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Genes & Diseases 2024年第3期11卷 136-139页

作者： Yuchao Yang Shutong wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu Jingxing Dai Jun Ouyang Guangdong Provincial Key Laboratory of Medical Biomechanics&National Key Discipline of Human Anatomy Schoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory Medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary Pathology Faculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of Orthopedics TCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China

Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout ***,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关键词： alterations injuries massive

Prevention of Osteopenia and Dyslipidemia in Rats after Ovariectomy with Combined Aspirin and Low-dose Diethylstilbestrol

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Biomedical and Environmental Sciences 2013年第4期26卷 249-257页

作者： LIN Si En HUANG Jian Ping wu ling Zhi wu Tie CUI Liao Department of Pharmacology Guangdong Medical College Department of Stomatology Guangdong Medical College Guangdong Key Laboratory for Research and Development of Natural Drugs

Objective To study whether effect of aspirin plus low-dose diethylstilbestrol is more effective and safer than high diethylstilbestrol dose alone on prevention of ovariectomy-induced osteopenia and dyslipidemia. Methods Thirty-eight 4-month-old female SD rats were divided into baseline （BAS） group （n=6）, sham operation group （n=8） and ovariectomy （OVX） group （n=24）. The OVX group was further divided into vehicle treatment group （n=8）, diethylstilbestrol （30 ug/kg.d） treatment group （OVX＋D30 group, n=8）, and aspirin （9 mg/kg.d） plus diethylstilbestrol （10 ug/kg.d） treatment group （OVX＋A-D10 group, n=8）. Their left tibiae were collected for the bone histomorphometric analysis in undecalcified sections. Left femurs were collected for the bone mineral density measurement. Results The body weight and serum cholesterol were increased, while uterine weight and cancellous bone mass were decreased in OVX rats compared with the SHAM group. Cancellous bone mass was significantly increased, while body weight and bone resorption parameters were decreased in both A-D10 and D30 treatment group compared with OVX group. The rats treated with A-D10 showed significantly increased in bone formation parameters and decreased in serum triglyceride compared with the D30-treated rats. Conclusion Aspirin plus low-dose diethylstilbestrol can effectively prevent osteopenia by reducing bone resorption, and is thus a better treatment modality for preventing dyslipidemia than high-dose diethylstilbestrol alone.

关键词： Aspirin Diethylstilbestrol Ovariectomy Osteoporosis Dyslipidemia Rat

习近平文化思想对中国社会主义文化建设理论的创新

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北京交通大学学报（社会科学版） 2024年第1期23卷 1-7页

作者：孙成武吴玥东北师范大学马克思主义学部吉林长春130024

习近平文化思想从中国特色社会主义事业全局出发,站在实现中华民族伟大复兴的高度,着眼于中国文化建设具体实际,适应文化发展新要求,对新时代我国社会主义文化建设进行了系统深入的理论阐述,提出和阐明了新时代文化建设的总目标总任务... 详细信息

习近平文化思想从中国特色社会主义事业全局出发,站在实现中华民族伟大复兴的高度,着眼于中国文化建设具体实际,适应文化发展新要求,对新时代我国社会主义文化建设进行了系统深入的理论阐述,提出和阐明了新时代文化建设的总目标总任务、文化建设的地位和作用以及基本方针和战略举措等,在新时代背景下实现了对中国社会主义文化建设理论的又一次重大创新。

关键词：习近平文化思想社会主义文化建设理论创新

Dendritic Boundary Corrosion of AA2198 Weld Using Fiber Laser Welding with Al–Cu Filler Wire

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 735-741页

作者： Jun-Xia Lu ling Chang Shi-Kai wu Shi-Kun Yin Institute of Laser Engineering Beijing University of Technology

The microstructures and corrosion behaviors of AA2198-T851 alloy and weld were analyzed under corrosive conditions. Weld was formed using an innovative fiber laser welding process with AA2319 Al-Cu filler wire. The metallurgic morphology and distribution of the chemical compositions were determined using imaging techniques such as optical micrograph, scanning electron micrograph, high-resolution transmission electron microscopy, energy-dispersive X-ray spectrometry and X-ray diffraction. Corrosion was evaluated using an immersion test and electrochemical impedance spectroscopy in 3.5% NaC1 solution at room temperature. Results indicate that the parent alloy suffered from pitting corrosion during the initial 4-h immersion which was caused by the inhomogeneous distribution of its chemical compo- nents and the different intermetallics formed during the rolling process. The weld experienced dendritic boundary corrosion under the same conditions due to the addition of the Al-Cu filler and rapid solidification during laser welding, which led to the precipitates Cu enrichment along the grain boundary. When a welding joint was immersed in the solution for 5 days, a big crack was observed across the center of the weld. In comparison, there was good corrosion resistance in the heat- affected zone with a compact protective film.

