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Advance in Nicotine to Nornicotine Conversion in Tobacco

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烟草科技 2004年第11期37卷 17-22页

作者： shihong-zhi ZhengzhouTobaccoResearchInstituteofCNTC 88ErqiRoadZhengzhouChina

Nicotine to nornicotine conversion in cultivated tobacco was reviewed in four aspects, including the effect on TSNAs formation and flavor quality, genetic control and biochemical process, conversion frequency and time... 详细信息

关键词：烟草制品降烟碱工艺生产技术烟草工业

早产孕妇外周血、脐血及胎膜组织中S100钙结合蛋白A12表达及其与亚临床绒毛膜羊膜炎的关系

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中国妇产科临床杂志 2016年第6期17卷 523-525页

作者：崔世红职云晓张林东陈娟申琳娜高亚南赵志英郑州大学第三附属医院妇产科 450052

目的探讨S100钙结合蛋白A12(S100A12)在早产孕妇外周血、脐血及胎膜组织中的表达及其与亚临床绒毛膜羊膜炎(subclinical chorioamnionitis,HCA)的关系。方法选择早产临产孕妇46例,根据产后胎膜病理结果是否合并亚临床绒毛膜羊膜炎,分为... 详细信息

目的探讨S100钙结合蛋白A12(S100A12)在早产孕妇外周血、脐血及胎膜组织中的表达及其与亚临床绒毛膜羊膜炎(subclinical chorioamnionitis,HCA)的关系。方法选择早产临产孕妇46例,根据产后胎膜病理结果是否合并亚临床绒毛膜羊膜炎,分为感染组(n=21)与未感染组(n=25)。采用ELISA法检测两组孕妇外周血、脐血中S100A12水平;逆转录RT-PCR法检测胎膜组织中S100A12 m RNA表达水平。结果感染组孕妇外周血、脐血、胎膜组织中S100A12水平[(173.30±18.92)、(105.71±8.72)、(1.38±0.37)]与未感染组[(138.26±11.02)、(88.26±7.00)、(1.07±0.15)]比较,差异有统计学意义(P<0.05);感染组孕妇外周血中S100A12水平与脐血及胎膜组织中S100A12水平均呈正相关(r=0.861,0.883;P<0.05);感染组新生儿感染发病率(86%,18/21)高于未感染组(56%,14/25)(P<0.05)。结论孕妇外周血、脐血、胎膜组织中S100A12表达水平升高,可能与合并亚临床绒毛膜羊膜炎及新生儿感染有关。

关键词：早产亚临床绒毛膜羊膜炎 S100钙结合蛋白A12 新生儿

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泛等时线法同位素定年的理论构想

科教文汇 2016年第29期 182-183页

作者：侯广顺李冉向世红支风岐齐永安吴成斌河南理工大学资源环境学院河南焦作454003 河南省有色金属地质勘查总院河南郑州450052

等时线法同位素定年是经典的地质年代学方法,并衍生出内部等时线和亚样品等时线等方法。根据等时线法的基本原理及前提条件,本文提出了泛等时线定年的理论构想。以Rb-Sr法为例,可以证明,用矿物+全岩构建的内部等时线与全岩等时线属于同... 详细信息

等时线法同位素定年是经典的地质年代学方法,并衍生出内部等时线和亚样品等时线等方法。根据等时线法的基本原理及前提条件,本文提出了泛等时线定年的理论构想。以Rb-Sr法为例,可以证明,用矿物+全岩构建的内部等时线与全岩等时线属于同一直线方程。用某一样品的单矿物外加其他若干全岩样品也能构成等时线。这种泛等时线可以结合不同等时线法定年的优点,避免其缺点,更有利于定年。

关键词：等时线法定年全岩等时线内部等时线泛等时线

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病

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Science Bulletin 2024年第8期69卷 1137-1152页

作者：苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝 Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430030China Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Department of Physiology and PathophysiologySchool of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453003China Department of Pathophysiology School of Basic Medical SciencesWuhan UniversityWuhan 430030China Department of Anesthesiology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China The Core Facility and Technical Support Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430030China Research Center for Medicine and Structural Biology Wuhan UniversityWuhan 430030China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesPeking UniversityKey Laboratory for NeuroscienceMinistry of Education/National Health CommissionBeijing 100083China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other *** elimination of hyperphosphorylated tau is promising for the therapy of these *** have conceptualized a strategy,named dephosphorylation-targeting chimeras(DEPTACs),for specifically hijacking phosphatases to tau to debilitate its ***,we conducted the step-by-step optimization of each constituent motif to generate DEPTACs with reasonable effectiveness in facilitating the dephosphorylation and subsequent clearance of pathological ***,for one of the selected chimeras,D16,we demonstrated its significant efficiency in rescuing the neurodegeneration caused by neurotoxic K18-tau seeds in ***,intravenous administration of D16 also alleviated tau pathologies in the brain and improved memory deficits in AD *** results suggested DEPTACs as targeted modulators of tau phosphorylation,which hold therapeutic potential for AD and other tauopathies.

