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Tangled but ordered human mitochondrial tRNA maturation

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Science China Life Sciences 2025年

作者： shi-Ying Yao xiao-Long Zhou Key Laboratory of RNA Innovation Science and Engineering CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences

Mitochondria are cellular organelles that originate from an endosymbiotic bacterial ancestor and are primarily responsible for ATP generation via oxidative phosphorylation (OXPHOS). OXPHOS is conducted by five mitochondrial respiratory complexes in the inner mitochondrial membrane. Human mitochondria possess a distinct genome, a small, circular, doublestranded DNA (mtDNA) of 16,569 base pairs.

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船舶企业人力资源管理方法探究

中小企业管理与科技 2022年第5期6卷 37-39页

作者：施晓越南通润邦海洋工程装备有限公司江苏启东226200

船舶企业具有典型的劳动密集型产业特征,人才是船舶企业长远稳定发展的基础。近年来,船舶企业高度重视对人才的挖掘、培养与使用。论文运用调查法、分析法对船舶企业人力资源管理现状与管理方法进行深入的探究与论述,重点就如何优化企... 详细信息

船舶企业具有典型的劳动密集型产业特征,人才是船舶企业长远稳定发展的基础。近年来,船舶企业高度重视对人才的挖掘、培养与使用。论文运用调查法、分析法对船舶企业人力资源管理现状与管理方法进行深入的探究与论述,重点就如何优化企业人力资源管理提出几点建议,以期为相关工作提供些许帮助。

关键词：船舶企业人力资源管理管理现状管理方法

Upcycling of polyethylene terephthalate to1,4-cyclohexanedimethanol in water

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Science China Chemistry 2025年

作者： Shuhui Fang Zhiwen Gao Xinrui shi Min Zhang Wei Zhang yue Liu State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University Engineering Center for Sustainable Carbon Science and Technology East China Normal University Institute of Eco-Chongming

The recycling of waste polyethylene terephthalate（PET）, an extensively used polymer as plastic and fiber materials, has become an urgent topic due to the rapid generation and accumulation of plastic waste into the environment. Current chemical recycling approaches to depolymerize and convert PET into 1,4-cyclohexanedimethanol（CHDM）, an important chemical in the production of advanced polyesters, predominantly use organic solvents, such as alcohols or dioxane. Herein, we developed an environmentally friendly and economically viable pathway for converting PET to CHDM using water as the solvent. In this process, PET is sequentially hydrolyzed in water, hydrogenated to 1,4-cyclohexane dicarboxylic acid（CHDA）, and then reduced to CHDM. The PET conversion rate is self-enhanced in aqueous medium via acid-catalyzed hydrolysis by the generated CHDA intermediate. A Pd-based catalyst（e.g., Pd/C） selectively hydrogenates the arene ring of the PET monomer, terephthalic acid intermediate, and a Ru-Sn/C bimetallic catalyst reduces its COOH to CH2OH group. At optimized reaction conditions, a complete conversion of PET and 80.1% yield of CHDM are obtained. Alternatively, this approach can also efficiently produce CHDA from PET, with a yield up to 86.4%.

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing Chen Huatian shi yue Wei Gui Chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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电能智能管理可视化控制系统

电力系统装备 2019年第18期 8-9页

作者：戴军施晓越南通润邦海洋工程装备有限公司江苏启东226255

随着我国电力行业的不断发展与完善,电能的管理工作开始逐渐偏向于节能环保,而且资源上的节省也是我国在新时代中的基本发展国策,同时寻求资源上的节约也是诸多科技企业的科学发展观,而对于一些制造型企业而言,生产过程中不可避免地会... 详细信息

随着我国电力行业的不断发展与完善,电能的管理工作开始逐渐偏向于节能环保,而且资源上的节省也是我国在新时代中的基本发展国策,同时寻求资源上的节约也是诸多科技企业的科学发展观,而对于一些制造型企业而言,生产过程中不可避免地会涉及到大量的能源消耗,而且其中对电能的使用占比尤其大,因此不少制造企业为响应国家的号召,开始引进了电力方面的技术人才,成立了专门的节能办公室,对企业内部的一些电力设备进行了改造,逐渐将过去传统的供配电方式进行了整改,以期能够做到科学用电,合理配置.

