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参芪降糖颗粒联合甲钴胺注射液对2型糖尿病周围神经病变患者MBP、BDNF、NGF水平的影响

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糖尿病新世界 2024年第5期27卷 19-23页

作者：林淑卿陈英周国灶厦门弘爱医院健康管理中心福建厦门361016 厦门前埔医院中医科福建厦门361008 厦门弘爱医院全科医学科福建厦门361016

目的探讨参芪降糖颗粒联合甲钴胺注射液对2型糖尿病周围神经病变患者人髓磷脂碱性蛋白(My-elin Basic Protein,MBP)、人脑源性神经营养因子(Brain-derived Neurotrophic Factor,BDNF)、神经生长因子(Nerve Growth Factor,NGF)水平的影... 详细信息

目的探讨参芪降糖颗粒联合甲钴胺注射液对2型糖尿病周围神经病变患者人髓磷脂碱性蛋白(My-elin Basic Protein,MBP)、人脑源性神经营养因子(Brain-derived Neurotrophic Factor,BDNF)、神经生长因子(Nerve Growth Factor,NGF)水平的影响。方法选取2019年5月—2020年12月厦门前埔医院收治的62例2型糖尿病周围神经病变患者为研究对象,通过随机数表法分为西药组和观察组,各31例。西药组肌内注射甲钴胺注射液治疗,观察组在西药组基础上加用参芪降糖颗粒治疗。比较两组临床效果和药物安全性,治疗前后的中医证候积分、神经传导速度和MBP、BDNF、NGF水平。结果观察组的总有效率(96.77%)高于西药组的74.19%,差异有统计学意义(χ^(2)=6.369,P0.05)。结论对2型糖尿病周围神经病变患者应用参芪降糖颗粒联合甲钴胺注射液治疗效果显著,明显降低患者中医证候积分及MBP水平,提升神经传导速度及BDNF、NGF水平。

关键词：参芪降糖颗粒甲钴胺注射液 2型糖尿病人脑源性神经营养因子

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基于供电所历史电费数据的用户风险评估

农村电气化 2024年第5期 15-18页

作者：林树青白敏陈永发广东电网有限责任公司韶关始兴供电局顿岗供电所广东始兴512500

电费作为供电企业经营成果的直接体现,因此加强电费管理、减轻电费风险显得尤为重要。精准高效的电费智能催收应用可以有效地建设电费回收风险,随着大数据、云计算等新技术的快速发展,电力用户画像库的建设和应用已具备充分条件。基于... 详细信息

电费作为供电企业经营成果的直接体现,因此加强电费管理、减轻电费风险显得尤为重要。精准高效的电费智能催收应用可以有效地建设电费回收风险,随着大数据、云计算等新技术的快速发展,电力用户画像库的建设和应用已具备充分条件。基于历史数据,提炼用户特征标签,多维度呈现用户画像,并筛选营销电费回收风险的特征指标,对电费回收方式预测,判断用户的电费预测风险等级,提高电费催收效率。

关键词：电费催收用户画像电费数据分析

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中国当代医药 2024年第11期31卷 125-128,134页

作者：林淑清沈雪娟洪彩霞厦门市海沧医院急诊科福建厦门361026

目的探讨发热门诊开设后急诊护理人员工作压力源与焦虑抑郁、自我效能及应对方式的相关性。方法选取2019年12月至2023年3月就职于厦门市海沧医院的40名护理人员作为研究对象,其中20名来自急诊发热门诊的护理人员作为试验组,20名来自非... 详细信息

目的探讨发热门诊开设后急诊护理人员工作压力源与焦虑抑郁、自我效能及应对方式的相关性。方法选取2019年12月至2023年3月就职于厦门市海沧医院的40名护理人员作为研究对象,其中20名来自急诊发热门诊的护理人员作为试验组,20名来自非急诊科的护理人员作为对照组,采用护士工作压力源量表、焦虑抑郁量表、一般自我效能感量表和简易应对方式量表对两组护理人员在发热门诊开设后进行问卷调查,根据评估结果分析其相关性及影响因素。结果试验组的压力源量表总得分、焦虑抑郁量表评分、简易应对方式量表中总分均高于对照组,差异有统计学意义(P<0.05);试验组的自我效能得分低于对照组,差异有统计学意义(P<0.05);相关性分析结果显示,急诊科护士压力源与发热门诊开设后的焦虑(r=0.821,P=0.016)、抑郁(r=0.802,P=0.021)呈正相关,与自我效能(r=-0.782,P=0.032)、简易应对方式(r=-0.718,P=0.026)呈负相关。结论运用科学的理论和实践指导急诊科护士应对此类突发公共卫生事件,针对不同时期护士的压力来源,医院管理者和护士自身需要采用不同的应对措施,只有两者互相结合,才能有效地解决急诊科护士的压力,从而提升护理质量。

