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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： singh shailendra ANAND Abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of S.Canbazoglu et al.The model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of charging.This study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of 3.27.So,it is the most recommended PCM for the storage tank of the SWH system.The study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and copper.This melt fraction analysis is performed by making a coding program in the FORTRAN programming language.Through the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

Impact of index admission cholecystectomy vs interval cholecystectomy on readmission rate in acute cholangitis: National Readmission Database survey

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 350-360页

作者： Abdullah Sohail Ahmed Shehadah Ammad Chaudhary Khadija Naseem Amna Iqbal Ahmad Khan shailendra singh Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Henry Ford HospitalDetroitMI 48202United States Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195-0001United States Department of Internal Medicine University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology Case Western Reserve University HospitalClevelandOH 44106United States Division of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Elective cholecystectomy(CCY)is recommended for patients with gallstone-related acute cholangitis(AC)following endoscopic decompression to prevent recurrent biliary events.However,the optimal timing and implications of CCY remain unclear.AIM To examine the impact of same-admission CCY compared to interval CCY on patients with gallstone-related AC using the National Readmission Database(NRD).METHODS We queried the NRD to identify all gallstone-related AC hospitalizations in adult patients with and without the same admission CCY between 2016 and 2020.Our primary outcome was all-cause 30-d readmission rates,and secondary outcomes included in-hospital mortality,length of stay(LOS),and hospitalization cost.RESULTS Among the 124964 gallstone-related AC hospitalizations,only 14.67%underwent the same admission CCY.The all-cause 30-d readmissions in the same admission CCY group were almost half that of the non-CCY group(5.56%vs 11.50%).Patients in the same admission CCY group had a longer mean LOS and higher hospitalization costs attrib-utable to surgery.Although the most common reason for readmission was sepsis in both groups,the second most common reason was AC in the interval CCY group.CONCLUSION Our study suggests that patients with gallstone-related AC who do not undergo the same admission CCY have twice the risk of readmission compared to those who undergo CCY during the same admission.These readmis-sions can potentially be prevented by performing same-admission CCY in appropriate patients,which may reduce subsequent hospitalization costs secondary to readmissions.

关键词： Acute cholangitis Gallstone-related complications National Readmission Database 30-d readmission rates Resource utilization In-hospital mortality

Painlevé analysis,auto-Bäcklund transformation and new exact solutions of(2+1)and(3+1)-dimensional extended Sakovich equation with time dependent variable coefficients in ocean physics

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Journal of Ocean Engineering and Science 2023年第3期8卷 246-262页

作者： shailendra singh S.Saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

This article considers time-dependent variable coefficients(2+1)and(3+1)-dimensional extended Sakovich equation.Painlevéanalysis and auto-Bäcklund transformation methods are used to examine both the considered equations.Painlevéanalysis is appeared to test the integrability while an auto-Bäcklund transformation method is being presented to derive new analytic soliton solution families for both the considered equations.Two new family of exact analytical solutions are being obtained success-fully for each of the considered equations.The soliton solutions in the form of rational and exponential functions are being depicted.The results are also expressed graphically to illustrate the potential and physical behaviour of both equations.Both the considered equations have applications in ocean wave theory as they depict new solitary wave soliton solutions by 3D and 2D graphs.

关键词： (2+1)-dimensional extended Sakovich equation (3+1)-dimensional extended Sakovich equation Auto-Bäcklund transformation Painlevéanalysis Solitary wave solution

Risk of pancreatic cancer in individuals with celiac disease in the United States:A population-based matched cohort study

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 523-532页

作者： Arunkumar Krishnan Yousaf Bashir Hadi Sarah Shabih Diptasree Mukherjee Ruhee A Patel Rushik Patel shailendra singh Shyam Thakkar Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia

