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LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer

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Biomedical and Environmental Sciences 2020年第11期33卷 849-856页

作者： ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHoU Ling TANG Min Zhong sj o`brien LAN Jiao ZHoU Xiang Yang WANG Yong Li TANG Juan ZHoU Zhi Xiang DU Hai Jun LIN Hui State Key Laboratory for Infectious Disease Prevention and Control National Institute of Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530021GuangxiChina Cancer center Wuzhou Red Cross HospitalWuzhou 543002GuangxiChina Guy Harvey oceanographic Center Halmos College of Natural Sciences and OceanographyNova Southeastern UniversityFlorida 33004USA College of Life Science and Bioengineering Beijing University of TechnologyBeijing 100124China

objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with *** prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth *** responses to LMP2 were detected by enzyme-linked immunospot(ELISPoT)assay at week 0 and at the fifth and eighth *** clinicians performed the follow-up and tracking of *** We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical ***-nine patients with NPC were enrolled in this clinical *** LMP2-DCs vaccine was well tolerated in all of the *** responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with *** follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in *** In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with *** CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing.

关键词： LMP2-DCs Nasopharyngeal carcinoma Immunotherapy

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Electrochemical reduction process of bilirubin in dimethylformamide

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Chinese Journal of Chemistry 1995年第4期13卷 289-298页

作者： NIU, JJ DoNG, sj CHINESE ACAD SCI CHANGCHUN INST APPL CHEMELECTROANALYT CHEM LABCHANGCHUN 130022PEOPLES R CHINA

The electrochemical reduction behavior of bilirubin (BR) at platinum electrode in DMF was investigated by cyclic voltammetry, in situ electron spin resonance spectroscopy and in situ rapid scanning thin layer spectroelectrochemistry. Experimental results revealed that the reduction of BR firstly undergoes an ECE process: GRAPHICS The generated (BR)(2)(3-). can be re-oxidized to BR and then to purpurin (Pu) by a series of oxidation processes: GRAPHICS However, the re-reduction reactions of Pu are not the reverse processes. The different reduction mechanisms are discussed in detail.

关键词： BILIRUBIN BILIVERDIN PURPURIN SPECTRoELECTRoCHEMISTRY BIoELECTRoCHEMISTRY

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SYNTHESIS　oF　BLoCK　CoPoLYMERS　oF　STYRENE　AND　N－（p－SUBSTITUTED　PHENYL）　MALEIMIDES　BY　ANIoNIC　PoLYMERIZATIoN

引用

Chinese Chemical Letters 1996年第4期7卷 367-370页

作者： Xu, sj Qiu, KY BEIJING UNIV COLL CHEM & MOL ENGNBEIJING 100871PEOPLES R CHINA

The block copolymers were synthesized by anionic pohymerization via two steps reaction. First, styrene was initiated by n-butyl lithium, then maleimides were added into the living styrene system to obtain block copolymers. 1H-NMR and FT-IR measurements indicated that block coplymers bad been formed From the esults of thermogravimetric, it could be concluded that the block copolymer had a much better thermal stability than random copolymers predared by radical polymerization. Also the surface hydrophilicities of the two kinds of copolymers were compared.

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Effects of pigment glands and gossypol on somatic cell culture of upland cotton (Gos-sypium hirsutum L.)

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Chinese Science Bulletin 2001年第23期46卷 1975-1980页

作者： Zhu, sj Ji, DF Zhejiang Univ Fac Agr & Biotechnol Dept Agron Hangzhou 310029 Peoples R China

The effects of pigment glands and gossypol on the somatic cell culture of upland cotton were studied, using the materials as follows: three pairs of glanded and gland less upland cotton near isogenic lines, TM-1, and Coker 312. The results showed that the pigment glands and gossypol contents in the explants had great inhibiting effect on the induction and growth of callus in somatic cell culture of upland cotton, and the induction rate of callus and the single callus weight of glandless cotton were much higher than those of their glanded near isogenic lines. It was easier to obtain regeneration plants from glandless cotton than from their glandednear isogenic lines. There was a significant inverse correlation between the gossypol contents in the explants and callus induction rate, with the correlation coefficient of -0.84. The vitro gossypol in the medium had some inhibiting effect on the induction and growth of callus, especially for the gland-less cotton. However, a certain concentration of vitro

关键词： pigment gland gossypol G. hirsutum somatic cell cul- ture.

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Phase Structure Change of Mo-Si System duringMechanical Alloying

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Journal of Materials Science & Technology 1999年第5期15卷 423-426页

作者： Liu, sj Qu, XH Liu, ZJ Huang, BY Cent S Univ Technol State Key Powder Met Changsha 410083 Peoples R China

The structure of Mo-15.16 Si, Mo-30 Si and Mo-36.3 Si (wt pct) elemental powder mixture during mechanical alloying was studied using electron microscopy and X-ray diffraction. It had been found that, in all the systems under study, silicon disappeared initially during mechanical alloying (MA). In the Mo-Si systems all products were in form of amorphous state after long time milling, but there were different intermediate products. MoSi2 and Mo5Si3 intermetallic compounds in the Mo-30Si and Mo-36.3Si (wt pct) were directly synthesized from elements through inter-diffussion process. The high density of defects and interface of nano-crystal lines induced by ball milling would promote the reaction process. only in the Mo-15.16Si (wt pct) system was Mo(Si) supersaturated solid solution formed as an intermediate product. Schematic free-energy diagram of Mo-Si system based on the thermodynamics was used to analyze the difference among the intermediate state products.

