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In vitro α-amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus macroptera ***

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Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 473-479页

作者： Nizam Uddin Rakib Hasan Monir Hossain Arjyabrata Sarker A.H.M.Nazmul Hasan A.F.M.Mahmudul Islam Mohd.Motaher H.Chowdhury sohel rana Laboratory of Natural Products Research Department of PharmacyJahangirnagar University

Objective:To investigate the therapeutic effects of methanol extract of Citrus macroptera Montr,fruit inα-amylase inhibitory activity(in vitro)and hypoglycemic activity in normal and glucose induced hyperglycemic rats(in vivo).Methods:Fruits of Citrus macroptera without rind was extracted with pure methanol following cold extraction and tested for presence of phytochemical constituents,α-amylase inhibitory activity,and hypoglycemic effect in normal rats and glucose induced hyperglycemic ***:Presence of saponin,steroid and terpenoid were identified in the *** results showed that fruit extract had moderateα-amylase inhibitory activity[IC_(50)value=(3.638±0.190)mg/mL]as compared to *** at 500 mg/kg and 1000 mg/kg doses fruit extract significantly(P<0.05 and P<0.01 respectively)reduced fasting blood glucose level in normal rats as compared to glibenclamide(5 mg/kg).In oral glucose tolerance test,500 mg/kg dose significantly reduced blood glucose level(P<0.05)at 2 h but 1000 mg/kg dose significantly reduced blood glucose level at 2 h and 3 h(P<0.05 and P<0.01 respectively)whereas glibenclamide(5 mg/kg)significantly reduced glucose level at every hour after *** time effect is also considered extremely significant with F value=23.83 and P value=0.0001 in oral glucose tolerance ***:These findings suggest that the plant may be a potential source for the development of new oral hypoglycemic agent.

关键词： Diabetes mellitus Hypoglycemic Citrus macroptera α-Amylase OGTT Glibenclamide

Cytotoxic, Antimicrobial and Antioxidant Properties of Commelina diffusaBurm. F.

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Pharmacology & Pharmacy 2019年第2期10卷 82-93页

作者： Mahmuda Nasrin Farhana Afroz Suriya Sharmin Md. sohel rana Md. Hossain Sohrab Department of Pharmacy Jahangirnagar University Dhaka Bangladesh Pharmaceutical Sciences Research Division BCSIR Laboratories Dhaka Bangladesh

Commelina diffusa Burm. F. is a herbaceous tropical plant with different traditional medicinal uses. Present study is aimed to isolate the bioactive compounds from DCM-Methanol extract of the powdered whole plant of Commelina diffusa and to investigate the cytotoxic, antimicrobial and antioxidant activities of the crude extract and its twelve vacuum liquid chromatographic fraction (CD1-12). Vacuum Liquid Chromatography (VLC) was employed to isolate bioactive metabolites. The physicochemical properties of the isolated compound were examined and the molecular structure was elucidated by NMR spectroscopy.?Cytotoxic, antibacterial, antioxidant activities were evaluated following brine shrimp lethality bioassay, disc diffusion method and DPPH free radical scavenging assay respectively. The isolated compound was identified as steroid (stigmasterol) which had significant cytotoxic effect on vero cell line. The crude extract and its fractions (CD8-CD12) exhibited strong cytotoxicity in brine shrimp lethality bioassay having LC50 values 3.79, 9.19, 29.49, 16.60, 19.36, 44.58 μg/mL respectively. The crude extract showed mild to strong antibacterial activity. Fractions (CD5-CD12) showed mild to strong antibacterial activity against Escherichia coli in comparison with Kanamycin (standard). Strong antioxidant activities were found in crude extract (IC50 value 30.52 μg/ml), CD11 (IC50 value 39.27 μg/ml) and CD12 (IC50 value 19.50 μg/ml). The study suggests Commelina diffusa plant extract to have strong antioxidant and cytotoxic activity which is indicative of presence of compounds with broad spectrum of curative applications. One compound namely stigmasterol has been isolated from the plant.

关键词： Commelina diffusa Stigmasterol Brine Shrimp Lethality Bioassay Disc Diffusion Method Free Radical Scavenging Assay

Evaluation of Antibacterial and Antidiarrhoeal Activities of Feronia limoniaLeaf Extract

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American Journal of Plant Sciences 2013年第11期4卷 2181-2185页

作者： Mohammad Abdul Motalib Momin Mizanur Rahaman Khan Johir Rayhan Afrina Afrose sohel rana Anjuman Ara Begum Department of Pharmacy Jahangirnagar University Savar Ban-gladesh Department of Pharmacy University of Science and Technology Chittagong Chittagong Bangladesh

The present study was carried out to investigate possible antibacterial and antidiarrhoeal activities of ethanol extract of Feronia limonia leaves. Phytochemical analysis of the crude extract was performed to detect presence of different kinds of phytoconstituents. The antibacterial activity was investigated against four Gram positive and four Gram negative bacteria by using disc diffusion method. The plant extract showed moderate antibacterial activity against Gram positive bacteria namely Staphylococcus saprophyticus and Staphylococcus pyogenes and all tested Gram negative bacteria namely Escherichia coli, Shigella boydii, Shigella dysentery and Shigella flexneri in dose dependant manner. The results of castor oil-induced diarrhoeal study showed that Feronia limonia extract significantly reduced the severity & frequency of diarrhoea in mice at a higher dose of 500 mg/kg compared with the standard drug loperamide (25 mg/kg). The present study clearly supports the medicinal value of this plant. The overall results indicate the possibility of presence of some active principles in the plant extract possessing antibacterial and antidiarrhoeal actions.

