The Interferon Signaling Network and Transcription Factor C/EBP-β

作     者：Hui Li Padmaja Gade Weihua Xiao Dhan V. Kalvakolanu 

作者机构：Department of Microbiology ＆ Immunology Greenebaum Cancer Center University of Maryland School of Medicine 660 W. Redwood Street Baltimore MD 21201 USA Institute of Medical Virology Wuhan University Wuhan China School of Life Sciences University of Science and Technology Hefei Anhui China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2007年第4卷第6期

页      面：407-418页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：National Cancer Institute NCI: R01CA078282 R01CA105005 

主　　题：cytokine gene expression signal transduction antiviral innate immunity 

摘      要：Cytokines like interferons （IFNs） play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-β in mediating these responses. Cellular ＆ Molecular Immunology.