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Feasible Resolution of Angular Displacement Measurement by an Optical Angle Sensor Based on Laser Autocollimation

Nanomanufacturing and Metrology 2023年第4期6卷 46-59页

作者： Hyunsung Lim yuki shimizu Division of Mechanical and Aerospace Engineering Hokkaido UniversitySapporoJapan

The feasible resolution of angular displacement measurement by an optical angle sensor based on laser autocollimation is investigated.Improving the sensor sensitivity while maintaining the noise level of the sensor signal as low as possible is necessary to achieve high-resolution angular displacement measurement.In this paper,the contribution of each component,such as a photodiode,a trans-impedance amplifer,and an analog-to-digital converter in the optical angle sensor,to the noise level of the sensor signal is frst estimated on the basis of theoretical equations.The feasible sensitivity of the optical angle sensor is also estimated in numerical calculations.The sensitivity of a photodiode element at the edge of its photosensitive area is evaluated in experiments to realize the estimation of the angle sensor sensitivity.Experimental results are applied to the numerical calculations.The infuences of the measurement laser beam diameter,the spot diameter of the focused laser beam on the photosensitive area,and the focal length of the collimator objective of the optical angle sensor are also consid-ered in the numerical calculations.Finally,a prototype optical setup is developed.Experiments are performed to demonstrate that a compact optical angle sensor based on laser autocollimation with a collimator objective having a focal length shorter than 100 mm can achieve a resolution beyond 0.001 arc-second with a bandwidth of 1 kHz.This resolution is better than those achieved by commercial autocollimators employing an image sensor or a position-sensitive detector.The industrial contribution of this paper lies in the detailed breakdown of noise components in the readout signal of an angle sensor in a practical condition and the systematic estimation of its feasible resolution as well as its sensitivity.

关键词： Angle measurement Resolution Laser autocollimation Photodiode Signal noise

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High Resolution Clinometers for Measurement of Roll Error Motion of a Precision Linear Slide

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 8-16页

作者： yuki shimizu Satoshi Kataoka Wei Gao Department of Finemechanics Tohoku University

This paper proposes a new method for measurement of the roll error motion of a slide table in a precision linear slide. The proposed method utilizes a pair of clinometers in the production process of a precision linear slide, where the roll error motion measurement will be carried out repeatedly to confirm whether the surface form errors of slide guideways in the linear slide are su ciently corrected by hand scraping process. In the proposed method, one of the clinometers is mounted on the slide table, while the other is placed on a vibration isolation table, on which the precision linear slide is mounted, so that influences of external disturbances can be cancelled. An experimental setup is built on a vibration isolation table, and some experiments are carried out to verify the feasibility of the proposed method.

关键词： Linear slide Clinometer Rotational error motion measurement

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Self-calibration and Compensation of Setting Errors for Surface Profile Measurement of a Microstructured Roll Workpiece

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Chinese Journal of Mechanical Engineering 2014年第1期27卷 14-22页

作者： GAO Wei XU Bin TAKEISHI Toshiki SHIMIZU Yuki ITO So Department of Nanomechanics Tohoku University School of Manufacturing Science and Engineering Sichuan University

Microstructured roll workpieces have been widely used as functional components in the precision industries. Current researches on quality control have focused on surface profile measurement of microstructured roll workpieces, and types of measurement systems and measurement methods have been developed. However, low measurement efficiency and low measurement accuracy caused by setting errors are the common disadvantages for surface profile measurement of microstructured roll workpieces. In order to shorten the measurement time and enhance the measurement accuracy, a method for self-calibration and compensation of setting errors is proposed for surface profile measurement of microstructured roll workpieces. A measurement system is constructed for the measurement, in which a precision spindle is employed to rotate the roll workpiece and an air-bearing displacement sensor with a micro-stylus probe is employed to scan the microstructured surface of the roll workpiece. The resolution of the displacement sensor is 0.14 nm and that of the rotary encoder of the spindle was 0.15r~. Geometrical and mathematical models are established for analyzing the influences of the setting errors of the roll workpiece and the displacement sensor with respect to the axis of the spindle, including the eccentric error of the roll workpiece, the offset error of the sensor axis and the zero point error of the sensor output. Measurement experiments are carded out on a roll workpiece on which periodic microstructures are a period of 133 i^m along the circumferential direction. Experimental results demonstrate the feasibility of the self-compensation method. The proposed method can be used to detect and compensate the setting errors without using any additional accurate artifact.

