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A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces

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Chinese Journal of Natural Medicines 2021年第7期19卷 551-560页

作者： GU Min YUAN Yi-Ping QIN Zi-nan XU Yan shi nan-nan WANG Yan-Ping ZHAI Hua-Qiang QIAN Zhong-Zhi Standardization Research Center of Traditional Chinese Medicine Dispensing Beijing University of Chinese MedicineBeijing 102488China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China National Pharmacopoeia Commission Beijing 100061China

The quality control of Chinese herbal medicine is a current challenge for the internationalization of traditional Chinese *** quality evaluation methods lack quantitative analysis,while modern quality evaluation methods ignore the origins and appearance ***,an integrated quality evaluation method is urgent in *** Rehmanniae Radix(RRR)is commonly used in Chinese herbal *** present,much attention has been drwan towards its quality control,which however is limited by the existing quality evaluation *** present study was designed to establish a comprehensive and practical method for the quality evaluation and control of RRR pieces based on its chemical constituents,appearance traits and ***-three batches of RRR pieces were collected from six provinces,while high-performance liquid chromatography(HPLC)was applied to determine the following five constituents,including catalpol,rehmannioside A,rehmannioside D,leonuride and verbascoside in RRR *** appearance traits were quantitatively ***,correlation analysis,principal components analysis(PCA),cluster analysis and t-test were performed to evaluate the qualities of RRR *** batches of RRR pieces were divided into three categories:samples from Henan province,samples from Shandong and Shanxi provinces,and those from other ***,the chemical constituents and appearance traits of RRR pieces were significantly different from diverse *** combined method of chemical contituents,appearance traits and origins can distinguish RRR pieces with different qualities,which provides basic reference for the quality control of Chinese herbal medicine.

关键词： Bioactive constituents Raw Rehmanniae Radix Quality evaluation Appearance traits Different origins

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Evidence-Based Chinese Medicine Clinical Practice Guideline for Stomach Pain in Hong Kong

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Chinese Journal of Integrative Medicine 2017年第10期23卷 793-800页

作者： ZHONG Linda LD shi nan-nan DAI Liang ZIEA Tat Chi NG Bacon TANG Xu-dong BIAN Zhao-xiang LU Ai-ping Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University Hong Kong SAR China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Institute of Basic Research in Clinical Medicine China Academy of Traditional Chinese Medicine Beijing (100091) China Department of Chinese Medicine Hong Kong Hospital Authority Hong Kong SAR China Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing (100091) China

Stomach pain in Chinese medicine（CM） is a very common disorder in clinical practice and it has been listed as one of the pilot three conditions in Hong Kong to develop evidence-based CM clinical practice guidelines（CM CPGs）. The aim of this stomach Pain CPG is to summarize the treatment methods of stomach pain with CM and evaluate reasonably, then to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we defined stomach pain in CM and the category of chronic gastritis in Western medicine. The clinical manifestation, CM pattern classification, and CM intervention including herbal medicine treatment based on pattern differentiation, symptomatic treatment, acupuncture treatment, regulation and nursing were illustrated.

关键词： clinical practice guideline Chinese medicine pattern Chinese herbal medicine stomach pain

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Qingfei Paidu Decoction for COVID-19: A Bibliometric Analysis

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Biomedical and Environmental Sciences 2021年第9期34卷 755-760页

作者： LIU Si Hong MA Yan shi nan nan TONG Lin ZHANG Lei CHEN Ren Bo FAN Yi Pin JI Xin Yu GE You Wen ZHANG Hua Min WANG Yan Ping WANG Yong Yan Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Traditional Chinese medicine(TCM)has been used for thousands of years in fighting epidemics and has achieved remarkable therapeutic effects[1].The coronavirus disease 2019(COVID-19)pandemic has been effectively contro... 详细信息

关键词： medicine(TCM) Decoction Qing

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Current Situation of International Organization for Standardization/Technical Committee 249 International Standards of Traditional Chinese Medicine

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Chinese Journal of Integrative Medicine 2017年第5期23卷 376-380页

作者： Liu Yu-qi WANG Yue-xi shi nan-nan HAN Xue-jie LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences School of Chinese medicine Hong Kong Baptist University

Objective： To review the current situation and progress of traditional Chinese medicine（TCM） international standards, standard projects and proposals in International Organization for Standardization（ISO）/technical committee（TC） 249. Methods： ISO/TC 249 standards and standard projects on the ISO website were searched and new standard proposals information were collected from ISO/TC 249 National Mirror Committee in China. Then all the available data were summarized in 5 closely related items, including proposed time, proposed country, assigned working group（WG）, current stage and classification. Results： In ISO/TC 249, there were 2 international standards, 18 standard projects and 24 new standard proposals proposed in 2014. These 44 standard subjects increased year by year since 2011. Twenty-nine of them were proposed by China, 15 were assigned to WG 4, 36 were in preliminary and preparatory stage and 8 were categorized into 4 fields, 7 groups and sub-groups based on International Classification Standards. Conclusion： A rapid and steady development of international standardization in TCM can be observed in ISO/TC 249.

