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Effect of Health Education Based on Integrative Therapy of Chinese and Western Medicine for Adult Patients with Type 2 Diabetes Mellitus： A Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2018年第2期24卷 94-102页

作者： shi Mai LIU Zhao-lan ZHU Yan-bo XU mei-yan DUAN Xue-ying shi hui-mei JIANG Bo ZHANG Xiao-mei YU Xiao-han School of Management Beijing University of Chinese Medicine Beijing 100029 China Department of Clinical Nutrition China-Japan Friendship Hospital Beijing 100029China Centre for Evidence-Based Medicine Beijing University of Chinese Medicine Beijing 100029 China Department of Clinical Nutrition the Central Hospital of China Aerospace Corporation Beijing 100049 China Department of Clinical Nutrition. Yan-Hua Hosoital. Beiiina 100250 China

Objective： To investigate the effects of health education based on integrative therapy of Chinese and Western medicine for type 2 diabetes mellitus（T2DM） from the aspects of knowledge, attitude and practice（KAP）, health-related quality of life（HRQo L）, body mass index（BMI） and glucose control. Methods： Patients were individually randomized into intervention group（receiving integrative education, n=120） and control group（receiving usual education, n=120）. The primary outcome was the changes in glycosylated hemoglobin A1c（HbA1c） levels after 3, 6, 9 and 12 months from baseline. Hierarchical linear models（HLMs） were used to assess within-group changes in outcomes over time and between-group differences in patterns of change. Secondary outcomes were KAP scores, HRQo L scores and BMI after 6 and 12 months, paired-sample t test was used to assess within-group changes in outcomes in 6 and 12 months, independent-sample t test was used to assess between-group differences in patterns of change. Results： HbA1c decreased statistically from baseline to 3 months, from 3 to 6 months, from 6 to 9 months and from 9 to 12 months in the intervention group（all P〈0.01）; and decreased significantly from baseline to 3 months, and from 3 to 6 months in the control group（P〈0.01）. There were significant between-group differences from baseline to 3 months（P=0.044）, from 6 to 9 months（P〈0.01） and from 9 to 12 months（P〈0.01）. Significant improvements in the intervention group along with significant between-group differences were found in KAP and HRQo L scores respectively（all P〈0.05）. The number in the intervention group of normal weight increased from 56 at baseline to 81（6 months）, 94（12 months）, the number in the control group were 63（baseline）, 69（6 months）, 70（12 months）, the χ~2 of hierarchical analysis of BMI were 6.93（P=0.075）, 10.31（P=0.016）, 15.53（P〈0.01）, respectively. Conclusion： Health education based on integrative therapy of Chinese and Western medicine is beneficial to the contr

关键词： type 2 diabetes mellitus health education Chinese medicine glycosylated hemoglobin A1c health-related quality of life

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Protective effect of paeoniflorin on H_(2)O_(2) induced Schwann cells injury based on network pharmacology and experimental validation

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Chinese Journal of Natural Medicines 2021年第2期19卷 90-99页

作者： ZHANG Di YANG Bing CHANG shi-Quan MA Sheng-Suo SUN Jian-Xin YI Lin LI Xing shi hui-mei JING Bei ZHENG Ya-Chun ZHANG Chun-Lan CHEN Feng-Guo ZHAO Guo-Ping College of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China LiWan Hospital of Traditional Chinese Medicine Guangzhou 510665China

This study was to investigate the protective effect of paeoniflorin(PF)on hydrogen peroxide-induced ***,“SMILES”of PF was searched in Pubchem and further was used for reverse molecular docking in Swiss Target Prediction database to obtain potential ***-related molecules were obtained from GeenCards database,and the predicted targets of PF for injury treatment were selected by Wayne *** mechanism analysis,the protein-protein interactions were constructed by String,and the KEGG analysis was conducted in ***,cell viability and cytotoxicity assay were established by CCK8 ***,the experimental cells were allocated to control,model(200μmol·L^(−1) H_(2)O_(2)),SB20358010μmol·L^(−1)(200μmol·L^(−1) H_(2)O_(2)+SB20358010μmol·L^(−1)),PF 50μmol·L^(−1)(200μmol·L^(−1) H_(2)O_(2)+PF 50μmol·L^(−1)),and PF 100μmol·L^(−1)(200μmol·L^(−1) H_(2)O_(2)+PF 100μmol·L^(−1))*** measured the intracellular ROS,Hoechst 33258 staining,cell apoptosis,the levels of Bcl-xl,Bcl-2,Caspase-3,Cleaved-caspase3,Cleaved-caspase7,TRPA1,TRPV1,and the phosphorylation expression of *** are 96 potential targets that may be associated with PF for injury ***,we chose the“Inflammatory mediator regulation of TRP channels”pathway for the experimental verification from the first 10 KEGG *** experimental verification,H_(2)O_(2) decreased the cell viability moderately(P<0.05),and 100μmol·L^(−1) PF increased the cell viability significantly(P<0.05).Depending on the difference of intracellular ROS fluorescence intensity,PF inhibited H_(2)O_(2)-induced reactive oxygen species production in Schwann *** Hoechst 33258 staining,PF reversed the condensed chromatin and apoptotic nuclei following H_(2)O_(2) ***,Flow cytometry results showed that PF could substantially inhibit H_(2)O_(2) induced apoptosis(P<0.05).Pretreatment with PF obviously reduced the levels of Caspase3,Cleaved-caspase3,Cleaved-caspase7,TRPA1,TRPV1,and the pho

关键词： Paeoniflorin Hydrogen peroxide H_(2)O_(2) p38MAPK Schwann cells Network pharmacology

