检索结果-南通市图书馆

The Interferon Signaling Network and Transcription Factor C/EBP-β

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2007年第6期4卷 407-418页

作者： Hui Li Padmaja Gade Weihua Xiao Dhan v. Kalvakolanu Department of Microbiology ＆ Immunology Greenebaum Cancer Center University of Maryland School of Medicine 660 W. Redwood Street Baltimore MD 21201 USA Institute of Medical virology Wuhan University Wuhan China School of Life Sciences University of Science and Technology Hefei Anhui China

Cytokines like interferons （IFNs） play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-β in mediating these responses. Cellular ＆ Molecular Immunology.

关键词： cytokine gene expression signal transduction antiviral innate immunity

Problem of Nuclear Decay by Proton Emission in Fully Quantum Consideration: Calculations of Penetrability and Role of Boundary Conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Physics 2011年第6期2卷 572-585页

作者： Sergei P Maydanyuk Sergei v Belchikov 不详

We develop a new fully quantum method for determination of widths for nuclear decay by proton emission where multiple internal reflections of wave packet describing tunneling process inside proton-nucleus radial barrier are taken into account. Exact solutions for amplitudes of wave function, penetrability T and reflection R (estimated for the first time for decay problem) are found for n -step barrier (at arbitrary n) which approximates the realistic barrier. In contrast to semiclassical approach and two-potential approach, we establish by this method essential dependence of the penetrability on the starting point Rform in the internal well where proton starts to move outside (for example, for Ta the penetrability is changed up to 200 times;accuracy is T+R-1|-15 ). We impose a new condition: in the beginning of the proton decay the proton starts to move outside from minimum of the well. Such a condition provides minimal calculated half-life and gives stable basis for predictions. However, the half-lives calculated by such an approach turn out to be a little closer to experimental data in comparison with the semiclassical half-lives. Estimated influence of the external barrier region is up to 1.5 times for changed penetrability.

关键词： Tunneling Multiple Internal Reflections Wave Packet Decay by Proton Emission Penetrability and Reflection Half-Life

Optimization of Wax Esters Production from Palm Fatty Acid Distillate and Oleyl Alcohol over Amberlyst 15

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering 2011年第11期5卷 1427-1434页

作者： M. Tapanwong v. Punsuvon Department of Chemistry Faculty of Science Kasetsart University Bangkok 10900 Thailand Center of Excellence-Oil Palm Kasetsart University Bangkok 10900 Thailand Center for Advanced Studies in Tropical Natural Resources NRU-ku Kasetsart University Bangkok 10900 Thailand

Wax esters were derived from long chain fatty acids and long chain alcohols with chain length of 12 carbons or more. These compounds have many potential applications in cosmetics, pharmaceuticals and food industries. The present work focuses on the synthesis of wax esters using palm fatty acid distillate and oleyl alcohol catalyzed by Amberlyst 15. Response surface methodology （RSM） based on a five-level, three-variable central composite design （CCD） was used to evaluate the interactive effects of synthesis, of amount of Amberlyst 15 catalyst （21.6-38.4% w/w）, reaction time （18-102 min） and molar ratio （palm fatty acid distillate to oleyl alcohol, 1：1.16-1：2.84） on the percentage conversion of palm fatty acid distillate. The optimum conditions derived via RSM were： amount of catalyst 33% w/w, reaction time 95 minute and palm fatty acid to oleyl alcohol molar ratio 1：2.7. The actual experimental conversion was 81.52% under optimum condition, which compared well to the maximum predicted value of 80.50%. Analysis of the yield showed that at optimum condition, 80.54% wax esters were produced.

关键词： Palm fatty acid distillate wax esters response surface methodology esterification.

The Potential Role of a Health and Demographic Surveillance System in Rural Northern Nigeria to Reduce Maternal and Child Deaths

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2015年第12期7卷 1741-1746页

作者： Olatunji Alabi Henry v. Doctor Nahuche Health and Demographic Surveillance System Zamfara State Nigeria Demography and Social Statistics Federal University Birnin Kebbi Nigeria Regional Office for the Eastern Mediterranean Department of Information Evidence and Research World Health Organization Cairo Egypt