关键词： International Organization for Standardization/Technical Committee 249 international standards traditional Chinese medicine

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A Case Series of Olfactory Dysfunction in Imported COVID-19 Patients:A 12-Month Follow-Up Study

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Biomedical and Environmental Sciences 2022年第5期35卷 402-411页

作者： WANG Ni YANG Ming Bo YANG Pu Ye CHEN Ren Bo HUANG Fei shi nan nan MA Yan ZHANG Yan XU You LIU Si Hong LU Heng Yi FU Qing Qing FAN Yi Pin KAN Hong Min WANG Xiao Hong GUO Ya Ling National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hepatology Department of TCM Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Department of Integrated Chinese and Western Medicine Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Infection Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported *** A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, ***, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month *** Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent *** Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.

关键词： COVID-19 Olfactory Imported cases Hyposmia Anosmia Follow-up

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城市不同空间通勤行为可转移性研究

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交通运输系统工程与信息 2017年第3期17卷 205-212页

作者：刘灿齐史楠楠诸立超同济大学交通运输工程学院道路与交通工程教育部重点实验室上海201804 浙江财经大学工商管理学院杭州310018

通勤者因地域及个体特征差异造成选择行为显著不同,本文旨在识别这一差异并揭示城市不同空间通勤行为的可转移性.在分析上海市通勤出行行为影响因素基础上,建立融入OD(Origin and Destination)变量的全空间及分OD空间的通勤方式选择模型... 详细信息

通勤者因地域及个体特征差异造成选择行为显著不同,本文旨在识别这一差异并揭示城市不同空间通勤行为的可转移性.在分析上海市通勤出行行为影响因素基础上,建立融入OD(Origin and Destination)变量的全空间及分OD空间的通勤方式选择模型,依据转移度量指标研究通勤出行模型空间可转移性.结果表明:全空间模型不能准确揭示不同出行空间通勤行为差异,除全空间模型可转移至内环外—内环内出行空间外,其他空间模型均不可转移;此外,各空间通勤者更偏好常规公交、地铁,且不同出行空间通勤者偏好存在显著差异.

关键词：综合交通运输通勤出行离散选择空间可转移性

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Community assembly of ectomycorrhizal fungi along a subtropical secondary forest succession

Community assembly of ectomycorrhizal fungi along a subtropi...

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第十二届海峡两岸真菌学学术研讨会

作者： Guo,Liang-Dong Gao,Cheng Zhang,Yu shi,nan-nan Zheng,Yong State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences

＜正＞Assembly of mutualistic microbial community should be strongly correlated with plant community,but little is known about the dynamics of microbial community assembly during forest *** this study,functionally important root-associated microorganisms,ectomycorrhizal（EM）fungal communities were examined along secondary succession in a Chinese subtropical forest

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Treatment Outcomes in COVID-19 Patients with Brucellosis:Case Series in Heilongjiang and Systematic Review of Literature

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Biomedical and Environmental Sciences 2023年第10期36卷 930-939页

作者： YANG Man Li WANG Jing Ya ZONG Xing Yu GUAN Li LI Hui Zhen XIONG Yi Bai LIU Yu Qin LI Ting JI Xin Yu SHANG Xi Yu ZHANG Hui Fang GUO Yang GONG Zhao Yuan ZHANG Lei TONG Lin CHEN Ren Bo FAN Yi Pin QIN Jin WANG Fang LIN Gang shi nan nan WANG Yan Ping MA Yan nanjing University of Chinese Medicine Nanjing 210023JiangsuChina Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Beijing University of Chinese Medicine Beijing 101121China

Objective Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated,we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after *** We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15,2020 to April29,***,epidemiological,clinical symptoms,radiological and laboratory data,treatment medicines and outcomes,and follow up were analyzed,and findings of a systematic review were *** A total of four COVID-19 with brucellosis patients were *** patient had active brucellosis before covid and 3 patients had nonactive brucellosis before *** median age was54.5 years,and all were males(100.0%).Two cases(50.0%)were moderate,and one was mild and asymptomatic,*** cases(75.0%)had at least one comorbidity(brucellosis excluded).All4 patients were found in COVID-19 nucleic acid *** C and D had only headache and fever on admission,*** cases were treated with Traditional Chinese medicine,western medicines for three cases,no adverse reaction occurred during *** patients were cured and ***,one case(25.0%)had still active brucellosis without re-positive COVID-19,and other three cases(75.0%)have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after *** the literature review,two similar cases have been reported in two case reports,and were both recovered,whereas,no data of follow up after *** These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after *** clinical studies should be conducted to confirm our findings.