关键词： measurement profile setting error self-calibration compensation microstructure roll workpiece

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Foreword to the Special Issue on Micro- and Nano-Metrology in Japan(I)

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Nanomanufacturing and Metrology 2021年第1期4卷 1-2页

作者： yuki shimizu Yasuhiro Mizutani Masaki Michihata Department of Finemechanics Tohoku UniversitySendai 9808579Japan Department of Mechanical Engineering Osaka UniversitySuita 5650871Japan Department of Precision Engineering The University of TokyoBunkyo 1138654Japan

Micro-and nano-metrology occupies an important position in modern production engineering where higher-precision machining is required.A visualization of the process is indispensable for the creation of new technologies in stateof-the-art manufacturing that deals with the geometrical quantity in micrometers/nanometers.Precision micro-and nano-metrology is thus becoming more and more important as the platform of various manufacturing technologies,as well as strategic tools for responding to rapidly changing fabrication techniques in many scientific and industrial fields.

关键词： metrology becoming Japan

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Laser Interference Lithography for Fabrication of Planar Scale Gratings for Optical Metrology

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Nanomanufacturing and Metrology 2021年第1期4卷 3-27页

作者： yuki shimizu Department of Finemechanics Tohoku University6-6-01Aramaki Aza-AobaAoba-kuSendaiMiyagi 980-8579Japan

Laser interference lithography is an attractive method for the fabrication of a large-area two-dimensional planar scale grating,which can be employed as a scale for multi-axis optical encoders or a diffractive optical element in many types of optical sensors.Especially,optical configurations such as Lloyd's mirror interferometer based on the division of wavefront method can generate interference fringe fields for the patterning of grating pattern structures at a single exposure in a stable manner.For the fabrication of a two-dimensional scale grating to be used in a planar/surface encoder,an orthogonal two-axis Lloyd's mirror interferometer,which has been realized through innovation to Lloyd’s mirror interferometer,has been developed.In addition,the concept of the patterning of the two-dimensional orthogonal pattern structure at a single exposure has been extended to the non-orthogonal two-axis Lloyd’s mirror interferometer.Furthermore,the optical setup for the non-orthogonal two-axis Lloyd's mirror interferometer has been optimized for the fabrication of a large-area scale grating.In this review article,principles of generating interference fringe fields for the fabrication of a scale grating based on the interference lithography are reviewed,while focusing on the fabrication of a two-dimensional scale grating for planar/surface encoders.Verification of the pitch of the fabricated pattern structures,whose accuracy strongly affects the performance of planar/surface encoders,is also an important task to be addressed.In this paper,major methods for the evaluation of a grating pitch are also reviewed.

关键词： Planar scale grating Interference lithography Lloyd’s mirror interferometer Interference fringe

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Recurrence of unilateral angioedema of the tongue:A case report

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世界临床病例杂志 2023年第27期11卷 6603-6612页

作者： yuki Matsuhisa Tsuneaki Kenzaka Hironori shimizu Hideo Hirose Tadao Gotoh Department of General Medicine Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Pediatrics Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan

BACKGROUND Angioedema is a disorder characterized by edema of the face,lips,tongue,and extremities due to increased vascular permeability.Angioedema of the tongue usually occurs bilaterally,and the incidence of unilateral angioedema of the tongue is rare.This study reports a rare case of unilateral angioedema of the tongue with no identifiable cause and repeated recurrence even after discontinuation of an angiotensin-converting enzyme inhibitor.CASE SUMMARY The patient was a 65-year-old woman with pre-existing hypertension and hyperlipidemia and had been receiving 20 mg/d of lisinopril.She was diagnosed with angioedema due to unilateral swelling of the tongue.No airway obstruction was observed,and the symptoms improved following the administration of 0.3 mg of epinephrine intramuscularly and 125 mg of methylprednisolone intravenously.Although lisinopril was discontinued,unilateral angioedema of the tongue continued to recur every 2-5 mo,with the symptoms improving following the administration of prednisolone and an antihistamine.Daily oral administration of 500 mg of tranexamic acid after dinner prevented the recurrence of angioedema.CONCLUSION Careful monitoring and identification of the underlying mechanism play a crucial role in the treatment of angioedema.

