Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies

作     者：CHEN Da Wei SHI Ji Kang LI Yun YANG Yu REN Shu Ping 

作者机构：Department of Radiation ProtectionSchool of Public HealthJilin UniversityChangchun 130021JilinChina Department of Epidemiology and StatisticsSchool of Public HealthJilin UniversityChangchun 130021JilinChina Department of OphthalmologyChina-Japan Union HospitalJilin UniversityChangchun 130033JilinChina Function Experiment Center of College of Basic MedicineJilin UniversityChangchun 130021JilinChina Department of Occupational and Environmental HealthSchool of Public HealthJilin UniversityChangchun 130021JilinChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2019年第32卷第11期

页      面：823-838页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Jipa Ruida Environmental Inspection Corporation Limited,Beijing under Grant Radioactive Diagnosis and Treatment Construction Project-Radiation Protection and Evaluation [Grant No.2016YX137] Jilin Province Pharmacy Operation Corporation,Limited [Grant No.371182093427] 

主　　题：Apolipoprotein E Polymorphism Type 2 diabetes Meta-analysis 

摘      要：Objective To identify the important risk factors for type 2 Diabetes Mellitus(T2 DM) and develop effective strategies to address the problem of T2 DM. Our study aimed to evaluate the association between apolipoprotein E(Apo E) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2 *** Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of Apo E polymorphism and T2 DM published in Pub Med, Web of Science,Medline, Wan Fang, VIP, and CNKI databases by R soft-ware(version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models *** We had 59 studies covering 6,872 cases with T2 DM and 8,250 controls, and compared the alleles and genotypes of Apo E between cases and controls. When we conducted a comparison between Apo E ε4 and ε3 alleles, we produced a pooled OR of 1.18(95% CI: 1.09-1.28;P 0.001). Apo E ε2/ε2 genotype displayed a possible association with T2 DM(OR = 1.46;95% CI: 1.11-1.93;P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk(OR = 1.11;95% CI: 1.01-1.22;P = 0.039) and ε4/ε4 genotype had a1.71-fold risk of developing T2 DM(OR = 1.71;95% CI: 1.33-2.19;P 0.001) when they were compared with ε3/ε3 *** There is an association between Apo E polymorphism and T2 DM: allele ε4 and genotypes(ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2 DM, and they may be risk factors for T2 DM.