关键词： Molybdenum alloys

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Substituent effects on chloro meso-tetra-ortho-alkylphenylporphinato iron catalyzed biomimetic oxidation of cyclohexane

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Chinese Journal of Chemistry 1995年第5期13卷 442-447页

作者： Zhu, sj Gui, MD Jiang, DX NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA

Six sterically hindered chloro meso-tetra-ortho-alkylphenylporphinato irons (T(o-R)PPFe(III)Cl, R = Me, Et, n-Pr, i-Pr, n-Bu, t-Bu) were synthesized and used to catalyze the monooxygenation of cyclohexane with PhIo. Both the yields of cyclohexanol and the relative rates of monooxygenation of cyclohexane catalyzed by T(o-R) PPFe(IIl)Cl were higher than those of TPPFe(III)Cl respectively. The order of the yields(%) of cyclohexanol and the rate of cyclohexanol formation in the monooxygenation of cyclohexane catalyzed by T(o-R)PPFe(III)Cl for the different substituents are: i-Pr(58) > Et(57) > n-Pr(52) > Me(51) > n-Bu(48) > t-Bu(46) > H(35) and i-Pr > Et > t-Bu > n-PT greater than or equal to Me greater than or equal to n-Bu greater than or equal to H respectively. The special steric effect on the catalytic character of these different alkyl substituents in T(o-R)PPFe(III)Cl is proposed on the basis of the results.

关键词： chloro alkylphenylporphinato iron steric effect biomimetic catalysis

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MANNICH REACTIoN oN 1,2-DIHYDRo-1-PYRRoLIZINoNE

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Chinese Chemical Letters 1996年第1期7卷 9-10页

作者： Wang, sj Liu, FS Zhang, SF SHENYANG PHARMACEUT UNIV SHENYANG 110015PEOPLES R CHINA

The aminomethylation of the title compound can occur at 2-C or 5-C when it undergoes Mannich reaction with different amines. With aliphatic secondary amines, the reaction occurs at 2-C of the ketone, whereas with arom...

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Synthesis and Luminescence Properties of Barium Fluorotungstate Phosphors

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Chinese Chemical Letters 1997年第7期8卷 643-644页

作者： Yang, sj Sun, JT Qin, ZB HUBEI NoRMAL UNIV DEPT CHEMHUNGSHI 435002PEOPLES R CHINA WUHAN UNIV DEPT CHEMWUHAN 430072PEOPLES R CHINA

The investigation of the system BaF2-Wo3 revealed the existence of a fluoro-tungstate formulated as Ba2Wo3F4. The Ba2Wo3F4 was prepared with the solid state reaction method. Under UV or X-ray excitation, Ba2Wo3F4 exhibits a very strong blue-green emission peaking at 480 nm at room temperature. The luminescence properties are similar to those of the tungstate, especially MgWo4. The luminescence and energy transfer of tungstates are well known for a long time and was reviewed by Blasse([1]). But barium tungstate show only weak luminescence even down to liquid helium temperature([2]). We were surprised to find that Ba2Wo3F4 is an efficient phosphor which can be practically used. In this paper, the preparation method and luminescence properties of Ba2Wo3F4 phosphor were investigated. The relationship between the luminescent properties and crystal structure was discussed.

关键词： Ba nm

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Fracture of Aramid Fiber/Epoxy Resin Micro Composites

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Journal of Materials Science & Technology 1995年第4期11卷 260-264页

作者： WANG, X ZHANG, CX JIN, sj YU, YZ Inst of Chemistry Chinese Acad of Sciences Beijing China

Kevlar-49 fiber was modified through cold air plasma treatment and plasma grafting with acrylic monomers. Fracture of aramid fiber/epoxy resin micro composites has been studied by means of single fiber pull-out test. Tow types of pull-out curves are correlated with the different failure modes. A polyacrylic acid-co-ethyl acrylate graft layer can improve the adhesion and protect the fiber from damage caused by interfacial stresses.

关键词： Fiber reinforced plastics

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The　Electrochemistry　of　Cytochrome　c　at　a　Viologen-thiol　Self-Assembled　Monolayer

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Chemical Research in Chinese Universities 1998年第1期14卷 17-24页

作者： Li, JH Cheng, GJ Dong, sj Chinese Acad Sci Changchun Inst Appl Chem Electroanalyt Chem Lab Changchun 130022 Peoples R China

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－... 详细信息

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－ｊｕｎ（ＬａｂｏｒａｔｏｒｙｏｆＥ...

关键词： at Viologen-thiol Monolayer Self-Assembled The Cytochrome Electrochemistry

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