BACKGROUND Celiac disease(CD)has been associated with gastrointestinal malignancies.However,the magnitude of the risk of pancreatic cancer(PC)associated with CD is much less clear,and risks have not been estimated from large populations.AIM To assess the risk of PC in CD patients.METHODS We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive patients diagnosed with CD using the TriNeTx research network platform.We examined the incidence of PC in patients with CD compared with a matched cohort of patients without CD(non-CD,controls).Each patient in the main group(CD)was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.The incidence of PC was estimated using a Cox proportional hazards model with a hazard ratio(HR)and 95%confidence interval(CI).RESULTS A total of 389980 patients were included in this study.Among them,155877 patients had a diagnosis of CD,and the remaining 234103 individuals without CD were considered a control cohort.The mean duration of follow-up for patients in the CD and control cohorts was 5.8±1.8 and 5.9±1.1 years,respectively.During the follow-up,309 patients with CD developed PC,whereas 240 patients developed PC in the control group(HR=1.29;95%CI:1.09-1.53).In the secondary analyses in the first year after diagnosis of CD,patients with CD were at a significant increase in risk for PC;151 patients with CD had an incidence of PC compared with 96 incidences of PC among the patients in the non-CD control group(HR=1.56;95%CI:1.20-2.01)and sensitivity analysis showed similar magnitude to the one generated in the primary and secondary analysis.CONCLUSION Patients with CD are at increased risk of PC.Risk elevation persists beyond the first year after diagnosis to reference individuals without CD from the general population.

关键词： Celiac disease Cancer Epidemiology Pancreas Pancreatic cancer Malignancy Carcinoma

Clinical characteristics and outcomes of COVID-19 in patients with autoimmune hepatitis:A population-based matched cohort study

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World Journal of Hepatology 2023年第1期15卷 68-78页

作者： Arunkumar Krishnan Ruhee A Patel Yousaf Bashir Hadi Diptasree Mukherjee Sarah Shabih Shyam Thakkar shailendra singh Tinsay A Woreta Saleh A Alqahtani Section of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia Liver Transplant Center King Faisal Specialist Hospital and Research CenterRiyadh 12713Saudi Arabia

BACKGROUND Patients with autoimmune hepatitis(AIH)require life-long immunosuppressive agents that may increase the risk of poor coronavirus disease 2019(COVID-19)outcomes.There is a paucity of large data at the population level to assess whether patients with AIH have an increased risk of severe diseases.AIM To evaluate the impact of pre-existing AIH on the clinical outcomes of patients with COVID-19.METHODS We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive adult patients(≥18 years)diagnosed with COVID-19 using the TriNeTx research network platform.The outcomes of patients with AIH(main group)were compared to a propensity score-matched cohort of patients:(1)Without chronic liver disease(CLD);and(2)Patients with CLD except AIH(non-AIH CLD)control groups.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.The primary outcome was all-cause mortality,and secondary outcomes were hospitalization rate,need for critical care,severe disease,mechanical ventilation,and acute kidney injury(AKI).For each outcome,the risk ratio(RR)and confidence intervals(CI)were calculated to compare the association of AIH with the outcome.RESULTS We identified 375 patients with AIH,1647915 patients with non-CLD,and 15790 patients with non-AIH CLD with COVID-19 infection.Compared to non-CLD patients,the AIH cohort had an increased risk of all-cause mortality(RR=2.22;95%CI:1.07-4.61),hospitalization rate(RR=1.78;95%CI:1.17-2.69),and severe disease(RR=1.98;95%CI:1.19-3.26).The AIH cohort had a lower risk of hospitalization rate(RR=0.72;95%CI:0.56-0.92),critical care(RR=0.50;95%CI:0.32-0.79),and AKI(RR=0.56;95%CI:0.35-0.88)compared to the non-AIH CLD patients.CONCLUSION Patients with AIH are associated with increased hospitalization risk,severe disease,and all-cause mortality compared to patients without pre-existing CLD from the diagnosis of COVID-19.However,patients with AIH were not at risk for worse outc

关键词： Autoimmune hepatitis SARS-CoV-2 COVID-19 Mortality Outcomes Liver disease Severe

Development of Tunable Silk Fibroin/Xanthan Biopolymeric Scaffold for Skin Tissue Engineering Using L929 Fibroblast Cells