关键词： COVID-19 Brucellosis Treatment outcomes Sequelae Relapse

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一种9-苯基芴位阻功能化的苯胺中间体的设计合成、表征及其光电性质

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光谱学与光谱分析 2016年第4期36卷 1085-1089页

作者：赵祥华黎小胜史南南杨性坤李小雨信阳师范学院化学化工学院河南信阳464000

以醋酸为溶剂、浓硫酸为催化剂在120℃回流24h,通过傅克反应设计合成了一种大体积位阻型9,9-二芳基芴中间体[9-（4-苯胺基）-9-苯基芴]（FPPhNH2）。通过核磁氢谱、质谱、红外等方法对该化合物的分子结构进行了详细表征。核磁氢谱和红... 详细信息

以醋酸为溶剂、浓硫酸为催化剂在120℃回流24h,通过傅克反应设计合成了一种大体积位阻型9,9-二芳基芴中间体[9-（4-苯胺基）-9-苯基芴]（FPPhNH2）。通过核磁氢谱、质谱、红外等方法对该化合物的分子结构进行了详细表征。核磁氢谱和红外光谱分别在6.55ppm,3 481和3 385cm-1显示该化合物的特征官能团-氨基。用紫外-可见光谱和荧光光谱对9-（4-苯胺基）-9-苯基芴的光学性质进行了表征和初步探讨。研究结果表明,具有大体积空间位阻效应的9-（4-苯胺基）-9-苯基芴在二氯甲烷溶液中有四个主要吸收峰,其吸收波长分别为243,257,298和311nm;在波长为308nm的谱激发下,得到发射波长为300～500nm的发射光谱曲线,其荧光光谱最大发射波长为328nm,且在405nm左右有一个细小的峰并有一个长的拖尾至500nm,这可能源于苯胺基团中分子间氢键所引起的。恰当的荧光发射范围（300～500nm）,使其能够和经典蓝光客体材料双（4,6-二氟基吡啶-N,C2）吡啶甲酰合铱（FIrpic）的吸收光谱有较大的重叠（300～500nm）。通过巧妙的分子裁剪,或可得性能优异的主体材料,进而使制备高性能的发光器件成为可能。为了进一步了解该化合物的光电性能,以乙腈为溶剂,以四丁基六氟磷酸胺为电解质,通过循环伏安法对该化合物的电化学性能进行了表征。其起始氧化电位和还原电位分别为0.898和-0.759V,HOMO和LUMO能级分别为-5.38和-3.72eV,其较高的HOMO能级和较低的LUMO能级有利于空穴和电子的注入/传输,这将进一步优化成性能优异的主体材料,并为进一步制备性能优异的有机半导体发光器件提供有益参考。

关键词： 9,9-二芳基芴苯胺位阻傅克反应前线分子轨道

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基于文献分析的细辛在清肺排毒汤中合理应用

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中国中药杂志 2020年第7期45卷 1515-1520页

作者：秦子楠王梦昕史楠楠王燕平翟华强北京中医药大学中药调剂标准化研究中心北京102488 中国中医科学院中医临床基础医学研究所北京100700

清肺排毒汤是国家卫生健康委员会、国家中医药管理局针对新型冠状病毒肺炎推荐临床使用的中药复方,临床疗效显著,由于受到"细辛不过钱"传统认识的影响,部分学者对清肺排毒汤中使用细辛6 g提出质疑。该文基于文献回顾,系统整理了古代经... 详细信息

清肺排毒汤是国家卫生健康委员会、国家中医药管理局针对新型冠状病毒肺炎推荐临床使用的中药复方,临床疗效显著,由于受到"细辛不过钱"传统认识的影响,部分学者对清肺排毒汤中使用细辛6 g提出质疑。该文基于文献回顾,系统整理了古代经典方剂和现代临床中细辛的应用情况和使用剂量,梳理和分析了古今医家对细辛毒性的认识,探讨清肺排毒汤应用细辛的合理性。结果发现:①历代本草文献对细辛的毒性记载并不相同,"细辛不过钱""细辛有毒"认识的形成曲折而又复杂,具有一定的片面性;②现代临床应用细辛的剂量并未拘泥于"细辛不过钱"传统认识,多数临床医师根据临床实际情况,合理增加了使用剂量后获得疗效,未发现不良反应;③结合《中华人民共和国执业医师法》《处方管理办法》等政策法规,在特殊情况下,可以根据实际情况需要酌情增减药物的使用剂量。因此,以临床"急用、实用、效用"为导向,细辛在清肺排毒汤中的使用安全、有效、合理。

关键词：新型冠状病毒肺炎新型冠状病毒清肺排毒汤细辛用量

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