关键词： tau Dephosphorylation-targeting chimeras Therapeutic potential Tauopathy

A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

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Translational Neurodegeneration 2023年第1期12卷 154-169页

作者： Yang Gao Yuying Wang Huiyang Lei Zhendong Xu shihong Li Haitao Yu Jiazhao Xie Zhentao Zhang Gongping Liu Yao Zhang Jie Zheng Jian-zhi Wang Department of Pathophysiology Key Laboratory of Ministry of Education for Neurological DisordersSchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430030China Key Laboratory of Ministry of Education for Neurological Disorders Department of EndocrineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health CommissionPeking UniversityBeijing 100083China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease(AD).However,mouse models imitating AD-exclusive neuronal tau pathologies are *** We generated a new tet-on transgenic mouse model expressing truncated human tau N1-368(termed hTau368),a tau fragment increased in the brains of AD patients and aged mouse ***(dox)was administered in drinking water to induce hTau368 *** and Western blotting were performed to measure the tau *** sequencing was performed to evaluate gene expression,and several behavioral tests were conducted to evaluate mouse cognitive functions,emotion and *** Dox treatment for 1-2 months at a young age induced overt and reversible human tau accumulation in the brains of hTau368 transgenic mice,predominantly in the ***,the transgenic mice exhibited AD-like high level of tau phosphorylation,glial activation,loss of mature neurons,impaired hippocampal neurogenesis,synaptic degeneration and cognitive *** This study developed a well-characterized and easy-to-use tool for the investigations and drug development for AD and other tauopathies.

关键词： Alzheimer’s disease Animal model Tau hyperphosphorylation Truncated tau Tet-on system

稻田CH_4和N_2O综合排放对控制灌溉的响应

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农业工程学报 2012年第13期28卷 121-126页

作者：彭世彰侯会静徐俊增杨士红茆智河海大学水文水资源与水利工程科学国家重点实验室南京210098 河海大学水利水电学院南京210098 武汉大学水利水电学院武汉430072

为了揭示水稻控制灌溉对稻田CH4和N2O综合排放的影响,该文采用静态暗箱-气相色谱法对控制灌溉稻田CH4和N2O排放进行原位观测,分析稻田CH4和N2O综合排放对控制灌溉水分调控的动态响应。结果表明,控制灌溉稻田CH4排放通量多低于常规灌溉稻... 详细信息

为了揭示水稻控制灌溉对稻田CH4和N2O综合排放的影响,该文采用静态暗箱-气相色谱法对控制灌溉稻田CH4和N2O排放进行原位观测,分析稻田CH4和N2O综合排放对控制灌溉水分调控的动态响应。结果表明,控制灌溉稻田CH4排放通量多低于常规灌溉稻田,且主要集中在水稻分蘖前期,峰值出现在土壤脱水后第1～2d,排放总量较常规灌溉稻田减少81.2%～82.8%;N2O排放通量多高于常规灌溉稻田,峰值出现在肥后且土壤脱水后3～4d,排放总量较常规灌溉稻田增加了121.8%～144.3%。控制灌溉稻田CH4和N2O的综合全球增温潜势较常规灌溉稻田显著减少(p<0.05),减少幅度为15.0%～34.8%。控制灌溉显著降低了稻田CH4和N2O的综合温室效应。

关键词：灌溉节水温室效应排放 CH4 N2O 稻田

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涡轮叶片尾缘复合通道的换热

北京航空航天大学学报 2005年第2期31卷 202-205页

作者：李莉丁水汀陶智徐国强赵世红北京航空航天大学能源与动力工程学院北京100083

采用热色液晶测温法 ,测量了涡轮叶片尾缘带隔板的复合通道的温度场 ,分析了射流冲击强化扰流柱通道内换热的机理 ,讨论了两通道间隔板的不同开孔结构对换热的影响 .从工程应用的角度出发提出了几个换热评价指标 ,对不同开孔结构的隔板... 详细信息

采用热色液晶测温法 ,测量了涡轮叶片尾缘带隔板的复合通道的温度场 ,分析了射流冲击强化扰流柱通道内换热的机理 ,讨论了两通道间隔板的不同开孔结构对换热的影响 .从工程应用的角度出发提出了几个换热评价指标 ,对不同开孔结构的隔板进行了换热评价 .结果表明 :冷气由第 1通道进入 ,通过隔板上的孔不断由径向流动变为弦向流动后 ,对第 2通道的扰流柱区形成冲击 ,最后由劈缝排出 ,提高了尾缘的换热 ;开孔均匀的隔板换热效果相对较好 .