关键词：发热门诊急诊护理压力应对方式

系统护理干预对双相情感障碍狂躁症发作患者认知功能的影响评价

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中国医药指南 2024年第17期22卷 105-107页

作者：张小燕涂细金林淑清漳州市第四医院精神科漳州363000

目的分析系统护理干预方法在狂躁症患者护理中的价值以及对狂躁症患者认知功能的积极影响。方法选择医院2022年5月—2023年8月收治的50例双相情感障碍狂躁症发作患者,经随机数字表法分组,观察组患者(25例)采取系统护理干预,对照组患者(2... 详细信息

目的分析系统护理干预方法在狂躁症患者护理中的价值以及对狂躁症患者认知功能的积极影响。方法选择医院2022年5月—2023年8月收治的50例双相情感障碍狂躁症发作患者,经随机数字表法分组,观察组患者(25例)采取系统护理干预,对照组患者(25例)采用常规护理干预,比较两组患者护理结果差异。结果护理后,观察组患者认知功能评分以及生活质量评分均高于对照组(均P<0.05);观察组患者护理后不同阶段的狂躁症状评分均低于对照组(均P<0.05)。结论在双相情感障碍狂躁症发作患者临床干预中,利用系统护理干预方法成为增强患者认知功能、缓解临床症状的重要组成部分,并且与常规护理模式相比,更有助于提升患者生活质量。

关键词：系统护理干预双相情感障碍狂躁症认知功能

Uniqueness of Meromorphic Solutions for a Class of Complex linear Differential-Difference Equations

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Journal of Mathematical Research with Applications 2022年第4期42卷 331-348页

作者： Hongjin lin Junfan CHEN shuqing lin School of Mathematics and Statistics Fujian Normal University

In this paper,we mainly study the uniqueness of transcendental meromorphic solutions for a class of complex linear differential-difference ***,suppose that f（z）is a finite order transcendental meromorphic solution of complex linear differential-difference equation:W1（z）f'（z+1）+W2（z）f（z）=W3（z）,where W1（z）,W2（z）,W3（z） are nonzero meromorphic functions,with their orders of growth being less than one,such that W1（z）+W2（z）■*** f（z） and a meromorphic function g（z） share 0,1,∞ CM,then either f（z）≡g（z） or f（z）+g（z）≡f（z）g（z） or f2（z）(g（z）-1)2+g2（z）(f（z）-1)2≡f（z）g（z）(f（z）g（z）-1) or there exists a polynomial φ（z）=az+b0such that ■ where a（≠0）,a0,b0are constants with ea0≠eb0.

关键词： meromorphic solution complex differential-difference equation shared value uniqueness finite order

Fast Maximum Entropy Machine for Big Imbalanced Datasets

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Journal of Communications and Information Networks 2018年第3期3卷 20-30页

作者： Feng Yin shuqing lin Chuxin Piao Shuguang(Robert)Cui Shenzhen Research Institute of Big Data(SRIBD) Shenzhen 518172China The Chinese University of Hong Kong(Shenzhen) Shenzhen 518172China School of Information Science and Engineering Xiamen UniversityXiamen 361000China

Driven by the need of a plethora of machine learning applications,several attempts have been made at improving the performance of classifiers applied to imbalanced *** this paper,we present a fast maximum entropy machine(MEM)combined with a synthetic minority over-sampling technique for handling binary classification problems with high imbalance ratios,large numbers of data samples,and medium/large numbers of features.A random Fourier feature representation of kernel functions and primal estimated sub-gradient solver for support vector machine(PEGASOS)are applied to speed up the classic *** have been conducted using various real datasets(including two China Mobile datasets and several other standard test datasets)with various *** obtained results demonstrate that the proposed algorithm has extremely low complexity but an excellent overall classification performance(in terms of several widely used evaluation metrics)as compared to the classic MEM and some other state-of-the-art *** proposed algorithm is particularly valuable in big data applications owing to its significantly low computational complexity.