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融合全局和局部特征的下一个兴趣点推荐方法

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软件学报 2023年第2期34卷 786-801页

作者：石美惠申德荣寇月聂铁铮于戈东北大学计算机科学与工程学院辽宁沈阳110169

随着海量移动数据的积累,下一个兴趣点推荐已成为基于位置的社交网络中的一项重要任务.目前,主流方法倾向于从用户近期的签到序列中捕捉局部动态偏好,但忽略了历史移动数据蕴含的全局静态信息,从而阻碍了对用户偏好的进一步挖掘,影响了... 详细信息

随着海量移动数据的积累,下一个兴趣点推荐已成为基于位置的社交网络中的一项重要任务.目前,主流方法倾向于从用户近期的签到序列中捕捉局部动态偏好,但忽略了历史移动数据蕴含的全局静态信息,从而阻碍了对用户偏好的进一步挖掘,影响了推荐的准确性.为此,提出一种基于全局和局部特征融合的下一个兴趣点推荐方法.该方法利用签到序列中的顺序依赖和全局静态信息中用户与兴趣点之间、连续签到之间隐藏的关联关系建模用户移动行为.首先,引入两类全局静态信息,即User-POI关联路径和POI-POI关联路径,学习用户的全局静态偏好和连续签到之间的全局依赖关系.具体地,利用交互数据以及地理信息构建异构信息网络,设计关联关系表示学习方法,利用相关度引导的路径采样策略以及层级注意力机制获取全局静态特征.然后,基于两类全局静态特征更新签到序列中的兴趣点表示,并采用位置与时间间隔感知的自注意力机制来捕捉用户签到序列中签到之间的局部顺序依赖,进而评估用户访问兴趣点概率,实现下一个兴趣点推荐.最后,在两个真实数据集上进行了实验比较与分析,验证了所提方法能够有效提升下一个兴趣点推荐的准确性.此外,案例分析表明,建模显式路径有助于提供可解释的推荐结果.

关键词：兴趣点推荐注意力机制顺序依赖用户偏好可解释

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： hui-Feng Wang Wen-Jie shi Yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

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Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin shi Ziyang Guo Changhong Wang Mingze Gao Xiaoting Lin hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

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近10年成本-效用分析中EQ-5D与SF-6D应用现状的文献计量研究:基于PubMed数据库

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中国卫生经济 2014年第3期33卷 12-15页

作者：史会梅朱燕波北京中医药大学管理学院北京100029

目的:分析欧洲5维健康量表(EQ-5D)与6维健康调查短表(SF-6D)在成本-效用分析研究中的应用现状。方法:以PubMed数据库为数据源对2003—2012年发表的相关文献进行文献计量分析。结果:近10年应用EQ-5D与SF-6D进行成本-效用分析的文献量未... 详细信息

目的:分析欧洲5维健康量表(EQ-5D)与6维健康调查短表(SF-6D)在成本-效用分析研究中的应用现状。方法:以PubMed数据库为数据源对2003—2012年发表的相关文献进行文献计量分析。结果:近10年应用EQ-5D与SF-6D进行成本-效用分析的文献量未呈一定的增长趋势,主要的发表语言为英语,主要国家为英国。已形成6种核心期刊,核心作者尚未形成。文献所涉及的疾病分布广泛,且主要是运动系统和疼痛类疾病。效用绝大多数采用质量调整生命年表示,成本-效用分析的评价对象主要集中于药物、手术和健康干预3种。结论:应用EQ-5D与SF-6D进行成本-效用分析的文献及文献所研究内容分布范围均较广,虽然已经呈现出集中趋势,但未形成核心,有待于相关领域学者开展广泛的研究。

关键词： EQ-5D SF-6D 文献计量学成本-效用分析

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快速测定人血浆中洛匹那韦/利托那韦浓度的LC-MS/MS方法建立

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国际药学研究杂志 2016年第1期43卷 162-166页

作者：时美慧李俭甘慧郑颖孟志云窦桂芳军事医学科学院野战输血研究所北京100850

目的建立LC-MS/MS方法快速测定人血浆中洛匹那韦（lopinavir,LPV）/利托那韦（ritonavir,RTV）（克力芝）的含量。方法血浆样品采用蛋白沉淀法处理后,以甲醇-水（0.1%甲酸）为流动相进行梯度洗脱,流速为0.2 ml/min,色谱柱采用Thermo Hyp... 详细信息

目的建立LC-MS/MS方法快速测定人血浆中洛匹那韦（lopinavir,LPV）/利托那韦（ritonavir,RTV）（克力芝）的含量。方法血浆样品采用蛋白沉淀法处理后,以甲醇-水（0.1%甲酸）为流动相进行梯度洗脱,流速为0.2 ml/min,色谱柱采用Thermo Hypersil GOLD柱（2.1 mm×100 mm,5 mm）,柱温为25℃,采用ESI源以选择反应监测（SRM）方式进行正离子检测,用于定量分析的离子对为LPV（m/z 629.3→155.0）、RTV（m/z 721.3→268.0）,内标MS275（m/z 377.1→359.2）。结果两药在人血浆中浓度在20~1000 ng/ml时,线性关系良好（r〉0.994）。日内、日间精密度,低浓度〈20%,中高浓度〈15%,回收率为86.5%~96.3%。结论该检测方法简单、快速、灵敏、准确,适用于两药的临床血药浓度监测及其药物代谢动力学研究。

关键词：洛匹那韦利托那韦血药浓度监测液相色谱-质谱联用

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： Yi Li Bei-Qi Wang Xin-Yin Zhang shi-Jie Wang Cong-Yi Li hui-Long Yang Ran-Ran Su Tong Liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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