关键词： 2198 Aluminum alloy. Fiber laser welding Dendritic boundary corrosion Al-Cu filler wire

Modifying temperature-related cardiovascular mortality through green-blue space exposure

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Environmental Science and Ecotechnology 2024年第4期20卷 269-277页

作者： Kejia Hu Shiyi Wang Fangrong Fei Jinglu Song Feng Chen Qi Zhao Yujie Shen Jingqiao Fu Yunquan Zhang Jian Cheng Jieming Zhong Xuchao Yang Jiayu wu School of Public Health Zhejiang UniversityHangzhou310058China Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province Hangzhou310058China College of Agriculture and Biotechnology Zhejiang UniversityHangzhou310058China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310051China Department of Urban Planning and Design Xi'an Jiaotong-Liverpool UniversitySuzhou215123China Zhejiang Institute of Meteorological Sciences Hangzhou310008China School of Public Health Shandong UniversityJinan250012China Ocean College Zhejiang UniversityZhoushan316021China School of Public Health Wuhan University of Science and TechnologyWuhan430065China School of Public Health Anhui Medical UniversityHefei230032China

Green-blue spaces(GBS)are pivotal in mitigating thermal ***,their management lacks guidelines rooted in epidemiological evidence for specific planning and *** we show how various GBS types modify the link between non-optimal temperatures and cardiovascular mortality across different thermal *** merged fine-scale population density and GBS data to create novel GBS exposure index.A case time series approach was employed to analyse temperature-cardiovascular mortality association and the effect modifications of type-specific GBSs across 1085 subdistricts in south-eastern *** findings indicate that both green and blue spaces may significantly reduce high-temperature-related cardiovascular mortality risks(e.g.,for low(5%)***(95%)level of overall green spaces at 99th *** mortality temperature(MMT),Ratio of relative risk(RRR)=1.14(95%CI:1.07,1.21);for overall blue spaces,RRR=1.20(95%CI:1.12,1.29)),while specific blue space types offer protection against cold temperatures(e.g.,for the rivers at 1st vs MMT,RRR=1.17(95%CI:1.07,1.28)).Notably,forests,parks,nature reserves,street greenery,and lakes are linked with lower heat-related cardiovascular mortality,whereas rivers and coasts mitigate cold-related cardiovascular *** spaces provide greater benefits than green *** severity of temperature extremes further amplifies GBS's protective *** study enhances our understanding of how type-specific GBS influences health risks associated with non-optimal temperatures,offering valuable insights for integrating GBS into climate adaptation strategies for maximal health benefits.

关键词： Green space Blue space Temperature Mortality China

Comparisons and applications of numerical simulation methods for predicting aerodynamic heating around complex configurations

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Acta Mechanica Sinica 2011年第3期27卷 339-345页

作者： Jin-ling Luo Hong-Lin Kang Jian Li wu-Ye Dai Northwestern Polytechnical University 710072 Xi'an China Beijing Electro-Mechanical Engineering Institute100074 Beijing China

Numerical simulation methods of aerodynamic heating were compared by considering the inuence of numerical schemes and turbulence models,and attempting to investigate the applicability of numerical simulation methods on predicting heat flux in engineering applications. For some typical cases provided with detailed experimental data,four spatial schemes and four turbulence models were adopted to calculate surface heat flux. By analyzing and comparing,some inuencing regularities of numerical schemes and turbulence models on calculating heat flux had been acquired. It is clear that AUSM＋-up scheme with rapid compressibilitymodified high Reynolds number k鈥撓？model should be appropriate for calculating heat flux. The numerical methods selected as preference above were applied to calculate the heat flux of a 3-D complex geometry in high speed turbulent flows. The results indicated that numerical simulation can capture the complex flow phenomena and reveal the mechanism of aerodynamic heating. Especially,the numerical result of the heat flux at the stagnation point of the wedge was well in agreement with the prediction of Kemp鈥揜iddel formula,and the surface heat flux distribution was consistent with experiment results,which implied that numerical simulation can be introduced to predict heat flux in engineering applications.