关键词： binary classification imbalanced datasets maximum entropy machine PEGASOS random Fourier feature SMOTE

Soliton frequency comb generation in CMOS-compatible silicon nitride microresonators

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Photonics Research 2022年第5期10卷 1290-1296页

作者： YAOZU XIE JIAQI LI YANFENG ZHANG ZERU WU SHIHAO ZENG shuqing lin ZHAOYANG WU WENCHAO ZHOU YUJIE CHEN SIYUAN YU State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China

The monolithic integration of soliton microcomb devices with active photonic components and high-frequency electronics is highly desirable for practical applications. Among many materials, silicon nitride(SiN_(x)) waveguide layers prepared by low-pressure chemical vapor deposition(LPCVD) have been the main platform for on-chip optical frequency comb generation. However, the high temperatures involved in LPCVD render it incompatible as a back-end process with complementary metal oxide semiconductor(CMOS) or active Ⅲ-Ⅴ compound semiconductor fabrication flows. We report the generation of coherent soliton frequency combs in micro-ring resonators fabricated in deuterated silicon nitride(SiN_(x):D) waveguides with a loss of 0.09 d B/cm. Deposited at 270℃ by an inductance-coupled plasma chemical vapor deposition(ICP-CVD) process, the material preparation and fabrication flow are fully CMOS-compatible. These results enable the integration of silicon-nitride-based optical combs and photonic integrated circuits(PICs) on prefabricated CMOS and/or Ⅲ-Ⅴ substrates, therefore marking a major step forward in Si Nxphotonic technologies.

关键词： LPCVD waveguide soliton

Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： Bei Li Yong Zhang Xinyuan Liu Ziyang Zhang shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli Mo Shuhai lin Shicong Wang Chundong Yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

One-year direct and indirect costs of ischaemic stroke in China

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Stroke & Vascular Neurology 2024年第4期9卷 380-389,I0032-I0043页

作者： Wei Lv Anxin Wang Qianyi Wang Ruimin Wang Qin Xu shuqing Wu Yi Han Yong Jiang Jinxi lin Jing Jing Hao Li Yongjun Wang Xia Meng Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina School of Basic Medical Science Capital Medical UniversityBeijingChina Department of Cardiology Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityGuangzhouChina Health Economic Research Institute Sun Yat-Sen UniversityGuangzhouChina

Background This is the first real-world study to estimate the direct costs and indirect costs of first-ever ischaemic stroke with 1-year follow-up in China,based on a nationally representative *** Patients were chosen from 20 geographically diverse sites from the nationally representative database China National Stroke Registry-III(CNSR-III).The inclusion criteria were surviving patients who were hospitalised with first-ever ischaemic stroke from February 2017 to February 2018(the index event);aged 18–80 during the index event;no history of other stroke *** primary endpoints were direct medical costs,direct non-medical costs,indirect costs and total cost(ie,the sum of all cost components).Patient characteristics and clinical data were extracted from ***-related in-hospital direct medical costs were collected from hospital electronic medical *** patient survey collected data related to out-of-hospital direct medical costs,direct non-medical costs and indirect *** secondary objective was to explore clinical factors associated with cost outcomes through univariate analysis and multiple *** The study enrolled 520 *** total cost was 57567.48 CNY,with 26612.67 CNY direct medical costs,2787.56 CNY direct non-medical costs and 28167.25 CNY indirect *** analysis showed that longer lengths of stay during the index event,higher National Institutes of Health Stroke Scale(NIHSS)and modified Rankin Scale scores were associated with higher costs in all ***,EuroQol 5 Dimension utility scores were associated with decreased costs except direct non-medical *** regressions showed that higher admission NIHSS scores were independently associated with higher direct medical costs,indirect costs and total *** 3-month utilities were associated with lower total *** This real-world study showed substantial 1-year economic burden following first-ever ischaemic stroke

关键词： indirect costs Dimension