There exist a huge gap between generation of evidence-based research findings and its use to inform policies in most developing countries. Further, it is evident that most developing countries are lagging behind in formulating appropriate policies aimed at improving people’s lives due to lack of evidence-based research findings. We describe the potential of a Health and Demographic Surveillance System (HDSS) in informing appropriate health interventions towards reducing the high maternal and child deaths in rural communities of north western Nigeria through the verbal Autopsy (vA) data collection. vA data collection involves the use of vA questionnaires—set of open ended and closed ended questions adapted from the World Health Organization (WHO) module— administered to the caregivers, parents or family members of a deceased person to elicit information on signs and symptoms and their durations, and other pertinent information about the deceased in the period before death. vA interviews were conducted by trained vA enumerators on all 2100 deaths reported during the update round 4 of routine data collection (July-December, 2012) and returned forms were checked for consistencies and completeness by a trained research officer. The forms were later coded by trained medical doctors for possible cause of death using the WHO International Classification of Diseases (ICD 10) codes. Fifty cases of neonatal deaths, 1650 cases of infant and child deaths, and 400 cases of adult deaths were reported during the update round 4 data collection. Neonatal sepsis was reported as the leading cause of neonatal deaths (58%) while malaria and intestinal infectious diseases were reported as the leading cause of infant and child deaths and adult deaths respectively (45% and 17%, respectively). The study provides documented evidence of high neonatal deaths due to neonatal sepsis in an area with low hygiene and high home delivery rates. The findings from the vA data collection at Nahuche HDSS

关键词： Maternal and Child Deaths verbal Autopsy Chlorhexidine Demographic Surveillance Health Systems Nigeria

Early Growth Response gene 1 (Egr-1) regulates HSv-1 ICP4 and ICP22 gene expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2007年第6期17卷 546-555页

作者： Gautam R Bedadala Rajeswara C Pinnoji Shao-Chung v Hsia Department of Basic Pharmaceutical Sciences College of Pharmacy The University of Louisiana at Monroe 700 University AvenueMonroeLA 71209 USA

The molecular mechanisms mediating herpes simplex virus type 1 (HSv-1) gene silencing during latent infection arenot clear. Five copies of early growth response gene 1 (Egr-1) binding elements were identified in the intron of HSv-1ICP22 (infected cell protein No. 22) gene, leading to the hypothesis that Egr-1 binds to the viral genome and regulates theviral gene expression. Transient co-transfection assays indicated that Egr-1 negatively regulated the transcription of bothfull-length and intron-removed ICP22 promoters. The same assays also revealed that Egr-1 repressed ICP4 (infected cellprotein No. 4) promoter activity in a dose-dependent manner but showed less inhibition when the intron was *** deacetylation was not involved in this regulation since histone deacetylase inhibitor trichostatin Adid not exhibitany effect on Egr-1-mediated repression. Chromatin immunoprecipitation assays showed that Egr-1 reduced the bindingof Spl to the promoters and that the co-repressor Nab2 (NGFI-A/EGR1-binding protein) was recruited to the proximityof ICP4 in the presence of Egr-1. These results suggested that the multifunctional transcription factor Egr-1 can repressHSv-1 immediate-early gene expression through the recruitment of co-repressor Nab2 and reduction of Sp1 occupancy,and thus may play a critical role in HSv-1 gene silencing during latency.

关键词： HSv-1 latency Egr-1 Sp1 Nab2 transcription regulation

Status of the Streamer Mode in Gas Detectors

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Modern Instrumentation 2014年第2期3卷 9-11页

作者： v. I. Razin Institute for Nuclear Researches Russian Academy of Sciences Moscow Russia

This work shows the results of a streamer discharge mode studies in various gas detectors developed up-to-date. The results are based on a new experimental data from high-speed thin-gap gas detector application develo... 详细信息

关键词： Gaseous Detectors Micropattern Gaseous Detectors (MSGC GEM THGEM RETGHEM MICROMEGAS RPC etc.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用于激光器的电感储能发生器(英文)

光学精密工程 2011年第2期19卷 213-220页

作者： TARASENKO v F PANCHENK O A N TEL’MINOv A E GENIN D E Institute of High Current Electronics SB RAS Akademichesky ave.2/3634055TomskRussia

研制了适用于激光器的电感储能发生器（GIES）,并研究了它在高压混合气体中的放电和激光参数。研究表明,电感储能发生器可产生高压预脉冲并引起放电电流的突然增大,可在不同的混合气体中形成长时间的稳定放电,从而方便地控制和优化每一... 详细信息