关键词：电能智能管理可视化控制系统

含抑制弧和测试弧Petri网的建模及其行为分析

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系统仿真学报 2008年第S2期20卷 76-81,89页

作者：刘石坚乐晓波邹峥长沙理工大学计算机与通信工程学院长沙410076

由于原型Petri网在一些实际应用中不能满足设计的需要,人们在其概念上进行扩充形成了增广的Petri网。带抑制弧和带测试弧的Petri网正是其中的一种。分析总结了带测试弧Petri网的基本行为特征。针对零检测装置以及FIFO栈实例,应用测试弧... 详细信息

由于原型Petri网在一些实际应用中不能满足设计的需要,人们在其概念上进行扩充形成了增广的Petri网。带抑制弧和带测试弧的Petri网正是其中的一种。分析总结了带测试弧Petri网的基本行为特征。针对零检测装置以及FIFO栈实例,应用测试弧、抑制弧对系统进行了合理的建模与分析。

关键词：测试弧抑制弧建模零检测装置 FIFO栈

气相色谱-热能分析仪法测定缬沙坦及其制剂中的N-二甲基亚硝胺

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药物分析杂志 2019年第8期39卷 1501-1505页

作者：咸瑞卿巩丽萍邢晟石晓玥胡德福石峰山东省食品药品检验研究院济南250101 中国药科大学南京210009

目的:建立气相色谱-热能分析法(GC-TEA法)检测缬沙坦原料药及其制剂中N-二甲基亚硝胺(NDMA)含量。方法:色谱条件,采用INERTROAP-WAX(30 m×0.32 mm×0.5μm)毛细管气相色谱柱,柱温为程序升温(初始温60℃,保持2 min,以10℃·min^-1升至12... 详细信息

目的:建立气相色谱-热能分析法(GC-TEA法)检测缬沙坦原料药及其制剂中N-二甲基亚硝胺(NDMA)含量。方法:色谱条件,采用INERTROAP-WAX(30 m×0.32 mm×0.5μm)毛细管气相色谱柱,柱温为程序升温(初始温60℃,保持2 min,以10℃·min^-1升至120℃,保持1 min,以50℃·min^-1升至200℃,保持2 min),进样口温度230℃,不分流进样,进样量0.5μL;热能分析仪条件,接口温度250℃,热解室温度500℃,真空度59.85~66.5 Pa,氧气压力13.79 kPa;臭氧水平244(22.8 V)。结果:方法的专属性强,N-二甲基亚硝胺质量浓度在10~1 000 ng·m L^-1的范围内呈线性(r=1.000,n=8),检测下限为3 ng·m L^-1;13批样品中NDMA含量为0~87.09×10^-6。结论:本方法可用于缬沙坦及其制剂中的NDMA检测。

关键词：缬沙坦 N-二甲基亚硝胺气相色谱热能分析仪

马克思历史前提决定论及其中国式现代化创新形态

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河北学刊 2025年第1期45卷 37-46页

作者：肖士英陕西师范大学哲学学院

前提是事物演化及人行动的先决条件与基础。决定是一事物限定另一事物,使后者统一于前者的过程。《德意志意识形态》关于“全部人类历史的第一个前提无疑是有生命的个人的存在”的命题,把“有生命的个人的存在”判定为在全部人类历史中... 详细信息

前提是事物演化及人行动的先决条件与基础。决定是一事物限定另一事物,使后者统一于前者的过程。《德意志意识形态》关于“全部人类历史的第一个前提无疑是有生命的个人的存在”的命题,把“有生命的个人的存在”判定为在全部人类历史中居于统摄性、总揽性、贯穿性地位的决定力量,把生成该历史前提判定为全部人类历史的内涵,把该历史前提得以可能的内在要求及其满足活动的范围判定为全部人类历史的外延,从而基于此建构起了作为马克思历史决定论本然形态的历史前提决定论,有效地消解了马克思历史决定论被误解和攻击的诱因。中国特色社会主义现代化事业进入新时代,以“人民至上”统摄其全部内容和过程,把“人民的存在发展”确立为新历史时代得以可能的前提,建构起了“人民的存在发展”取向的历史前提决定论,形成了马克思历史前提决定论的中国式现代化创新形态。

关键词：马克思历史前提决定论中国式现代化人民的存在发展