关键词： Aerodynamic heating . Complex configurations . Numerical simulation

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

CO_(2)腐蚀-应力耦合下固井水泥环密封完整性

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钻井液与完井液 2024年第2期41卷 220-230页

作者：武治强武广瑷幸雪松中海油研究总院有限责任公司北京100028

CO_(2)地质封存过程中,与地层围岩中的水反应后腐蚀着固井水泥环,腐蚀损伤和套管内压(应力)耦合作用极大地影响着水泥环的密封完整性。基于CO_(2)腐蚀实验,获得不同腐蚀程度水泥石材料力学性能参数,采用混凝土损伤塑性(CDP)本构模型和Mo... 详细信息

CO_(2)地质封存过程中,与地层围岩中的水反应后腐蚀着固井水泥环,腐蚀损伤和套管内压(应力)耦合作用极大地影响着水泥环的密封完整性。基于CO_(2)腐蚀实验,获得不同腐蚀程度水泥石材料力学性能参数,采用混凝土损伤塑性(CDP)本构模型和Mohor-Coulomb准则描述腐蚀前后水泥环的应力-应变行为,利用ABAQUS软件建立考虑CO_(2)腐蚀与应力耦合作用的井筒组合体(套管-水泥环-地层围岩)有限元分析模型,分析和探讨了套管内压和腐蚀时间对水泥环完整性的影响。结果表明,较高套管内压下,井筒水泥环发生弹塑性变形,出现结构损伤,套管与水泥环界面易形成微间隙;受腐蚀和套管内压的耦合作用,水泥环更易于出现完整性失效问题,相比较于未腐蚀水泥环,腐蚀水泥环受压后径向应力、等效塑性应变、微间隙以及拉伸和压缩损伤均较大,与之相反,塑性半径是减小的;微间隙与拉伸和压缩损伤受腐蚀时间的影响不明显。

关键词：水泥环 CO_(2)腐蚀密封完整性塑性变形微间隙

Imitation of drug metabolism in cell co-culture microcapsule model using a microfluidic chip platform coupled to mass spectrometry

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Chinese Chemical Letters 2020年第2期31卷 451-454页

作者： Yajing Zheng Zengnan wu Jin-Ming Lin ling Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

In this work,a multi-functional analysis platform by coupling a microfluidic chip to a mass spectrometry(MS) detector was *** constructed a three-dimensional tumor-endothelial co-culture model for simulating drug resistance during tumor *** this specially designed integrated platform,the first step was to prepare heterogeneous cell-encapsulated alginate microcapsules for threedimensional co-culture,and the second step was to achieve on-line perfusion culture and continuous drug stimulation on *** facilitates cell proliferation analysis and the collection of metabolism *** micro solid phase extraction column(SPE) pretreatment,subsequent mass spectrometry could detect drug *** high activity of two kinds of cells(A549 and HUVEC) shows the biocompatibility of the *** was used as a model drug,the distinctions of drug absorption between the mono-culture group and co-culture group were clearly observed by electrospray ionization quadrupole time-of-flight mass spectrometry(ESI-Q-TOF MS).Therefore,the integrated platform has shown promise as a high throughput,low cost for cell metabolism research and drug screening processes.

关键词： Microfluidic chip ESI-Q-TOF MS Co-culture Drug metabolism Droplet technique Hydrogel microcapsule

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小剂量阿司匹林在子痫前期预防中的研究进展

国际妇产科学杂志 2024年第5期51卷 515-518,524页

作者：邓玲玲伍绍文(审校) 张为远首都医科大学附属北京妇产医院/北京妇幼保健院急诊科 100026 首都医科大学附属北京妇产医院/北京妇幼保健院围产医学部 100026

阿司匹林(aspirin)具有抗炎、解热镇痛和抗血小板聚集等作用。研究表明妊娠期服用低剂量阿司匹林可以有效降低高危孕妇子痫前期(preeclampsia,PE)的发生,目前已广泛应用于临床。但关于阿司匹林应用标准目前国内外指南尚未达成共识,临床... 详细信息

阿司匹林(aspirin)具有抗炎、解热镇痛和抗血小板聚集等作用。研究表明妊娠期服用低剂量阿司匹林可以有效降低高危孕妇子痫前期(preeclampsia,PE)的发生,目前已广泛应用于临床。但关于阿司匹林应用标准目前国内外指南尚未达成共识,临床上可能存在扩大适应证或盲从使用的情况,无法达到预期理想效果。基于国内外指南及专家学者推荐意见,对小剂量阿司匹林(low-dose aspirin)预防PE的适用人群、用药时机、推荐剂量及用药过程中的注意事项等进行综述,以更好地指导临床工作。

关键词：先兆子痫阿司匹林妊娠,高危治疗准则