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Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies

Biomedical and Environmental Sciences 2019年第11期32卷 823-838页

作者： CHEN Da Wei shi ji kang LI Yun YANG Yu REN Shu Ping Department of Radiation Protection School of Public HealthJilin UniversityChangchun 130021JilinChina Department of Epidemiology and Statistics School of Public HealthJilin UniversityChangchun 130021JilinChina Department of Ophthalmology China-Japan Union HospitalJilin UniversityChangchun 130033JilinChina Function Experiment Center of College of Basic Medicine Jilin UniversityChangchun 130021JilinChina Department of Occupational and Environmental Health School of Public HealthJilin UniversityChangchun 130021JilinChina

Objective To identify the important risk factors for type 2 Diabetes Mellitus(T2 DM) and develop effective strategies to address the problem of T2 DM. Our study aimed to evaluate the association between apolipoprotein E(Apo E) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2 *** Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of Apo E polymorphism and T2 DM published in Pub Med, Web of Science,Medline, Wan Fang, VIP, and CNKI databases by R soft-ware(version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models *** We had 59 studies covering 6,872 cases with T2 DM and 8,250 controls, and compared the alleles and genotypes of Apo E between cases and controls. When we conducted a comparison between Apo E ε4 and ε3 alleles, we produced a pooled OR of 1.18(95% CI: 1.09-1.28;P < 0.001). Apo E ε2/ε2 genotype displayed a possible association with T2 DM(OR = 1.46;95% CI: 1.11-1.93;P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk(OR = 1.11;95% CI: 1.01-1.22;P = 0.039) and ε4/ε4 genotype had a1.71-fold risk of developing T2 DM(OR = 1.71;95% CI: 1.33-2.19;P < 0.001) when they were compared with ε3/ε3 *** There is an association between Apo E polymorphism and T2 DM: allele ε4 and genotypes(ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2 DM, and they may be risk factors for T2 DM.

关键词： Apolipoprotein E Polymorphism Type 2 diabetes Meta-analysis

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Incidence and Risk Factors of Progression from Prehypertension or Hypertension to Diabetes among Older Adults of Northeastern China: A Prospective Cohort Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1150-1155页

作者： LIANG Zhuo Shuai shi ji kang TIAN Yu Yang HU Xin Meng REN Ya Xuan LIU Sai Nan WANG Yu jian CHENG Yi LIU Ya Wen Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun 130021JilinChina Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130021JilinChina

Approximately two-thirds of patients with type 2 diabetes have hypertension. Moreover, blood pressure(BP) increases with hyperglycemia progression. The nexus between prehypertension or hypertension and diabetes entails pathophysiological mechanisms, such as the involvement of the nitricoxide pathway in insulin resistance and the contribution of hyperinsulinemia to sympathetic activity, sodium-fluid retention.

关键词： hypertension involvement diabetes

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基于Anylogic仿真模拟的高密度传统街区应急疏散研究——以天津小白楼五号地为例

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南方建筑 2019年第3期 82-88页

作者：左进史吉康天津大学建筑学院

快速城镇化使我国许多城市已相继进入增存并行发展的时代,城市中心区往往呈现高密度、高强度、高复杂性的特点,面临着更加严峻的安全问题。城市更新成为高密度城区增强防灾避难能力、提升应急疏散效率的重要方式。选取天津小白楼五号地... 详细信息

快速城镇化使我国许多城市已相继进入增存并行发展的时代,城市中心区往往呈现高密度、高强度、高复杂性的特点,面临着更加严峻的安全问题。城市更新成为高密度城区增强防灾避难能力、提升应急疏散效率的重要方式。选取天津小白楼五号地传统街区为研究对象,深入调研与分析其建筑布局、公共空间、人群特征等作为模拟的基础数据,运用Anylogic软件对小白楼五号地街区更新规划初步方案进行疏散仿真模拟,剖析在面对震灾等突发灾害时人群疏散面临的核心问题,进而综合房屋产权、建筑保护价值等影响因素开展街区更新的可行性评估,将可行性评估与仿真模拟结果相叠加确定目标更新优化区域,提出更新优化策略并进行模拟验证,以探索在城市更新中提升高密度传统街区应急疏散能力的有效途径。

关键词：城市更新高密度传统街区应急疏散 Anylogic

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软锰矿协同电解活性染料模拟废水的机理研究

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四川大学学报（工程科学版） 2004年第3期36卷 52-55页

作者：师吉辉曾抗美郭梅林青龙四川大学建筑与环境学院四川成都610065

染料废水是一类高色度、高COD的废水,对环境的危害很大,一直是公认的难处理的废水之一。作者以添加软锰矿粉于活性嫩黄K-4G模拟废水中再进行电解,研究水样色度和COD(Cr)降低率的各种影响因素及其电化学机理。结果显示,适宜的处理条件为... 详细信息