关键词： Phytochemical Screening Antimicrobial Antidiarrhoeal Feronia limonia

Overview of an Emerging Coronavirus Infection, COVID-19: Current Status of Vaccine Development and Therapeutics

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Pharmacology & Pharmacy 2021年第1期12卷 25-41页

作者： Md. sohel rana Md. Maruf Hasan Md. Eshak Enan Fatema-Tuz Zohora A. T. M. Zafrul Azam Department of Pharmacy Faculty of Pharmacy University of Dhaka Dhaka Bangladesh Department of Pharmacy Primeasia University 9 Banani C/A Dhaka Bangladesh

Coronavirus infectious disease 2019 (COVID-19) first reported in Wuhan, China, causes serious respiratory illnesses such as lung failure and pneumonia. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) the pathogenic agent of COVID-19 has been confirmed as a novel coronavirus. WHO announced COVID-19 a global pandemic and now the whole world is eagerly waiting for vaccines and therapeutic treatment to get rid of this unstoppable coronavirus. As COVID-19 infection, a global threat creates unwanted human casualties and serious economic loss. To stop the ongoing uncontrolled situation researchers are racing to develop prevention and treatment strategies. Vaccines of different countries are in clinical and preclinical trials and the repurposed-drugs are providing to find out a positive result against COVID-19. The report is an analysis of published information focusing

Evaluation of Anxiolytic and Sedative-Like Activities of Methanolic Extract of Euphorbia hirtaLeaves in Mice

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Pharmacology & Pharmacy 2019年第6期10卷 283-297页

作者： S. M. Mushiur Rahman sohel rana Md. Nahinul Islam Alok Kumer Md. Mehedi Hassan Tonmoy Kumar Biswas Md. Atikullah Department of Pharmacy Jashore University of Science and Technology Jashore Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh

In indigenous or folk medicine, Euphorbia hirta is a very popular herb and used as a palliative to treat various ailments including intestinal parasites, diarrhoea, vomiting, amoebic dysentery, asthma, bronchitis, emphysema, coughs, kidney stones, menstrual problems etc. The objective of this study is to evaluate the anxiolytic and sedative-like effects of the methanol extract from the leaves of Euphorbia hirta (Euphorbiaceae). Methanolic extract of Euphorbia hirta was evaluated for its CNS depression effect using mice behavioral models such as, elevated plus maze and hole board test for its anxiolytic potential where hole cross and pentobarbital-induced sleeping time tests were performed for its sedative properties, respectively. The test group received three different doses of the MEHL (100 mg/kg, 200 mg/kg and 300 mg/kg) orally. The positive control group received diazepam (1 mg/kg) orally where the negative control group received distilled water (10 ml/kg) orally. In elevated plus maze test, the extract exhibited significant (p d the number of open arm entry and time spent in open arm by mice compared to control group. In addition, the number of head dips and hole crosses significantly (p < 0.05) decreased by mice in hole board and hole cross tests respectively, compared to control group. Moreover, mice treated with MEHL significantly decrease the onset of sleep and increase the duration of sleep in pentobarbital-induced sleeping time test in mice compared to control group. The data obtained from the present study clearly demonstrate that the methanolic extract of Euphorbia hirta has potential anxiolytic and sedative-like activity in the animal behavioral models. And the findings represent a rational explanation for its use in traditional medicine for the management of neurological disorder.

关键词： Euphorbia hirta Anxiolytic Sedative Elevated Plus Maze Hole Board Hole Cross

Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study

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Chinese Journal of Chemical Engineering 2018年第1期26卷 159-167页

作者： Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed rana Malik Abdul Rub Mohammad A.Halim Mohammed Abdullah Khan Farida Akhtar Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Division of Quantum Chemistry BICCBThe Red-Green Computing Centre218 Elephant RoadDhaka 1205Bangladesh Institut Lumière Matière Université Lyon 1-CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 *** drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed *** decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the *** ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the *** values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and *** thermodynamic properties of transfer for the micellization were also evaluated and discussed in *** dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and *** water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the *** hydrophobic core region is highly conserved and *** addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions.

关键词：相互作用溴化物动力学方法电解质学习分子尿道感染表面活化剂

Overview of an Emerging Coronavirus Infection, COVID-19: Current Status of Vaccine Development and Therapeutics

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