研制了适用于激光器的电感储能发生器（GIES）,并研究了它在高压混合气体中的放电和激光参数。研究表明,电感储能发生器可产生高压预脉冲并引起放电电流的突然增大,可在不同的混合气体中形成长时间的稳定放电,从而方便地控制和优化每一种气体混合物的预脉冲参数。在未知IES击穿电压和首次放电幅度下的参数时,电流尖峰会按因子1.52减少,从而产生纯激光参数。得到了氮气激光器的最大的辐射功率,输出能量和脉冲持续时间,在脉冲持续时间为40 ns时,紫外输出高达50 mJ,红外输出高于25 mJ,实现了氮分子激光跃迁的级联激射。因此C^3Пu-B^3Пg带总的脉冲持续时间延长至100 ns。在XeCl,XeF和KrF受激准分子激光器中,脉冲宽度和输出能量都得到了改善。XeF激光器的最大效率达到了1.6%,同时峰值输出能量达到了0.85 J,最大脉冲持续时间超过了200 ns。在248 nm波长处,效率3.3%的KrF激光器产生的160 ns脉冲能量高达650 mJ,最终得到了效率为7.7%10%的非链式HF（DF）激光器。演示了基于CO2分子高峰值功率的有效运行,结果表明,激光器在10 600 nm处的输出能量为6.2 J,转换效率高达25%。

关键词：电感储能发生器高压气体体放电激光参数

Generalization of the Force Approach to Radiation Reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2017年第3期5卷 569-573页

作者： Gustavo v. López Departamento de Física Universidad de Guadalajara Guadalajara Mexico

A new approach to radiation reaction for the correction of the linear and circular motion of a charged particle takes into account the emission of electromagnetic radiation due to its acceleration. This new formulation was based on expressing the radiation reaction force in terms of the external force rather than the acceleration of the charge. In this paper, a generalization of the radiation reaction force in terms of the external force approach is formulated for any arbitrary motion of the charged particle. This generalization includes the linear and circular acceleration cases previously investigated.

关键词： Synchrotron Radiation Radiation Reaction Force Relativistic Charged Particle

富血小板血浆和乏血小板血浆包被的屏障膜对成骨细胞附着的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华口腔医学杂志 2007年第8期42卷 496-500页

作者：徐燕蒋勇林潇 Bartold PM Marino v 安徽医科大学口腔医学院.口腔医院牙周科合肥230032 安徽医科大学口腔医学院病理科合肥230032 安徽医科大学卫生管理学院 Colgate Australian Clinical Dental Research Centre Dental SchoolUniversity of Adelaide

目的观察富血小板血浆(piateletrich plasma,PRP)和乏血小板血浆(platelet poorplasma,PPP)包被的屏障膜对人牙槽骨成骨细胞附着的影响。方法取第4代人牙槽骨成骨细胞用于实验。健康成人的全血经过两次离心得到 PRP 和 PPP。将 A 膜(Gor... 详细信息

目的观察富血小板血浆(piateletrich plasma,PRP)和乏血小板血浆(platelet poorplasma,PPP)包被的屏障膜对人牙槽骨成骨细胞附着的影响。方法取第4代人牙槽骨成骨细胞用于实验。健康成人的全血经过两次离心得到 PRP 和 PPP。将 A 膜(GoreTex-ePTFE^(TM)膜)、B 膜(GoreTex-Resolut^(TM)膜)和 C 膜(Inion-GTR^(TM)膜)冲切成直径为3 mm 的圆片并同定于24孔培养板底,用盖玻片作为阳性对照,将包被液分为 PRP、PPP、磷酸盐缓冲液(phosphate buffer solution,PBS)3个组,分别包被屏障膜或玻片(仅用磷酸盐)2 h,将成骨细胞以5×10~7个/L 每孔接种于屏障膜或玻片上并孵育24 h 使细胞附着。苏木素染色,光镜下观察并计数,扫描电镜观察成骨细胞附着膜上的形态。结果 PRP 组包被的 A、B、C 膜上的细胞数分别为23、35和41;PPP 组包被的 A、B、C 膜上的细胞数分别15、12和22;PBS 包被的 A、B、C膜上的细胞数分别为3、4和6。成骨细胞在 PRP、PPP 组的附着数量明显高于磷酸盐组(P<0.05);PRP 组较 PPP 组的附着数量多(P<0.05);盖玻片上的附着数量显著多于3种屏障膜。3种屏障膜相比,B 膜和 C 膜的成骨细胞附着量高于 A 膜(P<0.05)。扫描电镜结果显示,PRP 组屏障膜上成骨细胞呈梭形,贴壁好,膜表面可见血小板、交织成网状的纤维蛋白,细胞呈现复层生长;PPP 组或磷酸盐组成骨细胞贴壁不完全,呈圆形。结论 PRP 和 PPP 能促进成骨细胞在屏障膜上的附着数量;PRP 能改善成骨细胞在屏障膜上的附着方式。

关键词：血浆血小板成骨细胞引导组织再生膜