学资源与环境工程学院合肥230009

最近对与花岗岩相关的锂、稀土金属和贱金属(例如Cu和Mo)矿产需求重新激发了人们对其成矿作用研究的兴趣。本文综述了不同类型花岗质岩石及与其相关的矿床:1)与高分异花岗岩有关的浸染状稀有金属矿化;2)热液型锡和钨矿化(如:矽卡岩型矿... 详细信息

最近对与花岗岩相关的锂、稀土金属和贱金属(例如Cu和Mo)矿产需求重新激发了人们对其成矿作用研究的兴趣。本文综述了不同类型花岗质岩石及与其相关的矿床:1)与高分异花岗岩有关的浸染状稀有金属矿化;2)热液型锡和钨矿化(如:矽卡岩型矿床);3)伟晶岩型稀有元素矿化;4)斑岩型矿化。虽然花岗岩和相关矿化作用之间(特别是斑岩系统相对于稀有金属)的联系还没有明确,但最近这些成矿系统的相关研究进展为探讨两者之间的关系提供了条件。本文重点回顾了与花岗岩相关成矿作用的主要特征,以及与不同类型矿化有关的花岗质岩浆的多样性,并论述了不同类型矿床的成矿模式。尽管长英质侵入岩浆系统复杂多样,但近来与这些矿化系统有关的研究进展可望能够作为找矿勘探的指示。地球化学特征可以揭示岩浆系统的氧化还原状态,进而可以判断斑岩系统的成矿潜力,它还可以与其他找矿勘探指标如矿物的同位素和微量元素分析联合使用。本文还讨论了通过熔融包裹体分析,研究微量元素在硅酸盐岩浆与挥发分体系中的行为。

关键词：花岗岩成矿作用稀有金属伟晶岩斑岩

A new view of the local Universe

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 167-168页

作者： Lister Staveley-smith International Centre for Radio Astronomy Research(ICRAR) University of Western AustraliaCrawley WA 6009Australia ARC Centre of Excellence for All Sky Astrophysics(ASTRO 3D) Crawley WA 6009Australia

The distribution and kinematics of gas in and around dark matter halos, the formation of stellar populations from the gravitational collapse of gas clouds, and the interaction of stars and their remnants with interste... 详细信息

关键词： galaxies stars galactic

Inherent Complexities of a Multi-stakeholder Approach to Building Community Resilience

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International Journal of Disaster Risk Science 2020年第1期11卷 32-45页

作者： Josephine Adekola Denis Fischabcher-smith Moira Fischabcher-smith Finance Accounting and RiskGlasgow Caledonian UniversityGlasgow G40BAScotlandUK College of Social Sciences University of GlasgowGlasgow G128QQScotlandUK

Enhancing community resilience has increasingly involved national and regional governments adopting a multi-stakeholder approach because of the potential interagency benefits. This has led to questions about how best to involve stakeholder groups in translating community resilience policies into practice. This exploratory study contributes to this discussion by addressing two key areas that are fundamental in the concerted effort to build community resilience to natural hazards:(1) stakeholder understanding of community resilience as a concept;and(2) the difficulties associated with the processes of risk assessment and preparedness that stakeholders face locally in building community resilience. Data were collected through semistructured interviews with 25 practitioners and experts within Scotland’s resilience community, and were analyzed through an inductive approach to thematic analysis. These data show how the interpretation of community resilience differs across stakeholder groups. Analysis of the data reveals challenges around the nature of the risk assessment and its role in shaping risk perception and communication. Significant complications occur in communicating about low probability-high consequence events, perceived territoriality, competing risk prioritizations, and the challenges of managing hazards within a context of limited resources. The implications of these issues for policy and practice are also discussed.

关键词： Community disaster preparedness Community resilience Multi-stakeholder approach Natural hazards Risk assessment

Novel Heat Transfer Issues Associated with the Design and Safe Operation of the MEGAPIE Spallation Source Target

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Journal of Thermal Science 2007年第1期16卷 63-78页

作者： Brian L.smith Thermal Hydraulics Laboratory Paul Scherrer InstituteSwitzerland

Critical heat transfer problems are discussed in the context of the operation of a spallation source target, which represents a first demonstration of the feasibility of an innovative concept for generating energy using a particle accelerator. Within the framework of the umbrella project MEGAPIE, an R＆D support group was organized to take responsibility for target cooling. This involved the use of advanced numerical methods - Computational Fluid Dynamics （CFD） and Finite Element Method （FEM） - validated against suitable experimental data, and by means of appropriate benchmarking exercises. The design studies using CFD resulted in an optimum flow configuration being defined for the coolant circulation. Flow visualization tests were undertaken using a glass/water test section, with the velocity field mapped using optical and ultrasonic measuring techniques. These were followed by heat transfer tests, using the actual target materials （lead-bismuth-eutectic coolant and steel confinement）. Further CFD/FEM work to analyze operational transients and accident sequences was also carded out, and is described in the paper.

关键词： computational fluid dynamics finite element method liquid-metal coolant spallation source target

Evolving carbon dioxide emission rate intensities of coal-fired power plant on U.S. electricity operating systems

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Journal of Modern Power Systems and Clean Energy 2018年第6期6卷 1103-1112页

作者： Robert Kennedy smith U.S. Department of Energy Office of Fossil Energy

For many years, coal-fired power plant generation comprised the largest share of electricity in the *** sector. While natural gas plants now constitute a greater portion of the total, coal is projected to remain a shrinking but significant component of U.S. electricity production. Natural gas-fired technologies are dispatchable and versatile generation sources, but the recent and anticipated growth of wind and solar technologies will add nondispatchable, intermittent power generation sources to *** grids. Numerous emissions-related benefits arise from the deployment of these technologies, but they must coexist with coal plants, many of which run most efficiently under baseload operating procedures. Historical monthly emissions data has been analyzed on a sample of coal plants to show how modified coal operations have affected plant emission rates, as measured by carbon dioxide emitted per unit of electricity output. Statistically significant correlations between plant capacity factors and emission rate intensity have been observed by the majority of the sample, showing a worsening under more sporadic operations. Since nearly all of the coal plants in the sample are generating less electricity, determining the emission impact of operational decisions will assist policymakers as they seek to minimize total system emissions without severe disruptions to electricity cost and service reliability.

关键词： Coal Emission intensity Renewable generation Baseload power generation

Optimal Dearsenification Parameters of Gold Sulfide Concentrate with a High As Content

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Journal of Materials Science & Technology 2005年第2期21卷 274-276页

作者： YaozhongLAN RoseW.smith MaterialsDepartment YunnanUniversityKunming650091China MetallurgicalandMaterialsDepartment NevadaUniversityofRenoNV89503NevadaUSA

The gold sulfide concentrate with a high As content in Liangshan District, Sichuan Province, China, is a potentially important resource. This paper describes experiments of dearsenification of gold concentrate in a weakly reduced atmosphere in a rotary pipe furnace. The results showed that the optimal parameters were a temperature range of 650-700℃, 15%-16% CO2 of gas and a reaction time of 30-40 min. The removal rate of arsenic and sulfur was over 95% and 25%-28%, respectively. With further oxidization and roasting, residue sulfur in the roasted materials was dropped to below 4%, and the cyanide leaching recovery of gold was over 92%.

关键词： Gold sulfide concentrate with a high As content Weakly reduced atmosphere Dearsenification

No Longer Left Behind Journey to the West

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China International Business 2008年第12期 61-62页

作者： pete SWEENEY

Sichuan and Yunnan have benefited from massive investment since the 1960s, and this looks set to continue with the government＇s recently announced stimulus package.

关键词：投资西部地区开发利用