关键词： Angioedema Tongue Unilateral Bradykinin Tranexamic acid Case report

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Closed-Loop Control of an XYZ Micro-Stage and Designing of Mechanical Structure for Reduction in Motion Errors

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Nanomanufacturing and Metrology 2021年第1期4卷 53-66页

作者： Hiraku Matsukuma Keisuke Adachi Takuma Sugawara yuki shimizu Wei Gao Eiji Niwa Yoshihiro Sasaki Department of Finemechanics Graduate School of EngineeringTohoku UniversityMiyagiSendai 980-8579Japan Research Institute for Electromagnetic Materials 9-5-1 NaritaMiyagiTomiya 981-3341.Japan

This paper presents a compact XYZ micro-stage driven by an impact driving mechanism.A moving body is translationally actuated along the X-,Y-,and Z-axes in millimeter-scale range and with nanometer-scale resolution.Cr-N thin-film strain sensors are integrated into the micro-stage for closed-loop positioning.Closed-loop control is also carried out.The motion errors in six degrees of freedom are also investigated for this micro-stage.It is clarified by analysis of finite element method that rotational motion errors around the driving axis are caused by torques due to tensions from the elastic hinges of microstage.The mechanical structure of XYZ micro-stage to cancel out the torque generated is proposed and the second prototype is fabricated.Although the rotational motion error is successfully suppressed in the second prototype,a rotational motion error of more than 0.1°remains due to remaining torque and assembly error of the elastic hinges.Then,in order to reduce the rotational motion error,the prototype is designed in which the location of elastic hinges is single-layered.By designing a mechanical structure in which torque is suppressed,all rotational motion errors are successfully reduced to less than 0.05°in the prototype with single-layer hinges.

关键词： XYZ micro-stage Cr-N thin-film displacement sensor Closed-loop positioning Impact drive Friction drive

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Effects of ADH1C, ALDH2, and CYP2A6 Polymorphisms on Individual Risk of Tobacco-Related Lung Cancer in Male Japanese Smokers

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Journal of Cancer Therapy 2013年第8期4卷 29-35页

作者： Makiko shimizu yuki Ishii Maho Okubo Hideo Kunitoh Tetsuya Kamataki Hiroshi Yamazaki Mitsui Memorial Hospital Chiyoda-ku Tokyo Japan Showa Pharmaceutical University Machida Tokyo Japan

Recent genome-wide association studies have identified several lung cancer susceptibility loci. We previously carried out a replication study in male Japanese smokers that focused on chromosome 5p15 (telomerase reverse transcriptase) and 3q28 (tumor protein p63) (shimizu et al., Journal of Cancer Therapy, Vol. 2, No. 5, 2011, pp. 690-696). The current study was performed to confirm the association of traditional susceptibility loci [i.e., alcohol dehydrogenase 1C (ADH1C) and aldehyde dehydrogenase 2 (ALDH2)] in 1039 male Japanese smokers (573 lung cancer patients and 466 healthy control subjects) who were previously enrolled in a study to investigate the low odds ratio for lung cancer risk associated with functionally impaired and deletion polymorphisms in cytochrome P450 2A6 (CYP2A6). The minor allele frequency of rs671 in ALDH2 (0.304) was significantly higher in lung cancer cases than in controls (0.226), with an odds ratio of 1.42 [95% confidence interval (CI) of 1.12 - 1.80, p = 0.0033]. No significant association of rs698 in ADH1C with lung cancer risk was found in this population of male Japanese smokers. For light smokers categorized according to the 50th percentile Brinkman index value among the control subjects (620 daily cigarettes × years) and for the CYP2A6*1 wild-type non-carrier sub-population, significantly high odds ratios of 1.98 and 1.68 (95% CI of 1.28 - 3.06, p = 0.0022, and 1.07 - 2.66, p = 0.025), respectively, were observed for rs671 in ALDH2. The present results support the association of ALDH2 loci with lung cancers and suggest a specific effect of ALDH2 loci resulting in a higher risk of lung cancer in light smokers. CYP2A6 polymorphisms, including copy number polymorphisms, may lower the risk of heavy tobacco use-related lung cancer.