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Journal of Bionic Engineering 2021年第1期18卷 103-117页

作者： shailendra singh Shera Rathindra Mohan Banik Bioprocess Technology Laboratory Sschool of Biochemical Engineeringndian Institute of Technology(Banaras Hindu University)Varanasi 221005India Department of Biotechnology Faculty of Engineering&TechnologyRAMA Universit Uittar PradeshKanpur 209217India

Skin acts as protective barrier against a number of factors such as dust,opportunistic microbial and viral infections,regulates body temperature and waste discharge.Fibroblast cell population plays an important role in devclopment of skin architecturc.A scaffold having capability to support and enhance fibroblast growth is a viable option for wound dressing material which can shorten the time for wound to heal.In this work,Silk Fibroin(SF)and Xanthan(Xa)were blended in three ratios 80 SF:20 Xa(SFX82),60 SF:40 Xa(SFX64),and 50SF:50 Xa(SFX55)to create SF/Xa scaffold.Miscibility and other physicochemical properties of SF/Xa scaffold are functions of blending ratios and blend with the ratio 80 SF:20 Xa has the highest miscibility.Thermal properties of SF/Xa blends are a function of miscibility with SFX82 having superior thermal propertis of all fabricated scaffolds.The porosity of SF/Xa scaffolds is in the range of 67%to 50%,with pore size of 58.1 um-45.5 um,water uptake capacity of 92%-86%,and surface roughness of 49.95 nm-385 nm.SFX82 shows highest growth rate of L929 fibroblast cells indicating its superiority over other scaffolds for providing biological cues for the growth and proliferation of fibroblastic cells in natural environment.SFX82 scaffold is found to be most suitable for fibroblastic cells thereby enhancing the tissue regeneration at wound site.

关键词： blends miscibility FTIR imaging Atomic Force Microscopy(AFM) cytocompatibility wound healing

Role of endoscopic ultrasound in liver disease: Where do we stand in 2017?

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World Journal of Hepatology 2017年第24期9卷 1013-1021页

作者： Hamzeh A Saraireh Mohammad Bilal shailendra singh Department of Internal Medicine University of Texas Medical Branch Division of Gastroenterology and Hepatology University of Texas Medical Branch Division of Gastroenterology Hepatology and Nutrition Allegheny General Hospital

Endoscopic ultrasound(EUS) was first introduced into medical practice in 1980 s as a diagnostic imaging modality for pancreatic pathology. EUS has the unique advantage of combining ultrasound and endoscopy to obtain detailed information of the gastrointestinal tract. Over the past decade, the use of EUS in liver diseases has been increasing. EUS, which was initially used as a diagnostic tool, is now having increasing therapeutic role as well. We provide a review of the application of EUS in the diagnostic and therapeutic aspects of liver disease. We also look at the evolving future research on the role of EUS in liver diseases.

关键词：内视镜的超声肝疾病门高血压肝损害

Invitro Biodegradability of Silk Fibroin/Xanthan Biopolymeric Composite Scaffolds

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Journal of Bionic Engineering 2019年第2期16卷 299-310页

作者： shailendra singh Shera Shraddha Sahu Rathindra Mohan Banik Bioprocess Technology Laboratory School of Biochemical Engineering Indian Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India

Silk fibroin/xanthan scaffolds were prepared by blending silk fibroin and xanthan in the ratios 80SF:20Xa(SFX82),60SF:40Xa(SFX64),and 50SF:50Xa(SFX55)using freeze drying method.In-vitro degradation behavior of the prepared scaffolds was studied for 37 days in phosphate buffer saline.The degradation rate was the function of silk fibroin,xanthan and^-crystallite contents in the silk fibroin/xanthan composites.SFX82 degraded extremely slowly whereas SFX55 showed faster degradation rate.Hydrophilic xanthan was the main contributor of weight loss.SFX82 and SFX64 exhibited surface degradation whereas SFX55 showed bulk degradation which indicated that higher silk fibroin ratios favor surface degradation.Due to bulk degradation,SFX55 showed maximum surface roughness among the composite scaffolds.The FTIR spectrum revealed total loss of xanthan from the composites after degradation.The broad and low-intensity peaks in the FTIR spectrum of composite scaffolds con finned reduction in 0-sheet crystallite content during degradation.XRD analysis also confirmed reduction in 0-sheet crystals and revealed that degraded composite scaffold had predominantly amorphous structure.The degraded scaffold showed higher porous structure than the non-degraded scaffold.The in vitro degradability testing gives a good approximation of degradation of scaffold in vivo and helps in designing a robust biopolymeric composite scaffold for tissue engineering.