关键词：换热隔板液晶孔

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百年回顾:出土法律文献与秦汉令研究

上海师范大学学报（哲学社会科学版） 2011年第5期40卷 69-79页

作者：徐世虹中国政法大学法律古籍整理研究所北京100088

令作为中国古代法律重要的法源形式之一,自中国法制史研究之始即为学者关注。以沈家本、程树德为代表的早期辑佚复原、考证研究,开启了秦汉令的研究领域,为秦汉律令体系的构建奠定了基础。此后中田薰又将汉令研究推向一个新阶段。百年... 详细信息

令作为中国古代法律重要的法源形式之一,自中国法制史研究之始即为学者关注。以沈家本、程树德为代表的早期辑佚复原、考证研究,开启了秦汉令的研究领域,为秦汉律令体系的构建奠定了基础。此后中田薰又将汉令研究推向一个新阶段。百年来出土简牍的不断问世,丰富了秦汉令的资料来源,人们对汉令的形式、结构、性质及令的分化、律令转化、令的立法程序予以全面探讨,成果迭见,秦汉令研究呈现一个新局面。但由于对出土文献的认识及基本概念的解析各不相同,有关秦汉时有无令典,挈令的形态究竟如何,干支令、挈令、事项令的关系如何,令分甲乙丙的标准为何,对秦汉令的法律地位应当如何判断,如何定位它在中国法律史发展过程的作用,仍有待新资料的披露及研究的进一步深入。

关键词：出土法律文献简牍秦汉令研究历程

Pigsties near dwellings as a potential risk factor for the prevalence of Japanese encephalitis virus in adult in Shanxi,China

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Infectious Diseases of Poverty 2017年第1期6卷 900-910页

作者： Xiaojie Ren shihong Fu Peifang Dai Huanyu Wang Yuanyuan Li Xiaolong Li Wenwen Lei Xiaoyan Gao Ying He zhi Lv Jingxia Cheng Guiqin Wang Guodong Liang Department of Immunology and Microbiology Shanxi Medical UniversityTaiyuan 030001China State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310058China Shanxi Center for Disease Control and Prevention Taiyuan 030001China

Background:The increasing trend of adult cases of Japanese encephalitis(JE)in China,particularly in northern China,has become an important public health *** conducted an epidemiological investigation in the south of Shanxi Province to examine the relationships between mosquitoes,Japanese encephalitis virus(JEV),and adult JE ***:Mosquito specimens were collected from the courtyards of farmers’households and pig farms in Shanxi *** were pooled,homogenized,and *** transcription-polymerase chain reaction(RT-PCR)was used to detect mosquito-borne arbovirus genes in *** positive for these genes were inoculated into the baby hamster kidney cell line(BHK-21)to isolate *** infection rate was calculated and phylogenetic analyses were ***:A total of 7943 mosquitoes belonging to six species in four genera were collected;Culex tritaeniorhynchus accounted for 73.08%(5805/7943),*** pallens for 24.75%(1966/7943),and the remaining 3%(104/7943)consisted of Anopheles sinensis,Aedes vexans,***,and Armigeres *** pools were positive for JEV based on RT-PCR using JEV pre-membrane gene nested *** analyses showed that all JEVs belonged to genotype I;two pools were positive using Getah Virus(GETV)gene *** addition,one JEV strain(SXYC1523)was isolated from *** pallens *** results indicate that the minimum infection rate of JEV in mosquito specimens collected from the courtyards of farmers’households with pigsties was 7.39/1000;the rate for pig farms was 2.68/1000;and the rate for farmers’courtyards without pigsties was ***:The high-prevalence regions of adult JE investigated in this study are still the natural epidemic focus of *** pigsties near dwellings is a potential risk factor contributing to the prevalence of adult *** prevent the occurrence of local adult JE cases,a recommendation was raised that,besides con

关键词： Adult Japanese encephalitis Epidemic disease Mosquito-borne arbovirus Japanese encephalitis virus