关键词： Alcohol Dehydrogenase 1C Aldehyde Dehydrogenase 2 Cytochrome P450 2A6 Lung Cancer Tobacco

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Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus

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World Journal of Hepatology 2022年第6期14卷 1226-1234页

作者： Ryosuke Yamane Kentaro Yoshioka Kazuhiko Hayashi Yuko shimizu yuki Ito Komei Matsushita Michiyo Yoshizaki Go Kajikawa Taro Mizutani Atsuko Watarai Kosuke Tachi Hidemi Goto Department of Gastroenterology and Hepatology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Center for Liver Diseases Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Department of Diabetes and Endocrinology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan

BACKGROUND Type 2 diabetes mellitus(T2DM)is a risk factor for nonalcoholic fatty liver disease(NAFLD).AIM To determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with T2DM.METHODS Four hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography(CT)were assessed.The mean age was 74±13 years,and 269 were men.Hepatic attenuation minus splenic attenuation(CTL−S)less than 1 Hounsfield unit was considered fatty liver.NAFLD was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection.A multiple logistic regression was used to assess the independent factors associated with NAFLD.RESULTS NAFLD was identified in 25.2%of the participants.Young age(odds ratio[OR]=−0.945;95%confidence interval[CI]:0.922–0.969),higher hemoglobin levels(OR=1.501,95%CI:1.278–1.764),lower high-density lipoprotein(HDL)cholesterol levels(OR=0.971,95%CI:0.953–0.989),and the absence of dialysis(OR=0.109,95%CI:0.014–0.856)were independent predictors of NAFLD.CONCLUSION NAFLD was detected with CT in 25.2%of the participants.NAFLD was associated with younger age,higher hemoglobin levels,lower HDL cholesterol levels,and an absence of dialysis.

关键词： Age Computed tomography Dialysis Hemoglobin Nonalcoholic fatty liver disease Type 2 diabetes mellitus

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Optimization of body configuration and joint-driven attitude stabilization for transformable spacecraft under solar radiation pressure

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Astrodynamics 2024年第1期8卷 47-60页

作者： yuki Kubo Toshihiro Chujo Institute of Space and Astronautical Science Japan Aerospace Exploration AgencyKanagawa252-5210Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo152-8550Japan

The solar sail is one of the most promising space exploration systems due to its theoretically infinite specific impulse achieved through solar radiation pressure(SRP).Recently,researchers have proposed“transformable spacecraft”capable of actively reconfiguring their body configurations using actuatable joints.Transformable spacecraft,if used similarly to solar sails,are expected to significantly enhance orbit and attitude control capabilities owing to their high redundancy in control degrees of freedom.However,controlling them becomes challenging due to their large number of inputs,leading previous researchers to impose strong constraints to limit their potential control capabilities.This study focuses on novel attitude control techniques for transformable spacecraft under SRP.We developed two methods,namely,joint angle optimization to obtain arbitrary SRP force and torque,and momentum damping control driven by joint angle actuation.Our proposed methods are formulated in a general manner and can be applied to any transformable spacecraft comprising front faces that can predominantly receive the SRP on each body.The validity of our proposed method is confirmed through numerical simulations.Our study contributes to making most of the high control redundancy of transformable spacecraft without the need for expendable propellants,thus significantly enhancing the orbit and attitude control capabilities.

关键词： solar sail transformable spacecraft attitude-joint coupled motion attitudestabilization

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