关键词： biopolymer composites surface roughness biopolymer degradation surface degradation tissue engineering

Antifertility effect of chronically administered Tabernaemontana divaricata leaf extract on male rats

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 547-551页

作者： Sachin Jain Ankit Jain Pritesh Paliwal shailendra singh Solanki Department of Pharmacognosy College of PharmacyIPS AcademyRajendra NagarIndore(MP) India 452012

Objective:To investigate the antifertility effect of chronically administered Tabernaemontana divarkala(T.divaricata) leaf extract on male rats.Methods:The effect of 50%ethanol extract of T.divaricata leaves on reproduction was studied on male rats.The study was divided into four groups of five animals each.The first groups(1) received vehicle alone to serve as control. The second,third and fourth groups(Ⅱ,ⅡandⅣ) of animals were administered the leaf extract daily at 50 mg/kg body weight,p.o.,100 nig/kg body weight,p.o.,and 200 mg/kg body weight, p.o.,respectively,for a period of 60 days.Results:Significant decreases in the weight of testes, epididymis,seminal vesicle and ventral prostate were observed.A dose related reduction in the testicular sperm count,epididymal sperm count and motility,number of fertile male,ratio between delivered and inseminated females and numbers of pups were observed.The testis showed a clear correlation between the dose and severity of lesions of seminiferous epithelium. In general,the seminiferous tubules appear reduced in size with a frequently filled eosinophilic material.Spermatogenesis arrested at the secondary spermatocyte stage.Pachytene spermatocytes were undergoing degeneration.Disorganisation and sloughing of immature germ cell were visible. Leydinf cells were atrophied.No morphological changes were observed in Sertoli cells.Significant reduction in serum concentration of luteinizing hormone and testosterone were observed.No distinct change in serum FSH concentration was recorded.The final body weights of all groups were elevated markedly.No alterations were recorded in any hematologiocal parameters. Conclusions:It is concluded that the 50%ethanol extract of T.divaricata leaf produced dose related effect on male reproduction without altering general bodv metabolism.

关键词： Tabernaemontana divaricata Anti-fertility Male rats 50%ethanol extract Reproduction Hormone levels

Pseudoaneurysm of profunda femoris artery following dynamic hip screw fixation for intertrochanteric femoral fracture

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Chinese Journal of Traumatology 2013年第4期16卷 233-236页

作者： shailendra singh Sumit Arora Ankit Thora Ram Mohan, Sumit Sural Anti Dhal Maulana Azad Medical College & Associated Lok NayakHospital New Delhi India

动态新潮的螺丝钉固定是为 intertrochanteric 的内部固定的一个通常执行的过程大腿骨的破裂。跟随起作用的固定的动脉的损害是一个稀罕却严肃的事件。我们在场与一个动态新潮的螺丝钉在 intertrochanteric 骨折的内部固定以后开发了 pr... 详细信息

动态新潮的螺丝钉固定是为 intertrochanteric 的内部固定的一个通常执行的过程大腿骨的破裂。跟随起作用的固定的动脉的损害是一个稀罕却严肃的事件。我们在场与一个动态新潮的螺丝钉在 intertrochanteric 骨折的内部固定以后开发了 profunda femoris 动脉的 pseudoaneurysm 的一个病人。诊断被 angiographic 学习证实，它被卷 embolization 成功地对待。

关键词：骨折内固定股骨螺钉动脉假性内固定术血管造影 RIS