染料废水是一类高色度、高COD的废水,对环境的危害很大,一直是公认的难处理的废水之一。作者以添加软锰矿粉于活性嫩黄K-4G模拟废水中再进行电解,研究水样色度和COD(Cr)降低率的各种影响因素及其电化学机理。结果显示,适宜的处理条件为:粒度<0.1mm的软锰矿粉6g/L,pH≤7,浓度150～1200mg/L,电流密度1～3mA/cm2,电解时间≤30min;脱色率和COD(Cr)降低率分别为77%和16%;该过程使K-4G分子内生色基团氧化和弱键断裂,可能生成苯磺酸钠等高水溶性物质。

关键词：活性染料模拟废水电解软锰矿

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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35kV及以下XLPE电力电缆试验方法的研究

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电网技术 2000年第12期24卷 58-61页

作者：罗俊华马翠姣邱毓昌金祎陈守直史济康西安交通大学电气工程学院陕西省西安市710049 上海市东供电局上海200122

通过对交链聚乙烯 (XL PE)电力电缆试品的工频、0 .1Hz超低频和振荡波 3种击穿电压的平行比对试验研究 ,探讨能够有效发现、判别 XL PE电力电缆运行故障隐患的试验方法。试验研究结果表明 :振荡波电压试验能够有效地发现电力电缆及其附... 详细信息

通过对交链聚乙烯 (XL PE)电力电缆试品的工频、0 .1Hz超低频和振荡波 3种击穿电压的平行比对试验研究 ,探讨能够有效发现、判别 XL PE电力电缆运行故障隐患的试验方法。试验研究结果表明 :振荡波电压试验能够有效地发现电力电缆及其附件的制造和安装质量缺陷 ;超低频电压试验能够有效地发现电力电缆及其附件绝缘树枝状早期劣化缺陷 ;工频电压试验是一种较好的方法 ,需进一步深入研究。

关键词： XLPE电力电缆绝缘介质耐压试验

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一种新的交联聚乙烯(XLPE)电缆含水量评估方法

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华东电力 2013年第6期41卷 1283-1286页

作者：史济康胡为进崔浩华嘉成黄建涛艾芊上海电力公司奉贤供电公司上海201400 上海交通大学电子信息与电气工程学院上海200240

35 kV及以下交联聚乙烯电缆在运行过程中,由于运行环境的影响,主绝缘容易受潮。如果利用受潮的运行电缆做中间接头,会降低电缆中间接头的质量,缩短运行寿命。选取不同截面、不同电压等级的5种交联聚乙烯电缆作为研究对象,研究受潮的旧... 详细信息

35 kV及以下交联聚乙烯电缆在运行过程中,由于运行环境的影响,主绝缘容易受潮。如果利用受潮的运行电缆做中间接头,会降低电缆中间接头的质量,缩短运行寿命。选取不同截面、不同电压等级的5种交联聚乙烯电缆作为研究对象,研究受潮的旧电缆主绝缘层在加热去潮不同时间后电导率的变化,并与新电缆电导率相比较,得出可以用电导率作为XLPE电缆的含水量标准,得到XLPE电缆在受潮以后可以通过加热的方式去潮,恢复电缆的绝缘水平的结论,并给出5种电缆加热去潮至新电缆水平所需要的时间。

关键词：交联聚乙烯电缆电缆含水量加热去潮技术电导率

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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit

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World Journal of Clinical Cases 2025年第7期13卷 28-38页

作者： Mai-Qing shi Jun Chen Fu-Hai ji Hao Zhou Ke Peng Jun Wang Chun-Lei Fan Xu Wang Yang Wang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Intensive Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains *** To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic *** In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were *** were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with ***,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of ***,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the *** is highly recommended that hypernatremia be

关键词： Hypernatremia Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation Immunosuppression Catabolism syndrome Chronic critical illness Prognosis

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Thermodynamics of Ordering-Disordering Transformation in Cu-Zn Alloy System

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Journal of Materials Science & Technology 1999年第5期15卷 478-479页

作者： Wang, LD Chen, CG shi, YM kang, MK ji, BJ Northwestern Polytech Univ Xian 710072 Peoples R China Xian Inst Precis Mech Xian 710075 Peoples R China

The alpha and beta phases in Cu-Zn alloy system were regarded as regular solutions at elevated temperature, the results calculated from the experimental data have showed that the value of the interaction parameter of components Cu and Zn in the alpha phase E-CuZn(alpha) varied obviously with decreasing component Zn. Substituting the function relation between E-CaZn(alpha) and X-Zn obtained through curve-fitting into expression of free-energy variation of the system, the calculated martensitic transformation temperature M-s was in good agreement with experimental curve, so as to have more comprehensive information for fully making use of binary Cu-base functional materials.

关键词： Zn Thermodynamics of Ordering-Disordering Transformation in Cu-Zn Alloy System Cu

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Effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization in high myopia mice

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1034-1040页

作者： Yan-Yan ji shi-Xi Zhang Ye kang Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Eye Hospital Tianjin 300020China Liaocheng Aier Eye Hospital Liaocheng 252100Shandong ProvinceChina Dezhou Aier Eye Hospital Dezhou 253000Shandong ProvinceChina YanTai Aier Eye Hospital Yantai 264000Shandong ProvinceChina

AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia ***:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm *** changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was ***:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.

关键词： high myopia choroidal neovascularization low concentration atropine eye drops dopamine D1 receptor dopamine D2 receptor

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